Giant peritoneal cyst hydatid and albendazole-induced aplastic anemia in noncirrhotic portal hypertensive patient

Yıl 2012, Cilt: 11 Sayı: 1, 32 - 34, 01.04.2012

Ahmet Uyanıkoğlu Filiz Akyüz Fatih Ermiş Fatih Beşışık Atilla Ökten

Öz

Albendazole has broad-spectrum coverage as an antiparasitic drug, and the reported side effects have been minimal. We report the case of a patient with febrile neutropenia beginning during the second week of therapy for a hepatic, splenic and peritoneal echinococcal cyst. This case was a 49-year-old man who presented with a large cystic abdominal mass. His medical history was significant for non-cirrhotic portal hypertension and recurrent cholangitis. Albendazole sulfoxide peak dose and half-life are significantly prolonged by liver disease and concomitant administration of certain drugs. The severity and duration of albendazole-induced neutropenia in this case was likely related to the underlying liver disease. Frequent serial monitoring of blood counts and cessation of medication with any evidence of marrow toxicity in such patients are warranted.

Anahtar Kelimeler

Cyst hydatid, albendazole

Nonsirotik portal hipertansiyonlu hastada dev peritoneal kist hidatik ve albendazole bağlı aplastik anemi

Öz

Albendazol geniş spektrumlu antiparazitik bir ilaçtır. Yan etkilerinin minimal olduğu bildirilmiştir. Hepatik, splenik ve peritoneal ekinokokkal kist nedeniyle albendazol başlanan, ikinci haftada febril nötropeni gelişen bir vaka sunulmuştur. 49 yaşında erkek hasta karında büyük kistik kitleleri nedeniyle müracaat etti. Hastanın hikayesinde nonsirotik portal hipertansiyon ve tekrarlayan kolanjit atakları dikkat çekmekte idi. Albendazol sulfoksit peak dozu ve yarılanma ömrü karaciğer hastalıklarında ve başka ilaçlar kullanıldığında artmaktadır. Bu vakada ciddi nötropeni gelişmiş olmasının altta yatan karaciğer hastalığına bağlı olduğu düşünülmüştür. Albendazol başlanacak bu tür hastalar kemik iliği toksisitesi yönünden sık kan sayımları ile yakından takip edilmeli, verilecek diğer ilaçlara dikkat edilmelidir.

Anahtar Kelimeler

Kist hidatik, albendazol

Kaynakça

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