Ornidazole-induced liver toxicity: Report of two cases

Year 2011, Volume: 10 Issue: 3, 122 - 124, 01.12.2011

Tolga Köşeci Ümit Karabulut Bünyamin Sarıtaş Serkan Yaraş Fehmi Ateş Engin Altintaş Orhan Sezgin Orhan Sezgin

Abstract

Ornidazole is one of the nitroimidazole-derivative antibiotics and is often used in daily practice. Hepatotoxicity caused by ornidazole is rare, but when it occurs, it can have serious results. Acute liver injury is the most common type of drug-induced hepatitis and accounts for 10% of acute hepatitis. Here, we report two cases of drug-induced hepatitis caused by ornidazole.

Keywords

Ornidazole, toxic hepatitis

Ornidazol’e bağlı karaciğer toksisitesi: İki olgu sunumu

Abstract

Ornidazol günlük uygulamalarda sık kullanılan, nitroimidazol türevi antibiyotiklerdendir. Ornidazole bağlı toksik hepatit nadir olarak görülmekte olup fakat ciddi sonuçları olabilen bir durumdur. Akut karaciğer hasarı ilaca bağlı karaciğer hasarının en sık görülen biçimidir ve akut hepatitilerin %10'luk kısmını oluşturur. Kliniğimizde ornidazol kullanımına ikincil toksik hepatit tanısı koyduğumuz iki olguyu sunuyoruz.

Keywords

Ornidazol, toksik hepatit

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