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Kemik iliği biyopsisiyle tanı konulan bir intestinal tüberküloz vakası

Year 2011, Volume: 10 Issue: 1, 32 - 36, 01.04.2011

Abstract

İntestinal tüberküloz gelişmekte olan ülkelerde halen görülmekte olan ve vakaların yaklaşık 1/3'ünde pulmoner tüberkülozun eşlik ettiği bir hastalıktır. Özellikle pulmoner tüberkülozu olmayan vakalarda tanı koymak güçtür. Spesifik olmayan semptomatolojisi, Crohn hastalığıyla karışabilen yönleri ve tanı; koymaya yönelik testlerin farklı sensitivite ve spesifiteleri nedenleriyle tanı öncelikle bu hastalıktan şüphelenmek ve multiple diagnostik metodları bir arada kullanarak konulabilir. Burada sunduğumuz 30 yaşında diare, karın ağrısı, kilo kaybı şikayetleri ile başvuran anemi, hipoalbüminemisi saptanan ve kolonoskopik incelemede ileoçakal valv ve ileum ülserleri bulunan bayan hastada öncelikle Crohn hastalığı düşünülerek tedavi verilmiş ancak klinik yanıtsızlık nedeniyle yapılan uzun araştırmalar sonunda intestinal tüberküloz tanısı konulabilmiştir.

References

  • Khan R, Abid S, Jafri W, et al. Diagnostic dilemma of abdominal tuberculosis in non – HIV patients: an ongoing challenge for physicians. World J Gastroenterol 2006; 12: 6371-5.
  • Almadi MA, Ghosh S, Aljebreen AM. Differentiating intestinal tuberculosis from Crohn's disease: a diagnostic challenge. Am J Gastroenterol 2009; 104: 1003-12.
  • Leung VK, Law ST, Lam CW, et al. Intestinal tuberculosis in a regional hospital in Hong Kong: a 10 year experience. Hong Kong Med J 2006; 12: 264-71.
  • Sanai FM, Bzeizi KI. Systematic review: tuberculous peritonitis presenting features, diagnostic strategies and treatment. Aliment Pharmacol Ther 2005; 22: 685-700.
  • Bolukbas C, Bolukbas FF, Kendir T, et al. Clinical presentation of abdominal tuberculosis in HIV seronegative adults. BMC Gastroenterol 2005; 5: 21.
  • Demir K, Ökten A, Kaymako¤lu S, et al. Tuberculous peritonitis-reports of 26 cases, detailing diagnostic and therapeutic problems. Eur J Gastroenterol Hepatol 2001; 13: 581-5.
  • Zhou ZY, Luo HS. Differential diagnosis between Crohn’s disease and intestinal tuberculosis in China. Int J Clin Pract 2006; 60: 2124.
  • Pulimood AB, Peter S, Ramakrishna B, et al. Segmental colonoscopic biopsies in the differentiation of ileocolic tuberculosis from Crohn's disease. J Gastroenterol Hepatol 2005; 20: 688-96.
  • Yönal O, Hamzao¤lu HO. What is the most accurate method for the diagnosis of intestinal tuberculosis? Turk J Gastroenterol 2010; 21: 91-6.
  • de la Hoz RE, Stephens G, Sherlock C. Diagnosis and treatment approaches of CMV infections in adult patients. J Clin Virol 2002; 25 (Suppl 2): S1-12.
  • Domenech E, Vega R, Ojanguren I, et al. Cytomegalovirus infection in ulcerative colitis: a prospective, comparative study on prevalence and diagnostic strategy. Inflamm Bowel Dis 2008; 14: 13739.
  • Matsuoka K, Iwao Y, Mori T, et al. Cytomegalovirus is frequently reactivated and disappears without antiviral agents in ulcerative colitis patients. Am J Gastroenterol. 2007; 102: 331-7.
  • Riquelme A, Calvo M, Salech F, et al. Value of adenosine deaminase (ADA) in ascitic fluid for the diagnosis of tubercular peritonitis: a meta-analysis. J Clin Gastroenterol 2006; 40: 705-10.
  • Kim SG, Kim JS, Jung HC, Song IS. Is a 9-month treatment sufficient in tuberculous enterocolitis? A prospective, randomized, single-centre study. Aliment Pharmacol Ther 2003; 18: 85-91.
  • Chou CH, Ho MW, Ho CM, et al. Abdominal tuberculosis in adult: 10-year experience in a teaching hospital in central Taiwan. J Microbiol Immunol Infect 2010; 43: 395-400.

An intestinal tuberculosis case diagnosed by bone marrow biopsy

Year 2011, Volume: 10 Issue: 1, 32 - 36, 01.04.2011

Abstract

Intestinal tuberculosis is still seen in developing countries, and approximately one-third of the cases are accompanied by pulmonary tuberculosis. Because of the non-specific symptomatology, similar findings to Crohn's disease and different sensitivity and specificity rates of diagnostic tests, a high index of suspicion and combination of multiple diagnostic modalities are required to diagnose intestinal tuberculosis. A 30-year-old woman was admitted to our hospital with a two-year history of diarrhea, abdominal pain and weight loss. Laboratory tests showed anemia and hypoalbuminemia, and ulcers were found in the ileum and ileocecal valve on colonoscopic examination. Crohn's disease was diagnosed, but there was no clinical remission with mesalazine and steroid treatment. Intestinal tuberculosis was diagnosed after an extended work-up period.

References

  • Khan R, Abid S, Jafri W, et al. Diagnostic dilemma of abdominal tuberculosis in non – HIV patients: an ongoing challenge for physicians. World J Gastroenterol 2006; 12: 6371-5.
  • Almadi MA, Ghosh S, Aljebreen AM. Differentiating intestinal tuberculosis from Crohn's disease: a diagnostic challenge. Am J Gastroenterol 2009; 104: 1003-12.
  • Leung VK, Law ST, Lam CW, et al. Intestinal tuberculosis in a regional hospital in Hong Kong: a 10 year experience. Hong Kong Med J 2006; 12: 264-71.
  • Sanai FM, Bzeizi KI. Systematic review: tuberculous peritonitis presenting features, diagnostic strategies and treatment. Aliment Pharmacol Ther 2005; 22: 685-700.
  • Bolukbas C, Bolukbas FF, Kendir T, et al. Clinical presentation of abdominal tuberculosis in HIV seronegative adults. BMC Gastroenterol 2005; 5: 21.
  • Demir K, Ökten A, Kaymako¤lu S, et al. Tuberculous peritonitis-reports of 26 cases, detailing diagnostic and therapeutic problems. Eur J Gastroenterol Hepatol 2001; 13: 581-5.
  • Zhou ZY, Luo HS. Differential diagnosis between Crohn’s disease and intestinal tuberculosis in China. Int J Clin Pract 2006; 60: 2124.
  • Pulimood AB, Peter S, Ramakrishna B, et al. Segmental colonoscopic biopsies in the differentiation of ileocolic tuberculosis from Crohn's disease. J Gastroenterol Hepatol 2005; 20: 688-96.
  • Yönal O, Hamzao¤lu HO. What is the most accurate method for the diagnosis of intestinal tuberculosis? Turk J Gastroenterol 2010; 21: 91-6.
  • de la Hoz RE, Stephens G, Sherlock C. Diagnosis and treatment approaches of CMV infections in adult patients. J Clin Virol 2002; 25 (Suppl 2): S1-12.
  • Domenech E, Vega R, Ojanguren I, et al. Cytomegalovirus infection in ulcerative colitis: a prospective, comparative study on prevalence and diagnostic strategy. Inflamm Bowel Dis 2008; 14: 13739.
  • Matsuoka K, Iwao Y, Mori T, et al. Cytomegalovirus is frequently reactivated and disappears without antiviral agents in ulcerative colitis patients. Am J Gastroenterol. 2007; 102: 331-7.
  • Riquelme A, Calvo M, Salech F, et al. Value of adenosine deaminase (ADA) in ascitic fluid for the diagnosis of tubercular peritonitis: a meta-analysis. J Clin Gastroenterol 2006; 40: 705-10.
  • Kim SG, Kim JS, Jung HC, Song IS. Is a 9-month treatment sufficient in tuberculous enterocolitis? A prospective, randomized, single-centre study. Aliment Pharmacol Ther 2003; 18: 85-91.
  • Chou CH, Ho MW, Ho CM, et al. Abdominal tuberculosis in adult: 10-year experience in a teaching hospital in central Taiwan. J Microbiol Immunol Infect 2010; 43: 395-400.
There are 15 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Meltem Ergün This is me

Gülden Aydoğ This is me

Metin Başaranoğlu This is me

Aysel Ülker This is me

Bilge Tunç This is me

Sarper Ökten This is me

Nurgül Şaşmaz This is me

Publication Date April 1, 2011
Published in Issue Year 2011 Volume: 10 Issue: 1

Cite

APA Ergün, M., Aydoğ, G., Başaranoğlu, M., Ülker, A., et al. (2011). Kemik iliği biyopsisiyle tanı konulan bir intestinal tüberküloz vakası. Akademik Gastroenteroloji Dergisi, 10(1), 32-36.

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