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The rate of hepatitis B virus exposure in subjects with chronic hepatitis C infection in Şanlıurfa

Year 2007, Volume: 6 Issue: 1, 10 - 13, 01.04.2007

Abstract

We aimed to investigate the rate of hepatitis B virus exposure in subjects with chronic hepatitis C infection who were immunocompetent and not treated with antiviral agent. Materials and methods: Twenty-two patients with chronic hepatitis C (9 female, 13 male, mean age: 52±9.7) were enrolled into this study. Hepatitis B profile was investigated by EIA and hepatitis C virus RNA and hepatitis B virus DNA by real time PCR. Results: AntiHBc antibody positivity, which suggested exposure to hepatitis B virus, was 68.2% in chronic hepatitis C patients. Four patients (18.2%) in the study group were seronegative and 3 patients (13.6%) were vaccinated against hepatitis B virus infection. Only 2 (9.1%) of 22 patients were HBsAg positive, and taking into account hepatitis B virus DNA positivity, 3 patients (20%) had replicative hepatitis B virus infection of 15 patients who were exposed to hepatitis B virus. Conclusions: According to our results, the rate of hepatitis B virus exposure and permanency of hepatitis B virus infection are higher in chronic hepatitis C patients than in the general population. Especially in regions endemic for hepatitis B virus, the occult hepatitis B virus infection, which can increase the severity or deteriorate the prognosis of the disease, should be investigated by sensitive PCR technique in patients with chronic hepatitis C virus infection.

References

  • Kao JH, and Chen DS. Overview of hepatitis B and C viruses. In: Goedert JJ, Editor. Infectious causes of cancer: targets for interven- tion. Totowa, NJ. Humana Press Inc 2000; 313-30.
  • Liaw YF. Role of hepatitis C virus in dual and triple hepatitis virus infection. Hepatology 1995; 22: 1101-8.
  • Crespo J, Lozano JL, de la Cruz F, et al. Prevalence and significan- ce of hepatitis C viremia in chronic active hepatitis B. Am J Gastroenterol 1994; 89: 1147-51.
  • Rodriguez M, Navascues CA, Martinez A, et al. Prevalence of anti- body to hepatitis C virus in chronic HBsAg carriers. Arch Virol Suppl 1992; 4: 327-8.
  • Ishikawa T, Ichida T, Yamagiwa S, et al. High viral loads, serum alanine aminotransferase and gender are predictive factors for the development of hepatocellular carcinoma from viral compensated liver cirrhosis. J Gastroenterol Hepatol 2001; 16: 1274-81.
  • Chiaramonte M, Stroffolini T, Vian A, et al. Rate of incidence of he- patocellular carcinoma in patients with compensated viral cirrho- sis. Cancer 1999; 85: 2132-7.
  • Sagnelli E, Coppola N, Scolastico C, et al. HCV genotype and "si- lent" HBV coinfection: two main risk factors for a more severe liver disease. J Med Virol 2001; 64: 350-5.
  • Lee DS, Huh K, Lee EH, et al. HCV and HBV coexist in HBsAg.ne- gative patients with HCV viraemia: possibility of coinfection in these patients must be considered in HBV high endemic area. J Gastroenterol Hepatol 1997; 12: 855-61.
  • Colombari R, Dhillon AP, Piazzola E, et al. Chronic hepatitis in multiple virus infection: histopathological evaluation Histopatho- logy 1993; 22: 319-25.
  • Shiratori Y, Shiina S, Zhang PY, et al. Does dual infection by hepa- titis B and C viruses play an important role in the pathogenesis of hepatocellular carcinoma in Japan? Cancer 1997; 80: 2060-7.
  • Ruiz J, Sangro B, Cuende JI, et al. Hepatitis B and C viral infecti- ons in patients with hepatocellular carcinoma. Hepatology 1992; 16: 637-41.
  • Kao JH, Chen PJ, Lai MY, et al. Occult hepatitis B virus infection and clinical outcomes of patients with chronic hepatitis C. J Clin Microbiol 2002; 40: 4068-71.
  • Cacciola I, Pollicino T, Squadrito G, et al. Occult hepatitis B virus infection in patients with chronic hepatitis C liver disease. N Engl J Med 1999; 341: 22-6.
  • Sheu JC, Huang GT, Shih LN, et al. Hepatitis C and B viruses in he- patitis B surface antigen.negative hepatocellular carcinoma. Gastroenterology 1992; 103: 1322-7.
  • Yotsuyanagi H, Shintani Y, Moriya K, et al. Virologic analysis of non.B, non.C hepatocellular carcinoma in Japan: frequent involve- ment of hepatitis B virus. J Infect Dis 2000; 181: 1920-8.
  • Fukuda R, Ishimura N, Niigaki M, et al. Serologically silent hepati- tis B virus coinfection in patients with hepatitis C virus associated chronic liver disease: clinical and virological significance. J Med Virol 1999; 58: 201-7.
  • Zignego AL, Fontana R, Puliti S, et al. Relevance of inapparent co- infection by hepatitis B virus in alpha interferon treated patients with hepatitis C virus chronic hepatitis. J Med Virol 1997; 51: 313- 8.
  • Hu KQ. Occult hepatitis B virus infection and its clinical implicati- ons. J Viral Hepat 2002; 9: 243-57.
  • Brechot C, Thiers V, Kremsdorf D, et al. Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen: clinically significant or purely "occult"? Hepatology 2001; 34: 194-203.
  • Fan CL, Wei L, Jiang D, et al. Spontaneous viral clearance after 6.21 years of hepatitis B and C viruses coinfection in high HBV en- demic area. World J Gastroenterol 2003; 9: 2012-6.
  • Liaw YF, Tsai SL, Chang JJ, et al. Displacement of hepatitis B virus by hepatitis C virus as the cause of continuing chronic hepatitis. Gastroenterology 1994; 106: 1048-53.
  • Crespo J, Lozano JL, Carte B, et al. Viral replication in patients with concomitant hepatitis B and C virus infections. Eur J Clin Microbiol Infect Dis 1997; 16: 445-51.
  • Pontisso P, Gerotto M, Ruvoletto MG, et al. Hepatitis C genotypes in patients with dual hepatitis B and C virus infection. J Med Virol 1996; 48: 157-60.
  • Pontisso P, Ruvoletto MG, Fattovich G, et al. Clinical and virologi- cal profiles in patients with multiple hepatitis virus infections. Gastroenterology 1993; 105: 1529-33.
  • Boom R, Sol CJ, Salimans MM, Jansen CL, et al. Rapid and simple method for purification of nucleic acids. J Clin Microbiol 1990; 28: 495-503.
  • Boom R, Sol CJ, Heijtink R, et al. Rapid purification of hepatitis B virus DNA from serum. J Clin Microbiol 1991; 29: 1804-11.
  • Weinberger KM, Bauer T, Bohm S, et al. High genetic variability of the group-specific a-determinant of hepatitis B virus surface antigen (HBsAg) and the corresponding fragment of the viral polymerase in chronic virus carriers lacking detectable HBsAg in serum. J Gen Virol 2000; 81: 1165-74.
  • Conjeevaram HS, Lok AS. Occult hepatitis B virus infection: a hid- den menace? Hepatology 2001; 34: 204-6.
  • Chan HL, Tsang SW, Leung NW, et al. Occult HBV infection in cryptogenic liver cirrhosis in an area with high prevalence of HBV infection. Am J Gastroenterol 2002; 97: 1211-5.
  • Uchida T, Kaneita Y, Gotoh K, et al. Hepatitis C virus is frequently coinfected with serum marker negative hepatitis B virus: probable replication promotion of the former by the latter as demonstrated by in vitro cotransfection. J Med Virol 1997; 52: 399-405.
  • Besisik F, Karaca C, Akyuz F, et al. Occult HBV infection and YMDD variants in hemodialysis patients with chronic HCV infecti- on. J Hepatol 2003; 38: 506-10.
  • Kao JH, Chen PJ, Lai MY, et al. GB virus-C/hepatitis G virus infec- tion in an area endemic for viral hepatitis, chronic liver disease, and liver cancer. Gastroenterology 1997; 112: 1265-70.
  • Michalak TI, Pardoe IU, Coffin CS, et al. Occult lifelong persisten- ce of infectious hepadnavirus and residual liver inflammation in wo- odchucks convalescent from acute viral hepatitis. Hepatology 1999; 29: 928-38.
  • Değertekin H. Türkiye’de HBV epidemiyoloji ve bulaşım yolları. In: Çakaloğlu Y, Ökten A, Editors. Hepatit B ulusal uzlaşma toplantı me- tinleri. 1. baskı. İstanbul. İstanbul Medikal Yayıncılık 2003; 99-109.
  • Taşyaran MA. HBV enfeksiyonu epidemiyolojisi. In: Tekeli E, Balık İ, Editors. Viral Hepatit 2003. 1. baskı. Ankara. Viral Hepatit Savaşım Derneği 2003; 121-8.
  • Değertekin H. Türkiye’de kronik viral hepatitlerin seroprevalansı (1980-2003). III. Doğu-Güneydoğu Anadolu Hepato-Gastroentero- loji Sempozyumu, Erzurum 2003; 38-44.

Şanlıurfa'da kronik C hepatitinde hepatit B virüs enfeksiyonu ile karşılaşma sıklığı

Year 2007, Volume: 6 Issue: 1, 10 - 13, 01.04.2007

Abstract

İmmunsuprese kronik hepatit C'lilerde artmış okkült HBV enfeksiyon bildirimleri mevcuttur. Bu çalışmada, immunsuprese olmayan ve antiviral tedavi başlanmamış kronik hepatit C'lilerde hepatit B virüsü ile karşılaşma sıklığı araştırıldı. Gereç ve yöntem: Hepatit C virüs antikoru ve hepatit C virüs RNA pozitifliği ile kronik hepatit C tanı sı almış 22 olgu (9 kadın/13 erkek, yaş ortalaması: 52±9.7 yıl) bu çalı şmaya alındı. Tüm olgularda hepatit profili mikropartikül enzim immun assay, hepatit B virüs DNA'sı ve hepatit C virüs RNA'sı ise real-time polymerase chain reaksiyonu yöntemiyle bakıldı. Bulgular: Hepatit C virüsüne bağlı kronik hepatitlilerin %68.2'sinin anti-HBc antikor pozitifliği ile hepatit B virüs enfeksiyonu ile karşılaştığı, %31.8'inin ise hepatit B virüsü ile karşılaşmamış olduğu saptandı. Hepatit C virüsüne bağlı kronik hepatitli 22 olgudan sadece 2 olguda (%9.1) hepatit B yüzey antijenin pozitif olduğu ve buna göre hepatit B virüs ile karşılaşmış olan 15 olgunun 3'ünde (%20) hepatit B virüs DNA'sının pozitifliği ile birlikte hepatit B virüsünün kalıcılığı belirlendi. Sonuç: Bizim sonuçlarımıza göre, kronik C hepatitlilerde hepatit B virüsü ile karşılaşma sık ve enfeksiyon kalıcılığı genel populasyondan daha yüksektir. Hastalığın ciddiyeti ve prognozuna katkısı olabileceğinden, özellikle de hepatit B açısından endemik bölgelerde sensitif yöntemler ile okkült hepatit B virüs enfeksiyonu araştırılmalıdır.

References

  • Kao JH, and Chen DS. Overview of hepatitis B and C viruses. In: Goedert JJ, Editor. Infectious causes of cancer: targets for interven- tion. Totowa, NJ. Humana Press Inc 2000; 313-30.
  • Liaw YF. Role of hepatitis C virus in dual and triple hepatitis virus infection. Hepatology 1995; 22: 1101-8.
  • Crespo J, Lozano JL, de la Cruz F, et al. Prevalence and significan- ce of hepatitis C viremia in chronic active hepatitis B. Am J Gastroenterol 1994; 89: 1147-51.
  • Rodriguez M, Navascues CA, Martinez A, et al. Prevalence of anti- body to hepatitis C virus in chronic HBsAg carriers. Arch Virol Suppl 1992; 4: 327-8.
  • Ishikawa T, Ichida T, Yamagiwa S, et al. High viral loads, serum alanine aminotransferase and gender are predictive factors for the development of hepatocellular carcinoma from viral compensated liver cirrhosis. J Gastroenterol Hepatol 2001; 16: 1274-81.
  • Chiaramonte M, Stroffolini T, Vian A, et al. Rate of incidence of he- patocellular carcinoma in patients with compensated viral cirrho- sis. Cancer 1999; 85: 2132-7.
  • Sagnelli E, Coppola N, Scolastico C, et al. HCV genotype and "si- lent" HBV coinfection: two main risk factors for a more severe liver disease. J Med Virol 2001; 64: 350-5.
  • Lee DS, Huh K, Lee EH, et al. HCV and HBV coexist in HBsAg.ne- gative patients with HCV viraemia: possibility of coinfection in these patients must be considered in HBV high endemic area. J Gastroenterol Hepatol 1997; 12: 855-61.
  • Colombari R, Dhillon AP, Piazzola E, et al. Chronic hepatitis in multiple virus infection: histopathological evaluation Histopatho- logy 1993; 22: 319-25.
  • Shiratori Y, Shiina S, Zhang PY, et al. Does dual infection by hepa- titis B and C viruses play an important role in the pathogenesis of hepatocellular carcinoma in Japan? Cancer 1997; 80: 2060-7.
  • Ruiz J, Sangro B, Cuende JI, et al. Hepatitis B and C viral infecti- ons in patients with hepatocellular carcinoma. Hepatology 1992; 16: 637-41.
  • Kao JH, Chen PJ, Lai MY, et al. Occult hepatitis B virus infection and clinical outcomes of patients with chronic hepatitis C. J Clin Microbiol 2002; 40: 4068-71.
  • Cacciola I, Pollicino T, Squadrito G, et al. Occult hepatitis B virus infection in patients with chronic hepatitis C liver disease. N Engl J Med 1999; 341: 22-6.
  • Sheu JC, Huang GT, Shih LN, et al. Hepatitis C and B viruses in he- patitis B surface antigen.negative hepatocellular carcinoma. Gastroenterology 1992; 103: 1322-7.
  • Yotsuyanagi H, Shintani Y, Moriya K, et al. Virologic analysis of non.B, non.C hepatocellular carcinoma in Japan: frequent involve- ment of hepatitis B virus. J Infect Dis 2000; 181: 1920-8.
  • Fukuda R, Ishimura N, Niigaki M, et al. Serologically silent hepati- tis B virus coinfection in patients with hepatitis C virus associated chronic liver disease: clinical and virological significance. J Med Virol 1999; 58: 201-7.
  • Zignego AL, Fontana R, Puliti S, et al. Relevance of inapparent co- infection by hepatitis B virus in alpha interferon treated patients with hepatitis C virus chronic hepatitis. J Med Virol 1997; 51: 313- 8.
  • Hu KQ. Occult hepatitis B virus infection and its clinical implicati- ons. J Viral Hepat 2002; 9: 243-57.
  • Brechot C, Thiers V, Kremsdorf D, et al. Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen: clinically significant or purely "occult"? Hepatology 2001; 34: 194-203.
  • Fan CL, Wei L, Jiang D, et al. Spontaneous viral clearance after 6.21 years of hepatitis B and C viruses coinfection in high HBV en- demic area. World J Gastroenterol 2003; 9: 2012-6.
  • Liaw YF, Tsai SL, Chang JJ, et al. Displacement of hepatitis B virus by hepatitis C virus as the cause of continuing chronic hepatitis. Gastroenterology 1994; 106: 1048-53.
  • Crespo J, Lozano JL, Carte B, et al. Viral replication in patients with concomitant hepatitis B and C virus infections. Eur J Clin Microbiol Infect Dis 1997; 16: 445-51.
  • Pontisso P, Gerotto M, Ruvoletto MG, et al. Hepatitis C genotypes in patients with dual hepatitis B and C virus infection. J Med Virol 1996; 48: 157-60.
  • Pontisso P, Ruvoletto MG, Fattovich G, et al. Clinical and virologi- cal profiles in patients with multiple hepatitis virus infections. Gastroenterology 1993; 105: 1529-33.
  • Boom R, Sol CJ, Salimans MM, Jansen CL, et al. Rapid and simple method for purification of nucleic acids. J Clin Microbiol 1990; 28: 495-503.
  • Boom R, Sol CJ, Heijtink R, et al. Rapid purification of hepatitis B virus DNA from serum. J Clin Microbiol 1991; 29: 1804-11.
  • Weinberger KM, Bauer T, Bohm S, et al. High genetic variability of the group-specific a-determinant of hepatitis B virus surface antigen (HBsAg) and the corresponding fragment of the viral polymerase in chronic virus carriers lacking detectable HBsAg in serum. J Gen Virol 2000; 81: 1165-74.
  • Conjeevaram HS, Lok AS. Occult hepatitis B virus infection: a hid- den menace? Hepatology 2001; 34: 204-6.
  • Chan HL, Tsang SW, Leung NW, et al. Occult HBV infection in cryptogenic liver cirrhosis in an area with high prevalence of HBV infection. Am J Gastroenterol 2002; 97: 1211-5.
  • Uchida T, Kaneita Y, Gotoh K, et al. Hepatitis C virus is frequently coinfected with serum marker negative hepatitis B virus: probable replication promotion of the former by the latter as demonstrated by in vitro cotransfection. J Med Virol 1997; 52: 399-405.
  • Besisik F, Karaca C, Akyuz F, et al. Occult HBV infection and YMDD variants in hemodialysis patients with chronic HCV infecti- on. J Hepatol 2003; 38: 506-10.
  • Kao JH, Chen PJ, Lai MY, et al. GB virus-C/hepatitis G virus infec- tion in an area endemic for viral hepatitis, chronic liver disease, and liver cancer. Gastroenterology 1997; 112: 1265-70.
  • Michalak TI, Pardoe IU, Coffin CS, et al. Occult lifelong persisten- ce of infectious hepadnavirus and residual liver inflammation in wo- odchucks convalescent from acute viral hepatitis. Hepatology 1999; 29: 928-38.
  • Değertekin H. Türkiye’de HBV epidemiyoloji ve bulaşım yolları. In: Çakaloğlu Y, Ökten A, Editors. Hepatit B ulusal uzlaşma toplantı me- tinleri. 1. baskı. İstanbul. İstanbul Medikal Yayıncılık 2003; 99-109.
  • Taşyaran MA. HBV enfeksiyonu epidemiyolojisi. In: Tekeli E, Balık İ, Editors. Viral Hepatit 2003. 1. baskı. Ankara. Viral Hepatit Savaşım Derneği 2003; 121-8.
  • Değertekin H. Türkiye’de kronik viral hepatitlerin seroprevalansı (1980-2003). III. Doğu-Güneydoğu Anadolu Hepato-Gastroentero- loji Sempozyumu, Erzurum 2003; 38-44.
There are 36 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Füsun F. Bölükbaş This is me

Cengiz Bölükbaş This is me

Mehmet Aslan This is me

Esen Dolgun This is me

Mustafa Ulukanlıgil This is me

Publication Date April 1, 2007
Published in Issue Year 2007 Volume: 6 Issue: 1

Cite

APA Bölükbaş, F. F., Bölükbaş, C., Aslan, M., Dolgun, E., et al. (2007). Şanlıurfa’da kronik C hepatitinde hepatit B virüs enfeksiyonu ile karşılaşma sıklığı. Akademik Gastroenteroloji Dergisi, 6(1), 10-13.

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