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Helicobacter pylori enfeksiyonunun D vitamini, hemogram parametreleri ve kan grubu ile ilişkisi

Year 2017, Volume: 16 Issue: 1, 1 - 5, 24.04.2017
https://doi.org/10.17941/agd.315551

Abstract

Giriş ve Amaç: Helicobacter pylori bölgemizde ve dünyada yüksek prevalansa sahip olup yaygın kronik inflamasyona neden olur. Biz bu çalışmamızda D vitamini, hemogram parametreleri ve kan grupları ile Helicobacter pylori arasında ilişki olabileceğini göstermeyi amaçladık. Gereç ve Yöntem: Çalışmaya dispeptik şikâyetlerle iç hastalıkları polikliniğine başvurup endoskopi yapılan ve biyopsi ile Helicobacter pylori tanısı konan 91 hasta alındı. Hastalar Helicobacter pylori pozitif ve negatif olarak iki gruba ayrıldı. Demografik ve laboratuvar verileri hasta kayıtlarından elde edildi. Bulgular: Hastaların (n=91) yaş ortalaması 42.5±13 yıl, 70 (%76.9)’ı kadın, 21 (%23.1)’i erkek ve 57 (%62.6)’si Helicobacter pylori pozitifti. Helicobacter pylori pozitif hastalarla negatif hastalar arasında yaş, beden kitle indeksi bakımından istatiksel olarak anlamlı fark vardı (sırasıyla P=0.001, P=0.048). Cinsiyet ile Helicobacter pylori arasında ilişki yoktu (Pearson Chi-Square r= 0.186, P=0.663). Helicobacter pylori enfeksiyonu tespit edilen hastalarda kandaki nötrofil, lenfosit sayısında, nötrofil lenfosit oranında belirgin azalma saptanmıştır ancak istatistiksel açıdan sadece nötrofil sayısındaki düşüklük anlamlıdır, sırasıyla (P <0.007, P=0.258, P=0.155). Helicobacter pylori tespit edilen hastalar negatif hastalarla karşılaştırıldığında 25-OH D3 düzeyleri düşüktü (Pearson Chi-Square r= 3.95 and P=0.047). Helicobacter pylori ile kan grupları ve Rh arasında korelasyon yoktu (sırasıyla Pearson Chi-Square r= 6.383 ve P=0.094, Pearson Chi-Square r= 0.131 ve P=0.717). Sonuç: Helicobacter pylori pozitif hastalardaki nötrofil sayısı, düşük serum vitamin D düzeyleri ile Helicobacter pylorinin yol açtığı kronik inflamasyona bağlı olabilir.

References

  • Liou J-M, Lin J-T, Lee Y-C, et al. Helicobacter pylori infection in the elderly. Int J Geront 2008;2:145-53.
  • Theoharides TC, Cochrane DE. Critical role of mast cells in inflammatory diseases and the effect of acute stres. J Neuroimmunol 2004;146:1-12.
  • Nakajima S, Krishnan B, Ota H, et al. Mast cell involvement in gastritis with or withouth Helicobacter pylori infection. Gastroenterology 1997;113:746-54.
  • Nakajima S, Graham DY, Hattori T, Bamba T. Strategy for treatment of Helicobacter pylori infection in adults. I. Updated indications for test and eradication therapy suggested in 2000. Curr Pharm Des 2000;6:1503-14.
  • 5. Gionchetti P, Vaira D, Campieri M, et al. Enhanced mucosal Interleukin 6 and 8 in Helicobacter pylori-positive dyspeptic patients. Am J Gastroenterol 1994;89:883-7. 6. Brooks GF, Janet SB, Stephen AM. Jawetz M. Melinck&Adelberg’s Medical Microbiology, 21. Appleton & Lange, Connecticut, s:242-3;1995. 7. Dunn BE. Pathogenic mechanisms of Helicobacter pylori. Gastroenterol Clin North Am 1993;22:43-57. 8. Knipp U, Birkholz S, Kaup W, Opferkuch W. Immune supressive effects of Helicobacter pylori on human peripheral blood mononuclear cells. Med Microbiol Immunol 1993;182:63-76. 9. Mansournia N, Mansournia MA, Saeedi S, Dehghan J. The association between serum 25OHD levels and hypothyroid Hashimoto's thyroiditis. J Endocrinol Invest 2014;37:473-6. 10. Yamshchikov AV1, Desai NS, Blumberg HM, et al. Vitamin D for treatment and prevention of et al infectious diseases: A systematic review of randomized controlled trials. Endocr Pract 2009;15:438-49. 11. Von Essen MR, Kongsback M, Schjerling P, et al. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol 2010;11: 344-9. 12. Guo L, Chen W, Zhu H, et al. Helicobacter pylori induces increased expression of the vitamin D receptor in immune responses. Helicobacter 2013;19:37-47. 13. Bao A, Li Y, Tong Y, et al. Tumor suppressive effects of 1.25-dihydroxiyvitamin D3 in gastric cancer cells. Hepatogastroenterology 2013;60:943-8. 14. Braden B, Caspary WF. Detection of Helicobacter pylori infection: when to perform which test? Ann Med 2001;33:91-7. 15. El-Zimaity HM, Graham DY, al-Assi MT, et al. Interobserver variation in the histopathologic assessment of Helicobacter pylori gastritis. Human Pathol 1996;27:35-41. 16. Kawaura A. Inhibitory effect of long term 1 alpha-hydroxyvitamin D3 administration on Helicobacter pylori infection. J Clin Biochem Nutr 2006;38:103-6. 17. Nasri H, Baradaran A. The influence of serum 25-hydroxy vitamin D levels on Helicobacter pylori Infections in patients with end-stage renal failure on regular hemodialysis. Saudi J Kidney Dis Transpl 2007;18:215-9. 18. Antico A, Tozzoli R, Giavarina D, et al. Hypovitaminosis D as predisposing factor for atrophic type A gastritis: a case-control study and review of the literature on the interaction of vitamin D with the immune system. Clin Rev Allergy Immunol 2012;42:355-64. 19. Telatar B, Bayramiçli OU, Kılıç D, et al. Helicobacter pylori enfeksiyonunun kan lökositlerinde oluşturduğu sayısal değişiklikler. KEAH Tıp Dergisi 1997;8:1-4. 20. Stasi R, Sarpatwari A, Segal JB, et al. Effects of eradication of Helicobacter pylori infection in patients with immune trombocytopenic purpura: a systemic review. Blood 2009;113:1231-40. 21. Huang X, Qu X, Yan W, et al. Iron deficiency anemia can be improved after eradication of Helicobacter pylori. Postgrad Med J 2010;86:272-8. 22. Boltin D, Niv Y. Ghrelin, Helicobacter pylori and body mass: is there an association? Isr Med Assoc J 2012; 14: 130-2. 23. Ioannou GN, Weiss NS, Kearney DJ. Is Helicobacter pylori seropositivity related to body mass index in the United States? Aliment Pharmacol Ther 2005;21:765-72. 24. Korkmaz M, Sadıç M, Koca G, ve ark. The relationship of Helicobacter pylori infection with demographic, socio economic and environmental factors: Ankara hospital experience. Kafkas J Med Sci 2013;3:74-9. 25. Aird I, Bentall HH, Mehigan JA, Roberts JA. The blood groups in relation to peptic ulceration and carcinoma of the colon, rectum, breast and bronchus. Br Med J 1954;2:315-21. 26. Clarke CA, Cowan WK, Edwards JW, et al. The relationship of ABO blood groups to duodenal and gastric ulceration. Br Med J 1955;2:643-6. 27. Boren T, Falk P, Roth KA, et al. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science 1993;262:1892-5. 28. Petrović M, Artiko V, Novosel S, et al. Relationship between Helicobacter pylori infection estimated by 14C-urea breath test and gender, blood groups and Rhesus factor. Hell J Nucl Med 2011;14:21-4. 29. Stettin D, Waldmann A, Ströhle A, et al. Association between Helicobacter pylori-infection, C-reactive protein and status of B vitamins. Adv Med Sci 2008;53:205-13. 30. Jafarzadeh A, Hassanshahi GH, Nemati M. Serum levels of high-sensitivity C-reactive protein (hs-CRP) in Helicobacter pylori-infected peptic ulcer patients and its association with bacterial Cag A virulence factor. Dig Dis Sci 2009;54:2612-6. 31. Serin E, Gümürdülü Y, Ozer B, et al. Impact of Helicobacter pylori on the development of vitamin B12 deficiency in the absence of gastric atrophy. Helicobacter 2002;7:337-41.

Association of Helicobacter pylori infection with vitamin D, hemogram parameters, and blood group

Year 2017, Volume: 16 Issue: 1, 1 - 5, 24.04.2017
https://doi.org/10.17941/agd.315551

Abstract

Background and Aims: Helicobacter pylori infection is highly prevalent in developing countries, including Turkey, and causes widespread chronic inflammation. We suggest there may be an association between Helicobacter pylori infection and vitamin D, hemogram parameters, and blood group. Methods: In this study, 91 patients presented to an internal medicine outpatient clinic with dyspepsia and were found to have Helicobacter pylori infection by endoscopy. Patients were divided into two groups according to Helicobacter pylori positivity. Demographic and laboratory characteristics were obtained from medical records.Results: Mean age was 42.5±13 years; 77% were women, and 62.6% were Helicobacter pylori positive. Age and body mass index differed significantly between Helicobacter pylori positive and negative patients (P=0.001, P=0.048, respectively). There was no association between gender and Helicobacter pylori positivity (Pearson Chi-Square=0.186, P=0.663). Neutrophil, lymphocyte, and neutrophil lymphocyte ratio were remarkably lower in Helicobacter pylori positive patients but only the reduction in neutrophil counts was statistically significant (P < 0.007, P 0.258, P=0.155, respectively). Levels of 25-OH D3 were lower in patients who were Helicobacter pylori positive compared with those who were negative (Pearson Chi-Square 3.95, P=0.047). There were no associations between Helicobacter pylori positivity and blood group or Rh status (Pearson Chi-Square=6.383, P=0.094; Pearson Chi-Square=0.131, P=0.717, respectively). Conclusion: Low neutrophil counts in Helicobacter pylori positive patients might be due to interactions between low vitamin D levels and chronic inflammation caused by Helicobacter pylori.

References

  • Liou J-M, Lin J-T, Lee Y-C, et al. Helicobacter pylori infection in the elderly. Int J Geront 2008;2:145-53.
  • Theoharides TC, Cochrane DE. Critical role of mast cells in inflammatory diseases and the effect of acute stres. J Neuroimmunol 2004;146:1-12.
  • Nakajima S, Krishnan B, Ota H, et al. Mast cell involvement in gastritis with or withouth Helicobacter pylori infection. Gastroenterology 1997;113:746-54.
  • Nakajima S, Graham DY, Hattori T, Bamba T. Strategy for treatment of Helicobacter pylori infection in adults. I. Updated indications for test and eradication therapy suggested in 2000. Curr Pharm Des 2000;6:1503-14.
  • 5. Gionchetti P, Vaira D, Campieri M, et al. Enhanced mucosal Interleukin 6 and 8 in Helicobacter pylori-positive dyspeptic patients. Am J Gastroenterol 1994;89:883-7. 6. Brooks GF, Janet SB, Stephen AM. Jawetz M. Melinck&Adelberg’s Medical Microbiology, 21. Appleton & Lange, Connecticut, s:242-3;1995. 7. Dunn BE. Pathogenic mechanisms of Helicobacter pylori. Gastroenterol Clin North Am 1993;22:43-57. 8. Knipp U, Birkholz S, Kaup W, Opferkuch W. Immune supressive effects of Helicobacter pylori on human peripheral blood mononuclear cells. Med Microbiol Immunol 1993;182:63-76. 9. Mansournia N, Mansournia MA, Saeedi S, Dehghan J. The association between serum 25OHD levels and hypothyroid Hashimoto's thyroiditis. J Endocrinol Invest 2014;37:473-6. 10. Yamshchikov AV1, Desai NS, Blumberg HM, et al. Vitamin D for treatment and prevention of et al infectious diseases: A systematic review of randomized controlled trials. Endocr Pract 2009;15:438-49. 11. Von Essen MR, Kongsback M, Schjerling P, et al. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol 2010;11: 344-9. 12. Guo L, Chen W, Zhu H, et al. Helicobacter pylori induces increased expression of the vitamin D receptor in immune responses. Helicobacter 2013;19:37-47. 13. Bao A, Li Y, Tong Y, et al. Tumor suppressive effects of 1.25-dihydroxiyvitamin D3 in gastric cancer cells. Hepatogastroenterology 2013;60:943-8. 14. Braden B, Caspary WF. Detection of Helicobacter pylori infection: when to perform which test? Ann Med 2001;33:91-7. 15. El-Zimaity HM, Graham DY, al-Assi MT, et al. Interobserver variation in the histopathologic assessment of Helicobacter pylori gastritis. Human Pathol 1996;27:35-41. 16. Kawaura A. Inhibitory effect of long term 1 alpha-hydroxyvitamin D3 administration on Helicobacter pylori infection. J Clin Biochem Nutr 2006;38:103-6. 17. Nasri H, Baradaran A. The influence of serum 25-hydroxy vitamin D levels on Helicobacter pylori Infections in patients with end-stage renal failure on regular hemodialysis. Saudi J Kidney Dis Transpl 2007;18:215-9. 18. Antico A, Tozzoli R, Giavarina D, et al. Hypovitaminosis D as predisposing factor for atrophic type A gastritis: a case-control study and review of the literature on the interaction of vitamin D with the immune system. Clin Rev Allergy Immunol 2012;42:355-64. 19. Telatar B, Bayramiçli OU, Kılıç D, et al. Helicobacter pylori enfeksiyonunun kan lökositlerinde oluşturduğu sayısal değişiklikler. KEAH Tıp Dergisi 1997;8:1-4. 20. Stasi R, Sarpatwari A, Segal JB, et al. Effects of eradication of Helicobacter pylori infection in patients with immune trombocytopenic purpura: a systemic review. Blood 2009;113:1231-40. 21. Huang X, Qu X, Yan W, et al. Iron deficiency anemia can be improved after eradication of Helicobacter pylori. Postgrad Med J 2010;86:272-8. 22. Boltin D, Niv Y. Ghrelin, Helicobacter pylori and body mass: is there an association? Isr Med Assoc J 2012; 14: 130-2. 23. Ioannou GN, Weiss NS, Kearney DJ. Is Helicobacter pylori seropositivity related to body mass index in the United States? Aliment Pharmacol Ther 2005;21:765-72. 24. Korkmaz M, Sadıç M, Koca G, ve ark. The relationship of Helicobacter pylori infection with demographic, socio economic and environmental factors: Ankara hospital experience. Kafkas J Med Sci 2013;3:74-9. 25. Aird I, Bentall HH, Mehigan JA, Roberts JA. The blood groups in relation to peptic ulceration and carcinoma of the colon, rectum, breast and bronchus. Br Med J 1954;2:315-21. 26. Clarke CA, Cowan WK, Edwards JW, et al. The relationship of ABO blood groups to duodenal and gastric ulceration. Br Med J 1955;2:643-6. 27. Boren T, Falk P, Roth KA, et al. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science 1993;262:1892-5. 28. Petrović M, Artiko V, Novosel S, et al. Relationship between Helicobacter pylori infection estimated by 14C-urea breath test and gender, blood groups and Rhesus factor. Hell J Nucl Med 2011;14:21-4. 29. Stettin D, Waldmann A, Ströhle A, et al. Association between Helicobacter pylori-infection, C-reactive protein and status of B vitamins. Adv Med Sci 2008;53:205-13. 30. Jafarzadeh A, Hassanshahi GH, Nemati M. Serum levels of high-sensitivity C-reactive protein (hs-CRP) in Helicobacter pylori-infected peptic ulcer patients and its association with bacterial Cag A virulence factor. Dig Dis Sci 2009;54:2612-6. 31. Serin E, Gümürdülü Y, Ozer B, et al. Impact of Helicobacter pylori on the development of vitamin B12 deficiency in the absence of gastric atrophy. Helicobacter 2002;7:337-41.
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Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Ahmet Nalbant

Ayhan Aydın This is me

Publication Date April 24, 2017
Published in Issue Year 2017 Volume: 16 Issue: 1

Cite

APA Nalbant, A., & Aydın, A. (2017). Helicobacter pylori enfeksiyonunun D vitamini, hemogram parametreleri ve kan grubu ile ilişkisi. Akademik Gastroenteroloji Dergisi, 16(1), 1-5. https://doi.org/10.17941/agd.315551

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