Is Helicobacter pylori Positiveness a factor in the Success of the Intragastric Injection of Botulinum Toxin in the Treatment of Obesity?

Year 2024, Volume: 23 Issue: 2, 41 - 48, 27.08.2024

Mevlüt Hamamcı , Kerem Kenarlı , Hasan Tankut Köseoğlu , Ahmet Akbay Çağdaş Erdoğan , Alper Macif Meryem Didem Göktaş , Çağdaş Kalkan , Fırathan Sarıaltın , Mahmut Yüksel

https://doi.org/10.17941/agd.1533988

Abstract

Background and Aims: Obesity is becoming more common around the world. Although there have been many developments in the treatment of obesity recently, endoscopic treatment methods have an important place due to their low side effects and higher success rate compared to behavioral treatments. Although studies on intragastric botulinum toxin injection have had confusing results, the reason why the treatment causes these different results has not been clarified. Our aim in this study was to evaluate the presence of Helicobacter pylori infection, which may affect the success of intragastric botulinum toxin injection treatment. Materials and Methods: Patients with a body mass index of greater than 25 kg/m2 and at least one obesity-related complication, or a body mass index of greater than 30 kg/m2 without complications, were eligible for the study if they were between the ages of 18 and 65. In all patients, a biopsy was taken for Helicobacter pylori evaluation from the stomach antrum simultaneously with intragastric botulinum toxin administration. Results: In our study on 80 patients, compared to their beginning weight, the patients' weights in all groups decreased statistically significantly (p  0.001). However, neither Helicobacter pylori density nor Helicobacter pylori presence had a statistically significant impact on weight loss in the second or sixth months. Conlusion: It has been shown that Helicobacter pylori infection, which is one of the conditions that may cause conflicting results of intragastric botulinum toxin administration, has no effect on weight loss.

Keywords

Obesity, botulinum, Helicobacter pylori, body mass index, endoscopic treatment, intragastric injection

Mide İçi Botulinum Toksini Enjeksiyonunun Obezite Tedavisindeki Başarısında Helicobacter pylori Pozitifliği Bir Faktör müdür?

Abstract

Giriş ve Amaç: Obezite dünya çapında giderek yaygınlaşmaktadır. Son yıllarda obezite tedavisinde pek çok gelişme yaşansa da endoskopik tedavi yöntemleri, davranışsal tedavilere göre yan etkilerinin düşük olması ve başarı oranının daha yüksek olması nedeniyle önemli bir yere sahiptir. İntragastrik Botulinum toksin enjeksiyonu ile ilgili yapılan çalışmalarda kafa karıştırıcı sonuçlar olmasına rağmen bunun sebebi hala açıklığa kavuşturulamamıştır. Bu çalışmadaki amacımız Helicobacter pylori enfeksiyonunun intragastrik Botulinum toksin enjeksiyon tedavisi başarısı üzerindeki etkilerini değerlendirmektir. Gereç ve Yöntem: On sekiz ile 65 yaşları arasında, vücut kitle indeksi 25 kg/m2'nin üzerinde ve en az bir obezite ile ilişkili komplikasyonu olan veya komplikasyon olmadan vücut kitle indeksi 30 kg/m2'den fazla olan 80 hasta çalışmaya dahil edildi. Helicobacter pylori değerlendirmesi için intragastrik Botulinum toksini uygulaması esnasında mide antrumundan biyopsiler alındı ve hastalar Helicobacter pylori pozitifliği veya negatifliğine göre iki gruba ayrıldı. Bulgular: Çalışmamızda her iki grupta da başlangıç kilolarına göre istatistiksel olarak anlamlı azalma görüldü (p < 0.001). Ancak mide mukozasında Helicobacter pylori varlığı veya yoğunluğunun kilo kaybı üzerinde istatistiksel olarak anlamlı bir etkisi yoktu. Sonuç: İntragastrik Botulinum toksini uygulamasında çelişkili sonuçlara neden olabilecek durumlardan biri olan Helicobacter pylori enfeksiyonunun kilo kaybına etkisinin olmadığı gösterilmiştir.

Keywords

Obezite, botulinum, Helicobacter pylori, vücut kitle indeksi, endoskopik tedavi, intragastrik enjeksiyon

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