Review
PDF EndNote BibTex Cite

Year 2022, Volume 3, Issue 1, 1 - 8, 30.06.2022

Abstract

References

  • [1] L. Shen, W. Zhang, F. Jin, L. Zhang, Z. Chen, et al., “Expression of recombinant AccMRJP1 protein from royal jelly of Chinese honeybee in Pichia pastoris and its proliferation activity in an insect cell line”, Journal of Agricultural and Food Chemistry, vol. ED-58 pp. 9190-9197, 2010.
  • [2] M. H. Alu’datt, T. Rababah, H. A. Sakandar, M. Imran, N. Mustafa, et al., “Fermented food-derived bioactive compounds with anticarcinogenic properties: Fermented royal jelly as a novel source for compounds with health benefits”, in Anticancer Plants: Properties and Application, Ed. Singapore: Springer, 2018, pp. 141-165.
  • [3] L. I. Bărnuţiu, L. A. Mărghitaş, D. S. Dezmirean, C. M. Mihai and O. Bobiş, “Chemical composition and antimicrobial activity of royal jelly-review”, Scientific Papers Animal Science and Biotechnologies, vol. ED-44, pp. 67-72, 2011.
  • [4] J. Schmitzova, J. Klaudiny, S. Albert, W. Schroder, W. Schreckengost et al., “A family of major royal jelly proteins of the honey bee Apis Mellifera L.”, Cell Molecular Life Science, vol. ED-54, pp. 1020-1030, 1998.
  • [5] D. Vucevic, E. Melliou, S. Vasilijic, S. Gasic, P. Ivanovski et al., “Fatty acids isolated from royal jelly modulate dendritic cell-mediated immune response in vitro”, International Immunopharmacology, vol. ED-7, pp. 1211–1220, 2007.
  • [6] H. Oka, Y. Emori, N. Kobayashi, Y. Hayashi, K. Nomoto, “Suppression of allergic reactions by royal jelly in association with the restoration of macrophage function and the improvement of Th1/Th2 cell responses”, International Immunopharmacology, vol. ED-1, pp. 521-532, 2001.
  • [7] J. Zhou, X. Xue, Y. Li, J. Zhang, J. Zhao “Optimized determination method for trans-10-hydroxy-2-decenoic acid content in royal jelly by high-performance liquid chromatography with an internal standard”, Journal of AOAC International, vol. ED-90, pp. 244-249, 2007.
  • [8] A. Bozorgi, S. Khazaei, A. Khademi and M. Khazaei, “Natural and herbal compounds targeting breast cancer, a review based on cancer stem cells” Iranian Journal of Basic Medical Sciences, vol. ED-23, pp. 970, 2020.
  • [9] B. C. Bloodworth, C. S. Harn, C. T. Hock, and Y. O. Boon, “Liquid chromatographic determination of trans-10-hydroxy-2-decenoic acid content of commercial products containing royal jelly”. Journal of AOAC International, vol. ED-78, pp. 1019-1023, 1995.
  • [10] M. Khazaei, A. Ansarian, E. Ghanbari, “New findings on biological actions and clinical applications of royal jelly: a review”, Journal of Dietary Supplements, vol. ED-15, pp. 757-775, 2018.
  • [11] A. Buttstedt, R. F. Moritz and S. Erler, “Origin and function of the major royal jelly proteins of the honeybee (Apis mellifera) as members of the yellow gene family”, Biological Reviews, vol. ED-89, pp. 255-269, 2014.
  • [12] X. Xue, L. Wu, K. Wang, “Chemical composition of royal jelly”, in Bee Products-chemical and Biological Properties, 2017, Springer, Cham, pp. 181-190.
  • [13] A. N. K. G. Ramanathan, A. J. Nair, V. S. Sugunan, “A review on Royal Jelly proteins and peptides”, Journal of Functional Foods, vol. ED-44, pp. 255-264, 2018.
  • [14] N. Collazo, M. Carpena, B. Nuñez-Estevez, P. Otero, J. Simal-Gandara, et al., “Health promoting properties of bee royal jelly: Food of the queens”, Nutrients, vol. ED-13, pp. 543, 2011.
  • [15] H. Rembold, “Biologically active substances in royal jelly”, Vitamins and Hormones, vol. ED-23, pp. 359-382, 1965.
  • [16] G. Lercker, M. F. Caboni, M. A. Vecchi, A. G. Sabatini, A. Nanetti, “Characterizaton of the main constituents of royal jelly”, Apicoltura, vol. ED-8, pp. 27-37, 1992.
  • [17] F. L. Hu, K. Bíliková, H. Casabianca, G. Daniele, F. Salmen Espindola, et al., “Standard methods for Apis mellifera royal jelly research”, Journal of Apicultural Research, vol. ED-58, pp. 1-68, 2019.
  • [18] L. A. Mărghitaş, “Produsele apicole şi principalele lor însuşiri terapeutice”, Albinele şi produsele lor. LA Mărghitaş, 2nd ed., Ceres, Bucharest, Romania, 2008, pp. 280-378.
  • [19] A. Fuji, S. Kobayashi, N. Kuboyama, Y. Furukawa, Y. Kaneko, et al., “Augmentation of wound healing by royal jelly (RJ) in streptozotocin-diabetic rats”, The Japanese Journal of Pharmacology, vol. ED-53, pp. 331-337, 1990.
  • [20] L. A. Salazar-Olivo, V. Paz-Gonzalez, “Screening of biological activities present in honeybee (Apis mellifera) royal jelly”, Toxicology in vitro, 19(5), 645-651, 2005.
  • [21] S. Koya-Miyata, I. Okamoto, S. Ushio, K. Iwaki, M. Ikeda, et al., “Identification of a collagen production-promoting factor from an extract of royal jelly and its possible mechanism”, Bioscience, Biotechnology, and Biochemistry, vol. ED-68, pp. 767-773, 2004.
  • [22] S. Ahmad, M. G. Campos, F. Fratini, S. Z. Altaye, and J. Li, “New insights into the biological and pharmaceutical properties of royal jelly”, International journal of molecular sciences, vol. ED-21 pp. 382, 2020.
  • [23] C. I. Pavel, L. A. Mărghitaş, O. Bobiş, D. S. Dezmirean, A. Şapcaliu, et al., “Biological activities of royal jelly-review”, Scientific Papers Animal Science and Biotechnologies, vol. ED-44, pp. 108-118, 2011.
  • [24] H. Guo, Y. Kouzuma, M. Yonekura, “Structures and properties of antioxidative peptides derived from royal jelly protein”, Food Chemistry, vol. ED-113, pp. 238-245, 2009.
  • [25] T. Nagai, R. Inoue, “Preparation and the functional properties of water and alkaline extract of royal jelly”, Food Chemistry, vol. ED-84, pp. 181-186, 2004.
  • [26] J. R. Liu, Y. C. Yang, L. S. Shi, C. C. Peng, “Antioxidant properties of royal jelly associated with larval age and time of harvest”, Alternative Medicine Review, vol. ED-13, pp. 330‐333, 2008.
  • [27] S. Pourmoradian, R. Mahdavi, M. Mobasseri, E. Faramarzi, M. Mobasseri, “Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: a randomized clinical trial”, Chinese Journal of Integrative Medicine, vol. ED-20, pp. 347-352, 2014.
  • [28] A. A. El-Nekeety, W. El-Kholy, N. F. Abbas, A. Ebaid, H. A. Amra, M. A. Abdel-Wahhab, “Efficacy of royal jelly against the oxidative stress of fumonisin in rats”, Toxicon, vol. ED-50, pp. 256-269, 2007.
  • [29] S. I. Inoue, S. Koya-Miyata, S. Ushio, K. Iwaki, M. Ikeda, et al., “Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage”, Experimental Gerontology, vol. ED-38, pp. 965-969, 2003.
  • [30] K. Çavuşoğlu, K. Yapar and E. Yalçin, “Royal jelly (honey bee) is a potential antioxidant against cadmium-induced genotoxicity and oxidative stress in albino mice”, Journal of medicinal food, vol. ED-12, 1286-1292, 2009.
  • [31] W. A. Moselhy, A. M. Fawzy, A. A. Kamel, “An evaluation of the potent antimicrobial effects and unsaponifiable matter analysis of the royal jelly”, Life Science Journal, vol. ED-2, pp. 290-296, 2013.
  • [32] S. Eshraghi, F. Seifollahi, “Antibacterial effects of royal jelly on different strains of bacteria”, Iranian Journal of Public Health, 32(1), 25-30, 2003.
  • [33] S. Eshraghi, “An evaluation of the potent inhibitory effects of royal jelly fractions against Streptomyces bacteria”, Pakistan Journal of Medical Sciences, vol. ED-21, pp. 63-68, 2005.
  • [34] Y. Miyata, H. Sakai, “Anti-cancer and protective effects of royal jelly for therapy-induced toxicities in malignancies”, International journal of molecular sciences, vol. ED-19, pp. 3270, 2018.
  • [35] S. Zhang, Q. Shao, H. Geng, S. Su, “The effect of royal jelly on the growth of breast cancer in mice”, Oncology Letters, vol. ED-14, pp. 7615-7621, 2017.
  • [36] M. Nakaya, H. Onda, K. Sasaki, A. Yukiyoshi, H. Tachibana, et al., “Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells”, Bioscience, Biotechnology, and Biochemistry, vol. ED-71, pp. 253-255, 2007.
  • [37] A. Gismondi, E. Trionfera, L. Canuti, G. Di Marco, A. Canini, “Royal jelly lipophilic fraction induces antiproliferative effects on SH-SY5Y human neuroblastoma cells”, Oncology Reports, vol. ED-38, pp. 1833-1844.
  • [38] S. Zhang, Q. Shao, Z. Shen, S. Su, “Immunomodulatory response of 4T1 murine breast cancer model to camellia royal jelly”, Biomedical Research, vol. ED-28, pp.0970-938X, 2017.
  • [39] M. Shirzad, R. Kordyazdi, N. Shahinfard, M. Nikokar, “Does Royal jelly affect tumor cells?”, Journal of HerbMed Pharmacology, vol. ED-2, 2013.
  • [40] S. A. Abdelnour, M. E. Abd El‐Hack, M. Alagawany, A. E. Taha, S. S. Elnesr, et al., “Useful impacts of royal jelly on reproductive sides, fertility rate and sperm traits of animals”, Journal of Animal Physiology and Animal Nutrition”, vol. ED-104, pp.1798-1808, 2020.
  • [41] A. Kato, “Effect of royal jelly on development of genital organs in male mice”, The Journal of Veterinary Medical Science, vol. ED-35, pp. 1-4, 1988.
  • [42] B. Du, K. Takahashi, G. M. Ishida, K. Nakahar, H. Saito, H. Kurachi H. “Usefulness of intraovarian artery pulsatility and resistance indices measurement on the day of follicle aspiration for the assessment of oocyte quality”, Fertility and Sterility, vol. ED-85, pp. 366-370, 2006.
  • [43] M. Attaran, E. Pasqualotto, T. Falcone, J. M. Goldberg, K. F. Miller et al., “The effect of follicular fluid reactive oxygen species on the outcome of in vitro fertilization”. International Journal of Fertility and Women's Medicine, vol. ED- 45, pp. 314-320, 2000.
  • [44] E. Ghanbari, V. Nejati, M. Khazaei “Antioxidant and protective effects of royal jelly on histopathological changes in testis of diabetic rats”, International Journal of Reproductive BioMedicine, vol. ED-14, pp. 519-529, 2016.
  • [45] A. T. Abdelhafiz and J. A. Muhamad, “Midcycle pericoital intravaginal bee honey and royal jelly for male factor infertility”, International Journal of Gynecology & Obstetrics, vol. ED-101, pp.146-149, 2008.
  • [46] K. Suzuki, Y. Isohama, H. Maruyama, Y. Yamada, Y. Narita, et al., “Estrogenic activities of fatty acids and a sterol isolated from royal jelly”, Evidence Based Complementary Alternative Medicine, vol. ED-5, pp. 295-302, 2008.
  • [47] M. Bucekova, M. Sojka, I. Valachova, S. Martinotti, E. Ranzato, et al., “Bee-derived antibacterial peptide, defensin-1, promotes wound reepithelialisation in vitro and in vivo”, Wound Healing Southern Africa, vol. ED-10, pp. 25-35, 2017.
  • [48] K. Kohno, I. Okamoto, O. Sano, N. Arai, K. Iwaki, et al., “Royal jelly inhibits the production of proinflammatory cytokines by activated macrophages”, Bioscience, biotechnology, and biochemistry, vol. ED-68, pp. 138-145, 2004.
  • [49] Y. Lin, M. Zhang, L. Wang, T. Lin, G. Wang, et al., “The in vitro and in vivo wound-healing effects of royal jelly derived from Apis mellifera L. during blossom seasons of Castanea mollissima Bl. and Brassica napus L. in South China exhibited distinct patterns”, BMC Complementary Medicine and Therapies, vol. ED-20, pp. 1-13, 2020.
  • [50] J. Kim, Y. Kim, H. Yun, H. Park, S. Kim, et al., “Royal jelly enhances migration of human dermal fibroblasts and alters the levels of cholesterol and sphinganine in an in vitro wound healing model”, Nutrition Research and Practice, vol. ED-4, pp. 362-368, 2010.
  • [51] M. Siavash, S. Shokri, S. Haghighi, M. Mohammadi, M. A. Shahtalebi, et al., “The efficacy of topical Royal Jelly on diabetic foot ulcers healing: A case series”, Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences, vol. ED-16, pp. 904, 2011.
  • [52] K. Suemaru, R. Cui, B. Li, S. Watanabe, K. Okihara, et al., “Topical application of royal jelly has a healing effect for 5-fluorouracil-induced experimental oral mucositis in hamsters”. Methods & Findings in Experimental & Clinical Pharmacology, vol. ED-30, pp. 103-106, 2008.
  • [53] H. Y. Kim, H. M. Choi, S. G. Kim, S. O. Woo, H. J. Moon, et al., “Skin health improving effects of Korean freeze-dried royal jelly in human keratinocytes”, Asian Journal of Beauty and Cosmetology, vol. ED-18, pp. 413-422, 2020.
  • [54] M. L. B. Severo, S. Thieme, F. M. Silveira, R. P. M. Tavares, A. K. G. Gonzaga, et al., “Royal jelly and propolis therapies reduce inflammation and stimulate healing of oral mucositis in rats”, 2021.
  • [55] F. Fratini, G. Cilia, S. Mancini, A. Felicioli, “Royal Jelly: An ancient remedy with remarkable antibacterial properties”, Microbiological Research, vol. ED-192, pp. 130-141, 2016.
  • [56] X. X. Xin, Y. Chen, D. Chen, F. Xiao, L. D. Parnell, et al., “Supplementation with major royal-jelly proteins increases lifespan, feeding, and fecundity in Drosophila”, Journal of Agricultural and Food Chemistry, vol. ED-64, pp. 5803-5812, 2016.
  • [57] G. Detienne, W. De Haes, U. R. Ernst, L. Schoofs and L. Temmerman “Royalactin extends lifespan of Caenorhabditis elegans through epidermal growth factor signaling”, Experimental gerontology, vol. ED-60, pp. 129-135, 2014.
  • [58] J. Halloran, S. A. Hussong, R. Burbank, N. Podlutskaya, K. E. Fischer, et al., “Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice”, Neuroscience, vol. ED-223, pp. 102-113, 2012.
  • [59] A. M. Ali and H. Kunugi, “Royal Jelly as an intelligent anti-aging agent-A focus on cognitive aging and Alzheimer’s disease: A review”, Antioxidants, vol. ED-9, pp. 937, 2020.
  • [60] A. M., Kirova, R. B. Bays, S. Lagalwar, “Working memory and executive function decline across normal aging, mild cognitive impairment, and Alzheimer’s disease”, BioMed Research International, 2015.
  • [61] N. J. Raine-Fenning, M. P. Brincat, Y. Muscat-Baron, “Skin aging and menopause”, American Journal of Clinical Dermatology, vol. ED-4, pp. 371-378, 2003.
  • [62] H. M. Park, M. H. Cho, Y. Cho, S. Y. Kim, “Royal jelly increases collagen production in rat skin after ovariectomy”, Journal of Medicinal Food, vol. ED-15, pp. 568-575, 2012.
  • [63] A. Bălan, M. A. Moga, L. Dima, S. Toma, A. Elena Neculau, et al., “Royal jelly—A traditional and natural remedy for postmenopausal symptoms and aging-related pathologies”, Molecules, vol. ED-25, pp. 3291, 2020.
  • [64] S. Wild, G. Roglic, A. Green, R. Sicree, H. King, “Global prevalence of diabetes: estimates for the year 2000 and projections for 2030”, Diabetes Care, vol. ED-25, pp. 1047-1053, 2004.
  • [65] K. O’Connor, “The demonstration of insulin-like material in the honey bee Apis mellifera”, Comparative Biochemistry and Physiology, vol. ED-81, pp. 755-776, 1985.
  • [66] K. Münstedt, M. Bargello, A. Hauenschild, “Royal jelly reduces the serum glucose levels in healthy subjects”, Journal of Medicinal food, vol. ED-12, pp. 1170-1172, 2009
  • [67] Y. Zamami, S. Takatori, M. Goda, T. Koyama, Y. Iwatani et al., “Royal jelly ameliorates insulin resistance in fructose-drinking rats”, Biological and Pharmaceutical Bulletin, vol. ED-31, pp. 2103-3107, 2008.

Biological activities of royal jelly: a mini-review

Year 2022, Volume 3, Issue 1, 1 - 8, 30.06.2022

Abstract

Royal jelly is a bee product made by cephalic glands of nurse bees that has been utilized in medicine for ages because of its unique therapeutic properties. Proteins, royalisin, jelleins, fatty acids, and 10-hydroxy-2-decenoic acid are among the bioactive components found in royal jelly. There are many studies vouch that royal jelly has antioxidant, antimicrobial, anticancer, fertilization, wound-healing, anti-aging, insulin-like, antimutagenic, antidiabetic, anti-inflammatory potentials. The bioactive components it contains are primarily responsible for these functions. This study is aimed to review the biological activities of royal jelly.

References

  • [1] L. Shen, W. Zhang, F. Jin, L. Zhang, Z. Chen, et al., “Expression of recombinant AccMRJP1 protein from royal jelly of Chinese honeybee in Pichia pastoris and its proliferation activity in an insect cell line”, Journal of Agricultural and Food Chemistry, vol. ED-58 pp. 9190-9197, 2010.
  • [2] M. H. Alu’datt, T. Rababah, H. A. Sakandar, M. Imran, N. Mustafa, et al., “Fermented food-derived bioactive compounds with anticarcinogenic properties: Fermented royal jelly as a novel source for compounds with health benefits”, in Anticancer Plants: Properties and Application, Ed. Singapore: Springer, 2018, pp. 141-165.
  • [3] L. I. Bărnuţiu, L. A. Mărghitaş, D. S. Dezmirean, C. M. Mihai and O. Bobiş, “Chemical composition and antimicrobial activity of royal jelly-review”, Scientific Papers Animal Science and Biotechnologies, vol. ED-44, pp. 67-72, 2011.
  • [4] J. Schmitzova, J. Klaudiny, S. Albert, W. Schroder, W. Schreckengost et al., “A family of major royal jelly proteins of the honey bee Apis Mellifera L.”, Cell Molecular Life Science, vol. ED-54, pp. 1020-1030, 1998.
  • [5] D. Vucevic, E. Melliou, S. Vasilijic, S. Gasic, P. Ivanovski et al., “Fatty acids isolated from royal jelly modulate dendritic cell-mediated immune response in vitro”, International Immunopharmacology, vol. ED-7, pp. 1211–1220, 2007.
  • [6] H. Oka, Y. Emori, N. Kobayashi, Y. Hayashi, K. Nomoto, “Suppression of allergic reactions by royal jelly in association with the restoration of macrophage function and the improvement of Th1/Th2 cell responses”, International Immunopharmacology, vol. ED-1, pp. 521-532, 2001.
  • [7] J. Zhou, X. Xue, Y. Li, J. Zhang, J. Zhao “Optimized determination method for trans-10-hydroxy-2-decenoic acid content in royal jelly by high-performance liquid chromatography with an internal standard”, Journal of AOAC International, vol. ED-90, pp. 244-249, 2007.
  • [8] A. Bozorgi, S. Khazaei, A. Khademi and M. Khazaei, “Natural and herbal compounds targeting breast cancer, a review based on cancer stem cells” Iranian Journal of Basic Medical Sciences, vol. ED-23, pp. 970, 2020.
  • [9] B. C. Bloodworth, C. S. Harn, C. T. Hock, and Y. O. Boon, “Liquid chromatographic determination of trans-10-hydroxy-2-decenoic acid content of commercial products containing royal jelly”. Journal of AOAC International, vol. ED-78, pp. 1019-1023, 1995.
  • [10] M. Khazaei, A. Ansarian, E. Ghanbari, “New findings on biological actions and clinical applications of royal jelly: a review”, Journal of Dietary Supplements, vol. ED-15, pp. 757-775, 2018.
  • [11] A. Buttstedt, R. F. Moritz and S. Erler, “Origin and function of the major royal jelly proteins of the honeybee (Apis mellifera) as members of the yellow gene family”, Biological Reviews, vol. ED-89, pp. 255-269, 2014.
  • [12] X. Xue, L. Wu, K. Wang, “Chemical composition of royal jelly”, in Bee Products-chemical and Biological Properties, 2017, Springer, Cham, pp. 181-190.
  • [13] A. N. K. G. Ramanathan, A. J. Nair, V. S. Sugunan, “A review on Royal Jelly proteins and peptides”, Journal of Functional Foods, vol. ED-44, pp. 255-264, 2018.
  • [14] N. Collazo, M. Carpena, B. Nuñez-Estevez, P. Otero, J. Simal-Gandara, et al., “Health promoting properties of bee royal jelly: Food of the queens”, Nutrients, vol. ED-13, pp. 543, 2011.
  • [15] H. Rembold, “Biologically active substances in royal jelly”, Vitamins and Hormones, vol. ED-23, pp. 359-382, 1965.
  • [16] G. Lercker, M. F. Caboni, M. A. Vecchi, A. G. Sabatini, A. Nanetti, “Characterizaton of the main constituents of royal jelly”, Apicoltura, vol. ED-8, pp. 27-37, 1992.
  • [17] F. L. Hu, K. Bíliková, H. Casabianca, G. Daniele, F. Salmen Espindola, et al., “Standard methods for Apis mellifera royal jelly research”, Journal of Apicultural Research, vol. ED-58, pp. 1-68, 2019.
  • [18] L. A. Mărghitaş, “Produsele apicole şi principalele lor însuşiri terapeutice”, Albinele şi produsele lor. LA Mărghitaş, 2nd ed., Ceres, Bucharest, Romania, 2008, pp. 280-378.
  • [19] A. Fuji, S. Kobayashi, N. Kuboyama, Y. Furukawa, Y. Kaneko, et al., “Augmentation of wound healing by royal jelly (RJ) in streptozotocin-diabetic rats”, The Japanese Journal of Pharmacology, vol. ED-53, pp. 331-337, 1990.
  • [20] L. A. Salazar-Olivo, V. Paz-Gonzalez, “Screening of biological activities present in honeybee (Apis mellifera) royal jelly”, Toxicology in vitro, 19(5), 645-651, 2005.
  • [21] S. Koya-Miyata, I. Okamoto, S. Ushio, K. Iwaki, M. Ikeda, et al., “Identification of a collagen production-promoting factor from an extract of royal jelly and its possible mechanism”, Bioscience, Biotechnology, and Biochemistry, vol. ED-68, pp. 767-773, 2004.
  • [22] S. Ahmad, M. G. Campos, F. Fratini, S. Z. Altaye, and J. Li, “New insights into the biological and pharmaceutical properties of royal jelly”, International journal of molecular sciences, vol. ED-21 pp. 382, 2020.
  • [23] C. I. Pavel, L. A. Mărghitaş, O. Bobiş, D. S. Dezmirean, A. Şapcaliu, et al., “Biological activities of royal jelly-review”, Scientific Papers Animal Science and Biotechnologies, vol. ED-44, pp. 108-118, 2011.
  • [24] H. Guo, Y. Kouzuma, M. Yonekura, “Structures and properties of antioxidative peptides derived from royal jelly protein”, Food Chemistry, vol. ED-113, pp. 238-245, 2009.
  • [25] T. Nagai, R. Inoue, “Preparation and the functional properties of water and alkaline extract of royal jelly”, Food Chemistry, vol. ED-84, pp. 181-186, 2004.
  • [26] J. R. Liu, Y. C. Yang, L. S. Shi, C. C. Peng, “Antioxidant properties of royal jelly associated with larval age and time of harvest”, Alternative Medicine Review, vol. ED-13, pp. 330‐333, 2008.
  • [27] S. Pourmoradian, R. Mahdavi, M. Mobasseri, E. Faramarzi, M. Mobasseri, “Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: a randomized clinical trial”, Chinese Journal of Integrative Medicine, vol. ED-20, pp. 347-352, 2014.
  • [28] A. A. El-Nekeety, W. El-Kholy, N. F. Abbas, A. Ebaid, H. A. Amra, M. A. Abdel-Wahhab, “Efficacy of royal jelly against the oxidative stress of fumonisin in rats”, Toxicon, vol. ED-50, pp. 256-269, 2007.
  • [29] S. I. Inoue, S. Koya-Miyata, S. Ushio, K. Iwaki, M. Ikeda, et al., “Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage”, Experimental Gerontology, vol. ED-38, pp. 965-969, 2003.
  • [30] K. Çavuşoğlu, K. Yapar and E. Yalçin, “Royal jelly (honey bee) is a potential antioxidant against cadmium-induced genotoxicity and oxidative stress in albino mice”, Journal of medicinal food, vol. ED-12, 1286-1292, 2009.
  • [31] W. A. Moselhy, A. M. Fawzy, A. A. Kamel, “An evaluation of the potent antimicrobial effects and unsaponifiable matter analysis of the royal jelly”, Life Science Journal, vol. ED-2, pp. 290-296, 2013.
  • [32] S. Eshraghi, F. Seifollahi, “Antibacterial effects of royal jelly on different strains of bacteria”, Iranian Journal of Public Health, 32(1), 25-30, 2003.
  • [33] S. Eshraghi, “An evaluation of the potent inhibitory effects of royal jelly fractions against Streptomyces bacteria”, Pakistan Journal of Medical Sciences, vol. ED-21, pp. 63-68, 2005.
  • [34] Y. Miyata, H. Sakai, “Anti-cancer and protective effects of royal jelly for therapy-induced toxicities in malignancies”, International journal of molecular sciences, vol. ED-19, pp. 3270, 2018.
  • [35] S. Zhang, Q. Shao, H. Geng, S. Su, “The effect of royal jelly on the growth of breast cancer in mice”, Oncology Letters, vol. ED-14, pp. 7615-7621, 2017.
  • [36] M. Nakaya, H. Onda, K. Sasaki, A. Yukiyoshi, H. Tachibana, et al., “Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells”, Bioscience, Biotechnology, and Biochemistry, vol. ED-71, pp. 253-255, 2007.
  • [37] A. Gismondi, E. Trionfera, L. Canuti, G. Di Marco, A. Canini, “Royal jelly lipophilic fraction induces antiproliferative effects on SH-SY5Y human neuroblastoma cells”, Oncology Reports, vol. ED-38, pp. 1833-1844.
  • [38] S. Zhang, Q. Shao, Z. Shen, S. Su, “Immunomodulatory response of 4T1 murine breast cancer model to camellia royal jelly”, Biomedical Research, vol. ED-28, pp.0970-938X, 2017.
  • [39] M. Shirzad, R. Kordyazdi, N. Shahinfard, M. Nikokar, “Does Royal jelly affect tumor cells?”, Journal of HerbMed Pharmacology, vol. ED-2, 2013.
  • [40] S. A. Abdelnour, M. E. Abd El‐Hack, M. Alagawany, A. E. Taha, S. S. Elnesr, et al., “Useful impacts of royal jelly on reproductive sides, fertility rate and sperm traits of animals”, Journal of Animal Physiology and Animal Nutrition”, vol. ED-104, pp.1798-1808, 2020.
  • [41] A. Kato, “Effect of royal jelly on development of genital organs in male mice”, The Journal of Veterinary Medical Science, vol. ED-35, pp. 1-4, 1988.
  • [42] B. Du, K. Takahashi, G. M. Ishida, K. Nakahar, H. Saito, H. Kurachi H. “Usefulness of intraovarian artery pulsatility and resistance indices measurement on the day of follicle aspiration for the assessment of oocyte quality”, Fertility and Sterility, vol. ED-85, pp. 366-370, 2006.
  • [43] M. Attaran, E. Pasqualotto, T. Falcone, J. M. Goldberg, K. F. Miller et al., “The effect of follicular fluid reactive oxygen species on the outcome of in vitro fertilization”. International Journal of Fertility and Women's Medicine, vol. ED- 45, pp. 314-320, 2000.
  • [44] E. Ghanbari, V. Nejati, M. Khazaei “Antioxidant and protective effects of royal jelly on histopathological changes in testis of diabetic rats”, International Journal of Reproductive BioMedicine, vol. ED-14, pp. 519-529, 2016.
  • [45] A. T. Abdelhafiz and J. A. Muhamad, “Midcycle pericoital intravaginal bee honey and royal jelly for male factor infertility”, International Journal of Gynecology & Obstetrics, vol. ED-101, pp.146-149, 2008.
  • [46] K. Suzuki, Y. Isohama, H. Maruyama, Y. Yamada, Y. Narita, et al., “Estrogenic activities of fatty acids and a sterol isolated from royal jelly”, Evidence Based Complementary Alternative Medicine, vol. ED-5, pp. 295-302, 2008.
  • [47] M. Bucekova, M. Sojka, I. Valachova, S. Martinotti, E. Ranzato, et al., “Bee-derived antibacterial peptide, defensin-1, promotes wound reepithelialisation in vitro and in vivo”, Wound Healing Southern Africa, vol. ED-10, pp. 25-35, 2017.
  • [48] K. Kohno, I. Okamoto, O. Sano, N. Arai, K. Iwaki, et al., “Royal jelly inhibits the production of proinflammatory cytokines by activated macrophages”, Bioscience, biotechnology, and biochemistry, vol. ED-68, pp. 138-145, 2004.
  • [49] Y. Lin, M. Zhang, L. Wang, T. Lin, G. Wang, et al., “The in vitro and in vivo wound-healing effects of royal jelly derived from Apis mellifera L. during blossom seasons of Castanea mollissima Bl. and Brassica napus L. in South China exhibited distinct patterns”, BMC Complementary Medicine and Therapies, vol. ED-20, pp. 1-13, 2020.
  • [50] J. Kim, Y. Kim, H. Yun, H. Park, S. Kim, et al., “Royal jelly enhances migration of human dermal fibroblasts and alters the levels of cholesterol and sphinganine in an in vitro wound healing model”, Nutrition Research and Practice, vol. ED-4, pp. 362-368, 2010.
  • [51] M. Siavash, S. Shokri, S. Haghighi, M. Mohammadi, M. A. Shahtalebi, et al., “The efficacy of topical Royal Jelly on diabetic foot ulcers healing: A case series”, Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences, vol. ED-16, pp. 904, 2011.
  • [52] K. Suemaru, R. Cui, B. Li, S. Watanabe, K. Okihara, et al., “Topical application of royal jelly has a healing effect for 5-fluorouracil-induced experimental oral mucositis in hamsters”. Methods & Findings in Experimental & Clinical Pharmacology, vol. ED-30, pp. 103-106, 2008.
  • [53] H. Y. Kim, H. M. Choi, S. G. Kim, S. O. Woo, H. J. Moon, et al., “Skin health improving effects of Korean freeze-dried royal jelly in human keratinocytes”, Asian Journal of Beauty and Cosmetology, vol. ED-18, pp. 413-422, 2020.
  • [54] M. L. B. Severo, S. Thieme, F. M. Silveira, R. P. M. Tavares, A. K. G. Gonzaga, et al., “Royal jelly and propolis therapies reduce inflammation and stimulate healing of oral mucositis in rats”, 2021.
  • [55] F. Fratini, G. Cilia, S. Mancini, A. Felicioli, “Royal Jelly: An ancient remedy with remarkable antibacterial properties”, Microbiological Research, vol. ED-192, pp. 130-141, 2016.
  • [56] X. X. Xin, Y. Chen, D. Chen, F. Xiao, L. D. Parnell, et al., “Supplementation with major royal-jelly proteins increases lifespan, feeding, and fecundity in Drosophila”, Journal of Agricultural and Food Chemistry, vol. ED-64, pp. 5803-5812, 2016.
  • [57] G. Detienne, W. De Haes, U. R. Ernst, L. Schoofs and L. Temmerman “Royalactin extends lifespan of Caenorhabditis elegans through epidermal growth factor signaling”, Experimental gerontology, vol. ED-60, pp. 129-135, 2014.
  • [58] J. Halloran, S. A. Hussong, R. Burbank, N. Podlutskaya, K. E. Fischer, et al., “Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice”, Neuroscience, vol. ED-223, pp. 102-113, 2012.
  • [59] A. M. Ali and H. Kunugi, “Royal Jelly as an intelligent anti-aging agent-A focus on cognitive aging and Alzheimer’s disease: A review”, Antioxidants, vol. ED-9, pp. 937, 2020.
  • [60] A. M., Kirova, R. B. Bays, S. Lagalwar, “Working memory and executive function decline across normal aging, mild cognitive impairment, and Alzheimer’s disease”, BioMed Research International, 2015.
  • [61] N. J. Raine-Fenning, M. P. Brincat, Y. Muscat-Baron, “Skin aging and menopause”, American Journal of Clinical Dermatology, vol. ED-4, pp. 371-378, 2003.
  • [62] H. M. Park, M. H. Cho, Y. Cho, S. Y. Kim, “Royal jelly increases collagen production in rat skin after ovariectomy”, Journal of Medicinal Food, vol. ED-15, pp. 568-575, 2012.
  • [63] A. Bălan, M. A. Moga, L. Dima, S. Toma, A. Elena Neculau, et al., “Royal jelly—A traditional and natural remedy for postmenopausal symptoms and aging-related pathologies”, Molecules, vol. ED-25, pp. 3291, 2020.
  • [64] S. Wild, G. Roglic, A. Green, R. Sicree, H. King, “Global prevalence of diabetes: estimates for the year 2000 and projections for 2030”, Diabetes Care, vol. ED-25, pp. 1047-1053, 2004.
  • [65] K. O’Connor, “The demonstration of insulin-like material in the honey bee Apis mellifera”, Comparative Biochemistry and Physiology, vol. ED-81, pp. 755-776, 1985.
  • [66] K. Münstedt, M. Bargello, A. Hauenschild, “Royal jelly reduces the serum glucose levels in healthy subjects”, Journal of Medicinal food, vol. ED-12, pp. 1170-1172, 2009
  • [67] Y. Zamami, S. Takatori, M. Goda, T. Koyama, Y. Iwatani et al., “Royal jelly ameliorates insulin resistance in fructose-drinking rats”, Biological and Pharmaceutical Bulletin, vol. ED-31, pp. 2103-3107, 2008.

Details

Primary Language English
Subjects Biology
Journal Section Reviews
Authors

İlkay CİVELEK> (Primary Author)
NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ
0000-0002-8241-1596
Türkiye

Publication Date June 30, 2022
Published in Issue Year 2022, Volume 3, Issue 1

Cite

EndNote %0 Anatolian Journal of Biology Biological activities of royal jelly: a mini-review %A İlkay Civelek %T Biological activities of royal jelly: a mini-review %D 2022 %J Anatolian Journal of Biology %P 2687-444X- %V 3 %N 1 %R %U