INFLAMMATORY MARKERS AND MORTALITY IN PATIENTS WITH GRAM NEGATIVE BACTEREMIA

Year 2023, Volume: 5 Issue: 2, 53 - 60, 31.07.2023

Recai Aci , Adem Keskin , Murat Arı

Abstract

Background/aim:In our study, we aimed to determine the relationship between C-reactive protein (CRP), neutrophils, lymphocytes, platelets, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), length of hospitalization and mortality in patients with gram negative bacteremia in blood cultures.
Materials and methods :The files of patients who were hospitalized in our hospital between January 2022 and May 2022 and for whom CRP and CBC (complete blood count) tests were requested simultaneously with blood culture were retrospectively analyzed. The study included 50 patients between the ages of 31 and 88 who were diagnosed with gram (-) sepsis.
Results :There was no significant difference between the groups in terms of age, CRP, neutrophil, lymphocyte, platelet and NLR levels. The length of hospitalization in the ex group was higher than the length of hospitalization in the discharge group. In addition, the PLR rate in the ex group was lower than the PLR rate in the discharge group. CRP levels were positively correlated with NLR levels in patients with gram negative bacterial sepsis.
Conclusion :In this study, it was found that NLR and CRP values were not statistically significant in determining the prognosis of patients diagnosed with Gram negative bacteremia. However, due to the high mortality rate and hospitalization duration of these patients, it was concluded that follow-up and treatment of these patients is important together with some markers. These findings emphasize that the correct approach in the treatment of patients diagnosed with Gram-negative bacteremia should be planned by considering the symptoms.

Keywords

Bacteremia, sepsis, C-reactive protein, NLR, PLR, Mortality

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