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Bioactive Compounds in Olive Oil and Their Health Benefits

Year 2012, Volume: 10 Issue: 1, 77 - 84, 01.03.2012

Abstract

Along with its high content of monounsaturated fatty acids, olive oil is an important source of health beneficial phytochemicals such as phenolic compounds, squalene, and vitamin E. It is also considered as a ‘natural functional food’, and it may have protective effects on oxidative stress derived illnesses such as cancer, cardiovascular diseases, ulcer, diabetes and age-related disorders such as Alzheimer and dementia. It has been stated that high consumption of olive oil is associated with a reduced risk of incidence and mortality of cardiovascular disease and cancer. This protective effect is more likely to be the synergistic interactions between bioactive compounds in olive oil. In this review, the health benefits of olive oil bioactive compounds and their mechanisms of actions are reviewed

References

  • Trichopoulou, A, Costacou, T., Bamia, C., 2003. Adherence to a Mediterranean diet and survival in a Greek population. New England Journal of Medicine 348: 2599-2608.
  • Sofi, F., Cesari, F., Abbate, R., Gensini, G.F., Casini, A., 2008. Adherence to Mediterranean diet and health status: meta-analysis. BMJ 337:1344- 1350.
  • Alonso, A., Martínez-González, M.A., 2004. Olive oil consumption and reduced incidence of hypertension: the SUN study. Lipids 39: 1233-1238.
  • Esposito, K., Marfella, R., Ciotola, M., 2004. Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA 292: 1440-1446.
  • Estruch, R., Martínez-González, M.A., Corella, D., 2006. Effects of a Mediterranean style diet on cardiovascular risk factors: a randomized trial. Annals of Intern Medicine 145: 1-11
  • Kontogianni, M.D., Panagiotakos, D.B., Chrysohoou, C., Pitsavos, C., Zampelas, A., Stefanadis, C., 2007. The impact of olive oil consumption pattern on the risk of acute coronary syndromes: the CARDIO2000 case-control study. Clinical Cardiology 30: 125-129.
  • Visioli, F., Poli, A., Galli, C., 2002. Antioxidant and other biological activities of phenols from olives and olive oil. Medicinal Research Reviews 22: 65-75.
  • Liu, Z., Sun, L., Zhu, L., Jia, X., Li, X., Jia, H., 2007. Hydroxytyrosol protects retinal pigmentepithelial cells from acrolein-induced oxidative stress and mitochondrial Neurochemistry 103: 2690-2700. Journal of
  • Loru, D, Incani, A., Deiana, M., Corona, G., Atzeri, A., Melis, M.P., Rosa, A., Dessì, M.A., 2009. Protective effect of hydroxytyrosol and tyrosol against oxidative stress in kidney cells. Toxicology and Industrial Health 25: 301-310.
  • Bogani, P., Galli, C., Villa, M., Visioli, F., 2007. Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil. Atherosclerosi, 190: 181-186.
  • Zhang, X., Cao, J., Zhong, L., 2009. Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells. Naunyn-Schmied Archives of Pharmacology 379: 581-586.
  • Visioli, F., Galli, C., 2000. Olive oil: more than just oleic acid. American Journal of Clinical Nutrition 72: 853-856.
  • Serrano, P., Yago, M.A.D., Manas, M., Calpena, R., Mataix, J.A., Martinez-Victoria, E., 1997. Influence of type of dietary fat (olive and sunflower oil) upon gastric acid secretion and release of gastrin, somatostatin, and peptide YY in man. Digestive Diseases and Sciences 42: 626-633.
  • Della Ragione, F., Cucciolla, V., Borriello, A., Della Pietra, V., Pontoni, G., Racioppi, L., Manna, C., Galletti, P., Zappia, V., 2000. Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis. Biochemical and Biophysical Research Communications 278: 733-739
  • Quiles, J.L., Ochoa, J.J., Ramirez-Tortosa, C., Battino, M., Huertasa, J.R., Martina, Y., Mataix, J., 2004. Dietary fat type (virgin olive vs. sunflower oils) affects age-related changes in DNA double- strand-breaks, antioxidant capacity and blood lipids in rats. Experimental Gerontology 39: 1189-1198.
  • Gill, C.I.R., Boyd, A., McDermott, E., McCann, M.
  • Servili, M., Selvaggini, R., Taticchi, A., Esposto, S., Montedoro, G., McGlynn, H., Rowland, I., 2005. Potential anti-cancer effects of virgin olive oil phenols on colorectal carcinogenesis models in vitro. International Journal of Cancer 117: 1-7.
  • Medina, E., De Castro, A., Romero, C., Brenes, M., 2006. Comparison of the concentrations of phenolic compounds in olive oils and other plant oils: correlation with antimicrobial activity. Journal of Agricultural and Food Chemistry 54: 4954-4961.
  • Soriguer, F, Esteva, I, Rojo-Martinez, G, Ruiz de Adana M.S., Dobarganes, M.C., Garcia-Almeida, J.M., 2004. Oleic acid from cooking oils is associated with lower insulin resistance in the general population (Pizarra study). European Journal of Endocrinology 150: 33-39
  • Al-Azzawie, H.F., Alhamdani, M.S.S., 2006. Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbit. Life Sciences 78: 1371- 1377.
  • Schaffer, S., Podstawa, M., Visioli, F., Bogani, P., Muller, W.E., Eckert, G.P., 2007. Hydroxytyrosol- rich olive mill wastewater extract protects brain cells in vitro and ex vivo. Journal of Agricultural and Food Chemistry 55: 5043-5049.
  • Perugini, P., Vettor, M., Rona, C., Troisi, L., Villanova, L., Genta, I., Conti, B., Pavanetto, F., 2008. Efficacy of oleuropein against UVB irradiation: preliminary evaluation. International Journal of Cosmecautical Science 30: 113–120.
  • Hao, J., Shen, W., Yu, G., Jiaa, H., Li, X., Feng, Z., Wang, Y., Weber, P., Wertz, K., Sharman, E., Liu, J., 2010. Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes. Journal of Nutritional Biochemistry 21: 634-644.
  • Anonim, 2004 http://www.fda.gov/bbs/topics/news/ 2004/NEW01129.html. Erişim Tarihi: Kasım 2011.
  • Trichopolou, A., Dilis, V., 2007. Olive oil and longevity. Molecular Nutrition and Food Research 51: 1275-1278.
  • Servili, M., Selvaggini, R., Esposto, S., Taticchi, A., Montedoro, G., Morozzi, G., 2004. Health and sensory properties of virgin olive oil hydrophilic phenols: agronomic and technological aspects of production that affect their occurrence in the oil. Journal of Chromatography A 1054: 113-127
  • Tovar, M.J., Motilva, M.J., Romero, M.P. 2001. Changes in the phenolic composition of virgin olive oil from young trees (Olea europaea L. cv. Arbequina) grown under linear irrigation strategies. Journal of Agricultural and Food Chemistry 49: 5502-5508.
  • Briante, R., Patumi, M., Limongelli, S., Febbraio, F., Vaccaio, C., DiSalle, A., LaCara, F., Nucci, R., 2002. Changes in phenolic and enzymatic activities content during fruit ripening in two Italian cultivars of Olea europaea. Plant Science 162: 791-798.
  • Criado, M.N., Morelló, J.R., Motilva, M.J., Romero, M.P., 2004. Effect of growing area on pigment and phenolic fractions of virgin olive oils of the arbequina variety in Spain. Journal of American Oil Chemist’s Society 81: 633-640.
  • Carrasco-Pancorbo, A., Cerretani, L., Bendini, A., A., Segura-Carretero
  • Gallina-Toschi, T., A., 2005. Analytical
  • García-González, D.L., Aparicio-Ruiz, R., Aparicio
  • R., 2008. Virgin olive oil- chemical implications on quality and health. European Journal of Lipid Science and Technology 110: 602-607.
  • Reaven, P.D., Witztum, J.L., 1996. Oxidized low density lipoproteins in atherogenesis: role of dietary modification. Annual Reviews of Nutrition 16: 51-71
  • Vincent-Baudry, S., Defoort, C., Gerber, M., 2005. The cardiovascular disease risk factors after a 3-mo intervention with a Mediterranean-type diet or a low- fat diet. American Journal of Clinical Nutrition 82: 964-971. study: reduction of
  • Kris-Etherton, P.M., Pearson, T.A., Wan, Y., 1999. High monounsaturated fatty acid diets lower both plasma concentrations. American Journal of Clinical Nutrition 70: 1009-1015. and triacylglycerol
  • Teres, S., Barcelo-Coblijn, G., Benet, M., Alvarez, R., Bressani, R., Halver, J.E., 2008. Oleic acid content is responsible for the reduction in blood pressure induced by olive oil. Proceedings of National Academy of Sciences USA 105: 13811- 13816.
  • Smith, R.D., Kelly, C.N., Fielding, B.A., 2003. Long- term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects. British Journal of Nutrition 90: 597-606.
  • Jeffery, N.M., Yaqoob, P., Newsholme, E.A., Calder, P.C., 1996. The effects of olive oil upon rat serum lipid levels and lymphocyte functions appear to be due to oleic acid. Annals of Nutrition and Metabolism 40: 71-80.
  • Escrich, E., Moral, R., Grau, L., Costa, I., Solanas, M., 2007. Molecular mechanisms of the effects of olive oil and other dietary lipids on cancer. Molecular Nutrition and Food Research 51: 1279- 1292.
  • Yamaki, T., Yano, T., Satoh, H., Endo, T., 2002. High oleic acid oil suppresses lung tumorigenesis in mice through the modulation of extracellular signal- regulated kinase cascade. Lipids 37: 783-788.
  • Lopez, S., Bermudez, B., Pacheco, Y.M., Villar, J., Abia, R., Muriana, F.J., 2008. Distinctive postprandial modulation of beta cell function and insulin sensitivity by dietary fats: monounsaturated compared with saturated fatty acids. American Journal of Clinical Nutrition 88: 638- 644.
  • Paniagua, J.A., de la Sacristana, A.G., Sanchez, E., Romero, I., Vidal- Puig, A., Berral, F.J., 2007. A MUFA-rich diet improves posprandial glucose, lipid and GLP-1 responses in insulin-resistant subjects. Journal of American Collaborative Nutrition 26: 434- 444.
  • Solfrizzi, V., Colacicco, A.M., D’Introno, A., Capurso, C., Torres, F., Rizzo, C., 2006. Dietary intake of unsaturated fatty acids and agerelated cognitive decline: a 8.5-year follow-up of the Italian longitudinal study on aging. Neurobiology of Aging 27: 1694-1704.
  • Barberger-Gateau, P., Raffaitin, C., Letenneur, L., Berr, C.,Tzourio, C., Dartigues, J.F., 2007. Dietary patterns and risk of dementia: the Three-City cohort study. Neurology 69: 1921-1930.
  • Servili, M., Esposto, S., Fabiani, R., Urbani, S., Taticchi, A., Mariucci, F., Selvaggini, R., Montedoro, G. F., 2009. Phenolic compounds in olive oil: antioxidant, health and organoleptic activities according Inflammopharmacology 17: 76-84. chemical structure.
  • Cicerale, S., Conlan, X.A., Sinclair, A.J., Keast, R.S., 2009. Chemistry and health of olive oil phenolics. Critical Reviews in Food Science and Nutrition, 49: 218-236.
  • Hashim, Y.Z.H.Y., Rowland, I.R., McGlynn, H.
  • Servili, M., Selvaggini, R., Gill, C.I.R., 2008. Inhibitory effects of olive oil phenolics on invasion in human colon adenocarcinoma cells in vitro. International Journal of Cancer 122: 495-500.
  • Han, J., Talorete, T.P.N.,Yamada, P., Isoda, H., 2009. Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cells. Cytotechnology 59: 45-53.
  • Romero, C., Medina, E., Vargas, J., Brenes, M., De Castro, A., 2007. In vitro activity of olive oil polyphenols against Helicobacter pylori. Journal of Agricultural and Food Chemistry 55: 680-686.
  • Bu, Y., Rho, S., Kim, J., Kim, M.Y., Lee, D.H., Kim, S.Y., Choi, H., Kim, H., 2007. Neuroprotective effect of tyrosol on transient focal cerebral ischemia in rats. Neuroscience Letters 414: 218-221.
  • Puel, C., Mardon, J., Agalias, A., Davicco, M.J., Lebecque, P., Mazur, A., Skaltsounis, A.L., Coxam, V., 2008. Major phenolic compounds in olive oil modulate bone loss in an ovariectomy/inflammation experimental model. Journal of Agricultural and Food Chemistry 56: 9417-9422.
  • Bianco, A., Coccioli, F., Guiso, M., Marra, C., 2001. The occurrence in olive oil of a new class of phenolic compounds: hydroxyl isochromans. Food Chemistry 77: 405-411.
  • Zeh, M., Lorenz, P., Kreutzmann, P., Schönfeld, P.
  • Hydroxy-1-aryl-isochromans: 2008.
  • compounds against lipid peroxidation and cellular
  • nitrosative stress. Redox Report 13: 23-30.
  • Togna, G.I., Togna, A.R., Franconi, M., Marra, C., Guiso, M., 2003. Olive oil isochromans inhibit human platelet reactivity. Journal of Nutrition 133: 2532-2536.
  • Schönfeld, P., Kruska, N., Reiser, G., 2009. Antioxidative activity of the olive oil constituent hydroxy-1-aryl-isochromans in cells and cell-free systems. Biochimica. Biophysica. Acta 1790: 1698- 1704.
  • Reddy, L.H., Couvreur, P., 2009. Squalene: A
  • natural triterpene for use in disease management and therapy. Advanced Drug Delivery Reviews 61: 1412-1426.
  • Newmark, H.L., 1997. Squalene, olive oil, and
  • cancer risk: a review and hypothesis. Cancer Epidemiology, Biomarkers and Prevention 6: 1101- 1103. [56] Smith, T.J., 2000. Squalene: potential chemopreventive agent. Expert Opinion on Investigational Drugs 9:1841-1848.
  • Bernstein, P.S., 2002. New insights into the role of the macular carotenoids in age-related macular degeneration. Pure Applied Chemistry 74: 1419- 1425.
  • Rock, C.L., 2002. Carotenoids and cervical, breast, ovarian, and colorectal cancer. Epidemiology and clinical trials. Pure Applied Chemistry. 74:1451- 1459.
  • Palozza, P., 2004. Carotenoids and modulation of cancer: Pharmacogenomics 2: 35-45. targets. Current
  • Voutilainen, S., Nurmi, T., Mursu, J., Rissanen, T.H., 2006. Carotenoids and cardiovascular health. American Journal of Clinical Nutrition 83: 1265- 1271.
  • Young, A.J., Lowe, G.M., 2001. Antioxidant and prooxidant properties of carotenoids. Archieves of Biochemistry and Biophysics 385: 20-27.
  • Wang, X.D., Russell, R.M., 1999. Procarcinogenic and anticarcinogenic effects of beta-carotene. Nutrition Reviews 57: 263-272.
  • Russell, R.M., 2002. Beta-carotene and lung cancer. Pure Applied Chemistry 74:1461-1457.
  • Kim, Y., Lian, F., Yeum, K.J., Chongviriyaphan, N., Choi, S.W., Russell, R.M., Wang, X.D., 2007. The effects of combined antioxidant (beta-carotene, a- tocopherol and ascorbic acid) supplementation on antioxidant capacity, DNA single-strand breaks and levels of insulin-like growth factor-1/IGF-binding protein 3 in the ferret model of lung cancer. International Journal of Cancer 120: 1847-1854.
  • Palozza, P., Serini, S., Di Nicuolo, F., Piccioni, E., Calviello, G., 2003. Prooxidant effects of β- carotene in cultured cells. Molecular Aspects of Medicine 24: 353-362.
  • Trumbo, P.R., Ellwood, K.C., 2006. Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration’s evidence-based review system for health claims. American Journal of Clinical Nutrition 84: 971-974.
  • Carpentier, S., Knaus, M., Suh, M.Y., 2009. Associations between lutein, zeaxanthin, and agerelated macular degeneration: an overview. Critical Reviews in Food Science and Nutrition 49: 313-236.
  • Broniowska, K.A, Kirilyuk, I., Wisniewska, A., 2007. Spin-labelled lutein as a new antioxidant in protection against lipid peroxidation. Free Radical Research 41: 1053-1060.
  • Santocono, M., Zurria, M., Berrettini, M., Fedeli, D., Falcioni, G., 2007. Lutein, zeaxanthin and astaxanthin protect against DNA damage in SK-N- SH human neuroblastoma cells induced by reactive nitrogen species. Journal of Photochemistry and Photobiology B 88: 1-10.
  • Kamat, J.P., Boloor, K.K., Devasagayam, T.P.A., 2000. Chlorophyllin as an effective antioxidant against membrane damage in vitro and ex vivo. Biochimica Biophysica Acta- Molecular Cell Biology and Lipids 1487: 113-127.
  • Lanfer-Marquez, U.M., Barros, R.M.C., Sinnecker, P., 2005. Antioxidant activity of chlorophylls and their derivatives. Food Research International 38: 885-891.
  • Ferruzzi, M.G., Blakeslee, J., 2007. Digestion, absorption, and cancer preventative activity of dietary chlorophyll derivatives. Nutrition Research 27: 1-12.
  • Dutta, A., Dutta, S.K., 2003. Vitamin E and its role in the prevention of atherosclerosis and carcinogenesis: a review. Journal of American Collaborative Nutrition 22: 258-268.
  • Munteanu, A., Zingg, J.M., 2007. Cellular, molecular and clinical aspects of vitamin E on atherosclerosis prevention. Molecular Aspects in Medicine 28 (5-6): 538-590.
  • Kaul, N., Devaraj, S., Jialal, I., 2001. α-Tocopherol and atherosclerosis. Experimental Biology and Medicine 226: 5-12.
  • Morris, M.C., Evans, D.A., Tangney, C.C., Bienias, J.L., Wilson, R.S., Aggarwal, N.T., 2005. Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. American Journal of Clinical Nutrition 81 (2): 508-514.
  • Fariss, M.W., Zhang, J.G., 2003. Vitamin E therapy in Parkinson’s disease. Toxicology 189: 129-146.
  • Thiele, J.J., Ekanayake-Mudiyanselage, S., 2007. Vitamin E in human skin: organ-specific physiology and considerations for its use in dermatology. Molecular Aspects in Medicine 28: 646-667.
  • Covas, M.I., Ruiz-Gutiérrez, V., de la Torre, R., Kafatos, A., Lamuela-Raventos, R. M., Osada, J., Visioli, F., 2006. Minor components of olive oil: evidence to date of health benefits in humans. Nutrition Reviews 64 (10): 20-30.
  • Martinez-Gonzalez, J., Rodriguez-Rodriguez, R., Gonzalez- Diez, M., Rodriguez, C., Herrera, M.D., Ruiz-Gutierrez, V., 2008. Oleanolic acid induces prostacyclin release in human vascular smooth muscle cells through a cyclooxygenase-2- dependent mechanism. Journal of Nutrition 138: 443-448.
  • Rodríguez-Rodríguez, R., Herrera, M.D., Perona, S.J., vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids contained in “orujo” olive oil, on rat aorta. British Journal of Nutrition 92: 635-642. V., 2004. Potential
  • Gutierrez, F., Jimenez, B., Ruiz, A., Albi, M.A., 1999. Effect of olive ripeness on the oxidative stability of virgin olive oil extracted from the varieties picual and hojiblanca and on the different components involved. Journal of Agricultural and Food Chemistry 47: 121-127.
  • van Rensburg, S.J., Daniels, W.M., van Zyl, J.M., Taljaard, J.J., 2000. A comparative study of the effects of cholesterol, beta-sitosterol, betasitosterol glucoside, dehydroepiandrosterone sulphate and melatonin on in vitro lipid peroxidation. Metabolic Brain Disease 15: 257-265.
  • Devaraj, S., Autret, B.C., Jialal, I., 2006. Reduced- calorie orange juice beverage with plant sterols lowers C-reactive protein concentrations and improves the lipid profile in human volunteers. American Journal of Clinical Nutrition 84: 756-761.
  • Seppo, L., Jauhiainen, T., Nevala, R., Poussa, T., Korpela, R., 2007. Plant stanol esters in low-fat milk products lower serum total and LDL cholesterol. European Journal of Nutrition 46: 111-117.
  • Rudkowska, I., AbuMweis, S.S., Nicolle, C., Jones, P.J., 2008. Cholesterol-lowering efficacy of plant sterols in low-fat yogurt consumed as a snack or with a meal. Journal of American Collaborative Nutrition 27: 588-595.
  • Ntanios, F.Y., van de Kooij, A.J., de Deckere, E.A., Duchateau, G.S., Trautwein, E.A., 2003. Effects of various amounts of dietary plant sterol esters on plasma and hepatic sterol concentration and aortic foam cell formation of cholesterol-fed hamsters. Atherosclerosis 169: 41-50.
  • Raitakari, O.T., Salo, P., Gylling, H., Miettinen, T.A., 2008. Plant stanol ester consumption and arterial elasticity and endothelial function. British Journal of Nutrition 100: 603-608.
  • Hallikainen, M., Lyyra-Laitinen, T., Laitinen, T., 2006. Endothelial function in hypercholesterolemic subjects: effects of plant stanol and sterol esters. Atherosclerosis 188: 425-432.
  • Mendilaharsu, M., De Stefani, E., Deneo-Pellegrini, H., Carzoglio, J., Ronco, A., 1998. Phytosterols and risk of lung cancer: a case-control study in Uruguay. Lung Cancer 21:37-45.
  • Ronco, A., De Stefani, E., Boffetta, P., Deneo- Pellegrini, H., Mendilaharsu, M., Leborgne, F., 1999. Vegetables, fruits, and related nutrients and risk of breast cancer: a case-control study in Uruguay. Nutrition and Cancer 35:111-119.
  • De Stefani, E., Boffetta, P., Ronco, A.L., Brennan, P., Mendilaharsu, M., 2000a. Plant sterols and risk of stomach cancer: a case-control study in Uruguay. Nutrition and Cancer 37: 140-144. J.C.
  • De Stefani E, Brennan P, Boffetta P, Ronco AL, Mendilaharsu M, Deneo-Pellegrini H., 2000b. Vegetables, fruits, related dietary antioxidants, and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay. Nutrition and Cancer 38: 23-29.
  • Bradford, P.G., Awad, A.B., 2007. Phytosterols as anticancer compounds. Molecular Nutrition and Food Research 51:161-170.
  • Anonim, 2003. http://www.zae.gov.tr/zeytinyagi. Erişim Tarihi: Kasım 2011.

Zeytinyağının Biyoaktif Bileşenleri ve Sağlık Üzerine Yararları

Year 2012, Volume: 10 Issue: 1, 77 - 84, 01.03.2012

Abstract

Zeytinyağı içerdiği yüksek oranda tekli doymamış yağ asitleri ile karakterize edilmekte olup, sağlık üzerine yararlı etkilileri bulunan fenolik bileşikler, sekualen ve E vitamini gibi fitokimyasallar açısından önemli bir kaynaktır. Zeytinyağı ‘doğal fonksiyonel gıda’ olarak da bilinmekte ve oksidatif strese bağlı olarak oluşan kanser, kalp damar hastalıkları, ülser ve diyabet gibi hastalıklar ile Alzheimer ve bunama gibi yaşlanmaya bağlı oluşan hastalıklar üzerine koruyucu etkileri bulunmaktadır. Zeytinyağı tüketimine bağlı olarak kanser, kalp damar hastalıklarının oluşum riski ve bu hastalıklardan olan ölüm oranlarının daha az olduğu belirtilmektedir. Bu koruyucu etki zeytinyağı içinde bulunan biyoaktif bileşenlerin sinerjistik etkileşimi ile sağlanmaktadır. Bu çalışmada zeytinyağındaki biyoaktif bileşenlerinin sağlık üzerine yararları ve ilgili etki mekanizmaları derlenmiştir

References

  • Trichopoulou, A, Costacou, T., Bamia, C., 2003. Adherence to a Mediterranean diet and survival in a Greek population. New England Journal of Medicine 348: 2599-2608.
  • Sofi, F., Cesari, F., Abbate, R., Gensini, G.F., Casini, A., 2008. Adherence to Mediterranean diet and health status: meta-analysis. BMJ 337:1344- 1350.
  • Alonso, A., Martínez-González, M.A., 2004. Olive oil consumption and reduced incidence of hypertension: the SUN study. Lipids 39: 1233-1238.
  • Esposito, K., Marfella, R., Ciotola, M., 2004. Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA 292: 1440-1446.
  • Estruch, R., Martínez-González, M.A., Corella, D., 2006. Effects of a Mediterranean style diet on cardiovascular risk factors: a randomized trial. Annals of Intern Medicine 145: 1-11
  • Kontogianni, M.D., Panagiotakos, D.B., Chrysohoou, C., Pitsavos, C., Zampelas, A., Stefanadis, C., 2007. The impact of olive oil consumption pattern on the risk of acute coronary syndromes: the CARDIO2000 case-control study. Clinical Cardiology 30: 125-129.
  • Visioli, F., Poli, A., Galli, C., 2002. Antioxidant and other biological activities of phenols from olives and olive oil. Medicinal Research Reviews 22: 65-75.
  • Liu, Z., Sun, L., Zhu, L., Jia, X., Li, X., Jia, H., 2007. Hydroxytyrosol protects retinal pigmentepithelial cells from acrolein-induced oxidative stress and mitochondrial Neurochemistry 103: 2690-2700. Journal of
  • Loru, D, Incani, A., Deiana, M., Corona, G., Atzeri, A., Melis, M.P., Rosa, A., Dessì, M.A., 2009. Protective effect of hydroxytyrosol and tyrosol against oxidative stress in kidney cells. Toxicology and Industrial Health 25: 301-310.
  • Bogani, P., Galli, C., Villa, M., Visioli, F., 2007. Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil. Atherosclerosi, 190: 181-186.
  • Zhang, X., Cao, J., Zhong, L., 2009. Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells. Naunyn-Schmied Archives of Pharmacology 379: 581-586.
  • Visioli, F., Galli, C., 2000. Olive oil: more than just oleic acid. American Journal of Clinical Nutrition 72: 853-856.
  • Serrano, P., Yago, M.A.D., Manas, M., Calpena, R., Mataix, J.A., Martinez-Victoria, E., 1997. Influence of type of dietary fat (olive and sunflower oil) upon gastric acid secretion and release of gastrin, somatostatin, and peptide YY in man. Digestive Diseases and Sciences 42: 626-633.
  • Della Ragione, F., Cucciolla, V., Borriello, A., Della Pietra, V., Pontoni, G., Racioppi, L., Manna, C., Galletti, P., Zappia, V., 2000. Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis. Biochemical and Biophysical Research Communications 278: 733-739
  • Quiles, J.L., Ochoa, J.J., Ramirez-Tortosa, C., Battino, M., Huertasa, J.R., Martina, Y., Mataix, J., 2004. Dietary fat type (virgin olive vs. sunflower oils) affects age-related changes in DNA double- strand-breaks, antioxidant capacity and blood lipids in rats. Experimental Gerontology 39: 1189-1198.
  • Gill, C.I.R., Boyd, A., McDermott, E., McCann, M.
  • Servili, M., Selvaggini, R., Taticchi, A., Esposto, S., Montedoro, G., McGlynn, H., Rowland, I., 2005. Potential anti-cancer effects of virgin olive oil phenols on colorectal carcinogenesis models in vitro. International Journal of Cancer 117: 1-7.
  • Medina, E., De Castro, A., Romero, C., Brenes, M., 2006. Comparison of the concentrations of phenolic compounds in olive oils and other plant oils: correlation with antimicrobial activity. Journal of Agricultural and Food Chemistry 54: 4954-4961.
  • Soriguer, F, Esteva, I, Rojo-Martinez, G, Ruiz de Adana M.S., Dobarganes, M.C., Garcia-Almeida, J.M., 2004. Oleic acid from cooking oils is associated with lower insulin resistance in the general population (Pizarra study). European Journal of Endocrinology 150: 33-39
  • Al-Azzawie, H.F., Alhamdani, M.S.S., 2006. Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbit. Life Sciences 78: 1371- 1377.
  • Schaffer, S., Podstawa, M., Visioli, F., Bogani, P., Muller, W.E., Eckert, G.P., 2007. Hydroxytyrosol- rich olive mill wastewater extract protects brain cells in vitro and ex vivo. Journal of Agricultural and Food Chemistry 55: 5043-5049.
  • Perugini, P., Vettor, M., Rona, C., Troisi, L., Villanova, L., Genta, I., Conti, B., Pavanetto, F., 2008. Efficacy of oleuropein against UVB irradiation: preliminary evaluation. International Journal of Cosmecautical Science 30: 113–120.
  • Hao, J., Shen, W., Yu, G., Jiaa, H., Li, X., Feng, Z., Wang, Y., Weber, P., Wertz, K., Sharman, E., Liu, J., 2010. Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes. Journal of Nutritional Biochemistry 21: 634-644.
  • Anonim, 2004 http://www.fda.gov/bbs/topics/news/ 2004/NEW01129.html. Erişim Tarihi: Kasım 2011.
  • Trichopolou, A., Dilis, V., 2007. Olive oil and longevity. Molecular Nutrition and Food Research 51: 1275-1278.
  • Servili, M., Selvaggini, R., Esposto, S., Taticchi, A., Montedoro, G., Morozzi, G., 2004. Health and sensory properties of virgin olive oil hydrophilic phenols: agronomic and technological aspects of production that affect their occurrence in the oil. Journal of Chromatography A 1054: 113-127
  • Tovar, M.J., Motilva, M.J., Romero, M.P. 2001. Changes in the phenolic composition of virgin olive oil from young trees (Olea europaea L. cv. Arbequina) grown under linear irrigation strategies. Journal of Agricultural and Food Chemistry 49: 5502-5508.
  • Briante, R., Patumi, M., Limongelli, S., Febbraio, F., Vaccaio, C., DiSalle, A., LaCara, F., Nucci, R., 2002. Changes in phenolic and enzymatic activities content during fruit ripening in two Italian cultivars of Olea europaea. Plant Science 162: 791-798.
  • Criado, M.N., Morelló, J.R., Motilva, M.J., Romero, M.P., 2004. Effect of growing area on pigment and phenolic fractions of virgin olive oils of the arbequina variety in Spain. Journal of American Oil Chemist’s Society 81: 633-640.
  • Carrasco-Pancorbo, A., Cerretani, L., Bendini, A., A., Segura-Carretero
  • Gallina-Toschi, T., A., 2005. Analytical
  • García-González, D.L., Aparicio-Ruiz, R., Aparicio
  • R., 2008. Virgin olive oil- chemical implications on quality and health. European Journal of Lipid Science and Technology 110: 602-607.
  • Reaven, P.D., Witztum, J.L., 1996. Oxidized low density lipoproteins in atherogenesis: role of dietary modification. Annual Reviews of Nutrition 16: 51-71
  • Vincent-Baudry, S., Defoort, C., Gerber, M., 2005. The cardiovascular disease risk factors after a 3-mo intervention with a Mediterranean-type diet or a low- fat diet. American Journal of Clinical Nutrition 82: 964-971. study: reduction of
  • Kris-Etherton, P.M., Pearson, T.A., Wan, Y., 1999. High monounsaturated fatty acid diets lower both plasma concentrations. American Journal of Clinical Nutrition 70: 1009-1015. and triacylglycerol
  • Teres, S., Barcelo-Coblijn, G., Benet, M., Alvarez, R., Bressani, R., Halver, J.E., 2008. Oleic acid content is responsible for the reduction in blood pressure induced by olive oil. Proceedings of National Academy of Sciences USA 105: 13811- 13816.
  • Smith, R.D., Kelly, C.N., Fielding, B.A., 2003. Long- term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects. British Journal of Nutrition 90: 597-606.
  • Jeffery, N.M., Yaqoob, P., Newsholme, E.A., Calder, P.C., 1996. The effects of olive oil upon rat serum lipid levels and lymphocyte functions appear to be due to oleic acid. Annals of Nutrition and Metabolism 40: 71-80.
  • Escrich, E., Moral, R., Grau, L., Costa, I., Solanas, M., 2007. Molecular mechanisms of the effects of olive oil and other dietary lipids on cancer. Molecular Nutrition and Food Research 51: 1279- 1292.
  • Yamaki, T., Yano, T., Satoh, H., Endo, T., 2002. High oleic acid oil suppresses lung tumorigenesis in mice through the modulation of extracellular signal- regulated kinase cascade. Lipids 37: 783-788.
  • Lopez, S., Bermudez, B., Pacheco, Y.M., Villar, J., Abia, R., Muriana, F.J., 2008. Distinctive postprandial modulation of beta cell function and insulin sensitivity by dietary fats: monounsaturated compared with saturated fatty acids. American Journal of Clinical Nutrition 88: 638- 644.
  • Paniagua, J.A., de la Sacristana, A.G., Sanchez, E., Romero, I., Vidal- Puig, A., Berral, F.J., 2007. A MUFA-rich diet improves posprandial glucose, lipid and GLP-1 responses in insulin-resistant subjects. Journal of American Collaborative Nutrition 26: 434- 444.
  • Solfrizzi, V., Colacicco, A.M., D’Introno, A., Capurso, C., Torres, F., Rizzo, C., 2006. Dietary intake of unsaturated fatty acids and agerelated cognitive decline: a 8.5-year follow-up of the Italian longitudinal study on aging. Neurobiology of Aging 27: 1694-1704.
  • Barberger-Gateau, P., Raffaitin, C., Letenneur, L., Berr, C.,Tzourio, C., Dartigues, J.F., 2007. Dietary patterns and risk of dementia: the Three-City cohort study. Neurology 69: 1921-1930.
  • Servili, M., Esposto, S., Fabiani, R., Urbani, S., Taticchi, A., Mariucci, F., Selvaggini, R., Montedoro, G. F., 2009. Phenolic compounds in olive oil: antioxidant, health and organoleptic activities according Inflammopharmacology 17: 76-84. chemical structure.
  • Cicerale, S., Conlan, X.A., Sinclair, A.J., Keast, R.S., 2009. Chemistry and health of olive oil phenolics. Critical Reviews in Food Science and Nutrition, 49: 218-236.
  • Hashim, Y.Z.H.Y., Rowland, I.R., McGlynn, H.
  • Servili, M., Selvaggini, R., Gill, C.I.R., 2008. Inhibitory effects of olive oil phenolics on invasion in human colon adenocarcinoma cells in vitro. International Journal of Cancer 122: 495-500.
  • Han, J., Talorete, T.P.N.,Yamada, P., Isoda, H., 2009. Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cells. Cytotechnology 59: 45-53.
  • Romero, C., Medina, E., Vargas, J., Brenes, M., De Castro, A., 2007. In vitro activity of olive oil polyphenols against Helicobacter pylori. Journal of Agricultural and Food Chemistry 55: 680-686.
  • Bu, Y., Rho, S., Kim, J., Kim, M.Y., Lee, D.H., Kim, S.Y., Choi, H., Kim, H., 2007. Neuroprotective effect of tyrosol on transient focal cerebral ischemia in rats. Neuroscience Letters 414: 218-221.
  • Puel, C., Mardon, J., Agalias, A., Davicco, M.J., Lebecque, P., Mazur, A., Skaltsounis, A.L., Coxam, V., 2008. Major phenolic compounds in olive oil modulate bone loss in an ovariectomy/inflammation experimental model. Journal of Agricultural and Food Chemistry 56: 9417-9422.
  • Bianco, A., Coccioli, F., Guiso, M., Marra, C., 2001. The occurrence in olive oil of a new class of phenolic compounds: hydroxyl isochromans. Food Chemistry 77: 405-411.
  • Zeh, M., Lorenz, P., Kreutzmann, P., Schönfeld, P.
  • Hydroxy-1-aryl-isochromans: 2008.
  • compounds against lipid peroxidation and cellular
  • nitrosative stress. Redox Report 13: 23-30.
  • Togna, G.I., Togna, A.R., Franconi, M., Marra, C., Guiso, M., 2003. Olive oil isochromans inhibit human platelet reactivity. Journal of Nutrition 133: 2532-2536.
  • Schönfeld, P., Kruska, N., Reiser, G., 2009. Antioxidative activity of the olive oil constituent hydroxy-1-aryl-isochromans in cells and cell-free systems. Biochimica. Biophysica. Acta 1790: 1698- 1704.
  • Reddy, L.H., Couvreur, P., 2009. Squalene: A
  • natural triterpene for use in disease management and therapy. Advanced Drug Delivery Reviews 61: 1412-1426.
  • Newmark, H.L., 1997. Squalene, olive oil, and
  • cancer risk: a review and hypothesis. Cancer Epidemiology, Biomarkers and Prevention 6: 1101- 1103. [56] Smith, T.J., 2000. Squalene: potential chemopreventive agent. Expert Opinion on Investigational Drugs 9:1841-1848.
  • Bernstein, P.S., 2002. New insights into the role of the macular carotenoids in age-related macular degeneration. Pure Applied Chemistry 74: 1419- 1425.
  • Rock, C.L., 2002. Carotenoids and cervical, breast, ovarian, and colorectal cancer. Epidemiology and clinical trials. Pure Applied Chemistry. 74:1451- 1459.
  • Palozza, P., 2004. Carotenoids and modulation of cancer: Pharmacogenomics 2: 35-45. targets. Current
  • Voutilainen, S., Nurmi, T., Mursu, J., Rissanen, T.H., 2006. Carotenoids and cardiovascular health. American Journal of Clinical Nutrition 83: 1265- 1271.
  • Young, A.J., Lowe, G.M., 2001. Antioxidant and prooxidant properties of carotenoids. Archieves of Biochemistry and Biophysics 385: 20-27.
  • Wang, X.D., Russell, R.M., 1999. Procarcinogenic and anticarcinogenic effects of beta-carotene. Nutrition Reviews 57: 263-272.
  • Russell, R.M., 2002. Beta-carotene and lung cancer. Pure Applied Chemistry 74:1461-1457.
  • Kim, Y., Lian, F., Yeum, K.J., Chongviriyaphan, N., Choi, S.W., Russell, R.M., Wang, X.D., 2007. The effects of combined antioxidant (beta-carotene, a- tocopherol and ascorbic acid) supplementation on antioxidant capacity, DNA single-strand breaks and levels of insulin-like growth factor-1/IGF-binding protein 3 in the ferret model of lung cancer. International Journal of Cancer 120: 1847-1854.
  • Palozza, P., Serini, S., Di Nicuolo, F., Piccioni, E., Calviello, G., 2003. Prooxidant effects of β- carotene in cultured cells. Molecular Aspects of Medicine 24: 353-362.
  • Trumbo, P.R., Ellwood, K.C., 2006. Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration’s evidence-based review system for health claims. American Journal of Clinical Nutrition 84: 971-974.
  • Carpentier, S., Knaus, M., Suh, M.Y., 2009. Associations between lutein, zeaxanthin, and agerelated macular degeneration: an overview. Critical Reviews in Food Science and Nutrition 49: 313-236.
  • Broniowska, K.A, Kirilyuk, I., Wisniewska, A., 2007. Spin-labelled lutein as a new antioxidant in protection against lipid peroxidation. Free Radical Research 41: 1053-1060.
  • Santocono, M., Zurria, M., Berrettini, M., Fedeli, D., Falcioni, G., 2007. Lutein, zeaxanthin and astaxanthin protect against DNA damage in SK-N- SH human neuroblastoma cells induced by reactive nitrogen species. Journal of Photochemistry and Photobiology B 88: 1-10.
  • Kamat, J.P., Boloor, K.K., Devasagayam, T.P.A., 2000. Chlorophyllin as an effective antioxidant against membrane damage in vitro and ex vivo. Biochimica Biophysica Acta- Molecular Cell Biology and Lipids 1487: 113-127.
  • Lanfer-Marquez, U.M., Barros, R.M.C., Sinnecker, P., 2005. Antioxidant activity of chlorophylls and their derivatives. Food Research International 38: 885-891.
  • Ferruzzi, M.G., Blakeslee, J., 2007. Digestion, absorption, and cancer preventative activity of dietary chlorophyll derivatives. Nutrition Research 27: 1-12.
  • Dutta, A., Dutta, S.K., 2003. Vitamin E and its role in the prevention of atherosclerosis and carcinogenesis: a review. Journal of American Collaborative Nutrition 22: 258-268.
  • Munteanu, A., Zingg, J.M., 2007. Cellular, molecular and clinical aspects of vitamin E on atherosclerosis prevention. Molecular Aspects in Medicine 28 (5-6): 538-590.
  • Kaul, N., Devaraj, S., Jialal, I., 2001. α-Tocopherol and atherosclerosis. Experimental Biology and Medicine 226: 5-12.
  • Morris, M.C., Evans, D.A., Tangney, C.C., Bienias, J.L., Wilson, R.S., Aggarwal, N.T., 2005. Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change. American Journal of Clinical Nutrition 81 (2): 508-514.
  • Fariss, M.W., Zhang, J.G., 2003. Vitamin E therapy in Parkinson’s disease. Toxicology 189: 129-146.
  • Thiele, J.J., Ekanayake-Mudiyanselage, S., 2007. Vitamin E in human skin: organ-specific physiology and considerations for its use in dermatology. Molecular Aspects in Medicine 28: 646-667.
  • Covas, M.I., Ruiz-Gutiérrez, V., de la Torre, R., Kafatos, A., Lamuela-Raventos, R. M., Osada, J., Visioli, F., 2006. Minor components of olive oil: evidence to date of health benefits in humans. Nutrition Reviews 64 (10): 20-30.
  • Martinez-Gonzalez, J., Rodriguez-Rodriguez, R., Gonzalez- Diez, M., Rodriguez, C., Herrera, M.D., Ruiz-Gutierrez, V., 2008. Oleanolic acid induces prostacyclin release in human vascular smooth muscle cells through a cyclooxygenase-2- dependent mechanism. Journal of Nutrition 138: 443-448.
  • Rodríguez-Rodríguez, R., Herrera, M.D., Perona, S.J., vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids contained in “orujo” olive oil, on rat aorta. British Journal of Nutrition 92: 635-642. V., 2004. Potential
  • Gutierrez, F., Jimenez, B., Ruiz, A., Albi, M.A., 1999. Effect of olive ripeness on the oxidative stability of virgin olive oil extracted from the varieties picual and hojiblanca and on the different components involved. Journal of Agricultural and Food Chemistry 47: 121-127.
  • van Rensburg, S.J., Daniels, W.M., van Zyl, J.M., Taljaard, J.J., 2000. A comparative study of the effects of cholesterol, beta-sitosterol, betasitosterol glucoside, dehydroepiandrosterone sulphate and melatonin on in vitro lipid peroxidation. Metabolic Brain Disease 15: 257-265.
  • Devaraj, S., Autret, B.C., Jialal, I., 2006. Reduced- calorie orange juice beverage with plant sterols lowers C-reactive protein concentrations and improves the lipid profile in human volunteers. American Journal of Clinical Nutrition 84: 756-761.
  • Seppo, L., Jauhiainen, T., Nevala, R., Poussa, T., Korpela, R., 2007. Plant stanol esters in low-fat milk products lower serum total and LDL cholesterol. European Journal of Nutrition 46: 111-117.
  • Rudkowska, I., AbuMweis, S.S., Nicolle, C., Jones, P.J., 2008. Cholesterol-lowering efficacy of plant sterols in low-fat yogurt consumed as a snack or with a meal. Journal of American Collaborative Nutrition 27: 588-595.
  • Ntanios, F.Y., van de Kooij, A.J., de Deckere, E.A., Duchateau, G.S., Trautwein, E.A., 2003. Effects of various amounts of dietary plant sterol esters on plasma and hepatic sterol concentration and aortic foam cell formation of cholesterol-fed hamsters. Atherosclerosis 169: 41-50.
  • Raitakari, O.T., Salo, P., Gylling, H., Miettinen, T.A., 2008. Plant stanol ester consumption and arterial elasticity and endothelial function. British Journal of Nutrition 100: 603-608.
  • Hallikainen, M., Lyyra-Laitinen, T., Laitinen, T., 2006. Endothelial function in hypercholesterolemic subjects: effects of plant stanol and sterol esters. Atherosclerosis 188: 425-432.
  • Mendilaharsu, M., De Stefani, E., Deneo-Pellegrini, H., Carzoglio, J., Ronco, A., 1998. Phytosterols and risk of lung cancer: a case-control study in Uruguay. Lung Cancer 21:37-45.
  • Ronco, A., De Stefani, E., Boffetta, P., Deneo- Pellegrini, H., Mendilaharsu, M., Leborgne, F., 1999. Vegetables, fruits, and related nutrients and risk of breast cancer: a case-control study in Uruguay. Nutrition and Cancer 35:111-119.
  • De Stefani, E., Boffetta, P., Ronco, A.L., Brennan, P., Mendilaharsu, M., 2000a. Plant sterols and risk of stomach cancer: a case-control study in Uruguay. Nutrition and Cancer 37: 140-144. J.C.
  • De Stefani E, Brennan P, Boffetta P, Ronco AL, Mendilaharsu M, Deneo-Pellegrini H., 2000b. Vegetables, fruits, related dietary antioxidants, and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay. Nutrition and Cancer 38: 23-29.
  • Bradford, P.G., Awad, A.B., 2007. Phytosterols as anticancer compounds. Molecular Nutrition and Food Research 51:161-170.
  • Anonim, 2003. http://www.zae.gov.tr/zeytinyagi. Erişim Tarihi: Kasım 2011.
There are 103 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Banu Bayram This is me

Beraat Özçelik This is me

Publication Date March 1, 2012
Published in Issue Year 2012 Volume: 10 Issue: 1

Cite

APA Bayram, B., & Özçelik, B. (2012). Zeytinyağının Biyoaktif Bileşenleri ve Sağlık Üzerine Yararları. Akademik Gıda, 10(1), 77-84.
AMA Bayram B, Özçelik B. Zeytinyağının Biyoaktif Bileşenleri ve Sağlık Üzerine Yararları. Akademik Gıda. March 2012;10(1):77-84.
Chicago Bayram, Banu, and Beraat Özçelik. “Zeytinyağının Biyoaktif Bileşenleri Ve Sağlık Üzerine Yararları”. Akademik Gıda 10, no. 1 (March 2012): 77-84.
EndNote Bayram B, Özçelik B (March 1, 2012) Zeytinyağının Biyoaktif Bileşenleri ve Sağlık Üzerine Yararları. Akademik Gıda 10 1 77–84.
IEEE B. Bayram and B. Özçelik, “Zeytinyağının Biyoaktif Bileşenleri ve Sağlık Üzerine Yararları”, Akademik Gıda, vol. 10, no. 1, pp. 77–84, 2012.
ISNAD Bayram, Banu - Özçelik, Beraat. “Zeytinyağının Biyoaktif Bileşenleri Ve Sağlık Üzerine Yararları”. Akademik Gıda 10/1 (March 2012), 77-84.
JAMA Bayram B, Özçelik B. Zeytinyağının Biyoaktif Bileşenleri ve Sağlık Üzerine Yararları. Akademik Gıda. 2012;10:77–84.
MLA Bayram, Banu and Beraat Özçelik. “Zeytinyağının Biyoaktif Bileşenleri Ve Sağlık Üzerine Yararları”. Akademik Gıda, vol. 10, no. 1, 2012, pp. 77-84.
Vancouver Bayram B, Özçelik B. Zeytinyağının Biyoaktif Bileşenleri ve Sağlık Üzerine Yararları. Akademik Gıda. 2012;10(1):77-84.

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