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RESVERATROL IN WINES: THE EFFECTS ON CORONORY HEART DISEASES AND CANCER

Year 2006, Volume: 4 Issue: 3, 12 - 14, 01.06.2006

Abstract

Resveratrol is a non-flavonoid polyphenol that has attracted attention as a potential anti-cancer agent. On the other hand, it is expressed that coronory heart diseases are prevented by resveratrol. It has been related with resveratrol the benefits of drinking red wine 1or 2 glasses in a day. An inverse correlation between consumption of red wine and incidence of cardiovascular diseases led to the concept of the “French paradox”

References

  • Nonomura, S., Kanagawa, H. & Makimoto, A. 1963. Chemical
  • constituents of polygonaceus plants. Studies on the components of Ko-jokan
  • (Polyganum Cuspidatum SIEB et zucc). Yakugaku Zasshi, 83:983-988. 25. Aktan, N. 2000. Bir yudum şarap. Doğa Ofset, 48 sayfa. 26. Bisson, L. F., Butzke, C. E. & Ebeler, S. E. 1995. The role of moderate ethanol consumption in health and human nutrition. American Journal of Tissue Reaction, 17, 1-3.
  • A comparison of four red wine polyphenols. Clinical biochemistry, 35, 119- 124. 27. Blond, J., Denis, M. & Bezard, J. 1995. Antioxidant action of resveratrol in lipid peroxidation. Sciences des Aliments, 15, 347-358.
  • Langcake, P. & Pryce, R. J. 1976. The production of resveratrol by Vitis
  • vinifera and other members of the Vita ceae as a response to infection or injury.
  • Physiol plant., Pathol. 9:77-86. 28. Demrow, H. S., Slane, P. R. & Flots, J. D. 1995. Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronory arteries, Circulation, 91, 1182-1188.
  • Siemann, H.E. & Creasy. L. L. 1992. Concentration of the phytoalexin
  • resveratrol in wine. American Journal of Enology and Viticulture, 43, 49-52. 29. Fittzpatrick, D. E., Hirschfield, S. L. & Coffey, R. G. 1993. Endothelium- dependent vasorelex-ing activity of wine, grapes and other plant products. American Journal of Physiology, 265, H774-H778.
  • Improvement on enzymatic hydrolysis of resveratrol glucosides in wine.
  • Food Chem., 42; 2077-2083. 30. Frankel, E. N., Kanner, J., German, J. B., Parks, E. & Kinsella, J. E. 1993. Inhibition of oxidation of human low density lipoprotein by phenolic substances in red wine, Lancet. 341:454-457.
  • Goldberg, D. M., Yan, J., Ng. E., Diamandis, E. P., Karumanchiri, A.
  • Soleas, G. & Waterhouse, A. L. 1995. A global survey of trans-resveratrol
  • concentrations im commercial wines. American Journal of Enology and Viticulture, 46, 159-165. 31. Fuhrman, B., Lavy, A. & Aviram, M. 1995. Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein peroxidation. American Journal of Clinical Nutrition, 61, 549-554.
  • Soleas, G. J., Diamandis, E.P. & Goldberg. D. M. 1997. Clinical
  • biochemistry, 30:91-113. 32. Rimm, E. B., Giovannocci, E.L., Willett, W. C., Colditz, G. A., Ascherio, A., Rosner, B. & Stampfer, M. J. 1991. Prospective study of alcohol consuption and risk of coronary disease in men. Lancet, 338, 464-468.
  • Lopez-Velez, M., Martinez-Martinez, F. & Del Valle-Ribes, C. 2003. The
  • study of phenolic compounds as natural antioxidants in wine. Critical Reviews in
  • Food Science and Nutrition, 43(3): 233-244. 33. Seigneur, M., Bonnet, J., Dorian, B., Benchimol, D., Drouillet, F., Gouverneur, G., Larrue, J., Crockett, R., Boisseau, M., Ribereau-Gayon, P. & Bricaud, H. 1990. Effect of the consumption of alcohol, white wine and red wine on platelet function and serum lipids. Journal of applied and Viticulture, 43, 49-52.
  • De Santi, C., Pietrabissa, A., Spisni, R., Mosca, F. & Pacifici, G. M.
  • Sulphation of resveratrol a natural compoundpresent in wine and its
  • inhibition by natural favonoids. Xenobiotica, Vol: 30. No: 9, 857-866. 34. Ferraroni, M., Decarli., Franceschi, S. 1996. Validity and reproducibility of alcohol consumption in Italy. Int. J. Epidemiol., 25:775-82.
  • Vrhovsek, U., Wendelin, S. & Eder, R. 1997. Effects of various vinification
  • techniques on the concentration of cis- and trans resveratrol and resveratrol
  • glucoside isomers in wine. American Journal of Enology and Viticulture, 48, 214 219. 35. St Leger, A. S., Cochrana, A. L. & Moore, F. 1979. Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet., 1017-1020. 36. Bertelli, A. A., Giovannini, l., Gianessi , D., Migliori, M., Bernini. W., Fregoni, M. & Bertelli, A. 1995. Antiplatelet activity of synthetic and natural rsveratrol in red wine. International Journal of Enology and Viticulture, 38, 65-68.
  • determination of cis and trans-resveratrol in wines by capillary zone
  • electrophoresis. Analyst., 124, 61-66. 37. Hertog, M. G. L., Hollman, P.C.H. & Katan, M. B. 1992. Content of potentially anticarcinogenic flavonoids of 28 vegetables and nine fruits commonly consumed in the Netherlands. J. Agric.Food Chem., 40: 2379-83.
  • isomers in commercially available wines made from grapes cultivated in Japan.
  • Bioscience Biotechnology and Bichemistry, 61, 1800-1805. 38. Hollman, P. C. & Katan, M. B. 1997. Absorbtion, metabolism and health effects of dietary flavonoids. in. Man. Biomed Pharmacother, 51:305-10.
  • compounds from the grape wine to wine.. Drugs under Experimental and Clinical
  • Research, 25, 57-63. 39. Landofi, R., Moer, R. & Steiner, M. 1984. Modification of platelet function and arachidonic acid metabolism by flavonoids. Biochemistry Pharmacology, 33:1525-1530.
  • sefence mechanisms. Tansley Review. No.72, New Phytologist., 127, 617-633.
  • Fremont, L. 1999. Biological effects of resveratrol. Life Sciences, Vol.66, No.8, 663-673. 40. Subbarrmaiah, K., Chung, W. J., Michaluart, P., Telang, N., Tanabe, T. & Inoue, H. 1998. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J. Biol. Chem., 273: 21875-82.
  • Yücel, U. 2000. Geleneksel şarap üretiminde ekolojik yaklaşımlar. Dünya Gıda Ocak, 54-55. 41. Maccarrone, M., Lorenzon, T. & Guerrieri, P. 1999. Resveratrol prevents apontosis in K562 cells by inhibiting lipoxygenase activity. Eur. J. Biochem., 265: 27-34.
  • wine by capillary electrophoresis. Journal of Chromatography A, 881, 471-481.
  • Romero- Perez, A. I., Lamuela- Raventos, R. M., C, Andres Lacueva
  • C. & de La Torre- Boronat, M. C. 2001. Method for the quantitative extraction
  • of resveratrol and piceid isomers in grape berry skins. Effect of powdery mildew on
  • Chemistry, 76, 371-375
  • Tinttunen, S. & Lehtonen, P. 2001. Distinguishing organic wines from
  • normal wines on the basis of concentrations of phenolic compounds and spectral
  • data. Eur Food Res. Technol., 212;390-394
  • Savouret, J.F & Quesne. M. 2002. Resvereatrol and Cancer: A review.
  • Biomed Pharma cother, 56: 84-87.

Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları ve Kanser Üzerine Etkileri

Year 2006, Volume: 4 Issue: 3, 12 - 14, 01.06.2006

Abstract

Resveratrol flavonoid olmayan bir polifenol olup, potansiyel bir antikanserojen bileşik olarak değerlendirilmekte bunun yanı sıra söz konusu bileşiğin koroner kalp hastalıklarını önlemede etkili olduğu ifade edilmektedir. Günde 1-2 kadeh kırmızı şarap tüketiminin yararları bu bileşikle ilişkilendirilmiştir. Kırmızı şarap tüketimi ile kardiovasküler hastalıkların oluşumu arasındaki ters orantı Fransız paradoksu olarak tanımlanmaktadır

References

  • Nonomura, S., Kanagawa, H. & Makimoto, A. 1963. Chemical
  • constituents of polygonaceus plants. Studies on the components of Ko-jokan
  • (Polyganum Cuspidatum SIEB et zucc). Yakugaku Zasshi, 83:983-988. 25. Aktan, N. 2000. Bir yudum şarap. Doğa Ofset, 48 sayfa. 26. Bisson, L. F., Butzke, C. E. & Ebeler, S. E. 1995. The role of moderate ethanol consumption in health and human nutrition. American Journal of Tissue Reaction, 17, 1-3.
  • A comparison of four red wine polyphenols. Clinical biochemistry, 35, 119- 124. 27. Blond, J., Denis, M. & Bezard, J. 1995. Antioxidant action of resveratrol in lipid peroxidation. Sciences des Aliments, 15, 347-358.
  • Langcake, P. & Pryce, R. J. 1976. The production of resveratrol by Vitis
  • vinifera and other members of the Vita ceae as a response to infection or injury.
  • Physiol plant., Pathol. 9:77-86. 28. Demrow, H. S., Slane, P. R. & Flots, J. D. 1995. Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronory arteries, Circulation, 91, 1182-1188.
  • Siemann, H.E. & Creasy. L. L. 1992. Concentration of the phytoalexin
  • resveratrol in wine. American Journal of Enology and Viticulture, 43, 49-52. 29. Fittzpatrick, D. E., Hirschfield, S. L. & Coffey, R. G. 1993. Endothelium- dependent vasorelex-ing activity of wine, grapes and other plant products. American Journal of Physiology, 265, H774-H778.
  • Improvement on enzymatic hydrolysis of resveratrol glucosides in wine.
  • Food Chem., 42; 2077-2083. 30. Frankel, E. N., Kanner, J., German, J. B., Parks, E. & Kinsella, J. E. 1993. Inhibition of oxidation of human low density lipoprotein by phenolic substances in red wine, Lancet. 341:454-457.
  • Goldberg, D. M., Yan, J., Ng. E., Diamandis, E. P., Karumanchiri, A.
  • Soleas, G. & Waterhouse, A. L. 1995. A global survey of trans-resveratrol
  • concentrations im commercial wines. American Journal of Enology and Viticulture, 46, 159-165. 31. Fuhrman, B., Lavy, A. & Aviram, M. 1995. Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein peroxidation. American Journal of Clinical Nutrition, 61, 549-554.
  • Soleas, G. J., Diamandis, E.P. & Goldberg. D. M. 1997. Clinical
  • biochemistry, 30:91-113. 32. Rimm, E. B., Giovannocci, E.L., Willett, W. C., Colditz, G. A., Ascherio, A., Rosner, B. & Stampfer, M. J. 1991. Prospective study of alcohol consuption and risk of coronary disease in men. Lancet, 338, 464-468.
  • Lopez-Velez, M., Martinez-Martinez, F. & Del Valle-Ribes, C. 2003. The
  • study of phenolic compounds as natural antioxidants in wine. Critical Reviews in
  • Food Science and Nutrition, 43(3): 233-244. 33. Seigneur, M., Bonnet, J., Dorian, B., Benchimol, D., Drouillet, F., Gouverneur, G., Larrue, J., Crockett, R., Boisseau, M., Ribereau-Gayon, P. & Bricaud, H. 1990. Effect of the consumption of alcohol, white wine and red wine on platelet function and serum lipids. Journal of applied and Viticulture, 43, 49-52.
  • De Santi, C., Pietrabissa, A., Spisni, R., Mosca, F. & Pacifici, G. M.
  • Sulphation of resveratrol a natural compoundpresent in wine and its
  • inhibition by natural favonoids. Xenobiotica, Vol: 30. No: 9, 857-866. 34. Ferraroni, M., Decarli., Franceschi, S. 1996. Validity and reproducibility of alcohol consumption in Italy. Int. J. Epidemiol., 25:775-82.
  • Vrhovsek, U., Wendelin, S. & Eder, R. 1997. Effects of various vinification
  • techniques on the concentration of cis- and trans resveratrol and resveratrol
  • glucoside isomers in wine. American Journal of Enology and Viticulture, 48, 214 219. 35. St Leger, A. S., Cochrana, A. L. & Moore, F. 1979. Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet., 1017-1020. 36. Bertelli, A. A., Giovannini, l., Gianessi , D., Migliori, M., Bernini. W., Fregoni, M. & Bertelli, A. 1995. Antiplatelet activity of synthetic and natural rsveratrol in red wine. International Journal of Enology and Viticulture, 38, 65-68.
  • determination of cis and trans-resveratrol in wines by capillary zone
  • electrophoresis. Analyst., 124, 61-66. 37. Hertog, M. G. L., Hollman, P.C.H. & Katan, M. B. 1992. Content of potentially anticarcinogenic flavonoids of 28 vegetables and nine fruits commonly consumed in the Netherlands. J. Agric.Food Chem., 40: 2379-83.
  • isomers in commercially available wines made from grapes cultivated in Japan.
  • Bioscience Biotechnology and Bichemistry, 61, 1800-1805. 38. Hollman, P. C. & Katan, M. B. 1997. Absorbtion, metabolism and health effects of dietary flavonoids. in. Man. Biomed Pharmacother, 51:305-10.
  • compounds from the grape wine to wine.. Drugs under Experimental and Clinical
  • Research, 25, 57-63. 39. Landofi, R., Moer, R. & Steiner, M. 1984. Modification of platelet function and arachidonic acid metabolism by flavonoids. Biochemistry Pharmacology, 33:1525-1530.
  • sefence mechanisms. Tansley Review. No.72, New Phytologist., 127, 617-633.
  • Fremont, L. 1999. Biological effects of resveratrol. Life Sciences, Vol.66, No.8, 663-673. 40. Subbarrmaiah, K., Chung, W. J., Michaluart, P., Telang, N., Tanabe, T. & Inoue, H. 1998. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J. Biol. Chem., 273: 21875-82.
  • Yücel, U. 2000. Geleneksel şarap üretiminde ekolojik yaklaşımlar. Dünya Gıda Ocak, 54-55. 41. Maccarrone, M., Lorenzon, T. & Guerrieri, P. 1999. Resveratrol prevents apontosis in K562 cells by inhibiting lipoxygenase activity. Eur. J. Biochem., 265: 27-34.
  • wine by capillary electrophoresis. Journal of Chromatography A, 881, 471-481.
  • Romero- Perez, A. I., Lamuela- Raventos, R. M., C, Andres Lacueva
  • C. & de La Torre- Boronat, M. C. 2001. Method for the quantitative extraction
  • of resveratrol and piceid isomers in grape berry skins. Effect of powdery mildew on
  • Chemistry, 76, 371-375
  • Tinttunen, S. & Lehtonen, P. 2001. Distinguishing organic wines from
  • normal wines on the basis of concentrations of phenolic compounds and spectral
  • data. Eur Food Res. Technol., 212;390-394
  • Savouret, J.F & Quesne. M. 2002. Resvereatrol and Cancer: A review.
  • Biomed Pharma cother, 56: 84-87.
There are 44 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Ufuk Yücel This is me

Eren Akçiçek This is me

Publication Date June 1, 2006
Published in Issue Year 2006 Volume: 4 Issue: 3

Cite

APA Yücel, U., & Akçiçek, E. (2006). Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları ve Kanser Üzerine Etkileri. Akademik Gıda, 4(3), 12-14.
AMA Yücel U, Akçiçek E. Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları ve Kanser Üzerine Etkileri. Akademik Gıda. June 2006;4(3):12-14.
Chicago Yücel, Ufuk, and Eren Akçiçek. “Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları Ve Kanser Üzerine Etkileri”. Akademik Gıda 4, no. 3 (June 2006): 12-14.
EndNote Yücel U, Akçiçek E (June 1, 2006) Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları ve Kanser Üzerine Etkileri. Akademik Gıda 4 3 12–14.
IEEE U. Yücel and E. Akçiçek, “Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları ve Kanser Üzerine Etkileri”, Akademik Gıda, vol. 4, no. 3, pp. 12–14, 2006.
ISNAD Yücel, Ufuk - Akçiçek, Eren. “Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları Ve Kanser Üzerine Etkileri”. Akademik Gıda 4/3 (June 2006), 12-14.
JAMA Yücel U, Akçiçek E. Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları ve Kanser Üzerine Etkileri. Akademik Gıda. 2006;4:12–14.
MLA Yücel, Ufuk and Eren Akçiçek. “Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları Ve Kanser Üzerine Etkileri”. Akademik Gıda, vol. 4, no. 3, 2006, pp. 12-14.
Vancouver Yücel U, Akçiçek E. Şaraplarda Resveratrol Bileşiği: Koroner Kalp Hastalıkları ve Kanser Üzerine Etkileri. Akademik Gıda. 2006;4(3):12-4.

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