Kersetin

Year 2005, Volume: 3 Issue: 2, 16 - 21, 01.04.2005

Derya Arslan Ahmet Ünver Musa Özcan

Abstract

Quercetin is a flavonoid molecule, which has been thought to exhibit a variety of biological activities including cardiovascular protection, anti-cancer activity and anti-inflammation. Quercetin appears to be associated with little toxicity when administered orally or intravenously. Some research data showed that quercetin induce cancer in animals. Most further research did not find this to be true, however. In fact quercetin has been found to inhibit both tumor and cancer cells. More research is needed to elucidate the functional effects of quercetin in human body

Kersetin

Abstract

Kersetin kalp hastalıklarına karşı koruma, antiKersetinin kimyasal yapısı ve özelliklerikanser ve anti-enflamasyon gibi çeşitli biyolojik aktiviteler gösterdiği düşünülen bir flavonoit molekülüdür. Kersetinin, ağız ya da damar yoluyla vücuda alındığında çok az da olsa toksisite gösterebildiği öne sürülmüştür. Bazı araştırma sonuçları hayvanlarda kansere yol açtığını göstermiştir. Ancak daha sonra yapılan bir çok araştırma bu sonuçları doğrulamamıştır. Esasen kersetin tümör gelişimini değişmesiyle çok sayıda farklı flavonoit tipleri meydana stimule eden bileşikleri ve insan kanser hücrelerini inhibe edebilmektedir. Kersetinin insan vücudunda fonksiyonel etkilerinin belirlenmesi için daha çok araştırmaya ihtiyaç vardır

References

• Aeschbacher H-U, Meier H, RuchE. Nonmutagenicity in vivo of the food flavonol quercetin. Nutr Cancer 1982;2:90.
• Ambrose AM, Robbins DJ, DeEds F. Comparative toxicities of quercetin and quercitrin. J Am Pharm Assoc 1952;41:119-122.
• ] Andlauer, W., Stumpf, C., and Fürst, P. Influence of the acetification process on phenolic compounds. J. Agric. Food Chem., 2000, 48, 3533-3536
• Bate-Smith, E.C., 194. astringency in food. Foods, 23, 124
• Berhow, M., Tisserat, B., Kanes, K., and Vandercook, C. Survey of phenolic compounds produced in citrus. Technical Bulletin Number 1856, ARS, USDA, December 1998.
• Betes-Saura, C., Andres-Lacueva, C., and Lamuela-Raventos, R. M. Phenolics in white free run juices and wines from Penedes by high performance liquid chromatography: Changes during vinification. J. Agric. Food Chem., 1996, 44, 3040-3046.
• Bilyk, A., Cooper, P. L., and Sapers, G. M. Vaietal differences in distribution of qercetin and kaempferol in onion (Allium cepa L.) Tissue.J. Agric. Food Chem., 1984, 32, 274-276.
• Bilyk, A., and Sapers, G. M. Distribution of quercetin and kaempferol in lettuce, kale, chive, garlic chive, leek, horseradish, red radish, and red cabbage tissues. J. Agric. Food Chem., 1985, 33, 226-228
• Bilyk, A., and Sapers, G. M. Varietal differences in the quercetin, kaempferol, and myricetin contents of highbush blueberry, cranberry, and thornless blackberry fruits. J. Agric. Food Chem., 1986, 34, 585-588
• Bjeldanes LF, Chang GW. Mutagenic activity of quercetin and related compounds. Science 1977;197:577-578.
• Bonvehí, J. S., Torrentó, M. S., and Lorente, E. C. Evaluation of polyphenolic and flavonoid compounds in honeybee-collected polen produced in Spain. J. Agric. Food Chem., 2001, 49, 1848-1853.
• Bronner C. Kinetics of the inhibitory effect of flavonoids on histamine secretion from mast cells. Agents Actions 1985; 16:147
• Burda, S., Oleszek, W., and Lee, C. Y. Phenolic compounds and their changes in apples during maturation and cold storage. J. Agric. Food Chem., 1990, 38, 945-948.
• Butland B. Diet, lung function, and lung function decline in a cohort of 2512 middle aged men. Thorax 2000; 55:102 .
• Chang WS, Lee YJ, Lu FJ, Chiang HC. Inhibitory effects of flavonoids on xanthine oxidase. Anticancer Res 1993; 13:2165-2170.
• Chen YT, Zheng RL, Jia ZJ, Ju Y. Flavonoids as soperoxide scavengers and antioxidants. Free Radic Biol Med 1990;9:19-21.
• Chu, Y-H., Chang, C-L., and Hsu, H-F. Flavonoid content of several vegetables and their antioxidant activity. J. Sci. Food Agric., 2000, 80, 561-566
• Crataegus Oxycantha. Common Name: Hawthorne. Alternative Medicine Review. 3(2): 138-139. April 1998.
• Crebelli R, Aquilina G, Falcone E, Carere A. Urinary and faecal mutagenicity in Sprague-Dawley rats dosed with the food mutagen quercetin and rutin. Food Chem Toxicol 1987;25:9-15
• Crozier, A., Jensen, E., Lean, M. E. J., and McDonald, M. S. Quantitative analysis of flavonoids by reversed-phase high performance liquid chromatography. J. Chromatogr. A, 1997, 761, 315- 321
• Crozier, A., Lean, M. E. J., McDonald, M. S., and Black, C. Quantitative analysis of the flavonoid content of commercial tomatoes, onions, lettuce, and celery.J. Agric. Food Chem., 1997, 45, 590-595
• Davis W. Lamson, MS, ND, and Matthew S. Brignall, ND. Antioxidants and Cancer III: Quercetin. Altern Med Rev (2000) 5; 196-208
• Dunnick, J.K. & Hailey, J.R. (1992) Toxicity and carcinogenicity studies of quercetin, a natural component of foods. Fund. Appl. Tox., 19,423-431.
• Ferreres, F., Gil, M. I., and Tomás-Barberán, F. A. Anthocyanins and flavonoids from shredded red onion and changes during storage in perforated films. Food Res. Int., 1996, 29, 389-395.
• Frankel, E. N., Waterhouse, A. l., and Teissedre, P. L. Principal phenolic phytochemicals in selected California wines and their antioxidant activity in inhibiting oxidation of human low-density lipoproteins. J. Agric. Food Chem., 1995, 43, 890-894
• Gee JM et al. Quercetin glucosides interact with the intestinal glucose transport pathway. Free Rad Bio Med 1998; 25:19
• Gugler R, Leschik M, Dengler HJ. Disposition of quercetin in man after single oral and intravenous doses. EurJ Clin Pharmacol 1975;9:229-234.
• Häkkinen, S. H., Kärenlampi, S. O., Heinonen, I. M., Mykkänen, H. M., and Törrönen, A. R. Content of flavonols quercetin, myricetin, and kaempferol in edible berries. J. Agric. Food Chem., 1999, 47, 2274 2279.
• Häkkinen, S. H., Kärenlampi, S. O., Mykkänen, H. M., and Törrönen, A. R. Influence of domestic processing and storage on flavonol contents in berries. J. Agric. Food Chem., 2000, 48, 2960-2965
• Häkkinen, S. H., Törrönen, A. R. Content of flavonols and selected phenolic acids in strawberries and Vaccinium species: influence of cultivar, cultivation site and technique. Food Res. Int., 2000, 33, 517-524
• Hermann, J. F. (1988). Helping people cope : a guide for families facing cancer. Pennsylvania, Pennsylvania Dept. of Health.
• Hertog MGL, Feskens EJM, Hollman PCH, et al. Dietary flavonoids and cancer risk in the Zutphen elderly study. Nutr Cancer 1994;22:175-84
• Hertog, MGL, Hollman, PCH. Review: Potential health effects of the dietary flavonol quercetin. Eur J Clin Nutr. 1996 Feb; 50(2):63-71.
• Hertog, M. G. L., Hollman, P. C. H., and Katan, M. B. Content of potentially anticarcinogenic flavonoids of 28 vegetables and fruits commonly consumed in The Netherlands. J. Agric. Food Chem., 1992, 40, 2379-2383.