No-Reflow Fenomeni: Hikayenin Sonu mu?

Öz

Epikardiyal koroner arterde açıklığın elde edilmesine rağmen miyokard perfüzyonunun yeterli düzeyde sağlanamaması durumu no-Refl ow Fenomeni olarak isimlendirilmektedir. Akut miyokard infarktüsü sırasında gelişen no-refl ow prognozu olumsuz yönde etkilemektedir. Kullanılan tanısal görüntüleme yöntemlerine bağlı olarak farklı tanımlamaları mevcuttur. İntrakoroner uygulanan farmakolojik ajanlar, manuel trombüs aspirasyonu ve anjiyoplasti sırasında endotel hasarını arttıracak stratejilerden kaçınılması tedavinin temel prensiplerini oluşturmaktadır. Etkin tedavisinin olmaması nedeniyle klinik ve anjiyografi k risk faktörleri olan hastalarda no-refl ow gelişimini önlemeye yönelik stratejilerin uygulanması en önemli tedavi yaklaşımı olmayı sürdürmektedir

Anahtar Kelimeler

• Endotel, Miyokard perfüzyonu, No-refl ow, Trombüs

No-Refl ow Phenomenon: Is it the End of the Story?

Abstract

Ineffi cient myocardial perfusion in spite of successful accomplishment of epicardial coronary artery patency is referred to as the no-refl ow phenomenon. No-refl ow occurrence during the progression of acute myocardial infarction worsens the prognosis. There are many defi nitions of no-refl ow depending on the diagnostic imaging modality. Intracoronary drug administration, manual thrombus aspiration and avoiding strategies that cause endothelial injury are the main principles of no-refl ow treatment. Prevention in patients with clinical and angiographic high risk factors seems to be the mainstay strategy instead of using the present treatment options

Keywords

• Endothelium, Myocardial perfusion, No-refl ow, Thrombus

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