Böbrek Nakli Hastalarında Kalsinörin İnhibitörleri ile m-TOR İnhibitörlerinin Karşılaştırılması

Öz

amaç: Çalışmamızda böbrek nakli hastalarında kalsinörin inhibitörleri KNİ ile m-TORi’nin m-Target of Rapamisin İnhibitor etkinlik ve güvenilirliklerinin karşılaştırılması amaçlanmıştır. Gereç ve yöntemler: Çalışmaya 2005-2009 yılları arasında merkezimizde böbrek nakli yapılmış olan 983 hasta alındı. Hastalar immünosupresif tedavi protokollerine göre iki gruba ayrıldı. Grup 1: KNİ kullanılanlar: 632 hasta, Grup 2: m-TORi kullanılanlar: 351 hasta. Grupların greft ve hasta sağkalım süreleri, rejeksiyon oranları, gecikmiş greft fonksiyonu GGF , kronik allogreft disfonksiyon KAD , nakil sonrası gelişen diabetes mellitus NSDM ve greft fonksiyonları karşılaştırıldı. bulgular: Grupların demografik özellikleri benzerdi. Akut rejeksiyon oranları, hasta sağkalım süreleri, GGF, KAD ve greft fonksiyonlarının benzer, greft sağkalım süresinin ikinci grupta p= 0,007 , NSDM oranının ise 1.grupta p=0,001 daha yüksek olduğu tespit edildisonuç: M-TORi’nin greft sağkalımı açısından KNİ’den daha etkin olduğu gösterildi

Anahtar Kelimeler

• Böbrek nakli, Takrolimus, Siklosporin, Sirolimus, Everolimus

Comparison of Calcineurin Inhibitors with M-Tor Inhibitors in Renal Transplant Patients

Abstract

Objective: Our aim was to compare the efficacy and safety of calcineurin inhibitors with m-Tor inhibitors m-TORi in renal transplant patients.Material and Methods: We recruited 983 patients who had undergone renal transplantation between 2005 and 2009 at our center. Patients were evaluated in two groups according to their immunosuppressive protocol. Group 1 consisted of 632 patients treated with a regimen including calcineurin inhibitors and Group 2 consisted of 351 patients treated with a regimen including m-TORi. The two groups were compared in terms of graft and patient survival times, rejection rates, delayed graft function DGF , chronic allograft dysfunction CAD , post transplant diabetes mellitus PTDM and graft functions.results: Demographic characteristics of the two groups were similar. The acute rejection rates and patient survival times were also similar, but the graft survival times were better in the second group p=0.007 . DGF, CAD and graft functions did not differ between the two groups. The PTDM ratio was higher in the first group p=0.001 . conclusion: We found that m-TORi are more effective than calcineurin inhibitors in terms of graft survival

Keywords

• Kidney transplantation, Tacrolimus, Cyclosporine, Sirolimus, Everolimus

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