Otozomal Dominant Polikistik Böbrek Hastalarında Arteriyel Sertlik ile s-Klotho ve FGF23 Düzeyleri Arasındaki İlişki

Öz

Amaç: Bu kesitsel çalışmada; Otozomal Dominant Polikistik Böbrek hastalarında soluble Klotho, FGF23 düzeyleri ile arteriyel sertlik arasındaki ilişki incelenmiştir. Gereç ve Yöntemler: Otozomal Dominant Polikistik Böbrek Hastalığı ODPBH tanısı olan 74 hasta ortalama yaş:50,92±15,70 yıl ve 32 sağlıklı kontol ortalama yaş:49,53±7,32 yıl çalışmaya alınmıştır. Kan örnekleri soluble Klotho, FGF23, serum kreatinin, Kalsiyum, Fosfor ve Parathormon ölçümleri için toplanmıştır. Brakial arter nabız dalga hızı ve kan basıncı aynı monitör kullanılarak ölçülmüştür. Bulgular: Soluble Klotho, FGF23 ve Parathormon düzeyleri hastalarda kontrol grubuna göre anlamlı yüksek saptanmıştır p

Anahtar Kelimeler

• Soluble klotho, FGF23, Arteriyel sertlik, Polikistik böbrek hastalığı

Relationship Between Arterial Stiffness and s-Klotho, FGF23 Levels in Autosomal Dominant Polycystic Kidney Disease Patients

Abstract

Objective: In this cross-sectional study, we investigated the relationship between soluble Klotho levels, FGF23 levels and arterial stiffness in Autosomal Dominant Polycystic Kidney Disease patients.Material and Methods: 74 patients mean age: 50.92 ± 15.70 years with autosomal Dominant Polycystic Kidney Disease and 32 healthy controls mean age: 49.53 ± 7.32 years were included in the study. Blood samples were collected to measure the levels of soluble Klotho, FGF23, serum creatinine, Calcium, Phosphorus and parathyroid hormone. Brachial artery pulse wave velocity and blood pressure were also measured using a combined monitor.Results: Soluble Klotho, FGF23 and parathyroid hormone levels were significantly higher in the patients than in controls p

Keywords

• Soluble klotho, FGF23, Arterial stiffness, Polycystic renal disease

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