Esansiyel Hipertansiyonda Nötrofil-Lenfosit Oranı ve Hipertansif Retinopati Arasındaki İlişki

Öz

Amaç: Daha önceden yapılan çalışmalar artmış nötrofil lenfosit oranlarının sistemik inflamasyonun bir göstergesi olduğunu göstermiştir. Hipertansiyon, kardiyovasküler risk ve sistemik hedef organ hasarı ile ilişkilidir. Hipertansif retinopati HR hipertansiyonun en sık görülen göz komplikasyonudur. HR’nin patofizyolojik mekanizmaları henüz tam olarak belirlenememiştir. Kan basıncı yüksekliği retinopatinin patogenezini tek başına tamamen açıklayamaz, sistemik inflamasyon gibi diğer patofizyolojik mekanizmalar da ilgili olabilir. Bundan dolayı, bu çalışma şu sorulara cevap bulmak amacıyla yapıldı; i HR’de NLR düzeyi değişir mi ? ii HR evresi ile NLR düzeyleri arasında bir ilişki var mıdır?Gereç ve Yöntemler: Çalışmaya HR’si olan 92 hipertansiyon hastası alındı. Hipertansif hastalar Keith- Wagener sınıflandırmasına göre iki gruba ayrıldı. Grup 1 evre 1 HR’si olan 46 hastadan, Grup 2 evre 2 HR’si olan 46 hastadan oluşturuldu. Kontrol grubu olarak, yaş, cinsiyet ve vücut kitle indeksi açısından benzer 46 sağlıklı kişi alındı.Bulgular: Grup 2’deki NLR düzeyi Grup 1’dekinden 32,06±4,88 karşı 29,54±3,05, p

Anahtar Kelimeler

• Hipertansiyon, Hipertansif retinopati, Nötrofil lenfosit oranı, Sistemik inflamasyon

The Association Between the Neutrophil to Lymphocyte Ratio and Hypertensive Retinopathy in Essential Hypertension

Abstract

Objective: Previous studies have shown that an elevated neutrophil lymphocyte ratio NLR is indicative of systemic inflammation. Hypertension is associated with cardiovascular risk and systemic target organ damage. Hypertensive retinopathy HR is the most common ocular complication of hypertension. The pathophysiological mechanism of HR is not fully established. Elevated blood pressure alone does not fully account for the extent of retinopathy, and other pathophysiological mechanisms such as systemic inflammation may be involved. Therefore, this study was designed to answer the following questions; i Do NLR levels change in HR? ii Is there any relation between the degree of HR and NLR levels?Material and Methods: This study included 92 hypertensive patients with HR. The hypertensive patients were divided into two groups according to the Keith-Wagener classification. Group 1 comprised 46 patients with grade I HR, and Group 2 comprised 46 patients with grade II HR. We selected 46 healthy subjects matched for age, sex, and body mass index for the control group.Results: The level of NLR in Group 2 was significantly higher than in Group 1 32,06±4,88 vs 29,54±3,05, p

Keywords

• Hypertension, Hypertensive retinopathy, Neutrophil lymphocyte ratio, Systemic inflammation

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