Normal veya Normale Yakın PET/BT Görüntülerinde Kan Glukoz Düzeyi ile Dokulardaki FDG Uptake Arasındaki İlişki

Öz

Amaç: Bu çalışmanın amacı, normal veya normale yakın PET/BT görüntülerinde dokulardaki 18F-FDG tutulumunun kan glukoz düzeyi ile ilişkisini değerlendirmektir.Gereç ve Yöntemler: Yeni kanser tanı almış ve ilk evreleme amacıyla 18F-FDG PET/BT yapılan hastalar geriye dönük olarak değerlendirildi. Normal veya normale yakın FDG dağılımı olan 65 hasta 47 kadın, 18 erkek çalışmaya dahil edildi. Beyin, kalp, mediasten, pankreas, dalak, iskelet kası ve kemik iliği ortalama standardize uptake değerleri ölçüldü. FDG enjeksiyonundan hemen önce ölçülen kan glukoz düzeyleri değerlendirmede kullanıldı.Bulgular: Kan glukoz düzeyi ile karaciğer ve kas FDG tutulum düzeyleri arasında istatistiksel anlamlı pozitif korelasyon vardı. Beyin FDG tutulumu glukoz düzeyi ile negatif olarak korele idi. Diğer dokulardaki FDG tutulumu ile kan glukoz düzeyi arasında ilişki yoktu. Kan glukoz düzeyi yüksek olan hastalar, normal kan glukoz düzeyi olan hastalardan daha yüksek kas ve daha düşük beyin FDG tutulumu gösterdi.Sonuç: 18F-FDG PET/BT görüntülerinde hipergliseminin normal dokularda etkisi değişkendir. İskelet kası ve beyin en çok etkilenen dokular iken, karaciğer klinik olarak önemsiz şekilde daha düşük oranda etkilenmektedir

Anahtar Kelimeler

• Florodeoksiglukoz, Pozitron emisyon tomografi/bilgisayarlı tomografi, hiperglisemi, kan glukoz

The Relation Between the Blood Glucose Level and the FDG Uptake of Tissues at Normal or Near-Normal PET/CT Imaging

Abstract

Objective: The aim of this study was to evaluate the relation between the blood glucose level and 18F-FDG uptake in tissues at normal or near-normal PET/CT examinations.Material and Methods: Patients with newly diagnosed cancer who underwent 18F-FDG PET/CT for initial staging were evaluated retrospectively. Sixty five patients 47 female, 18 male with a normal or near normal FDG distribution were included this study. Mean standardized uptake value of the brain, heart, lung, mediastinum, pancreas, liver, spleen, skeletal muscle and bone marrow were calculated. Blood glucose levels measured immediately prior to administration of FDG were used.Results: There was a statistically significant positive correlation between the blood glucose level and liver and muscular FDG uptake. Brain FDG uptake value was negatively correlated with the glucose level. There was no correlation between the blood glucose level and other tissues' FDG uptake values. The patients with increased blood glucose levels showed significantly higher muscular and lower brain FDG uptake compared with patients with normal glucose levels.Conclusion: Effect of hyperglycemia during 18F FDG PET/CT imaging on normal tissues is variable. While skeletal muscle and brain are the most affected tissues, the liver is slightly affected in a clinically insignificant manner

Keywords

• Fluorodeoxyglucose, Positron emission tomography/computerized tomography, hyperglycemia, blood glucose

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