D Vitamini?ne Genel Bir Bakış

Öz

D vitamini yağda çözünen bir vitamin olup güneş ışığına cevap olarak sentezlenir. Aktif form 1, 25 OH 2D'dir. Kemik sağlığı, serum kalsiyum ve fosfor düzeyleri üzerinde önemli bir rol oynar. Son epidemiyolojik çalışmalar düşük D vitamini düzeyleri ve birçok hastalık arasındaki ilişkiyi göz önüne sermiştir. Düşük D vitamini düzeyleri erişkinlerde osteomalazi, otoimmün ve bulaşıcı hastalıklar, diabetes mellitus, artmış düşme ve kırık riski, kanser, hipertansiyon ve kardiyovasküler hastalıklar ile ilişkilidir. Burada D vitamini fizyolojisi, metabolizması, eksikliği ve takviye için yeni öneriler literatürde yayınlanan yeni bulgular dikkate alınarak gözden geçirilmiştir

Anahtar Kelimeler

• D vitamini, Fonksiyon, Eksiklik

Overview of Vitamin D

Abstract

Vitamin D, a fat-soluble vitamin, synthesised in response to sunlight. The active form is 1, 25- OH 2D. It plays an important role in bone health, serum calcium and phosphate levels. Recent epidemiologic studies have observed relationships between low vitamin D levels and multiple disease states. Low vitamin D levels are associated with osteomalacia in adults, autoimmune and infectious diseases, diabetes mellitus, increased risk of fall and fractures, cancer, hypertension and cardiovascular diseases. Here vitamin D physiology, metabolism, deficiency and new recommendations for supplementation are reviewed by taking into consideration new findings published in the literature

Keywords

• Vitamin D, Function, Deficiency

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