Organik Mitral Yetmezlikli ve Sol Ventrikül Fonksiyonu Korunmuş Asemptomatik Hastalarda BNP Serum Düzeyleri ile Sol Ventrikül Mekaniği ve Mitral Yetersizliği Ciddiyeti Arasındaki İlişki

Öz

Amaç: Orta ve ciddi mitral yetersizliğinde, sol ventrikül sistolik disfonksiyonu zamanla gelişir. Biz bu çalışmada, mitral yetersizliğinin, sol ventrikül mekanik fonksiyonlarına olan etkisini 2D strain ekokardiyografi ile araştırmayı amaçladık. Ayrıca BNP seviyesi ile LV mekaniği ve MY ciddiyeti arasındaki ilişkiyi araştırdık.Gereç ve Yöntemler: Organik orta ciddi mitral yetmezliği olan yirmi dört asemptomatik hasta çalışmaya dahil edildi. Sol ventrikül global longitudinal strain LV-GLS , global sirkumferensiyal ve global radyal strain hesaplandı ve serum BNP düzeyi ölçüldü. BNP değerlerine göre [≥140 pg /ml grup 1 ve

Anahtar Kelimeler

• Brain natriüretik peptit, Ekokardiyografi, Global longitudinal strain, Hemodinamik, Mitral yetmezliği

Relationship between Serum Levels of BNP and Left Ventricular Mechanics with Severity of Mitral Regurgitation in Asymptomatic Patients with Organic Mitral Regurgitation and Preserved Left Ventricular Function

Abstract

Objective: In moderate and severe mitral regurgitation MSMR , left ventricular systolic dysfunction develops in time. We aimed to investigate the effect of mitral regurgitation on left ventricular mechanics as assessed with 2D strain echocardiography. We also sought to explore the correlation between BNP and severity of MR and also between BNP and LV mechanics.Material and Methods: Twenty four asymptomatic patients with organic MSMR were included. Left ventricular global longitudinal strain LV-GLS , global circumferential strain and global radial strain were calculated and serum BNP was measured. Patients were divided into two groups according to their BNP value [≥140 pg/ml group 1 and < 140 pg/ml group 2 ].Results: Demographic data were similar in both groups. Group 1 had higher mitral E and A valve velocities 0.915±0.297 vs. 1.2±0.337, p=0.023 and 0.634±0.191 vs. 0.862±0.255, p=0,035 respectively . There was a significant difference in GLS values between group 1 and 2 -20.159 ± 0.386 vs. -15.35±0.912, p

Keywords

• Brain natriuretic peptide, Echocardiography, Global longitudinal strain, Hemodynamic, Mitral regurgitation

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