Hipertansif Retinopatisi Olan Hastalarda Seruloplazmin Düzeyleri

Öz

Amaç: Hipertansif retinopati HR hipertansiyonun en sık görülen göz komplikasyonudur. Hipertansif retinopati gelişiminin patolojik mekanizmaları henüz tam olarak belirlenememiştir. Kan basıncı yüksekliğine ilave olarak oksidatif stres gibi diğer patolojik mekanizmalar da sorumlu olabilir. Daha önceden yapılan çalışmalar artmış serum seruloplazmin düzeylerinin oksidatif stresin bir göstergesi olduğunu göstermiştir. Bundan dolayı, bu çalışma şu sorulara cevap bulmak amacıyla yapıldı; i HR’de seruloplazmin düzeyi değişir mi? ii HR evresi ile seruloplazmin düzeyleri arasında bir ilişki var mıdır?Gereç ve Yöntemler: Bu çalışmaya HR’si olan 90 hipertansiyon hastası alındı. Hipertansif hastalar Keith- Wagener-Barker sınıflandırmasına göre iki gruba ayrıldı. Grup 1 evre 1 HR’si olan 45 hastadan, Grup 2 evre 2 HR’si olan 45 hastadan oluşturuldu. Kontrol grubu olarak, yaş, cinsiyet ve vücut kitle indeksi açısından benzer 45 sağlıklı kişi alındı. Çalışma gruplarında serum seruloplazmin düzeyi ölçüldü.Bulgular: Grup 2’deki seruloplazmin düzeyi Grup 1’dekinden 32,06±4,88 karşı 29,54±3,05, p

Anahtar Kelimeler

• Hipertansiyon, Hipertansif Retinopati, Oksidatif Stres, Seruloplazmin

Levels of Ceruloplasmin in Patients with Hypertensive Retinopathy

Abstract

Objective: Hypertensive retinopathy HR is the most common eye complication of hypertension. The pathological mechanisms of HR development are not fully established. In addition to high blood pressure, other pathological mechanisms such as oxidative stress may also be responsible. Previous studies have shown that elevated serum ceruloplasmin levels are indicative of oxidative stress. Therefore, this study was designed to answer the following questions; i Do ceruloplasmin levels change in HR?; ii Is there any relation between the degree of HR and ceruloplasmin levels?Material and Methods: This study included 90 hypertensive patients with HR. The hypertensive patients were divided into two groups according to the Keith-Wagener-Barker classification. Group 1 comprised 45 patients with grade I HR, and Group 2 comprised 45 patients with grade II HR. We selected 45 healthy subjects matched for age, sex, and body mass index for the control group. The serum ceruloplasmin level was measured in the study groups.Results: The level of ceruloplasmin in Group 2 was significantly higher than in group 1 32.6±4.88 vs. 29.54±3.05, p

Keywords

• Hypertension, Hypertensive Retinopathy, Oxidative Stress, Ceruloplasmin

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