Akromegali Hastalarında Kolonoskopi Bulguları ve Kolon Polipi Sıklığı

Öz

Amaç: Akromegali hastalarında kolon polipi prevelansı artmıştır. Kolon poliplerinin malign potansiyele sahip olabilmeleri ve saptanan poliplerin eksizyonunun kolon kanseri insidansını azaltması nedeni ile akromegali hastalarında kolonoskopi taramalarının hasta izleminin bir parçası olması önerilmektedir. Çalışmada akromegali hastalarında kolon patolojilerini ve kolon polipi sıklığını ve ilişkili oldukları faktörleri araştırmayı amaçladık. Gereç ve Yöntemler: Total kolonoskopileri yapılmış 70 akromegali hastasının kayıtları retrospektif olarak incelendi. Kolonoskopi raporları incelenerek saptanan divertikül ve polip gibi patolojik bulgular, poliplerin yerleşim yerleri ve patoloji sonuçları incelendi. Kolon polipi olan ve olmayan hastaların verileri karşılaştırıldı.Bulgular: Hastaların medyan yaşları 49 yıldı ve 42’si %60 kadındı. Hastaların %62,8’inde n=44 kolonoskopi sonuçları normal olarak raporlanmıştı. Hastaların %21,4’ünde n=15 toplam 20 adet polip, %10’unda n=7 divertikül saptandı. Polipler en sık transvers kolonda %35, n=7 ve ikinci sıklıkta rektumda %25, n=5 lokalizeydi. Saptanan poliplerin %50’si n=10 hiperplastik polip, %45’i n=9 adenomatöz polip ve %5’i n=1 lipom idi. İki kez kolonoskopi yapılan hastaların n=32 %18,5’inde n=6 ikinci kolonoskopilerinde polip saptanmıştır. Sonuç: Çalışmamız akromegali hastalarında yeni kolon polipi saptama ihtimalinin az olmadığını ve ilk kolonoskopi sonrası aktif kolonoskopi takiplerinin devamının uygun olduğunu göstermiştir

Anahtar Kelimeler

• Akromegali, Kolonoskopi, Kolon polipi, Kolon divertikülü

Colonoscopy Findings and Colon Polyp Frequency in Patients with Acromegaly

Abstract

Objective: The prevalence of colon polyps is increased in acromegaly patients. Colon polyps may have malignant potential and excision reduces the colon cancer incidence. Screening with colonoscopy should therefore be included in the follow-up in acromegaly. In this study, we investigated colon pathologies, the frequency of colon polyps and related factors in acromegaly patients.Material and Methods: The retrospective records of 70 acromegaly patients who underwent colonoscopy were reviewed. Colonoscopy reports were examined and findings such as diverticulosis and polyps, polyp location and pathology results were evaluated. The data of the patients with and without colon polyps were compared.Results: The median age of the patients was 49 years and 42 60% were female. Colonoscopy results were normal in 62.8% n=44 . A total of 20 polyps were detected in 21.4% n=15 and diverticulosis was found in 10% n=7 . Polyps were most commonly localized in the transverse colon 35%, n = 7 and secondly in the rectum 25%, n=5 . Of these polyps, 50% n=10 were hyperplastic, 45% n=9 were adenomatous and 5% n=1 were lipomas. Polyps were detected during the second colonoscopy n=32 in 18.5% n=6 of the patients. Conclusion: Our study showed that the probability of detecting new colon polyps in acromegaly patients is not low and that repeated colonoscopic follow-up is appropriate

Keywords

• Acromegaly, Colonoscopy, Colon polyps, Colon diverticulum

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