Association Of ABO And Rh Blood Groups And COVID-19 Susceptibility And Disease Severity İn Turkish Population – A Retrospective Case-Control Study

Year 2022, , 257 - 262, 01.09.2022

Faruk Karandere , Hakan Kocoglu Ramazan Korkusuz , Betül Erismis Mehmet Hursitoglu Kadriye Kart Yasar

https://doi.org/10.53394/akd.1060576

Abstract

Abstract
Objective: To determine whether there is a difference in the frequency of blood groups between the general population and COVID –19 patients and whether there is a relationship between blood groups and mortality and severity of chest CT involvement at admission in COVID –19 patients.
Materials and Methods: 1546 COVID –19 patients were evaluated. Clinical data including age, sex, comorbidities, complaints at the time of admission, and outcome of the patients were obtained from medical records. In order to determine the normal distribution of the blood groups in the general population, a previous study conducted on Turkish population which consisted of 3,022,883 healthy blood donors of Turkish Red Crescent was identified as a control group.
Results: There was no significant difference in gender, CT results, duration of hospitalization, and mortality rates between the blood groups (p >0.05 for all). When we compared the frequency of blood groups between the population and the patients, a statistically significant difference was found in regard to the A Rh + blood group rates (p = 0.026). Also in our study, the rate of A Rh + was found to be higher in hospitalized COVID –19 patients than the population. Also, the frequency of A Rh+ blood group was higher in patients with severe chest CT involvement compared to the normal population (p = 0.007).

Conclusion: No significant difference was found between the blood groups and gender, severity of CT findings, duration of hospitalization, and mortality rates. But the rate of A Rh + was detected to be significantly higher in hospitalized COVID –19 patients than the population. Also, patients who had severe chest CT findings had higher frequency of A Rh+ blood group when compared to the normal population.
Keywords: ABO blood groups, Rh groups, COVID-19, Mortality, SARS-CoV-2

Keywords

ABO blood groups, Rh groups, COVID-19, Mortality, SARS-CoV-2

Türk Popülasyonunda ABO ve Rh Kan Grupları ve COVID-19 Duyarlılığı ve Hastalık Şiddeti İlişkisi - Retrospektif Bir Vaka Kontrol Çalışması

Abstract

Öz
Amaç: COVID-19 hastalarında genel popülasyon ile COVID-19 hastaları arasında kan gruplarının sıklığında bir fark olup olmadığını ve kan grupları ile mortalite ve göğüs BT tutulumunun şiddeti arasında bir ilişki olup olmadığını belirlemek.
Gereç ve Yöntem: 1546 COVID-19 hasta değerlendirildi. Hastaların yaş, cinsiyet, ek hastalıklar, başvuru sırasındaki şikayetleri ve sonuçları gibi klinik veriler tıbbi kayıtlardan elde edildi. Genel popülasyondaki kan gruplarının normal dağılımını belirlemek amacıyla Türk popülasyonu üzerinde yapılan ve Türk Kızılayı'nın 3.022.883 sağlıklı kan donöründen oluşan önceki bir çalışma kontrol grubu olarak belirlenmiştir.
Bulgular: Kan grupları arasında cinsiyet, BT sonuçları, hastanede kalış süresi ve ölüm oranları açısından anlamlı fark yoktu (tümü için p>0,05). Popülasyondaki kan gruplarının sıklığı ve hastalar karşılaştırıldığında, A Rh + kan grubu oranları açısından istatistiksel olarak anlamlı bir fark bulundu (p=0,026). Çalışmamızda hastanede yatan COVID-19 hastalarında A Rh + oranı popülasyona göre daha yüksek bulunmuştur. Ayrıca, ciddi göğüs BT tutulumu olan hastalarda A Rh + kan grubu sıklığı normal popülasyona göre daha yüksekti (p=0,007).
Sonuç: Kan grupları ile cinsiyet, BT bulgularının şiddeti, hastanede kalış süresi ve ölüm oranları arasında anlamlı bir fark bulunmadı. Ancak hastanede yatan COVID-19 hastalarında A Rh + oranının popülasyona göre önemli ölçüde daha yüksek olduğu tespit edildi. Ayrıca, ciddi göğüs BT bulguları olan hastalarda, normal popülasyona göre daha yüksek sıklıkta A Rh + kan grubu vardı.
Anahtar Sözcükler: ABO kan grupları, Rh grupları, COVID-19, Mortalite, SARS-CoV2

Keywords

BO kan grupları, Rh grupları, COVID-19, Mortalite, SARS-CoV2

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