Recurrence and Characteristics of Endometrial Cancer In Elderly Patients

Year 2024, , 494 - 499, 19.09.2024

Varol Gülseren , Zübeyde Emiralioğlu Çakır , Muzaffer Sancı , Aykut Özcan , Oğuzhan Kuru , İlker Çakır , Mehmet Gökçü , İsa Aykut Özdemir , Kemal Güngördük

https://doi.org/10.53394/akd.1339147

Abstract

Aim: In this study, evaluated the treatment options of patients of advanced age (≥70 years) with recurrence, survival results were analyzed.
Methods: The data of patients diagnosed with endometrial cancer (EC) in the Gynecological Oncology Clinic between 2001 and 2020 were evaluated retrospectively. Seventy six cases with advanced age and relapse were evaluated. Patients who underwent hysterectomy surgery in our center and continued their follow-up regularly were included in the study.
Results: The mean age at the time of recurrence was 74.6 ± 3.9 years. The endometrioid type, seen in half of the patients, was the most common histological type. Pelvic paraaortic lymph node (LN) sampling/dissection was performed in 84.2% of the patients. Deep myometrial invasion was detected in 56 (73.7%) patients, and LVSI was found in 42 (56.8%) patients. The mean time to recurrence was found to be 25.1 ± 17.8 months. Total survival times were calculated as 47.2 ± 28.2 months. The five-year overall survival (OS) rate was analyzed as 35.7%. The most common site of recurrence was lung, and isolated lung recurrence was seen in 14 (18.5%) patients. There was no significant difference for OS among patients with pelvic recurrence and extra-pelvic/multiple recurrences (P= 0.723).
Conclusion: Survival outcomes in recurrences are worse in advanced age endometrial cancer patients. This may be due to more limited treatment options for recurrence due to additional internal problems.

Keywords

Endometrial cancer, Elderly patients, Recurrence, Lymph node

Yaşlı Hastalarda Endometriyal Kanser Nüksü ve Özellikleri

Abstract

Amaç: Bu çalışmada nüks ile seyreden ileri yaş (≥70 yaş) hastaların tedavi seçenekleri değerlendirildi, sağkalım sonuçları analiz edildi.
Yöntemler: Jinekolojik Onkoloji Kliniği'nde 2001-2020 yılları arasında endometrial kanser (EK) tanısı alan hastaların verileri retrospektif olarak değerlendirildi. İleri yaş ve nüks olan 76 olgu değerlendirildi. Merkezimizde histerektomi ameliyatı olan ve takiplerini düzenli olarak sürdüren hastalar çalışmaya dahil edildi.
Bulgular: Nüks anındaki ortalama yaş 74.6 ± 3.9 idi. Hastaların yarısında görülen endometrioid tip en sık görülen histolojik tipti. Hastaların %84,2'sine pelvik paraaortik lenf nodu (LN) örnekleme/diseksiyon uygulandı. Elli altı (%73,7) hastada derin myometrial invazyon, 42 (%56,8) hastada lenfovasküler alan invazyonu (LVSI) saptandı. Ortalama nüks süresi 25,1 ± 17,8 ay bulundu. Toplam sağkalım süreleri 47,2 ± 28,2 ay olarak hesaplandı. Beş yıllık toplam sağkalım (TS) oranı %35,7 olarak analiz edildi. En sık nüks yeri akciğer olup, 14 (%18,5) hastada izole akciğer nüksü görüldü. Pelvik nüks ve ekstra pelvik/çoklu nüks olan hastalar arasında TS açısından anlamlı bir fark yoktu (P= 0.723).
Sonuç: İleri yaş endometriyum kanseri hastalarında nükslerde sağkalım sonuçları daha kötüdür. Bunun nedeni, ek dahili problemler nedeniyle nüks için daha sınırlı tedavi seçenekleri olabilir.

Keywords

Endometrial kanser, Yaşlı hastalar, Nüks, Lenf bezi

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