The Relationship Between Serum Lipids and Coronary Artery Disease in Patients Aged 85 and Over

Abstract

Objective: The aim of this study is to investigate the relationship between serum low-density lipoprotein cholesterol (LDL-C) level and coronary artery disease (CAD) in patients aged 85 and over in our country. Material and Methods: This study was conducted retrospectively by scanning the patient files of those aged 85 and over who were admitted to the hospital between January 2020 and July 2023. Serum lipid profiles of patients diagnosed with CAD and patients without CAD were examined. Serum lipid concentrations of the patients were measured with Cobas 501. Statistical analysis was done with SPSS. Variables were tested for normal distribution with the Kolmogorov Smirnov test. Mann-Whitney U test was used for comparisons. A value of p<0.05 was considered statistically significant. Results: A total of 726 patients were included in the study, 433 of whom were female (59.6%) and 293 were male (40.4%). Patients were divided into three groups according to LDL-C level. CAD was detected in 277 of 726 patients (38.2%). Of those with CAD, 142 are female (51.3%) and 135 are male (48.7%). Conclusion: CAD increases with age, independent of serum lipid levels. In terms of CAD frequency, the ratio between men and women becomes approximately equal in older ages. It was observed that there was no statistically significant relationship between serum lipid levels, especially LDL-C, and CAD disease.

Keywords

• 85 years and above
• coronary artery disease
• LDL
• HDL
• TC
• TG

Seksen beş Yaş ve Üzerindeki Hastalarda Serum Lipidleri ile Koroner Arter Hastalığı Arasındaki İlişki

Öz

Amaç: Bu çalışmanın amacı ülkemizdeki 85 yaş ve üstü hastalarda serum düşük dansiteli lipoprotein kolesterol (LDL-K) seviyesi ile koroner arter hastalığı (KAH) arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem: Bu çalışma retrospektif olarak Ocak 2020-Temmuz 2023 tarihleri arasında hastaneye kabul edilen 85 yaş ve üzerinde olanların hasta dosyaları taranarak yapılmıştır. KAH tanısı konulan hastalar ile KAH tanısı olmayan hastaların serum lipid profilleri incelenmiştir. Hastaların serum lipid konsantrasyonları Cobas 501 ile ölçüldü. İstatiksel analiz SPSS ile yapıldı. Normal dağılım için değişkenler Kolmogorov Smirnov testi ile test edildi. Karşılaştırmalar için Mann-Whitney U testi kullanıldı. p<0.05 değeri istatistiksel olarak anlamlı kabul edildi. Bulgular: Çalışmaya toplam 726 hasta alınmış olup bunların 433'ü kadın (% 59,6) 293'ü erkek (% 40,4) hastalardan oluşmaktadır. Hastalar LDL-K seviyesine göre üç gruba ayrıldı. Toplam 726 hastanın 277'sinde (% 38,2) KAH saptanmıştır. KAH olanların 142'si kadın (% 51,3), 135'i erkek (% 48,7) hastadır. Sonuç: KAH, serum lipid düzeylerinden bağımsız olarak yaşla birlikte artmaktadır. İleri yaşta KAH sıklığı açısından kadın-erkek oranı yaklaşık olarak eşit hale gelmektedir. Serum lipid seviyeleri ve özellikle LDL-K ile KAH hastalığı arasında istatistiksel olarak anlamlı bir ilişki olmadığı görülmüştür.

Anahtar Kelimeler

• 85 yaş ve üzeri
• koronrer arter hastalığı
• LDL
• HDL
• TK
• TG

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