Hiperplastik Gastrik Poliplerde Mast Hücre Dansitesi: Polip Oluşumu ve Metaplazi ile Korelasyonu

Öz

Amaç: Mast hücreleri tümör gelişimin dinamiklerinde önemli roller oynamaktadır, ancak hiperplastik gastrik polip oluşumunu yönlendiren spesifik faktörler net değildir. Çalışma, bu boşluğu açıklığa kavuşturmak amacıyla rastlantısal gastrik poliplerde mast hücre miktarlarını inceleyerek, özellikle hiperplastik lezyonlara odaklanarak, polip oluşumu ve metaplazi ile korelasyonlarını araştırmayı amaçlamaktadır. Yöntem: 2014-2023 yıllarına ait antral non-atrofik kronik inaktif gastrit gösteren 45 endoskopik örnek incelendi. Histolojik değerlendirmelerin ardından, vakalar intestinal metaplazisi olan ve olmayan hiperplastik gastrik polipler ve kontrol olarak kronik inaktif gastrit olacak şekilde üç gruba ayrıldı. Toluidin mavisi ile boyanmış kesitlerden birim alan başına mast hücresi yoğunluğu değerlendirildi. İstatistiksel analiz için polip çapı ve demografik bilgiler de kaydedildi. Bulgular: Hiperplastik polip, metaplazi ve gastritli hastaların ortalama yaşları sırasıyla 51.2±12.84, 55.93±13.58 ve 56.2±14.68 idi (p>0.05). Her grupta kadın oranı daha yüksekti. Mast hücre yoğunluğu, her grup içinde varyasyon göstermekle birlikte, istatistiksel olarak anlamlı bir fark göstermedi (p>0.05). Metaplazi ve hiperplastik polip grupları için ortalama polip çapları sırasıyla 0.26 ve 0.30 mm idi (p>0.05). Mast hücre yoğunluğu ile polip çapı arasında bir korelasyon bulunmadı (p>0.05). Sonuç: İntestinal metaplazi non-displastik, düşük malignite gösteren gastrik poliplerde mast hücre yoğunluğunu önemli ölçüde etkilemedi. 1 cm veya daha küçük hiperplastik gastrik poliplerde mast hücre yoğunluğu ve polip çapı arasında bir korelasyon bulunmadı. Sonuç olarak, kanseröz olmayan gastrik polip oluşumu ile mast hücre sayısı arasında tek yönlü bir ilişki bulunmamaktadır.

Anahtar Kelimeler

• Gastrit
• Mast Hücreleri
• Polipler
• Mide Hastalığı

Mast Cell Density in Hyperplastic Gastric Polyps: Correlations with Polypogenesis and Metaplasia

Abstract

Objective: Mast cells play pivotal roles in tumorigenesis dynamics, yet the specific factors driving hyperplastic gastric polyp formation remain unclear. This study aims to elucidate this gap by examining mast cell quantities in incidental gastric polyps, with a specific focus on hyperplastic lesions, and exploring their correlation with polypogenesis and metaplasia. Methods: 45 endoscopy specimens exhibiting anterior non-atrophic chronic inactive gastritis (2014-2023) were examined. Following histological evaluations, the cases were classified into three groups: hyperplastic gastric polyps with or without intestinal metaplasia, and chronic inactive gastritis as the control. Mast cell density per unit area was assessed from toluidine blue-stained sections. Polyp diameter and demographic information were also recorded for statistical analysis. Results: The average ages of patients with hyperplastic polyps, metaplasia, and gastritis were 51.2±12.84, 55.93±13.58, and 56.2±14.68, respectively (p>0.05). In each group, the proportion of women was higher. Mast cell density, which varied within each group, did not show a statistically significant difference (p>0.05). The average polyp diameters for the metaplasia and hyperplastic polyp groups were 0.26 and 0.30 mm, respectively (p>0.05). There was no correlation between mast cell density and polyp diameter (p>0.05). Conclusions: Intestinal metaplasia did not significantly influence mast cell density in non-dysplastic, low-malignant gastric polyps. Mast cell density and diameter in hyperplastic gastric polyps of 1 cm or smaller showed no correlation. Overall, non-cancerous gastric polypogenesis and mast cell count lack a unidirectional relationship.

Keywords

• Gastritis
• Mast Cells
• Polyps
• Stomach Disease

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