Can the Development and Recurrence of Uveitis in Behçet’s Disease be Predicted? Which Predictors Are at the Forefront?

Abstract

ABSTRACT Objective One of the main manifestations of Behçet's disease (BD) with the highest morbidity rate is uveitis. Uveitis recurrence (UR) rate is still high and can cause significant physical and mental distress in patients with BD, and prolonged treatment is also a major financial burden. We aimed to determine the factors predicting the development and recurrence of uveitis and to calculate the time to development and recurrence of uveitis. Material and Methods In a two-center retrospective study, a total of 78 BD patients who met the international criteria for Behçet’s disease (ICBD), 41 patients with uveitis and 37 patients without uveitis, were included. Results The absence of genital ulcer (GU) alone was found to be an independent factor with 65.3% probability of the development of uveitis (DoU). The rate of predicting DoU was 72.2% when the prolonged time to diagnosis and the absence of GA were combined. In patients with a body mass index (BMI) of 25 kg/m2, the risk of UR was 70%. Conclusion Two main findings of this study were that uveitis and UR were more common in patients without GU and with high BMI, respectively.

Keywords

• Behçet’s disease
• body mass index
• genital aphthae
• uveitis.

Behçet Hastalığında Üveit Gelişimi ve Rekürrensi Öngörülebilir mi? Ön Planda Hangi Öngörücüler Yer Almaktadır?

Öz

ÖZ Amaç Üveit, Behçet hastalığının (BH) en yüksek morbidite oranına sahip olan ana manifestasyonlarından biridir. BH'da üveit rekürrens (UR) oranı hâlâ yüksektir ve bu hastalarda fazlaca fiziksel ve ruhsal strese neden olabilir, uzun süreli tedavi de aynı zamanda büyük bir mali yük getirmektedir. Bu çalışmada üveit gelişimi ve rekürrensini öngören faktörleri belirlemeyi ve üveit gelişimi ve rekürrensine kadar geçen süreyi hesaplamayı amaçladık. Gereç ve Yöntemler İki merkezli retrospektif çalışmada, Behçet hastalığı için uluslararası kriterleri (ICBD) karşılayan 41 üveiti olan ve 37 üveiti olmayan toplam 78 BH hastası çalışmaya dahil edildi. Bulgular Sadece genital ülser (GU) olmaması, üveit gelişimi (DoU) için %65,3 olasılıkla bağımsız bir faktör olarak bulundu. Tanıya kadar geçen uzun süre ve GA'nın yokluğu kombine edildiğinde DoU'yu öngörme oranı %72,2 idi. Vücut kitle indeksi (VKİ) 25 kg/m2 olan hastalarda UR riskinin %70 olduğu belirlendi. Sonuç Çalışmamızın iki ana bulgusu, GU olmayan ve yüksek VKİ'si olan hastalarda üveit ve UR'nin daha yaygın olmasıdır.

Anahtar Kelimeler

• Behçet hastalığı
• genital aft
• üveit
• vücut kitle indeksi

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