Covid-19 Pandemisi ile Gündeme Gelen İlaçlar ve Potansiyel Etkin Olabilecek Auranofin’in Değerlendirilmesi

Öz

Sars-Cov 2 virüsünün neden olduğu ve Çin’den yayılarak dünyanın tamamını etkileyen Covid-19 salgınında, enfekte bireylerin tedavisini sağlamak amacıyla birçok ilaç denenmekte ve kullanılmaktadır. Bununla birlikte profilaksi için dünyanın dört bir yanındaki araştırma laboratuvarlarında yeni tip korona virüs için aşılar geliştirilmiş ve uygulamaya başlanmıştır. Bu gelişmelere rağmen aşının profilaktik etkinliği ve kullanılan ilaçların tedavideki etkinliği konusunda tartışmalar mevcuttur. Bu durumlar özellikle hastalığın tedavisinde alternatif acil yeni arayışlara yönlendirmektedir. Altın partikülleri içeren bir ilaç olan Auranofin’in (AF) antiviral, anti-inflamatuar ve immün sistemi baskılama özelliklerinden dolayı Covid-19 enfeksiyonunun neden olduğu sitokin fırtınası ve aşırı immün reaksiyonları yönetebileceği öngörülmektedir. Bu derlemedeki amacımız, covid-19 üzerine AF’nin terapötik potansiyele sahip olup olmayacağını etki mekanizmaları ve yapılan çalışmalar üzerinden değerlendirmektir.

Anahtar Kelimeler

• Korona virüsler
• Covid-19
• Auranofin
• Salgın

Covid-19 Pandemisi ile Gündeme Gelen İlaçlar ve Potansiyel Etkin Olabilecek Auranofin’in Değerlendirilmesi

Abstract

In the Covid-19 epidemic caused by the SARS-Cov 2 virus, which is spreading from China and affecting the entire world, many drugs are being tried and used to treat infected individuals. However, vaccines for a new type of corona virus have been developed and started to be used in research laboratories around the world for prophylaxis. Despite these developments, there is debate about the prophylactic effectiveness of the vaccine and the effectiveness of the drugs used in treatment. These conditions lead to urgent new searches for alternative emergencies, especially in the treatment of the disease. Auranofin (AF), a drug containing gold particles, is predicted to be able to manage cytokine storming and excessive immune reactions caused by Covid-19 infection due to its antiviral, anti-inflammatory and immune system suppression properties. Our aim in this review is to evaluate whether AF on covid-19 will have therapeutic potential or not, based on the mechanisms of action and the studies conducted.

Keywords

• Corona viruses
• Covid-19
• Auranofin
• Epidemic

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