Otolog Transplantasyon Sonrası Multipl Miyelom Hastasında Guillain Barré Sendromu: Olgu Sunumu

Öz

Guillain-Barre sendromu (GBS), çoklu sinir köklerini ve periferik sinirleri etkileyen bağışıklık aracılı bir periferik nöropatidir. Patogenez tam olarak anlaşılamamıştır ve etiyolojisi belirsizdir. Enfeksiyonlar, maligniteler, aşılama ve kemik iliği nakli suçlanmıştır. Plazmaferez ve intravenöz immünoglobulin tedavi için kullanılabilir. Multipl miyelom, klonal plazma hücrelerinin anormal proliferasyonu ile karakterize malign bir hastalıktır. Kemoterapi ve otolog transplantasyon, multipl miyelom için birincil tedavilerdir. Burada plazmaferez ile düzelen otolog transplantasyon sonrası Guillain-Barre sendromu gelişen multipl miyelom olgusu sunulmuştur.

Anahtar Kelimeler

• Guillan Barre sendromu
• Multiple myeloma
• Periferik otolog kök hücre nakli

Guillain Barré Syndrome in a Multiple Myeloma Patient After the Autologous Transplantation: A Case Report

Abstract

Guillain-Barre syndrome (GBS) is an immune-mediated peripheral neuropathy involving multiple nerve roots and peripheral nerves. The pathogenesis remains incompletely understood, and etiology is unclear. Infections, malignancies, vaccination, and bone marrow transplantation have been accused. Plasmapheresis and intravenous immunoglobulin can be used for treatment. Multiple myeloma is a malignant disease characterized by an abnormal proliferation of clonal plasma cells. Chemotherapy and autologous transplantation are primary therapies for multiple myeloma. Herein a case of multiple myeloma developing Guillain-Barre syndrome after autologous transplantation improved by plasmapheresis is presented.

Keywords

• Guillain Barre syndrome
• Multiple myeloma
• Peripheral autologous stem cell transplant

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