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Korneal Arkus Senilis Olgularında, Gri Skala ve Spektral Doppler Ultrasonografi ile Karotis Arter Değerlendirilmesi

Year 2022, Volume: 8 Issue: 1, 42 - 47, 01.01.2022
https://doi.org/10.53394/akd.1037473

Abstract

ÖZ
Amaç: Bu çalışmada korneal arkus senilis olan hastalarda gri skala ultrasonografi ve spektral analizli renkli doppler ultrasonografi ile ana karotis arter değerlendirilmesini amaçladık.
Yöntemler: Çalışmaya dahil edilen tüm korneal arkus senilisli hastalara detaylı bir oftalmolojik muayene yapıldıktan sonra tam kan sayımı, kan lipid profili, gri skala ultrasonografi ve spektral analizli renkli doppler ultrasonografi ile ana karotis arter değerlendirilmesi yapıldı.
Bulgular: Çalışmaya 32 hastanın 64 gözü dahil edildi. Ortalama yaş 64,9 ±9,52 (49-85) yıl ve kadın erkek oranı 10 (%30) / 22 (%70) idi. Tüm gözlerde arkus senilis bilateral, halka şeklindeydi ve hafif, orta, yoğun arkus senilis oranı sırasıyla %22, %26, %52 idi.
Arkus senilisli hastaların kandaki total kolesterol, TG, LDL, VLDL değerleri referans değerlere göre yüksekti. Arkus senilisin yoğunluğu arttıkça ana karotis arter intima-media kalınlığının arttığı gözlendi ve istatistiksel olarak anlamlı bulundu (p<0.05). Arkus senilisli olgularda ana karotis arter gri skala ultrasonografide %61 oranında plak tespit edildi ve bunların %65’i yumuşak karakterliydi. Arkus senilis yoğunluğu ile vücut kitle indeksi, sigara kullanımı, nötrofil-lenfosit oranı ve kan lipid profili arasında bir istatistiksel olarak anlamlı bir ilişki bulunmadı (p>0.05).
Sonuç: Korneal arkus senilis olgularında, ana karotis arterde intima-media kalınlığının ve plak oluşumunun arttığı gözlemlendi. Daha fazla hasta sayısına ihtiyaç duymakla beraber, korneal arkus senilisin kardiyovasküler ve serebrovasküler hastalıklar için bağımsız bir risk faktörü olabileceğini söyleyebiliriz.
Anahtar Sözcükler: Arkus senilis, Karotis arter, Ultrasonografi

References

  • 1) Friedlander MH, Smolin G. Corneal degenerations. Ann Ophthalmol 1979; 11:1485.
  • 2) Sugimura G. Unilateral corneal arcus. Arch Ophthalmol 1990; 108:780.
  • 3) Coşar B. Korneanın keratokonus dışı dejeneratif hastalıkları. Tamçelik N, ed. Kornea, 1. Baskı, Türk Oftalmoloji Derneği Eğitim Yayınları No:11, İstanbul, 2009:237-8.
  • 4) Rifkind BM, Dickson C. The incidence of arcus senilis in ischemic heart disease, its relation to serum-lipid levels. Lancet 1965: 312-4.
  • 5) Hickey N, Maurrer B, Mulcahy R. Arcus senilia: its relation to certain attributes and risk factors in patients with coronary artery disease. Br Med J 1970; 32:449-52.
  • 6) Chua BE, Mitchell P, Wang J, Rochtchina E. Corneal arcus and hyperlipidemia: findings from an older population. Am J Ophthalmol 2004; 137:363-5.
  • 7) Barchiesi BJ, Eckel RH, Ellis PP. The cornea and disorders of lipid metabolism. Surv Ophthalmol 1991; 36:1-22.
  • 8) Chambless LE, Fuchs FD, Linn S, Kritchevsky SB, Larosa JC, Segal P, Rifkind BM. The association of corneal arcus with coronary heart disease and cardiovascular disease mortality in the Lipid Research Clinics Mortality Follow-up Study. Am J Public Health 1990; 80:1200-4.
  • 9) Wu R, Wang JJ, Tai ES, Wong TY. Cardiovascular risk factors, inflammation, and corneal arcus: the singapore malay eye study. Am J Ophthalmol 2010; 150:581-7.
  • 10) Fernandez A, Sorokin A, Thompson PD. Corneal arcus as coronary artery disease risk factor. Atherosclerosis 2007; 193:235-40.
  • 11) Virchow VR. Uber parenchymatose entzundun. Virchows Arch Pathol Anat 1852; 4:261.
  • 12) Baboujian A, Bezwada P, Ayala-Rodriguez C. Diagonal Earlobe Crease, a Marker of Coronary Artery Disease: A Case Report on Frank's Sign. Cureus 2019; 11:4219.
  • 13) Lock JH, Ross CA, Flaherty M. Corneal arcus as the presenting sign of familial hypercholesterolemia in a young child. J AAPOS 2018; 22:467-8.
  • 14) Mayalı H, Kılıç Ş, Cansız Ç, Türkoğlu MŞ, Başer EF. Corneal Haze and Peripheral Corneal Arcus in a Young Patient: Lecithin-Cholesterol Acyltransferase Deficiency. Turkish Journal of Ophthalmology 2014; 44:319-21.
  • 15) Hoogerbrugge N, Happee C, van Domburg R, Poldermans D, van den Brand MJ. Corneal arcus: indicator for severity of coronary atherosclerosis? Neth J Med 1999; 55:184-7.
  • 16) Fernandez AB, Keyes MJ, Pencina M, D’Agostino R,O’Donnell CJ, Thompson PD. Relation of corneal arcus to cardiovascular disease (from the Framingham Heart Study data set). Am J Cardiol 2009; 103:64-6.
  • 17) Dikmetaş Ö, Mocan MC, Sevim DG, İrkeç M. The assocıatıon of arcus senılıs wıth exfolıatıon syndrome and cardıovascular dısease ın elderly populatıon. Turkish Journal of Geriatrics 2015; 18:36-41.
  • 18) Wong MYZ, Man REK, Gupta P, Lim SH, Lim B, Tham YC, Sabanayagam C, Wong TY, Cheng CY, Lamoureux EL. Is Corneal Arcus Independently Associated With Incident Cardiovascular Disease in Asians? Am J Ophthalmol 2017; 183:99-106.
  • 19) Ang M, Wong W, Park J, Wu R, Lavanya R, Zheng Y, Cajucom-Uy H, Tai ES, Wong TY. Corneal arcus is a sign of cardiovascular disease, even in low-risk persons. Am J Ophthalmol 2011; 152:864-71.
  • 20) Christoffersen M, Frikke-Schmidt R, Schnohr P, Jensen GB, Nordestgaard BG, Tybjærg-Hansen A. Xanthelasmata, arcus corneae, and ischaemic vascular disease and death in general population: prospective cohort study BMJ 2011; 15;343.
  • 21) Rouhiainen P, Salonen R, Rouhiainen H, Salonen JT. Association of corneal arcus with ultrasonographically assessed arterial wall thickness and serum lipids. Cornea 1993; 12:142-5.
  • 22) Nambi V, Chambless L, Folsom AR, He M, Hu Y, Mosley T, Volcik K, Boerwinkle E, Ballantyne CM. Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk In Communities) study. J Am Coll Cardiol 2010; 55:1600-7.
  • 23) Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and metaanalysis. Circulation 2007; 115:459-67.
  • 24) Kitamura A, Iso H, Imano H, Ohira T, Okada T, Sato S, Kiyama M, Tanigawa T, Yamagishi K, Shimamoto T. Carotid intima-media thickness and plaque characteristics as a risk factor for stroke in Japanese elderly men. Stroke 2004; 35:2788-94.
  • 25) Tosetto A, Prati P, Baracchini C, Manara R, Rodeghiero F. Ageadjusted reference limits for carotid intima-media thickness as better indicator of vascular risk: population-based estimates from the VITA Project. J Thromb Haemost 2005; 3:1224.

Evaluation of Carotid Artery by Gray Scale and Spectral Doppler Ultrasonography in Cases with Corneal Arcus Senile

Year 2022, Volume: 8 Issue: 1, 42 - 47, 01.01.2022
https://doi.org/10.53394/akd.1037473

Abstract

ABSTRACT
Objective: In this study, we aimed to evaluate the common carotid artery by gray scale ultrasonography and spectral analysis color doppler ultrasonography in patients with corneal arcus senilis.
Methods: After a detailed ophthalmologic examination of patients who included in the study with corneal arcus senilis, blood count, blood lipid profile, gray scale ultrasonography and spectral analysis color doppler ultrasonography evaluation of common carotid artery were performed.
Results: 64 eyes of 32 patients were included in the study. The mean age was 64.69±9.5(49-85) years, and the female to male ratio was 10(30%)/22(70%). In all eyes, the arcus senilis was bilateral and ring-shaped, and the rate of mild, moderate, dense arcus senilis was 22%, 26%, 52%, respectively. Total cholesterol, TG,LDL,VLDL values of the patients with arcus senilis were higher than the reference values. It was observed that intima-media thickness of the common carotid artery increased correlated with the density of the archus senilis and it was found to be statistically significant(p<0.05). In cases with arcus senilis, 61% of plaques were detected in common carotid artery gray scale ultrasonography, and 65% of them had soft character. There was also no statistically significant relationship between arcus senilis density and body mass index, smoking, neutrophil lymphocyte ratio, blood lipid profıle(p>0.05).
Conclusion: In corneal arcus senilis cases, it was observed that intima-media thickness and plaque formation increased in the common carotid artery. As well as more patients are needed, we can say that arcus senilis may be an independent risk factor for cardiovascular and cerebrovascular diseases.
Key Words: Arcus senilis, Carotid Arteries, Ultrasonography

References

  • 1) Friedlander MH, Smolin G. Corneal degenerations. Ann Ophthalmol 1979; 11:1485.
  • 2) Sugimura G. Unilateral corneal arcus. Arch Ophthalmol 1990; 108:780.
  • 3) Coşar B. Korneanın keratokonus dışı dejeneratif hastalıkları. Tamçelik N, ed. Kornea, 1. Baskı, Türk Oftalmoloji Derneği Eğitim Yayınları No:11, İstanbul, 2009:237-8.
  • 4) Rifkind BM, Dickson C. The incidence of arcus senilis in ischemic heart disease, its relation to serum-lipid levels. Lancet 1965: 312-4.
  • 5) Hickey N, Maurrer B, Mulcahy R. Arcus senilia: its relation to certain attributes and risk factors in patients with coronary artery disease. Br Med J 1970; 32:449-52.
  • 6) Chua BE, Mitchell P, Wang J, Rochtchina E. Corneal arcus and hyperlipidemia: findings from an older population. Am J Ophthalmol 2004; 137:363-5.
  • 7) Barchiesi BJ, Eckel RH, Ellis PP. The cornea and disorders of lipid metabolism. Surv Ophthalmol 1991; 36:1-22.
  • 8) Chambless LE, Fuchs FD, Linn S, Kritchevsky SB, Larosa JC, Segal P, Rifkind BM. The association of corneal arcus with coronary heart disease and cardiovascular disease mortality in the Lipid Research Clinics Mortality Follow-up Study. Am J Public Health 1990; 80:1200-4.
  • 9) Wu R, Wang JJ, Tai ES, Wong TY. Cardiovascular risk factors, inflammation, and corneal arcus: the singapore malay eye study. Am J Ophthalmol 2010; 150:581-7.
  • 10) Fernandez A, Sorokin A, Thompson PD. Corneal arcus as coronary artery disease risk factor. Atherosclerosis 2007; 193:235-40.
  • 11) Virchow VR. Uber parenchymatose entzundun. Virchows Arch Pathol Anat 1852; 4:261.
  • 12) Baboujian A, Bezwada P, Ayala-Rodriguez C. Diagonal Earlobe Crease, a Marker of Coronary Artery Disease: A Case Report on Frank's Sign. Cureus 2019; 11:4219.
  • 13) Lock JH, Ross CA, Flaherty M. Corneal arcus as the presenting sign of familial hypercholesterolemia in a young child. J AAPOS 2018; 22:467-8.
  • 14) Mayalı H, Kılıç Ş, Cansız Ç, Türkoğlu MŞ, Başer EF. Corneal Haze and Peripheral Corneal Arcus in a Young Patient: Lecithin-Cholesterol Acyltransferase Deficiency. Turkish Journal of Ophthalmology 2014; 44:319-21.
  • 15) Hoogerbrugge N, Happee C, van Domburg R, Poldermans D, van den Brand MJ. Corneal arcus: indicator for severity of coronary atherosclerosis? Neth J Med 1999; 55:184-7.
  • 16) Fernandez AB, Keyes MJ, Pencina M, D’Agostino R,O’Donnell CJ, Thompson PD. Relation of corneal arcus to cardiovascular disease (from the Framingham Heart Study data set). Am J Cardiol 2009; 103:64-6.
  • 17) Dikmetaş Ö, Mocan MC, Sevim DG, İrkeç M. The assocıatıon of arcus senılıs wıth exfolıatıon syndrome and cardıovascular dısease ın elderly populatıon. Turkish Journal of Geriatrics 2015; 18:36-41.
  • 18) Wong MYZ, Man REK, Gupta P, Lim SH, Lim B, Tham YC, Sabanayagam C, Wong TY, Cheng CY, Lamoureux EL. Is Corneal Arcus Independently Associated With Incident Cardiovascular Disease in Asians? Am J Ophthalmol 2017; 183:99-106.
  • 19) Ang M, Wong W, Park J, Wu R, Lavanya R, Zheng Y, Cajucom-Uy H, Tai ES, Wong TY. Corneal arcus is a sign of cardiovascular disease, even in low-risk persons. Am J Ophthalmol 2011; 152:864-71.
  • 20) Christoffersen M, Frikke-Schmidt R, Schnohr P, Jensen GB, Nordestgaard BG, Tybjærg-Hansen A. Xanthelasmata, arcus corneae, and ischaemic vascular disease and death in general population: prospective cohort study BMJ 2011; 15;343.
  • 21) Rouhiainen P, Salonen R, Rouhiainen H, Salonen JT. Association of corneal arcus with ultrasonographically assessed arterial wall thickness and serum lipids. Cornea 1993; 12:142-5.
  • 22) Nambi V, Chambless L, Folsom AR, He M, Hu Y, Mosley T, Volcik K, Boerwinkle E, Ballantyne CM. Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk In Communities) study. J Am Coll Cardiol 2010; 55:1600-7.
  • 23) Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and metaanalysis. Circulation 2007; 115:459-67.
  • 24) Kitamura A, Iso H, Imano H, Ohira T, Okada T, Sato S, Kiyama M, Tanigawa T, Yamagishi K, Shimamoto T. Carotid intima-media thickness and plaque characteristics as a risk factor for stroke in Japanese elderly men. Stroke 2004; 35:2788-94.
  • 25) Tosetto A, Prati P, Baracchini C, Manara R, Rodeghiero F. Ageadjusted reference limits for carotid intima-media thickness as better indicator of vascular risk: population-based estimates from the VITA Project. J Thromb Haemost 2005; 3:1224.
There are 25 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Research Articles
Authors

Yelda Yıldız Taşçı This is me 0000-0003-2741-1646

Özlem Ünal This is me 0000-0003-4297-4930

Publication Date January 1, 2022
Submission Date January 18, 2021
Published in Issue Year 2022 Volume: 8 Issue: 1

Cite

Vancouver Taşçı YY, Ünal Ö. Korneal Arkus Senilis Olgularında, Gri Skala ve Spektral Doppler Ultrasonografi ile Karotis Arter Değerlendirilmesi. Akd Med J. 2022;8(1):42-7.