Abstract
Sarkomlar tüm prostat malignensilerinin %0,1-0,2’sini oluşturur. Rabdomyosarkom, iskelet kası sarkomerik diferansiasyonu gösteren malign tümördür. %35 baş- boyun bölgesi, %40 ekstremite ve diğer alanlar, %25 genitoüriner sistemde izlenir. %5 oranında prostat ve mesanede görülür. Primer prostatik rabdomyosarkom genellikle infant ve çocukluk çağında ortalama 10 yaş civarında izlenir. 20 yaşında sağ-sol yan ağrısı yakınması ile hastanemize başvuran hastanın yapılan tetkikleri sonrası bilateral hidronefroz görüldü. Yapılan üretrografide prostatik üretranın çok daraldığı, sert ve fiske olduğu izlendi ve iğne biyopsi alındı. Mikroskobik incelemede prostat bez yapıları ve fibromüsküler stroması içinde invaziv tümör saptandı. Tümör, oval yuvarlak, yer yer düzensiz kontürlü hiperkromatik nukleusa sahip, arada eozinofilik sitoplâzmalı hücrelerden oluşmaktaydı. Tümör hücreleri immünhistokimyasal yöntemle uygulanan myogenin, desmin, c-kit ile pozitif immünreaksiyon gösterdi. Bu bulgularla olgu embriyonal rabdomyosarkom olarak tanı aldı. Olgu prostatik embriyonel rabdomyosarkomun nadir izlenmesi ve diğer prostatik tümörlerden ayrımı yönünden tartışıldı
References
- Nabi G, Dinda AK, Dogra PN. Primary embryonal rhabdomyosarcoma of prostate in adults: Diagnosis and management. Int Urol Nephrol 2002-2003;34(4):531-4.
- Dalal DD, Tongaonkar HB, Krishnamurthy S, Kulkarni JN. Embryonal rhabdomyosarcoma of prostate in an adult-a diagnostic dilemma. Indian J Cancer 2000;37(1):50-3.
- Singh NK, Gangappa M, Gupta V, Mohan A. Embryonal prostatic rhabdomyosarcomas disguised presentation in an adolescent male: A case report. Cases J 2009;2:7546.
- Ferrer FA, Isakoff M, Koyle MA. Bladder/prostate rhabdomyosarcoma: Past, present and future. J Urol 2006;176(4 Pt 1):1283-91.
- Amin MB, Lin DW, Gore JL, et al. The critical role of the pathologist in determining eligibility for active surveillance as a management option of patients with prostate cancer. Consensus statement with recommendations supported by the College of American Pathologists, International Society of Urological Pathology, Association of Directors of Anatomic and Surgical Pathology, the New Zealand Society of Pathologists and the Prostate Cancer Foundation. Arch Pathol Lab Med 2014; 138:1387–1405.
- Janet NL, May AW, Akins RS. Sarcoma of the prostate: A single institutional review. Am J Clin Oncol 2009;32(1):27- 9.
- Niimi K, Hashimoto Y, Kurokawa S, Okada A, Tozawa K, Kohri K. Embryonal rhabdomyosarcoma of the prostate. Int J Clin Oncol 2010;15(1):93-6.
Abstract
Sarcomas account for 0.1 to 0.2% of all prostatic malignancies. Rhabdomyosarcoma is a malignant tumor that shows skeletal muscle sarcomeric differentiation. About 35% of rhabdomyosarcomas occur in the head-neck, 40% on the limbs and other areas and 25% in the genitourinary system. Only 5% of them arise in the prostate or bladder. Primary prostatic rhabdomyosarcoma usually develops in infancy and childhood at around 10 years of age. A 20-year-old male presenting with a complaint of right-left side pain was diagnosed with bilateral hydronephrosis after a series of tests. His urethrography showed a severely narrowed, firm and fixed prostatic urethra, so a needle biopsy was performed. The microscopic examination detected an invasive tumor within fibromuscular stroma and prostate glands. The tumor consisted of oval to round tumor cells with hyperchromatic nuclei and irregular contours in places, as well as cells with occasional eosinophilic cytoplasm. Immunohistochemically, the tumor cells showed a positive immunoreaction for myogenin, desmin and c-kit. Based on these findings, the patient was diagnosed with embryonic rhabdomyosarcoma. The case has been presented for discussion, since prostatic embryonic rhabdomyosarcoma is a rare disease with diagnostic challenges in differentiating from other prostatic tumors
References
- Nabi G, Dinda AK, Dogra PN. Primary embryonal rhabdomyosarcoma of prostate in adults: Diagnosis and management. Int Urol Nephrol 2002-2003;34(4):531-4.
- Dalal DD, Tongaonkar HB, Krishnamurthy S, Kulkarni JN. Embryonal rhabdomyosarcoma of prostate in an adult-a diagnostic dilemma. Indian J Cancer 2000;37(1):50-3.
- Singh NK, Gangappa M, Gupta V, Mohan A. Embryonal prostatic rhabdomyosarcomas disguised presentation in an adolescent male: A case report. Cases J 2009;2:7546.
- Ferrer FA, Isakoff M, Koyle MA. Bladder/prostate rhabdomyosarcoma: Past, present and future. J Urol 2006;176(4 Pt 1):1283-91.
- Amin MB, Lin DW, Gore JL, et al. The critical role of the pathologist in determining eligibility for active surveillance as a management option of patients with prostate cancer. Consensus statement with recommendations supported by the College of American Pathologists, International Society of Urological Pathology, Association of Directors of Anatomic and Surgical Pathology, the New Zealand Society of Pathologists and the Prostate Cancer Foundation. Arch Pathol Lab Med 2014; 138:1387–1405.
- Janet NL, May AW, Akins RS. Sarcoma of the prostate: A single institutional review. Am J Clin Oncol 2009;32(1):27- 9.
- Niimi K, Hashimoto Y, Kurokawa S, Okada A, Tozawa K, Kohri K. Embryonal rhabdomyosarcoma of the prostate. Int J Clin Oncol 2010;15(1):93-6.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | January 1, 2017 |
| Published in Issue | Year 2017 Volume: 3 Issue: 3 |