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Kronik Prostatit Kategori Tip IIIA / Kronik Pelvik Ağrı Sendromlu Hastalarda Antioksidan Tedavinin Semptomlar Üzerine Etkisi

Year 2018, Volume: 4 Issue: 3, 215 - 219, 01.01.2018

Abstract

Amaç: Çalışmanın amacı kronik prostatit kategori tip IIIA / kronik pelvik ağrı sendromlu KP/KPAS hastalarda antioksidan tedavinin semptomlar üzerine etkisinin değerlendirilmesidir.Gereç ve Yöntemler: Ekim 2016 ile Aralık 2017 arasında antioksidan ajan olan Progeny-M® ile tedavi edilen KP/KPAS kategori IIIA hastaların verileri retrospektif olarak değerlendirildi. Tedavi öncesi ve tedavi sonrası semptomların değerlendirilmesinde National Institute of Health- Kronik Prostatit Semptom İndeksi NIH-KPSİ kullanıldı. Tedaviden sonra NIH-KPSİ toplam skorunda %25’ten fazla azalma tedaviye yanıt olarak kabul edildi. P

References

  • Krieger JN, Lee SW, Jeon J, Cheah PY, Liong ML, Riley DE. Epidemiology of prostatitis. Int J Antimicrob Agents 2008; 31 Suppl. 1: 85-90.
  • Krieger JN, Nyberg L Jr, Nickel JC. NIH consensus definition and classification of prostatitis. JAMA 1999; 282:236-7.
  • Nickel JC: Prostatitis syndromes: An update for urologic practice. Can J Urol 2000;7: 1091-8.
  • Schaeffer AJ, Datta NS, Fowler JE Jr, Krieger JN, Litwin MS, Nadler RB. Chronic Prostatitis Collaborative Research N. 2002 Overview summary statement. Diagnosis and management of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Urology 2002; 60:1-4.
  • Schaeffer AJ, Knauss JS, Landis JR, Propert KJ, Alexander RB, Litwin MS, Nyberg LM. Leukocyte and bacterial counts do not correlate with severity of symptoms in men with chronic prostatitis: The National Institutes of Health Chronic Prostatitis Cohort Study. Journal of Urology 2002; 168:1048-53.
  • Litwin MS, McNaughton-Collins M, Fowler FJ Jr, Nickel JC, Calhoun EA, Pontari MA, Alexander RB, Farrar JT, O'Leary MP. The National Institutes of Health chronic prostatitis symptom index: Development and validation of a new outcome measure. J Urology 1999; 162:369-75.
  • Breser ML, Salazar FC, Rivero VE, Motrich RD. Immunological mechanisms underlying chronic pelvic pain and prostate in chronic pelvic pain syndrome. Front Immunol 2017; 8:898.
  • Nickel JC, Downey J, Clark J, Casey RW, Pommerville PJ, Barkin J, Steinhoff G, Brock G, Patrick AB, Flax S, Goldfarb B, Palmer BW, Zadra J. Levofloxacin for chronic prostatitis/chronic pelvic pain syndrome in men: A randomized placebo-controlled multicenter trial. Urology 2003;62(4):614-7.
  • Nickel JC, Narayan P, McKay J, Doyle C. Treatment of chronic prostatitis/ chronic pelvic pain syndrome with tamsulosin: A randomized double blind trial. J Urol 2004;171(4):1594-7.
  • Zhao WP, Zhang ZG, Li XD, Yu D, Rui XF, Li GH, Ding GQ. Celecoxib reduces symptoms in men with difficult chronic pelvic pain syndrome (Category IIIA). Braz J Med Biol Res 2009;42(10):963-7.
  • Rugendorff EW, Weidner W, Ebeling L, Buck AC. Results of treatment with pollen extract (cernilton N) in chronic prostatitis and prostatodynia. Br J Urol 1993;71: 433-8.
  • Shahed AR, Shoskes DA. Oxidative stress in prostatic fluid of patients with chronic pelvic pain syndrome: correlation with gram positive bacterial growth and treatment response. J Androl 2000;21:669-75.
  • Pasqualotto FF, Sharma RK, Potts JM, Nelson DR, Thomas AJ, Agarwal A. Seminal oxidative stress in patients with chronic prostatitis. Urology 2000;55(6):881- 5.
  • Cai T, Verze P, La Rocca R, Palmieri A, Tiscione D, Luciani LG, Mazzoli S, Mirone V, Malossini G. The Clinical Efficacy of Pollen Extract and Vitamins on chronic prostatitis/chronic pelvic pain syndrome is linked to a decrease in the pro-inflammatory cytokine interleukin-8. World J Mens Health 2017; 35(2):120-8.
  • Potts JM, Pasqualotto FF. Seminal oxidative stress in patients with chronic prostatitis. Andrologia 2003; 35:304- 8.
  • Potts JM, Sharma RK, Pasqualotto FF, Nelson DR, Agarwal A. Association of Ureaplasma urealyticum infection with abnormal seminal reactive oxygen species and absence of leukocytospermia. J Urol 2000;163:1775-8.
  • Morgia G, Mucciardi G, Galì A, Madonia M, Marchese F, Di Benedetto A, Romano G, Bonvissuto G, Castelli T, Macchione L, Magno C. Treatment of chronic prostatitis/ chronic pelvic pain syndrome category IIIA with Serenoa repens plus selenium and lycopene (Profluss) versus S. repens alone: An Italian randomized multicenter- controlled study. Urol Int 2010; 84:400-6.
  • Shoskes DA, Zeitlin SI, Shahed A, Rajfer J. Quercetin in men with category III chronic prostatitis: A preliminary prospective, double-blind, placebo-controlled trial. Urology 1999;54(6): 960-3.
  • Oka M, Ueda M, Oyama T, Kyotani J, Tanaka, M. Effect of the phytotherapeutic agent Eviprostat on 17beta- estradiol-induced nonbacterial inflammation in the rat prostate. Prostate 2009;69:1404-10.
  • Hajighorbani M, Ahmadi-Hamedani M, Shahab E, Hayati F, Kafshdoozan K, Keramati K, Amini AH. Evaluation of the protective effect of pentoxifylline on carrageenan-induced chronic non-bacterial prostatitis in rats. Inflammopharmacology 2017;25(3):343-50.

Efficacy of Antioxidant Treatment on the Symptoms of Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome Category IIIA

Year 2018, Volume: 4 Issue: 3, 215 - 219, 01.01.2018

Abstract

Objective: The aim of this study was to evaluate the effect of antioxidant treatment on the symptoms in patients with chronic prostatitis/chronic pelvic pain syndrome CP/CPPS category IIIA.Material and Methods: We retrospectively evaluated the data of patients with chronic prostatitis/chronic pelvic pain syndrome category IIIA who were treated by Progeny- M®, an antioxidant agent, between October 2016 and December 2017. The pretreatment and posttreatment symptoms were assessed using the National Institutes of Health-Chronic Prostatitis Symptom Index NIH-CPSI . A reduction of the NIH-CPSI total score by ≥25% after the treatment was accepted as an improvement. A value of P < 0.05 was considered statistically significant.Results: Thirty-five out of 53 patients diagnosed with chronic prostatitis were CP/CPPS category IIIA. Seventeen of them were treated with antioxidant agent Progeny- M® for a month. Mean NIH-CPSI total score was significantly decreased after the treatment with Progeny-M® compared to the pretreatment mean score p < 0.001 . Pretreatment mean pain, urinary and quality of life scores of NIH- CPSI 12.1±3.8, 4.7±2.8, 7.6±2.7, respectively were significantly decreased compared to posttreatment scores 8.2±4.2, 3.1±2.0, 5.2±2.6 p < 0.001, p=0.002, p=0.004, respectively .Conclusion: The mean total, pain, urinary and quality of life NIH-CPSI scores significantly decreased after 4 weeks of Progeny-M® treatment in patients with CP/CPPS category IIIA. 58.8% the patients had improved NIH-CSPI scores after the treatment

References

  • Krieger JN, Lee SW, Jeon J, Cheah PY, Liong ML, Riley DE. Epidemiology of prostatitis. Int J Antimicrob Agents 2008; 31 Suppl. 1: 85-90.
  • Krieger JN, Nyberg L Jr, Nickel JC. NIH consensus definition and classification of prostatitis. JAMA 1999; 282:236-7.
  • Nickel JC: Prostatitis syndromes: An update for urologic practice. Can J Urol 2000;7: 1091-8.
  • Schaeffer AJ, Datta NS, Fowler JE Jr, Krieger JN, Litwin MS, Nadler RB. Chronic Prostatitis Collaborative Research N. 2002 Overview summary statement. Diagnosis and management of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Urology 2002; 60:1-4.
  • Schaeffer AJ, Knauss JS, Landis JR, Propert KJ, Alexander RB, Litwin MS, Nyberg LM. Leukocyte and bacterial counts do not correlate with severity of symptoms in men with chronic prostatitis: The National Institutes of Health Chronic Prostatitis Cohort Study. Journal of Urology 2002; 168:1048-53.
  • Litwin MS, McNaughton-Collins M, Fowler FJ Jr, Nickel JC, Calhoun EA, Pontari MA, Alexander RB, Farrar JT, O'Leary MP. The National Institutes of Health chronic prostatitis symptom index: Development and validation of a new outcome measure. J Urology 1999; 162:369-75.
  • Breser ML, Salazar FC, Rivero VE, Motrich RD. Immunological mechanisms underlying chronic pelvic pain and prostate in chronic pelvic pain syndrome. Front Immunol 2017; 8:898.
  • Nickel JC, Downey J, Clark J, Casey RW, Pommerville PJ, Barkin J, Steinhoff G, Brock G, Patrick AB, Flax S, Goldfarb B, Palmer BW, Zadra J. Levofloxacin for chronic prostatitis/chronic pelvic pain syndrome in men: A randomized placebo-controlled multicenter trial. Urology 2003;62(4):614-7.
  • Nickel JC, Narayan P, McKay J, Doyle C. Treatment of chronic prostatitis/ chronic pelvic pain syndrome with tamsulosin: A randomized double blind trial. J Urol 2004;171(4):1594-7.
  • Zhao WP, Zhang ZG, Li XD, Yu D, Rui XF, Li GH, Ding GQ. Celecoxib reduces symptoms in men with difficult chronic pelvic pain syndrome (Category IIIA). Braz J Med Biol Res 2009;42(10):963-7.
  • Rugendorff EW, Weidner W, Ebeling L, Buck AC. Results of treatment with pollen extract (cernilton N) in chronic prostatitis and prostatodynia. Br J Urol 1993;71: 433-8.
  • Shahed AR, Shoskes DA. Oxidative stress in prostatic fluid of patients with chronic pelvic pain syndrome: correlation with gram positive bacterial growth and treatment response. J Androl 2000;21:669-75.
  • Pasqualotto FF, Sharma RK, Potts JM, Nelson DR, Thomas AJ, Agarwal A. Seminal oxidative stress in patients with chronic prostatitis. Urology 2000;55(6):881- 5.
  • Cai T, Verze P, La Rocca R, Palmieri A, Tiscione D, Luciani LG, Mazzoli S, Mirone V, Malossini G. The Clinical Efficacy of Pollen Extract and Vitamins on chronic prostatitis/chronic pelvic pain syndrome is linked to a decrease in the pro-inflammatory cytokine interleukin-8. World J Mens Health 2017; 35(2):120-8.
  • Potts JM, Pasqualotto FF. Seminal oxidative stress in patients with chronic prostatitis. Andrologia 2003; 35:304- 8.
  • Potts JM, Sharma RK, Pasqualotto FF, Nelson DR, Agarwal A. Association of Ureaplasma urealyticum infection with abnormal seminal reactive oxygen species and absence of leukocytospermia. J Urol 2000;163:1775-8.
  • Morgia G, Mucciardi G, Galì A, Madonia M, Marchese F, Di Benedetto A, Romano G, Bonvissuto G, Castelli T, Macchione L, Magno C. Treatment of chronic prostatitis/ chronic pelvic pain syndrome category IIIA with Serenoa repens plus selenium and lycopene (Profluss) versus S. repens alone: An Italian randomized multicenter- controlled study. Urol Int 2010; 84:400-6.
  • Shoskes DA, Zeitlin SI, Shahed A, Rajfer J. Quercetin in men with category III chronic prostatitis: A preliminary prospective, double-blind, placebo-controlled trial. Urology 1999;54(6): 960-3.
  • Oka M, Ueda M, Oyama T, Kyotani J, Tanaka, M. Effect of the phytotherapeutic agent Eviprostat on 17beta- estradiol-induced nonbacterial inflammation in the rat prostate. Prostate 2009;69:1404-10.
  • Hajighorbani M, Ahmadi-Hamedani M, Shahab E, Hayati F, Kafshdoozan K, Keramati K, Amini AH. Evaluation of the protective effect of pentoxifylline on carrageenan-induced chronic non-bacterial prostatitis in rats. Inflammopharmacology 2017;25(3):343-50.
There are 20 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

İlter Alkan This is me

Erhan Ateş This is me

Publication Date January 1, 2018
Published in Issue Year 2018 Volume: 4 Issue: 3

Cite

APA Alkan, İ., & Ateş, E. (2018). Kronik Prostatit Kategori Tip IIIA / Kronik Pelvik Ağrı Sendromlu Hastalarda Antioksidan Tedavinin Semptomlar Üzerine Etkisi. Akdeniz Tıp Dergisi, 4(3), 215-219.