BibTex RIS Cite

Multi-Drug Resistance-1 [MDR1, P-gp, ABCB1] Gene Polymorphism in Patients with Abdominal Aortic Aneurysm and Their Family Members

Year 2018, Volume: 4 Issue: 3, 233 - 238, 01.01.2018

Abstract

Objective: The aim of this study was to investigate the relationship between the 3435C>T polymorphism in the multi-drug resistance-1 gene [MDR1, P-gp, ABCB1] and the development of abdominal aortic aneurysm AAA .Material and Methods: This study included 75 patients with AAA Group I , 75 individuals who were first-degree relatives of these patients but did not have AAA diagnosis Group II , and 75 healthy volunteers whose abdominal aortic diameters were in the normal range Group III . Genomic DNAs of these individuals were obtained from the peripheral blood. The MDR1:c.3435C>T polymorphism [CC Wild Type , CT Heterozygous and TT Homozygous genotypes] was investigated by using the real-time polymerase chain reaction technique real-time PCR .Results: MDR1 TT genotype was significantly more frequent in Groups I and II compared to Group III 33.3% and 38.6% vs. 8%, respectively, p

References

  • 1. Büket S, Yağdı T. Aort Cerrahisi. İstanbul: Yüce Yayınları, 2003.
  • 2. Gottesman MM, Pastan I. Resistance to multiple chemotherapeutic agents in human cancer cells. Trends Pharmacol Sci 1988;9:54-8.
  • 3. Schwab M, Eichelbaum M, Fromm M.F. Genetic polymorphism of the human MDR1 drug transporter. Annu Rev Pharmacol Toxicol 2003;43:285-307.
  • 4. Callen DF, Baker E, Simmers RN, Seshadri R, Roninson IB. Localization of the human multiple drug resistance gene, MDR1, to 7q21. Hum Genet 1987;77:142-4.
  • 5. Chen C, Clark D, Ueda K, Pastan I, Gottesman MM, Roninson IB. Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J Biol Chem 1990;265:506-14.
  • 6. Kurtulgan HK, Manduz S, Uslu A, Katrancioglu N, Karahan O, Yildiz F, Berkan O, Ozdemir O. The crucial role of mdr1 (ABCB1) gene polymorphisim in abdominal aortic aneurysm. Preliminary results of a pilot study. Chromosome Res 2009;17:90-1.
  • 7. Aydın M, Katrancıoğlu N, Karahan O, Manduz Ş, Özdemir Ö, Atahan E, Berkan Ö. Kemokin reseptör 5 Δ32 gen polimorfizmi ve abdominal aort anevrizmaları. Türk Göğüs Kalp Damar Cerrahisi Dergisi 2010;18:284- 9.
  • 8. Manduz Ş, Katrancıoğlu N, Karahan O, Yılmaz MB, Özdemir Ö, Berkan Ö. Multi-drug resistance [MDR-1 (ABCB1)] 3435 geni C>T varyantı ve abdominal aort anevrizması arasındaki ilişki. Pilot çalışma. Türk Göğüs Kalp Damar Cerrahisi Dergisi 2011;19:177-81.
  • 9. Clifton, MA Familial abdominal aortic aneurysms. Brit J Surg 1977;64:765-6.
  • 10. Dermatology. Rapini RP, Bolognia JL, Jorizzo JL (eds). St. Louis: Mosby, 2007.
  • 11. Giusti B, Saracini C, Bolli P, Magi A, Sestini I, Sticchi E, Pratesi G, Pulli R, Pratesi C, Abbate R. Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. J Med Genet 2008;45:721-30.
  • 12. Ghilardi G, Biondi ML, Battaglioli L, Zambon A, Guagnellini E, Scorza R. Genetic risk factor characterizes abdominal aortic aneurysm from arterial occlusive disease in human beings: CCR5 Delta 32 deletion. J Vasc Surg 2004;40:995-1000.
  • 13. Johansen K, Koepsell T. Familial tendency for abdominal aortic aneurysms. JAMA 1986;256:1934-6.
  • 14. Hobbs SD, Claridge MW, Quick CR, Day NE, Bradbury AW, Wilmink AB. LDL cholesterol is associated with small abdominal aortic aneurysms. Eur J VascEndovasc Surg 2003; 26:618-22.
  • 15. Badger SA, Soong CV, O’Donnell ME, Mercer C, Young IS, Hughes AE. C-reactive protein (CRP) elevation in patients with abdominal aortic aneurysm isindependent of the most important CRP genetic polymorphism. J Vasc Surg 2009;49:178-84.
  • 16. Piquette-Miller M, Pak A, Kim H, Anari R, Shahzamani A. Decreased expression and activity of p-glycoprotein in rat liver during acute inflammation. Pharma Res 1998;15:706-11.
  • 17. Rizas KD, Ippagunta N, Tilson III MD. Immune cells and molecular mediators in the pathogenesis of the abdominal aortic aneurysm. Cardio Rev 2009;17: 201-10.
  • 18. Li QQ, Wang WJ, Xu JD, Cao XX, Chen Q, Yang JM, Xu ZD. Up-regulation of CD147 and matrix metalloproteinase-2, -9 induced by P-glycoprotein substrates in multidrug resistant breast cancer cells. Cancer Sci 2007;98:1767-74.
  • 19. Shteinberg D, Halak M, Shapiro S, Kinarty A, Sobol E, Lahat N, Karmeli R. Abdominal aortic aneurysm and aortic occlusive disease: A comprison of risk factors and inflammatory response. Eur J Vasc Endovasc Surg 2000;20:462-5.
  • 20. Drach J, Gsur A, Hamilton G, Zhao S, Angerler J, Fiegl M, Zojer N, Raderer M, Haberl I, Andreeff M, Huber H. Involvement of P-gp in the transmembrane transport of IL-2, IL-4 and IFN-γ in normal human T-lymphocytes. Blood 1996;88:1747-54.
  • 21. Baumann F, Makaloski V, Diehm N. Aortic aneurysms and aortic dissection: Epidemiology, pathophysiology and diagnostics. Internist (Berl) 2013;54:535-42.
  • 22. Saratzis A, Bown MJ, Wild B, Nightingale P, Smith J, Johnson C, Melas N, Kitas GD. Association between seven single nucleotıde polymorphisms involved in inflammation and proteolysis and abdominal aortic aneurysm. J Vasc Surg 2014; 61(5):1120-8.e1.
  • 23. Abdul-Hussien H, Hanemaaijer R, Kleemann R, Verhaaren BF, van Bockel JH, Lindeman JH. The pathophysiology of abdominal aortic aneurysm growth: corresponding and discordant inflammatory and proteolytic processes in abdominal aortic and popliteal artery aneurysms. J Vasc Surg 2010;51:1479-87.
  • 24. Duellman T, Warren CL, Matsumura J ,Yang J. Analysis of multiple genetic polymorphisms in aggressive-growing and slow-growing abdominal aortic aneurysms. J Vasc Surg 2014;60(3):613-21.e3.
  • 25. Morris DR, Biros E, Cronin O, Kuivaniemi H, Golledge J. The association of genetic variants of matrix metalloproteinases with abdominal aortic aneurysm: A systematic review and meta-analysis. Heart 2014;100:295- 302.

Abdominal Aort Anevrizması Bulunan Hastalarda ve Aile Üyelerinde Multi-Drug Resistance-1 [MDR1, P-gp, ABCB1] Geni Polimorfizmi

Year 2018, Volume: 4 Issue: 3, 233 - 238, 01.01.2018

Abstract

Amaç: Bu çalışmanın amacı Multi-drug resistance-1 [MDR1, P-gp, ABCB1] genindeki 3435C>T polimorfizmi ile abdominal aort anevrizması AAA gelişimi arasındaki ilişkinin incelenmesidir.Gereç ve Yöntemler: AAA tanısı olan 75 hasta Grup I , bu hastaların AAA tanısı olmayan birinci derece akrabalarından oluşan 75 gönüllü Grup II ve aort çapları normal olan ve akrabaları olmayan 75 sağlıklı gönüllü Grup III çalışmaya alındı. Periferik kandan olgulara ait genomik DNA’lar elde edildi. MDR1:c.3435C>T polimorfizmi [CC Doğal genotip , CT Heterozigot ve TT Homozigot genotipler] eş zamanlı polimeraz zincir reaksiyonu real-time PCR tekniği kullanılarak araştırıldı.Bulgular: MDR1 TT genotipinin Grup I ve Grup II’de kontrol grubuna göre anlamlı derecede fazla olduğu görüldü sırasıyla %33,3 ve %38,6’e karşı %8, p

References

  • 1. Büket S, Yağdı T. Aort Cerrahisi. İstanbul: Yüce Yayınları, 2003.
  • 2. Gottesman MM, Pastan I. Resistance to multiple chemotherapeutic agents in human cancer cells. Trends Pharmacol Sci 1988;9:54-8.
  • 3. Schwab M, Eichelbaum M, Fromm M.F. Genetic polymorphism of the human MDR1 drug transporter. Annu Rev Pharmacol Toxicol 2003;43:285-307.
  • 4. Callen DF, Baker E, Simmers RN, Seshadri R, Roninson IB. Localization of the human multiple drug resistance gene, MDR1, to 7q21. Hum Genet 1987;77:142-4.
  • 5. Chen C, Clark D, Ueda K, Pastan I, Gottesman MM, Roninson IB. Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J Biol Chem 1990;265:506-14.
  • 6. Kurtulgan HK, Manduz S, Uslu A, Katrancioglu N, Karahan O, Yildiz F, Berkan O, Ozdemir O. The crucial role of mdr1 (ABCB1) gene polymorphisim in abdominal aortic aneurysm. Preliminary results of a pilot study. Chromosome Res 2009;17:90-1.
  • 7. Aydın M, Katrancıoğlu N, Karahan O, Manduz Ş, Özdemir Ö, Atahan E, Berkan Ö. Kemokin reseptör 5 Δ32 gen polimorfizmi ve abdominal aort anevrizmaları. Türk Göğüs Kalp Damar Cerrahisi Dergisi 2010;18:284- 9.
  • 8. Manduz Ş, Katrancıoğlu N, Karahan O, Yılmaz MB, Özdemir Ö, Berkan Ö. Multi-drug resistance [MDR-1 (ABCB1)] 3435 geni C>T varyantı ve abdominal aort anevrizması arasındaki ilişki. Pilot çalışma. Türk Göğüs Kalp Damar Cerrahisi Dergisi 2011;19:177-81.
  • 9. Clifton, MA Familial abdominal aortic aneurysms. Brit J Surg 1977;64:765-6.
  • 10. Dermatology. Rapini RP, Bolognia JL, Jorizzo JL (eds). St. Louis: Mosby, 2007.
  • 11. Giusti B, Saracini C, Bolli P, Magi A, Sestini I, Sticchi E, Pratesi G, Pulli R, Pratesi C, Abbate R. Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. J Med Genet 2008;45:721-30.
  • 12. Ghilardi G, Biondi ML, Battaglioli L, Zambon A, Guagnellini E, Scorza R. Genetic risk factor characterizes abdominal aortic aneurysm from arterial occlusive disease in human beings: CCR5 Delta 32 deletion. J Vasc Surg 2004;40:995-1000.
  • 13. Johansen K, Koepsell T. Familial tendency for abdominal aortic aneurysms. JAMA 1986;256:1934-6.
  • 14. Hobbs SD, Claridge MW, Quick CR, Day NE, Bradbury AW, Wilmink AB. LDL cholesterol is associated with small abdominal aortic aneurysms. Eur J VascEndovasc Surg 2003; 26:618-22.
  • 15. Badger SA, Soong CV, O’Donnell ME, Mercer C, Young IS, Hughes AE. C-reactive protein (CRP) elevation in patients with abdominal aortic aneurysm isindependent of the most important CRP genetic polymorphism. J Vasc Surg 2009;49:178-84.
  • 16. Piquette-Miller M, Pak A, Kim H, Anari R, Shahzamani A. Decreased expression and activity of p-glycoprotein in rat liver during acute inflammation. Pharma Res 1998;15:706-11.
  • 17. Rizas KD, Ippagunta N, Tilson III MD. Immune cells and molecular mediators in the pathogenesis of the abdominal aortic aneurysm. Cardio Rev 2009;17: 201-10.
  • 18. Li QQ, Wang WJ, Xu JD, Cao XX, Chen Q, Yang JM, Xu ZD. Up-regulation of CD147 and matrix metalloproteinase-2, -9 induced by P-glycoprotein substrates in multidrug resistant breast cancer cells. Cancer Sci 2007;98:1767-74.
  • 19. Shteinberg D, Halak M, Shapiro S, Kinarty A, Sobol E, Lahat N, Karmeli R. Abdominal aortic aneurysm and aortic occlusive disease: A comprison of risk factors and inflammatory response. Eur J Vasc Endovasc Surg 2000;20:462-5.
  • 20. Drach J, Gsur A, Hamilton G, Zhao S, Angerler J, Fiegl M, Zojer N, Raderer M, Haberl I, Andreeff M, Huber H. Involvement of P-gp in the transmembrane transport of IL-2, IL-4 and IFN-γ in normal human T-lymphocytes. Blood 1996;88:1747-54.
  • 21. Baumann F, Makaloski V, Diehm N. Aortic aneurysms and aortic dissection: Epidemiology, pathophysiology and diagnostics. Internist (Berl) 2013;54:535-42.
  • 22. Saratzis A, Bown MJ, Wild B, Nightingale P, Smith J, Johnson C, Melas N, Kitas GD. Association between seven single nucleotıde polymorphisms involved in inflammation and proteolysis and abdominal aortic aneurysm. J Vasc Surg 2014; 61(5):1120-8.e1.
  • 23. Abdul-Hussien H, Hanemaaijer R, Kleemann R, Verhaaren BF, van Bockel JH, Lindeman JH. The pathophysiology of abdominal aortic aneurysm growth: corresponding and discordant inflammatory and proteolytic processes in abdominal aortic and popliteal artery aneurysms. J Vasc Surg 2010;51:1479-87.
  • 24. Duellman T, Warren CL, Matsumura J ,Yang J. Analysis of multiple genetic polymorphisms in aggressive-growing and slow-growing abdominal aortic aneurysms. J Vasc Surg 2014;60(3):613-21.e3.
  • 25. Morris DR, Biros E, Cronin O, Kuivaniemi H, Golledge J. The association of genetic variants of matrix metalloproteinases with abdominal aortic aneurysm: A systematic review and meta-analysis. Heart 2014;100:295- 302.
There are 25 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Bayram Yağmur This is me

Ali İhsan Tekin This is me

Publication Date January 1, 2018
Published in Issue Year 2018 Volume: 4 Issue: 3

Cite

APA Yağmur, B., & Tekin, A. İ. (2018). Multi-Drug Resistance-1 [MDR1, P-gp, ABCB1] Gene Polymorphism in Patients with Abdominal Aortic Aneurysm and Their Family Members. Akdeniz Tıp Dergisi, 4(3), 233-238.