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Rare Tumors of the Lung; 74 Cases

Year 2019, Volume: 5 Issue: 1, 120 - 127, 01.01.2019

Abstract

Objective: We aimed to evaluate the rare tumors of the lung in a single article in this study. Thus, these cases, which were included in the literature as case reports, were collected under a single article.Material and Methods: In this retrospective study 6879 patients who were operated between January 2010 and December 2017 in our clinic. In the histological classification, tumors with an incidence of less than 5% were accepted as rare tumors. 74 cases of a rare tumor of the lung were examined by subgroups.Results: The average age of 74 patients in the study was 54.5 years. Twelve of the patients were female and 62 were male. While 83.3% of the patients with a diagnosis of tumorlet were female, 100% of patients with a diagnosis of large cell neuroendocrine tumor was male.Eighteen of the 74 patients included in the study had died and 56 were being followed up and treated.Conclusion: The rare tumors of the lung are usually presented in the literature as case reports and there is no definitive treatment protocol. Large series of patients are needed for better understanding of these tumors

References

  • Toraksın Nadir Tümörleri. Erdoğan Y, Çapan N, Demirağ F, eds. Ankara: AGHH yayınları, 2010.
  • Xiang H, Wu Z, Wang Z, Yao H. Nodular pulmonary amyloidosis and obvious ossification due to primary pulmonary MALT lymphoma with extensive plasmacytic differentiation: Report of a rare case and review of the literature. Int J Clin Exp Pathol 2015; 8(6):7482-7.
  • Troch M, Streubel B, Petkov V, Turetschek K, Chott A, Raderer M. Does MALT lymphoma of the lung require immediate treatment? An analysis of 11 untreated cases with long-term follow-up. Anticancer Res 2007; 27:3633- 7.
  • Wang B, Zhang C, Wang B, Zhang L. Comparisons of surgery and/or chemotherapy in the treatment of primary pulmonary mucosa-associated lymphoid tissue lymphoma. Ann Thorac Cardiovasc Surg 2015; 21:109- 13.
  • Elia D, Torre O, Cassandro R, Caminati A, Harari S. Pulmonary. Langerhans cell histiocytosis: A comprehensive analysis of 40 patients and literature review. Eur J Intern Med 2015; 26(5):351-6.
  • Yoshino N, Hirata T, Takeuchi C, Usuda J, Hosone M. A case of primary pulmonary diffuse large B-cell lymphoma diagnosed by transbronchial biopsy. Ann Thorac Cardiovasc Surg 2015; 21(4):396-8.
  • Cooksley N, Judge DJ, Brown J. Primary pulmonary Hodgkin’s lymphoma and a review of the literature since 2006. BMJ Case Rep 2014.
  • Chen CK, Jan CI, Tsei JS, Huang HC, Chen PR, Lin YS, Chen CY, Feng HY. Inflammatory myofibroblastic tumor of the lung- a case report. J Cardiothorac Surg 2010; 20(5):55.
  • Tanaka M, Kohashi K, Kushitani K, Yoshida M, Kurihara S, Kawashima M, Ueda Y, Souzaki R, Kinoshita Y, Oda Y, Takeshima Y Hiyama E, Taquchi T. Inflammatory myofibroblastic tumors of the lung carrying a chimeric A2M-ALK gene: Report of 2 infantile cases and review of the differential diagnosis of infantile pulmonary lesions. Hum Path 2017; 66:177-82.
  • Hafiza SA, Rizwan AD, Masooma N, Sandeep M, Misbahuddin K. A rare case of sarcomatoid carcinoma of the lung with spine metastasis, including a literature review. Am J Case Rep 2017; 18:760-5.
  • Çağırıcı U, Çakan A, Samancılar Ö, Veral A, Özhan M. Akciğerin büyük hücreli nöroendokrin karsinomunda cerrahi tedavi sonuçları. Tüberküloz ve Toraks Dergisi 2006; 54(1):30-3.
  • Cihan YB, Arslan A. Kombine tip küçük hücreli akciğer kanseri. Solunum 2011; 13(3):161-5.
  • Ping H, Xia G, Qinian W, Yunen L, Yingying G, Jianxing HJ. Pulmonary carcinoid tumorlet without underlying lung disease: Analysis of its relationship to fibrosis. Thorac Dis 2012; 4(6):655-8.
  • Wirtschafter E, Walts AE, Liu ST, Marchevsky AM. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia of the lung (DIPNECH): Current best evidence. Lung 2015; 193(5):659-67.
  • Gou YK, Jhingook K,Yong SC, Ho JK, Geunghwan A, Joungho H. Sixteen cases of sclerosing hemangioma of the lung including unusual presentations. J Korean Med Sci 2004; 19(3):352-8.
  • Çakır E, Demirağ F, Ertürk A, Taştepe İ, Çapan N.Pulmoner mukoepidermoid karsinom: Olgu sunumu. Solunum Hastalıkları 2007; 18:118-21.
  • Allen TC, Amrikachi M, Cagle PT. Pulmonary sclerosing papillary adenoma. Pathol Int 2013; 63(7):364-7.
  • Ozdemir N, Cangir AK, Kutlay H, Yavuzer ST. Primary malignant melanoma of the lung in oculocutaneous albino patient. Eur J Cardiothorac Surg 2001; 20(4):864-7.
  • Erdal NB, Karakurt Z, Pandul İ, Tahaoğlu C. A case report: primary pulmonary melanoma. Turkish Respiratory Journal 2000; 1(2):72-4.
  • Kaynak K, Demirkaya A. Kistik adenoid malformasyonlar. Turkiye Klinikleri J Thor Surg-Special Topics 2011; 4(2):126-9.

Akciğerin Nadir Tümörleri; 74 Olgu

Year 2019, Volume: 5 Issue: 1, 120 - 127, 01.01.2019

Abstract

Amaç: Bu çalışmada, akciğerin nadir görülen tümörlerinin birlikte değerlendirilmesi amaçlandı. Böylelikle olgu sunumları şeklinde literatürde yer alan bu olgular tek bir yazı altında toplanmaya çalışıldı. Gereç ve Yöntemler: Bu geriye dönük çalışmaya kliniğimizde Ocak 2010 ile Aralık 2017 tarihleri arasında opere edilen 6879 hasta dahil edildi. Histolojik sınıflamada, görülme sıklığı %5ʼden az olan tümörler nadir tümör olarak kabul edildi. Akciğerin nadir tümörü tanısı alan 74 olgu alt gruplara ayrılarak incelendi. Bulgular: Çalışmadaki 74 hastanın yaş ortalaması 54,5’dir. Hastaların 12 tanesi kadın 62 tanesi erkekti. Tümörlet tanısı alan olguların, %83,3’ü kadın iken büyük hücreli nöroendokrin tümör tanısı alan olguların %100’ü erkekti. Araştırmaya dâhil edilen 74 hastanın 18 tanesi eksitus olurken, 56 tanesinin takip ve tedavileri devam etmektedir.Sonuç: Akciğerin nadir tümörleri literatürde genellikle olgu sunumları şeklinde bulunmaktadır ve kesinleşmiş bir tedavi protokolleri yoktur. Bu tümörlerin daha iyi anlaşılabilmesi için geniş hasta serilerine ihtiyaç vardır

References

  • Toraksın Nadir Tümörleri. Erdoğan Y, Çapan N, Demirağ F, eds. Ankara: AGHH yayınları, 2010.
  • Xiang H, Wu Z, Wang Z, Yao H. Nodular pulmonary amyloidosis and obvious ossification due to primary pulmonary MALT lymphoma with extensive plasmacytic differentiation: Report of a rare case and review of the literature. Int J Clin Exp Pathol 2015; 8(6):7482-7.
  • Troch M, Streubel B, Petkov V, Turetschek K, Chott A, Raderer M. Does MALT lymphoma of the lung require immediate treatment? An analysis of 11 untreated cases with long-term follow-up. Anticancer Res 2007; 27:3633- 7.
  • Wang B, Zhang C, Wang B, Zhang L. Comparisons of surgery and/or chemotherapy in the treatment of primary pulmonary mucosa-associated lymphoid tissue lymphoma. Ann Thorac Cardiovasc Surg 2015; 21:109- 13.
  • Elia D, Torre O, Cassandro R, Caminati A, Harari S. Pulmonary. Langerhans cell histiocytosis: A comprehensive analysis of 40 patients and literature review. Eur J Intern Med 2015; 26(5):351-6.
  • Yoshino N, Hirata T, Takeuchi C, Usuda J, Hosone M. A case of primary pulmonary diffuse large B-cell lymphoma diagnosed by transbronchial biopsy. Ann Thorac Cardiovasc Surg 2015; 21(4):396-8.
  • Cooksley N, Judge DJ, Brown J. Primary pulmonary Hodgkin’s lymphoma and a review of the literature since 2006. BMJ Case Rep 2014.
  • Chen CK, Jan CI, Tsei JS, Huang HC, Chen PR, Lin YS, Chen CY, Feng HY. Inflammatory myofibroblastic tumor of the lung- a case report. J Cardiothorac Surg 2010; 20(5):55.
  • Tanaka M, Kohashi K, Kushitani K, Yoshida M, Kurihara S, Kawashima M, Ueda Y, Souzaki R, Kinoshita Y, Oda Y, Takeshima Y Hiyama E, Taquchi T. Inflammatory myofibroblastic tumors of the lung carrying a chimeric A2M-ALK gene: Report of 2 infantile cases and review of the differential diagnosis of infantile pulmonary lesions. Hum Path 2017; 66:177-82.
  • Hafiza SA, Rizwan AD, Masooma N, Sandeep M, Misbahuddin K. A rare case of sarcomatoid carcinoma of the lung with spine metastasis, including a literature review. Am J Case Rep 2017; 18:760-5.
  • Çağırıcı U, Çakan A, Samancılar Ö, Veral A, Özhan M. Akciğerin büyük hücreli nöroendokrin karsinomunda cerrahi tedavi sonuçları. Tüberküloz ve Toraks Dergisi 2006; 54(1):30-3.
  • Cihan YB, Arslan A. Kombine tip küçük hücreli akciğer kanseri. Solunum 2011; 13(3):161-5.
  • Ping H, Xia G, Qinian W, Yunen L, Yingying G, Jianxing HJ. Pulmonary carcinoid tumorlet without underlying lung disease: Analysis of its relationship to fibrosis. Thorac Dis 2012; 4(6):655-8.
  • Wirtschafter E, Walts AE, Liu ST, Marchevsky AM. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia of the lung (DIPNECH): Current best evidence. Lung 2015; 193(5):659-67.
  • Gou YK, Jhingook K,Yong SC, Ho JK, Geunghwan A, Joungho H. Sixteen cases of sclerosing hemangioma of the lung including unusual presentations. J Korean Med Sci 2004; 19(3):352-8.
  • Çakır E, Demirağ F, Ertürk A, Taştepe İ, Çapan N.Pulmoner mukoepidermoid karsinom: Olgu sunumu. Solunum Hastalıkları 2007; 18:118-21.
  • Allen TC, Amrikachi M, Cagle PT. Pulmonary sclerosing papillary adenoma. Pathol Int 2013; 63(7):364-7.
  • Ozdemir N, Cangir AK, Kutlay H, Yavuzer ST. Primary malignant melanoma of the lung in oculocutaneous albino patient. Eur J Cardiothorac Surg 2001; 20(4):864-7.
  • Erdal NB, Karakurt Z, Pandul İ, Tahaoğlu C. A case report: primary pulmonary melanoma. Turkish Respiratory Journal 2000; 1(2):72-4.
  • Kaynak K, Demirkaya A. Kistik adenoid malformasyonlar. Turkiye Klinikleri J Thor Surg-Special Topics 2011; 4(2):126-9.
There are 20 citations in total.

Details

Primary Language Turkish
Journal Section Case Report
Authors

Hakan Keskin This is me

Makbule Ergin This is me

Levent Dertsiz This is me

Alpay Sarper This is me

Abdullah Erdoğan This is me

Publication Date January 1, 2019
Published in Issue Year 2019 Volume: 5 Issue: 1

Cite

Vancouver Keskin H, Ergin M, Dertsiz L, Sarper A, Erdoğan A. Akciğerin Nadir Tümörleri; 74 Olgu. Akd Med J. 2019;5(1):120-7.