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Diş Hekimliğinde Tamamlayıcı Bitkisel Tedaviler

Year 2020, Volume: 6 Issue: 2, 145 - 153, 01.01.2020

Abstract

Amaç: Bu derlemenin amacı, diş hekimliği alanındaki bitkisel tedavilerin modern bilimin ışığında kullanılabilirliğini irdeleyerek, alternatif tedavi yöntemlerinin klinik kullanım alanlarını araştırmaktır. Gereç ve Yöntemler: PubMed, Cochrane Library, Evidence-Based Dentistry ve Google Scholar’da 2008-2018 yılları arasında yapılan uluslararası yayın taramasında; bitkisel tedaviler, ağız sağlığı, diş hekimliği, sarı kantaron, meyan kökü, sumak, karadut, aloe vera ve bu anahtar kelimelerin farklı kombinasyonları kullanılarak 179 yayına ulaşıldı. Bu yayınlardan, özetlerin okunması sonrasında belirlenen limitler dahilinde antimikrobiyal, antiinflamatuar, analjezik ve antiplak özelliklerinden herhangi birine sahip bitkilerle ilgili olan 50 yayın konu kapsamı içinde incelenmeye uygun görüldü. Bulgular: İncelenen yayınlarda, diş hekimliğinde bitkisel tedavi uygulamalarında analjezik ve antiinflamatuar özellikleri nedeniyle akut ağrıda sarı kantaron, antibakteriyel etkisiyle biyofilm oluşumunu azaltmak için sumak, avülse dişlerde taşıma ortamı olarak karadut, ağız ve diş enfeksiyonlarında karyojenik bakteriler ve perio-patojenlere karşı antimikrobiyal özelliğiyle aloe vera ve meyan kökü kullanıldığı tespit edildi.Sonuç: Tamamlayıcı ve alternatif bitkisel tedavi uygulamalarının, diş hekimliğinde kullanımının yaygınlaşması amacıyla konuya ilişkin bilimsel çalışmaların desteklenmesi gerekmektedir

References

  • Taheri JB, Azimi S, Rafieian N, Akhavan Zanjani H. Herbs in dentistry. Int Dent J 2011; 61:287-96.
  • Palombo EA. Traditional medicinal plant extracts and natural products with activity against oral bacteria: Potential application in the prevention and treatment of oral diseases. Evid Based Complement Alternat Med 2011; 2011 Article ID 680354:1-15.
  • Yiğit D, Yiğit N. Antibacterial activty of black mulberry (morus nigra) fruits and leaves. Erzincan Univ J Sci Technol 2008; 1:39-48.
  • Vahid-Dastjerdi E, Abdolazimi Z, Ghazanfarian M, Amdjadi P, Kamalinejad M, Mahmoubi A. Effect of Punica granatum l. flower water extract on five common oral bacteria and bacterial biofilm formation on orthodontic wire. Iran J Public Health 2014; 43:1688-94.
  • Özgen M, Serçe S, Kaya C. Phytochemical and antioxidant properties of anthocyanin-rich Morus nigra and Morus rubra fruits. Sci Hortic 2009; 119:275-9.
  • Souza GR, Oliveira-Junior RG, Diniz TC, Branco A, Lima-Saraiva SRG, Guimaraes AL, Oliveria AP, Pacheco AGM, Silva MG, Moraes-Filho MO, Costa MP, Pessoa CO, Almeida JRGS. Assessment of the antibacterial, cytotoxic and antioxidant activities of Morus nigra L. (Moraceae). Braz J Biol 2018; 78:248-54.
  • Özan F, Tepe B, Polat ZA, Er K. Evaluation of in vitro effect of Morus rubra (red mulberry) on survival of periodontal ligament cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 105:66-9.
  • Sidkey BAJ, Omran AH. Evaluation of the antibacterial effects of Eucalyptus camaldulensis L., Glycyrrhiza glabra L. and Morus nigra L. extracts against some pathogenic bacteria in vitro. Iraqi J Sci 2017; 58:1371-80.
  • Tahir L, Aslam A, Ahmed S. Morus nigra against dental caries causing pathogens: An in vitro study. Pak J Pharm Sci 2010; 30:163-9.
  • Abbas GM, Bar FMA, Baraka HN, Gohar AA, Lahloub MF. Natural product research: Formerly natural product letters a new antioxidant stilbene and other constituents from the stem bark of Morus nigra L. Nat Prod Res 2014; 28:952-9.
  • Assiri K, Alyami Y, Uyanik JM, Romero-Reyes M. Hypericum perforatum (St. John’s Wort) as a possible therapeutic alternative for the management of trigeminal neuralgia (TN) - A case report. Complement Ther in Med 2017; 30:36-9.
  • Raak C, Büssing A, Gassmann G, Boehm K, Ostermann T. A systematic review and meta-analysis on the use of Hypericum perforatum (St. John’s Wort) for pain conditions in dental practice. Homeopathy 2012; 101: 204-10.
  • Yücel A, Kan Y, Yesilada E, Akın O. Effect of St.John’s wort (Hypericum perforatum) oily extract for the care and treatment of pressure sores; A case report. J Ethnopharmacol 2017; 196:236-41.
  • Sardella A, Lodi G, Demarosi F, Tarozzi M, Canegallo L, Carrassi A. Hypericum perforatum extract in burning mouth syndrome: a randomized placebo-controlled study. J Oral Pathol Med 2008; 37:395-401.
  • Moghaddam AA, Radafshar G, Jahandideh Y, Kakaei N. Clinical evaluation of effects of local application of Aloe vera gel as an adjunct to scaling and root planning in patients with chronic periodontitis. J Dent Shiraz Univ Med Sci 2017; 18:165-172.
  • Badakhsh S, Eskandarian T, Esmaeilpour T. The use of Aloe Vera extract as a novel storage media for the avulsed tooth. Iran J Med Sci 2014; 39:327-32.
  • Sujatha G, Senthil Kumar G, Muruganandan J, Srinivasa Prasad T. Aloe vera in dentistry. J Clin Diagn Res 2014; 8:1-2.
  • Prabhakar K, Karuna YM, Yavagal C, Deepak BM. Cavity disinfection in minimally invasive dentistry- comparative evaluation of Aloe vera and propolis: A randomized clinical trial. ContempClin Dent 2015; 6:24- 31.
  • Abdulwahhab AR, Jassim RK. The effect of aloe vera extract on adherence of candida albicans and other properties of heat cure denture soft lining material. IJSR 2018; 7:94-103.
  • Nair GR, Naidu GS, Jain S, Nagi R, Makkad RS, Jha A. Clinical effectiveness of aloe vera in the management of oral mucosal diseases-a systematic review. J Clin Diagn Res 2016; 10:1-7.
  • Mansour G, Ouda S, Shaker A, Abdallah HM. Clinical efficacy of new aloe vera- and myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: A randomized, double-blind, vehicle- controlled study. J Oral Pathol Med 2014; 43:405-9.
  • Vangipuram S, Jha A, Bhashyam M. Comparative efficacy of aloe vera mouthwash and chlorhexidine on periodontal health: A randomized controlled trial. J Clin Exp Dent 2016; 18:442-7.
  • Kermanshah H, Kamangar S, Arami S, Kamalinegad M, Karimi M, Mirsalehian A, Jabalameli F, Fard MJK. The effect of hydro alcoholic extract of seven plants on cariogenic bacteria an in vitro evaluation. Oral Health Dent Manag 2014; 13:395-401.
  • Shetty P, Hegde V, Gomes L. Anticandidal efficacy of denture cleansing tablet, Triphala, Aloe vera, and Cashew leaf on complete dentures of institutionalized elderly. J Ayurveda Integr Med 2014; 5:11.
  • Navit S, Shahi N, Khan SA, Sharma A, Singh V, Mishra P, Navit P, Sharma P. Nature’s benefaction as a life saver for an avulsed tooth: An in vitro study. J Clin Diagn Res 2017; 11:1-4.
  • López-Jornet P, Camacho-Alonso F, Molino-Pagan D. Prospective, randomized, double-blind, clinical evaluation of Aloe vera Barbadensis, applied in combination with a tongue protector to treat burning mouth syndrome. J Oral Pathol Med 2013; 42:295-301.
  • Sharma G, Sardana D, Vohra P, Rehani S, Nagpal A. Oral lichen planus in a pediatric patient: A novel therapeutic approach. J Dent (Tehran) 2017; 14:109-14.
  • Mansourian A, Momen-Heravi F, Saheb-Jamee M, Esfehani M, Khalilzadeh O, Momen-Beitollahi J. Comparison of aloe vera mouthwash with triamcinolone acetonide 0.1% on oral lichen planus: A randomized double-blinded clinical trial. Am J Med Sci 2011; 342: 447-51.
  • Sudarshan R, Annigeri RG, Sree Vijayabala G. Aloe vera in the treatment for oral submucous fibrosis - a preliminary study. J Oral Pathol Med 2012; 41:755-61.
  • Najafi S, Koujan SE, Manifar S, Kharazifard MJ, Kidi S, Hajheidary S. Preventive effect of glycyrrhiza glabra extract on oral mucositis in patients under head and neck radiotherapy: A randomized clinical trial. J Dent (Tehran) 2017; 14:267-74.
  • Messier C, Epifano F, Genovese S, Grenier D. Licorice and its potential beneficial effects in common oro-dental diseases. Oral Dis 2012; 18:32-9.
  • Ahn SJ, Cho EJ, Kim HJ, Park SN, Lim YK, Kook JK. The antimicrobial effects of deglycyrrhizinated licorice root extract on Streptococcus mutans UA159 in both planktonic and biofilm cultures. Anaerobe 2012; 18:590- 6.
  • Sedighinia F, Safipour Afshar A, Soleimanpour S, Zarif R, Asili J, Ghazvini K. Antibacterial activity of Glycyrrhiza glabra against oral pathogens: An in vitro study. Avicenna J Phyto Med 2012; 3:118-24.
  • Aslani A, Zolfaghari B, Fereidani Y. Design, formulation, and evaluation of a herbal gel contains melissa, sumac, licorice, rosemary, and geranium for treatment of recurrent labial herpes infections. Dent Res J 2018; 15: 191-200.
  • Touyz LZ. Liquorice health check, Oro-dental implications, and a case report. Case Rep Med 2009; 170735:1-6.
  • Ghalayani P, Emami H, Pakravan F, Nasr Isfahani M. Comparison of triamcinolone acetonide mucoadhesive film with licorice mucoadhesive film on radiotherapy- induced oral mucositis: A randomized double-blinded clinical trial. Asia Pac J Clin Oncol 2017; 13:48-56.
  • Ajagannanavar SL, Battur H, Shamarao S, Sivakumar V, Patil PU, Shavanas P. Effect of aqueous and alcoholic licorice (glycyrrhiza glabra) root extract against streptococcus mutans and lactobacillus acidophilus in comparison to chlorhexidine: an in vitro study. J Int Oral Heal 2014; 6:29-34.
  • La VD, Tanabe S, Bergeron C, Gafner S, Grenier D. Modulation of Matrix Metalloproteinase and Cytokine Production by Licorice Isolates Licoricidin and Licorisoflavan A: Potential therapeutic approach for Periodontitis. J Periodontol 2011; 82:122-8.
  • Peters MC, Tallman JA, Braun TM, Jacobson JJ. Clinical reduction of S. mutans in pre-school children using a novel liquorice root extract lollipop: A pilot study. Eur Arch of Paediatr Dent 2010; 11:274-8.
  • Yu IC, Tsai YF, Fang JT, Yeh MM, Fang JY, Liu CY. Effects of mouthwash interventions on xerostomia and unstimulated whole saliva flow rate among hemodialysis patients: A randomized controlled study. Int J Nurs Stud 2016; 63:9-17.
  • Babpour E, Angaji SA, Angaji SM. Antimicrobial effects of four medicinal plants on dental plaque. J Med Plants Res 2009; 3:132-7.
  • Ardalani H, Moghadam MH, Hadipanah A, Fotovat F, Azizi A, Soltani J. Identification and characterization of chemical composition of Rhus coriaria L. fruit from Hamadan, Western Iran. J Herb Drugs 2016; 4:195-8.
  • Vahid-Dastjerdi E, Monadi E, Khalighi HR, Torshabi M. Down-regulation of glycosyl transferase genes in Streptococcus mutans by Punica granatum L. Flower and Rhus coriaria L. Fruit water extracts. Iran J Pharm Res 2016; 15:513-9.
  • You YO, Choi NY, Kang SY, Kim KJ. Antibacterial activity of Rhus javanica against methicillin-resistant Staphylococcus aureus. Evid Based Complement Alternat Med 2013; 2013 Article ID 549207:1-8.

Complementary Herbal Treatments in Dentistry

Year 2020, Volume: 6 Issue: 2, 145 - 153, 01.01.2020

Abstract

Objective: The purpose of this review is to investigate the clinical uses of alternative therapies by examining the usefulness of herbal therapies in the field of dentistry in the light of modern science.Material and Methods: Scans were conducted in PubMed, Cochrane Library, Evidence-Based Dentistry and Google Scholar for the 2008-2018 period; 179 articles which used different combinations of herbal medicines were obtained by using the key words herbal treatments, dentistry, hypericum perforatum, glycyrrhiza glabra, rhus, morus nigra, and aloe vera. Fifty articles related to plants with any of the antimicrobial, anti-inflammatory, analgesic and antiplaque properties within the limits were determined. After reading the summaries from these publications, 50 studies were found to be suitable for evaluation within the scope of the subject. Results: In the studies investigated, it has been found out that some herbs are used for treatment. Hypericum perforatum is used in acute pain due to its analgesic and anti-inflammatory properties in dentistry. By the same token, rhus is used to reduce biofilm formation with antibacterial effect, and morus nigra is used as a transport medium in avulsed teeth. Furthermore, aloe vera and glycyrrhiza glabra are used with antimicrobial properties against perio pathogens.Conclusion: In order to use complementary and alternative herbal therapies in dentistry, scientific studies on the subject should be supported

References

  • Taheri JB, Azimi S, Rafieian N, Akhavan Zanjani H. Herbs in dentistry. Int Dent J 2011; 61:287-96.
  • Palombo EA. Traditional medicinal plant extracts and natural products with activity against oral bacteria: Potential application in the prevention and treatment of oral diseases. Evid Based Complement Alternat Med 2011; 2011 Article ID 680354:1-15.
  • Yiğit D, Yiğit N. Antibacterial activty of black mulberry (morus nigra) fruits and leaves. Erzincan Univ J Sci Technol 2008; 1:39-48.
  • Vahid-Dastjerdi E, Abdolazimi Z, Ghazanfarian M, Amdjadi P, Kamalinejad M, Mahmoubi A. Effect of Punica granatum l. flower water extract on five common oral bacteria and bacterial biofilm formation on orthodontic wire. Iran J Public Health 2014; 43:1688-94.
  • Özgen M, Serçe S, Kaya C. Phytochemical and antioxidant properties of anthocyanin-rich Morus nigra and Morus rubra fruits. Sci Hortic 2009; 119:275-9.
  • Souza GR, Oliveira-Junior RG, Diniz TC, Branco A, Lima-Saraiva SRG, Guimaraes AL, Oliveria AP, Pacheco AGM, Silva MG, Moraes-Filho MO, Costa MP, Pessoa CO, Almeida JRGS. Assessment of the antibacterial, cytotoxic and antioxidant activities of Morus nigra L. (Moraceae). Braz J Biol 2018; 78:248-54.
  • Özan F, Tepe B, Polat ZA, Er K. Evaluation of in vitro effect of Morus rubra (red mulberry) on survival of periodontal ligament cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 105:66-9.
  • Sidkey BAJ, Omran AH. Evaluation of the antibacterial effects of Eucalyptus camaldulensis L., Glycyrrhiza glabra L. and Morus nigra L. extracts against some pathogenic bacteria in vitro. Iraqi J Sci 2017; 58:1371-80.
  • Tahir L, Aslam A, Ahmed S. Morus nigra against dental caries causing pathogens: An in vitro study. Pak J Pharm Sci 2010; 30:163-9.
  • Abbas GM, Bar FMA, Baraka HN, Gohar AA, Lahloub MF. Natural product research: Formerly natural product letters a new antioxidant stilbene and other constituents from the stem bark of Morus nigra L. Nat Prod Res 2014; 28:952-9.
  • Assiri K, Alyami Y, Uyanik JM, Romero-Reyes M. Hypericum perforatum (St. John’s Wort) as a possible therapeutic alternative for the management of trigeminal neuralgia (TN) - A case report. Complement Ther in Med 2017; 30:36-9.
  • Raak C, Büssing A, Gassmann G, Boehm K, Ostermann T. A systematic review and meta-analysis on the use of Hypericum perforatum (St. John’s Wort) for pain conditions in dental practice. Homeopathy 2012; 101: 204-10.
  • Yücel A, Kan Y, Yesilada E, Akın O. Effect of St.John’s wort (Hypericum perforatum) oily extract for the care and treatment of pressure sores; A case report. J Ethnopharmacol 2017; 196:236-41.
  • Sardella A, Lodi G, Demarosi F, Tarozzi M, Canegallo L, Carrassi A. Hypericum perforatum extract in burning mouth syndrome: a randomized placebo-controlled study. J Oral Pathol Med 2008; 37:395-401.
  • Moghaddam AA, Radafshar G, Jahandideh Y, Kakaei N. Clinical evaluation of effects of local application of Aloe vera gel as an adjunct to scaling and root planning in patients with chronic periodontitis. J Dent Shiraz Univ Med Sci 2017; 18:165-172.
  • Badakhsh S, Eskandarian T, Esmaeilpour T. The use of Aloe Vera extract as a novel storage media for the avulsed tooth. Iran J Med Sci 2014; 39:327-32.
  • Sujatha G, Senthil Kumar G, Muruganandan J, Srinivasa Prasad T. Aloe vera in dentistry. J Clin Diagn Res 2014; 8:1-2.
  • Prabhakar K, Karuna YM, Yavagal C, Deepak BM. Cavity disinfection in minimally invasive dentistry- comparative evaluation of Aloe vera and propolis: A randomized clinical trial. ContempClin Dent 2015; 6:24- 31.
  • Abdulwahhab AR, Jassim RK. The effect of aloe vera extract on adherence of candida albicans and other properties of heat cure denture soft lining material. IJSR 2018; 7:94-103.
  • Nair GR, Naidu GS, Jain S, Nagi R, Makkad RS, Jha A. Clinical effectiveness of aloe vera in the management of oral mucosal diseases-a systematic review. J Clin Diagn Res 2016; 10:1-7.
  • Mansour G, Ouda S, Shaker A, Abdallah HM. Clinical efficacy of new aloe vera- and myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: A randomized, double-blind, vehicle- controlled study. J Oral Pathol Med 2014; 43:405-9.
  • Vangipuram S, Jha A, Bhashyam M. Comparative efficacy of aloe vera mouthwash and chlorhexidine on periodontal health: A randomized controlled trial. J Clin Exp Dent 2016; 18:442-7.
  • Kermanshah H, Kamangar S, Arami S, Kamalinegad M, Karimi M, Mirsalehian A, Jabalameli F, Fard MJK. The effect of hydro alcoholic extract of seven plants on cariogenic bacteria an in vitro evaluation. Oral Health Dent Manag 2014; 13:395-401.
  • Shetty P, Hegde V, Gomes L. Anticandidal efficacy of denture cleansing tablet, Triphala, Aloe vera, and Cashew leaf on complete dentures of institutionalized elderly. J Ayurveda Integr Med 2014; 5:11.
  • Navit S, Shahi N, Khan SA, Sharma A, Singh V, Mishra P, Navit P, Sharma P. Nature’s benefaction as a life saver for an avulsed tooth: An in vitro study. J Clin Diagn Res 2017; 11:1-4.
  • López-Jornet P, Camacho-Alonso F, Molino-Pagan D. Prospective, randomized, double-blind, clinical evaluation of Aloe vera Barbadensis, applied in combination with a tongue protector to treat burning mouth syndrome. J Oral Pathol Med 2013; 42:295-301.
  • Sharma G, Sardana D, Vohra P, Rehani S, Nagpal A. Oral lichen planus in a pediatric patient: A novel therapeutic approach. J Dent (Tehran) 2017; 14:109-14.
  • Mansourian A, Momen-Heravi F, Saheb-Jamee M, Esfehani M, Khalilzadeh O, Momen-Beitollahi J. Comparison of aloe vera mouthwash with triamcinolone acetonide 0.1% on oral lichen planus: A randomized double-blinded clinical trial. Am J Med Sci 2011; 342: 447-51.
  • Sudarshan R, Annigeri RG, Sree Vijayabala G. Aloe vera in the treatment for oral submucous fibrosis - a preliminary study. J Oral Pathol Med 2012; 41:755-61.
  • Najafi S, Koujan SE, Manifar S, Kharazifard MJ, Kidi S, Hajheidary S. Preventive effect of glycyrrhiza glabra extract on oral mucositis in patients under head and neck radiotherapy: A randomized clinical trial. J Dent (Tehran) 2017; 14:267-74.
  • Messier C, Epifano F, Genovese S, Grenier D. Licorice and its potential beneficial effects in common oro-dental diseases. Oral Dis 2012; 18:32-9.
  • Ahn SJ, Cho EJ, Kim HJ, Park SN, Lim YK, Kook JK. The antimicrobial effects of deglycyrrhizinated licorice root extract on Streptococcus mutans UA159 in both planktonic and biofilm cultures. Anaerobe 2012; 18:590- 6.
  • Sedighinia F, Safipour Afshar A, Soleimanpour S, Zarif R, Asili J, Ghazvini K. Antibacterial activity of Glycyrrhiza glabra against oral pathogens: An in vitro study. Avicenna J Phyto Med 2012; 3:118-24.
  • Aslani A, Zolfaghari B, Fereidani Y. Design, formulation, and evaluation of a herbal gel contains melissa, sumac, licorice, rosemary, and geranium for treatment of recurrent labial herpes infections. Dent Res J 2018; 15: 191-200.
  • Touyz LZ. Liquorice health check, Oro-dental implications, and a case report. Case Rep Med 2009; 170735:1-6.
  • Ghalayani P, Emami H, Pakravan F, Nasr Isfahani M. Comparison of triamcinolone acetonide mucoadhesive film with licorice mucoadhesive film on radiotherapy- induced oral mucositis: A randomized double-blinded clinical trial. Asia Pac J Clin Oncol 2017; 13:48-56.
  • Ajagannanavar SL, Battur H, Shamarao S, Sivakumar V, Patil PU, Shavanas P. Effect of aqueous and alcoholic licorice (glycyrrhiza glabra) root extract against streptococcus mutans and lactobacillus acidophilus in comparison to chlorhexidine: an in vitro study. J Int Oral Heal 2014; 6:29-34.
  • La VD, Tanabe S, Bergeron C, Gafner S, Grenier D. Modulation of Matrix Metalloproteinase and Cytokine Production by Licorice Isolates Licoricidin and Licorisoflavan A: Potential therapeutic approach for Periodontitis. J Periodontol 2011; 82:122-8.
  • Peters MC, Tallman JA, Braun TM, Jacobson JJ. Clinical reduction of S. mutans in pre-school children using a novel liquorice root extract lollipop: A pilot study. Eur Arch of Paediatr Dent 2010; 11:274-8.
  • Yu IC, Tsai YF, Fang JT, Yeh MM, Fang JY, Liu CY. Effects of mouthwash interventions on xerostomia and unstimulated whole saliva flow rate among hemodialysis patients: A randomized controlled study. Int J Nurs Stud 2016; 63:9-17.
  • Babpour E, Angaji SA, Angaji SM. Antimicrobial effects of four medicinal plants on dental plaque. J Med Plants Res 2009; 3:132-7.
  • Ardalani H, Moghadam MH, Hadipanah A, Fotovat F, Azizi A, Soltani J. Identification and characterization of chemical composition of Rhus coriaria L. fruit from Hamadan, Western Iran. J Herb Drugs 2016; 4:195-8.
  • Vahid-Dastjerdi E, Monadi E, Khalighi HR, Torshabi M. Down-regulation of glycosyl transferase genes in Streptococcus mutans by Punica granatum L. Flower and Rhus coriaria L. Fruit water extracts. Iran J Pharm Res 2016; 15:513-9.
  • You YO, Choi NY, Kang SY, Kim KJ. Antibacterial activity of Rhus javanica against methicillin-resistant Staphylococcus aureus. Evid Based Complement Alternat Med 2013; 2013 Article ID 549207:1-8.
There are 44 citations in total.

Details

Primary Language Turkish
Journal Section Collection
Authors

Gülfem Ergün This is me

Zeynep Şahin This is me

İrem Kara This is me

Publication Date January 1, 2020
Published in Issue Year 2020 Volume: 6 Issue: 2

Cite

Vancouver Ergün G, Şahin Z, Kara İ. Diş Hekimliğinde Tamamlayıcı Bitkisel Tedaviler. Akd Med J. 2020;6(2):145-53.