WHICH TREATMENT SHOULD BE SELECTED FOR THE OPTIMUM APPROACH TO PATIENTS WITH NON-SMALL CELL LUNG CANCER WITH DRIVER MUTATION? A CASE REPORT AND LITERATURE REVIEW

Onur Yazdan Balçık; Esin Oktay; Gizem Dönmez Yalçın

doi:10.53394/akd.996247

Case Report

Birden Fazla Sürücü Mutasyonlu Küçük Hücre Olmayan Akciğer Kanserli Hastalarda Optimum Yaklaşım İçin Hangi Tedavi Seçilmelidir? Bir Vaka Raporu ve Literatür İncelemesi

Year 2023, Volume: 9 Issue: 2, 226 - 230, 01.05.2023

Onur Yazdan Balçık , Esin Oktay , Gizem Dönmez Yalçın

https://doi.org/10.53394/akd.996247

Abstract

59 yaşındaki bir hastada küçük hücreli olmayan akciğer kanserinde (KHDAK) bir anaplastik lenfoma kinaz (ALK) ve c-ros onkogen 1 (ROS1) füzyonu vakasını sunuyoruz ve ko-mutasyonların tedavi etkinliğini gözden geçiriyoruz. Tedavinin seçimi ve nadir ko-mutasyonlarla etkinliği oldukça ilgi çeken bir konudur. Bu derleme, birden fazla sürücü mutasyonu olan KHDAK hastalarına optimal tedavi yaklaşımına dair ipuçları sağlayacaktır. Bununla birlikte, hangi hastaların uygun TKI veya kemoterapiden fayda görebileceğini netleştirmek için randomize çalışmalara ihtiyaç vardır.
Anahtar Kelimeler: Akciğer, Mutasyon, Alk, Ros

Keywords

ALK, ROS, MUTASYON, AKCİĞER

References

1. Zhou C, Wu YL, Chen G, Feng J, Liu XQ, Wang C, Zhang S, Wang J. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol, 2011;12(8):735-742.
2. Mitsudomi T, Morita S, Yatabe Y, Negoro S, Okamoto I, Tsurutani J, Seto T. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol, 2010;11(2):121-128.
3. Mok TS, Wu Y, Thongprasert S, Yang, C, Chu D, Saijo N, Sunpaweravong P, Gefitinib or carboplatin–paclitaxel in pulmonary adenocarcinoma. New England Journal of Medicine, 2009;361(10): 947-957. 4. Zhang X, Zhang S, Yang Z, Yang J, Zhou Q, Yin Y, An S. Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression. Mol Cancer, 2010;9(1):1-12.
5. An SJ, Chen ZH, Su J, Zhang WZ, Zhong WZ, Yang JL, Zhou Q. Identification of enriched driver gene alterations in subgroups of non-small cell lung cancer patients based on histology and smoking status. PLoS One, 2012;7(6): e40109.
6. Cote ML, Haddad R, Edwards DJ, Atikukke G, Gadgeel S, Soubabi AO, Leonardo F. Frequency and type of epidermal growth factor receptor mutations in African Americans with non-small cell lung cancer. J Thorac Oncol, 2011;6(3): 627-30.
7. Kohno T, Takashi N, Tsuta K, Tsuchihara K, Matsumoto S, Yoh K, Goto K. Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer. Transl Lung Cancer Res, 2015;4(2):156.
8. Mazières J, Zalcman G, Crino L, Biondani P, Barlesi F, Filleron T, Dingemans AM. Crizotinib therapy for advanced lung adenocarcinoma and a ROS1 rearrangement: results from the EUROS1 cohort. J Clin Oncol, 2015;33(9):992-999.
9. Peters S, Mok TS, Gadgeel SM, Rosell R, Dziadziuszko R, Kim DW, Perol M. Updated overall survival (OS) and safety data from the randomized, phase III ALEX study of alectinib (ALC) versus crizotinib (CRZ) in untreated advanced ALK+ NSCLC. J Clin Oncol, 2020;38(15):9518-9518.
10. Soria JC, Ohe Y, Vansteenkiste J, Reungwetwattana T, Chewaskulyong B, Lee KH, Dechaphunkul A. Osimertinib in Untreated EGFR-Mutated Advanced Non–Small-Cell Lung Cancer. New England Journal of Medicine, 2018;378(2):113-125.
11. Shen L, Qiang T, Li Z, Ding D, Yu Y, Lu S. First-line crizotinib versus platinum-pemetrexed chemotherapy in patients with advanced ROS1-rearranged non-small-cell lung cancer. Cancer Med, 2020;9(10):3310-3318.
12. Zhang Y, Sun Y, Pan Y, Li C, Shen L, Li Y, Luo X, Ye T. Frequency of driver mutations in lung adenocarcinoma from female never-smokers varies with histologic subtypes and age at diagnosis. Clin. Cancer Res,2012;18(7):1947-1953.
13. Zhu YC, Zhang XG, Lin XP, Wang WX, Li XF, Wu LX, Chen HF. Clinicopathological features and clinical efficacy of crizotinib in Chinese patients with ROS1-positive non-small cell lung cancer. Oncol Lett, 2019;17(3):3466-3474.
14. Zhu YC, Liao XH, Wang WX, Xu CW, Zhuang W, Wei JG, Du K. Dual drive coexistence of EML4-ALK and TPM3-ROS1 fusion in advanced lung adenocarcinoma.Thorac Cancer, 2018;9(2):324-327.
15. Sahnane N, Frattini M, Bernosconi B, Zappa F, Schiavone G, Wannesson L, Antonelli P, Balzarini P. EGFR and KRAS Mutations in ALK-Positive Lung Adenocarcinomas: Biological and Clinical Effect. Clin Lung Cancer, 2016;17(1):56-61.
16. Schmid S, Gautschi O, Rothscill S, Mark M, Froesch P, Klingbiel D, Reichegger H. Clinical Outcome of ALK-Positive Non-Small Cell Lung Cancer (NSCLC) Patients with De Novo EGFR or KRAS Co-Mutations Receiving Tyrosine Kinase Inhibitors (TKIs). JThorac Oncol, 2017;12(4):681-688.
17. He Y, Sheng W, Hu W, Lin J, Liu J, Yu B, Mao X. Different Types of ROS1 Fusion Partners Yield Comparable Efficacy to Crizotinib.Oncol Res, 2019;27(8):901-910.
18. Lin JJ, Ritterhouse LL, Ali SM, Bailey M, Schrock AB, Gainor JF, Ferris LA. ROS1 Fusions Rarely Overlap with Other Oncogenic Drivers in Non-Small Cell Lung Cancer. J Thorac Oncol, 2017;12(5):872-877.
19. Zhu YC, Xu CW, Ye XQ, Yin MX, Zhang JX, Du KQ, Zhang ZH. Lung cancer with concurrent EGFR mutation and ROS1 rearrangement: a case report and review of the literature. Onco Targets Ther, 2016;9:4301-5.
20. Chen RL, Yang JJ, Zhang XC, Lou NN, Chen H, Zhoujian Q, Guo W. ROS1 rearrangement coexists with EGFR mutation in non-small-cell lung cancer. American Society of Clinical Oncology, 2015;33(15):e19003-e19003.
21. Pan W, Yang Y, Zhu H, Zhang Y, Zhou R, Sun X. KRAS mutation is a weak, but valid predictor for poor prognosis and treatment outcomes in NSCLC: A meta-analysis of 41 studies.Oncotarget,2016;7(7):8373.
22. Uguen A, Schick U, Quere G. A Rare Case of ROS1 and ALK Double Rearranged Non-Small Cell Lung Cancer. J Thorac Oncol, 2017;12(6):e71-e72.
23. Song Z, Zheng Y, Wang X, Su H, Zhang Y, Song Y. ALK and ROS1 rearrangements, coexistence and treatment in epidermal growth factor receptor-wild type lung adenocarcinoma: a multicenter study of 732 cases. J Thorac Dis, 2017;9(10):3919-3926.