Case Report
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Angiosarcoma Developing After Radiotherapy in The Breast: Case Report

Year 2024, Volume: 10 Issue: 3, 568 - 571, 19.09.2024
https://doi.org/10.53394/akd.1371604

Abstract

Angiosarcomas are aggressive, malignant tumors originating from the endothelium.
These tumors, which occur primarily and secondarily in the breast, constitute less
than 1% of breast malignancies. The most common risk factors include radiotherapy
and chronic lymphedema. Survival is quite low in these tumors, which tend
to frequently recur locally and metastasize. Due to its rarity, there is no standard
treatment regimen for this disease. Treatment includes surgery, chemotherapy and
radiotherapy. Diagnosis is made late because it is often confused with other skin
lesions. Angiosarcoma should be considered in the differential diagnosis of newly
developing suspicious lesions in patients with a history of radiotherapy to the breast.

References

  • 1- Gaballah AH, Jensen CT, Palmquist S, Pickhardt PJ, Duran A, Broering G, Elsayes KM. Angiosarcoma: clinical and imaging features from head to toe. The British journal of radiology 2017; 90(1075): 20170039.
  • 2-Anzalone CL, Cohen PR, Diwan AH, Prieto VG. Radiation-induced angiosarcoma. Dermatology online journal 2013; 19(1):2.
  • 3-Donghi D, Kerl K, Dummer R, Schoenewolf N, Cozzio A. Cutaneous angiosarcoma: own experience over 13 years. Clinical features, disease course and immunohistochemical profile. Journal of the European Academy of Dermatology and Venereology 2010; 24(10): 1230-34.
  • 4- Murgia, Robert D., and Gary P. Gross. "Stewart-Treves Syndrome." StatPearls [Internet]. StatPearls Publishing, 2022.
  • 5-Vojtíšek R, Sukovská E, Kylarová M, Kacerovská D, Baxa J, Divišová B, Fínek J. Stewart-Treves syndrome: Case report and literature review. Reports of Practical Oncology & Radiotherapy 2020; 25(6): 934-8.
  • 6-Ganesan S, Iype EM, Kapali AS, S R. Radiation Induced Sarcoma of Oral Cavity-A Rare Case Report and a Short Review. Journal of Clinical and Diagnostic Research 2013; 7(11): 2598-9.
  • 7-Body G, Sauvanet E, Calais G, Fignon A, Fetissof F, Lansac J. Cutaneous angiosarcoma of the breast following surgery and irradiation of breast adenocarcinoma. Journal de Gynecologie, Obstetrique et Biologie de la Reproduction 1987; 16(4): 479-83.
  • 8- Polgar C, Orosz Z, Szerdahelyi A, Fodor J, Major T, Magori A, Czeyda-Pommersheim F, Nagy IV, Szakolczai I, Fejös Z, Nemeth G. Postirradiation angiosarcoma of the chest wall and breast: issues of radiogenic origin, diagnosis and treatment in two cases. Oncology 2000; 60(1): 31-4.
  • 9- Abbenante D, Malosso M and Raone B. Radiation-induced cutaneous angiosarcoma of the breast. The American Journal of Medicine 2020; 133(10): 1156-7.
  • 10- Oliveira LAAD, PáduaFilho AFD, Medeiros e Melo MA, Galvão ERDCGN, Vieira MC, Ibiapina JO, Fontinele DRDS, Vieira SC. Radiation-induced angiosarcoma: case report. Einstein (São Paulo) 2020; 18: eRC5439.
  • 11- Dogan A, Kern P, Schultheis B, Häusler G, Rezniczek GA, Tempfer CB. Radiogenic angiosarcoma of the breast: case report and systematic review of the literature. BMC cancer 2018; 18(1): 463.
  • 12- Javed N and Stowman AM. Educational case: radiation-induced angiosarcoma of the breast. Academic Pathology 2021; 8: 23742895211060529.

Memede Radyoterapi Sonrası Gelişen Anjiosarkom: Olgu Sunumu

Year 2024, Volume: 10 Issue: 3, 568 - 571, 19.09.2024
https://doi.org/10.53394/akd.1371604

Abstract

Anjiosarkomlar endotel hücrelerden köken alan agresif, malign tümörlerdir. Memede
primer ve sekonder olarak ortaya çıkan bu tümörler meme malignitelerinin
%1’inden daha azını oluşturur. Risk faktörleri arasında en sık radyoterapi ve kronik
lenf ödem yer almaktadır. Sıklıkla lokal nüks ve metastaz yapma eğilimde olan
bu tümörlerde sağkalım oldukça düşüktür. Nadir görülmesi sebebiyle bu hastalığın
standart bir tedavi rejimi yoktur. Tedavisinde cerrahi, kemoterapi ve radyoterapi yer
almaktadır. Sıklıkla diğer deri lezyonları ile karıştığı için geç tanı konulmaktadır.
Memede radyoterapi öyküsü olan hastalarda yeni gelişen şüpheli lezyonlar için anjiosarkom
ayırıcı tanıda düşünülmelidir.

Supporting Institution

kocaeli üniversitesi tıp fakültesi

References

  • 1- Gaballah AH, Jensen CT, Palmquist S, Pickhardt PJ, Duran A, Broering G, Elsayes KM. Angiosarcoma: clinical and imaging features from head to toe. The British journal of radiology 2017; 90(1075): 20170039.
  • 2-Anzalone CL, Cohen PR, Diwan AH, Prieto VG. Radiation-induced angiosarcoma. Dermatology online journal 2013; 19(1):2.
  • 3-Donghi D, Kerl K, Dummer R, Schoenewolf N, Cozzio A. Cutaneous angiosarcoma: own experience over 13 years. Clinical features, disease course and immunohistochemical profile. Journal of the European Academy of Dermatology and Venereology 2010; 24(10): 1230-34.
  • 4- Murgia, Robert D., and Gary P. Gross. "Stewart-Treves Syndrome." StatPearls [Internet]. StatPearls Publishing, 2022.
  • 5-Vojtíšek R, Sukovská E, Kylarová M, Kacerovská D, Baxa J, Divišová B, Fínek J. Stewart-Treves syndrome: Case report and literature review. Reports of Practical Oncology & Radiotherapy 2020; 25(6): 934-8.
  • 6-Ganesan S, Iype EM, Kapali AS, S R. Radiation Induced Sarcoma of Oral Cavity-A Rare Case Report and a Short Review. Journal of Clinical and Diagnostic Research 2013; 7(11): 2598-9.
  • 7-Body G, Sauvanet E, Calais G, Fignon A, Fetissof F, Lansac J. Cutaneous angiosarcoma of the breast following surgery and irradiation of breast adenocarcinoma. Journal de Gynecologie, Obstetrique et Biologie de la Reproduction 1987; 16(4): 479-83.
  • 8- Polgar C, Orosz Z, Szerdahelyi A, Fodor J, Major T, Magori A, Czeyda-Pommersheim F, Nagy IV, Szakolczai I, Fejös Z, Nemeth G. Postirradiation angiosarcoma of the chest wall and breast: issues of radiogenic origin, diagnosis and treatment in two cases. Oncology 2000; 60(1): 31-4.
  • 9- Abbenante D, Malosso M and Raone B. Radiation-induced cutaneous angiosarcoma of the breast. The American Journal of Medicine 2020; 133(10): 1156-7.
  • 10- Oliveira LAAD, PáduaFilho AFD, Medeiros e Melo MA, Galvão ERDCGN, Vieira MC, Ibiapina JO, Fontinele DRDS, Vieira SC. Radiation-induced angiosarcoma: case report. Einstein (São Paulo) 2020; 18: eRC5439.
  • 11- Dogan A, Kern P, Schultheis B, Häusler G, Rezniczek GA, Tempfer CB. Radiogenic angiosarcoma of the breast: case report and systematic review of the literature. BMC cancer 2018; 18(1): 463.
  • 12- Javed N and Stowman AM. Educational case: radiation-induced angiosarcoma of the breast. Academic Pathology 2021; 8: 23742895211060529.
There are 12 citations in total.

Details

Primary Language Turkish
Subjects General Surgery
Journal Section Case Report
Authors

Miray Maden 0009-0009-0387-6407

Enes Şahin 0000-0003-3777-8468

Ahmet Tuğrul Eruyar 0000-0001-7074-1160

Nihat Zafer Utkan 0000-0002-2133-3336

Early Pub Date September 13, 2024
Publication Date September 19, 2024
Submission Date October 5, 2023
Published in Issue Year 2024 Volume: 10 Issue: 3

Cite

Vancouver Maden M, Şahin E, Eruyar AT, Utkan NZ. Memede Radyoterapi Sonrası Gelişen Anjiosarkom: Olgu Sunumu. Akd Med J. 2024;10(3):568-71.