Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri

Mehmet Ali Erkoç; Ceyhun Bereketoğlu; Davut Alptekin

EN TR

Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri

Abstract

KOAH erişkinlerde önemli bir morbidite ve mortalite nedenidir. KOAH'a ilişkin şüphesiz en önemli risk faktörü sigara içimidir. Sigara içenlerin ancak önemsiz bir oranında klinik olarak önemli hava yolu obstrüksiyonu gelişir. Ekzojen faktörlerle karşılaşma dışında, hastalığa karşı duyarlılık artışında ve hastalığın gelişmesinde genetik faktörlerin de önemli rol oynadığı düşünülmektedir. İyi bilinen α-1 antitripsin eksikliği dışında KOAH'ın genetik temeli tam anlaşılmamıştır. Ancak KOAH ile ilişkili olduğu düşünülen pek çok gen vardır. Bunların en önemlileri α-1-antitripsin (AAT), α-1-antikimotripsin (AACT), Matriks metalloproteinaz (MMP), Mikrozomal epoksit hidrolaz (EPHX1), Glutatyon S-transferaz (GST), Tümör nekroz faktör-α (TNF), Transforme edici büyüme faktörü (TGFβ) 'dır.

Keywords

Kronik Obstrüktif Akciğer Hastalığı, KOAH, genetik, α-1-antitripsin

References

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Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Mehmet Ali Erkoç This is me

Ceyhun Bereketoğlu This is me

Davut Alptekin This is me

Publication Date

September 1, 2010

Submission Date

October 30, 2014

Acceptance Date

-

Published in Issue

Year 2010 Volume: 19 Number: 3

IZ

https://izlik.org/JA65XS73CP

APA

Erkoç, M. A., Bereketoğlu, C., & Alptekin, D. (2010). Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri. Arşiv Kaynak Tarama Dergisi, 19(3), 168-179. https://izlik.org/JA65XS73CP

AMA

1.Erkoç MA, Bereketoğlu C, Alptekin D. Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri. Arşiv Kaynak Tarama Dergisi. 2010;19(3):168-179. https://izlik.org/JA65XS73CP

Chicago

Erkoç, Mehmet Ali, Ceyhun Bereketoğlu, and Davut Alptekin. 2010. “Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri”. Arşiv Kaynak Tarama Dergisi 19 (3): 168-79. https://izlik.org/JA65XS73CP.

EndNote

Erkoç MA, Bereketoğlu C, Alptekin D (September 1, 2010) Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri. Arşiv Kaynak Tarama Dergisi 19 3 168–179.

IEEE

[1]M. A. Erkoç, C. Bereketoğlu, and D. Alptekin, “Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri”, Arşiv Kaynak Tarama Dergisi, vol. 19, no. 3, pp. 168–179, Sept. 2010, [Online]. Available: https://izlik.org/JA65XS73CP

ISNAD

Erkoç, Mehmet Ali - Bereketoğlu, Ceyhun - Alptekin, Davut. “Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri”. Arşiv Kaynak Tarama Dergisi 19/3 (September 1, 2010): 168-179. https://izlik.org/JA65XS73CP.

JAMA

1.Erkoç MA, Bereketoğlu C, Alptekin D. Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri. Arşiv Kaynak Tarama Dergisi. 2010;19:168–179.

MLA

Erkoç, Mehmet Ali, et al. “Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri”. Arşiv Kaynak Tarama Dergisi, vol. 19, no. 3, Sept. 2010, pp. 168-79, https://izlik.org/JA65XS73CP.

Vancouver

1.Mehmet Ali Erkoç, Ceyhun Bereketoğlu, Davut Alptekin. Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri. Arşiv Kaynak Tarama Dergisi [Internet]. 2010 Sep. 1;19(3):168-79. Available from: https://izlik.org/JA65XS73CP

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Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri

Genetic Risk Factors in Chronic Obstructive Lung Disease (COPD)

Abstract

Keywords

Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri

Abstract

Keywords

References

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