Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri

Mehmet Ali Erkoç; Ceyhun Bereketoğlu; Davut Alptekin

EN TR

Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri

Öz

KOAH erişkinlerde önemli bir morbidite ve mortalite nedenidir. KOAH'a ilişkin şüphesiz en önemli risk faktörü sigara içimidir. Sigara içenlerin ancak önemsiz bir oranında klinik olarak önemli hava yolu obstrüksiyonu gelişir. Ekzojen faktörlerle karşılaşma dışında, hastalığa karşı duyarlılık artışında ve hastalığın gelişmesinde genetik faktörlerin de önemli rol oynadığı düşünülmektedir. İyi bilinen α-1 antitripsin eksikliği dışında KOAH'ın genetik temeli tam anlaşılmamıştır. Ancak KOAH ile ilişkili olduğu düşünülen pek çok gen vardır. Bunların en önemlileri α-1-antitripsin (AAT), α-1-antikimotripsin (AACT), Matriks metalloproteinaz (MMP), Mikrozomal epoksit hidrolaz (EPHX1), Glutatyon S-transferaz (GST), Tümör nekroz faktör-α (TNF), Transforme edici büyüme faktörü (TGFβ) 'dır.

Anahtar Kelimeler

Kronik Obstrüktif Akciğer Hastalığı, KOAH, genetik, α-1-antitripsin

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Mehmet Ali Erkoç Bu kişi benim

Ceyhun Bereketoğlu Bu kişi benim

Davut Alptekin Bu kişi benim

Yayımlanma Tarihi

1 Eylül 2010

Gönderilme Tarihi

30 Ekim 2014

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2010 Cilt: 19 Sayı: 3

IZ

https://izlik.org/JA65XS73CP

APA

Erkoç, M. A., Bereketoğlu, C., & Alptekin, D. (2010). Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri. Arşiv Kaynak Tarama Dergisi, 19(3), 168-179. https://izlik.org/JA65XS73CP

AMA

1.Erkoç MA, Bereketoğlu C, Alptekin D. Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri. aktd. 2010;19(3):168-179. https://izlik.org/JA65XS73CP

Chicago

Erkoç, Mehmet Ali, Ceyhun Bereketoğlu, ve Davut Alptekin. 2010. “Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri”. Arşiv Kaynak Tarama Dergisi 19 (3): 168-79. https://izlik.org/JA65XS73CP.

EndNote

Erkoç MA, Bereketoğlu C, Alptekin D (01 Eylül 2010) Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri. Arşiv Kaynak Tarama Dergisi 19 3 168–179.

IEEE

[1]M. A. Erkoç, C. Bereketoğlu, ve D. Alptekin, “Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri”, aktd, c. 19, sy 3, ss. 168–179, Eyl. 2010, [çevrimiçi]. Erişim adresi: https://izlik.org/JA65XS73CP

ISNAD

Erkoç, Mehmet Ali - Bereketoğlu, Ceyhun - Alptekin, Davut. “Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri”. Arşiv Kaynak Tarama Dergisi 19/3 (01 Eylül 2010): 168-179. https://izlik.org/JA65XS73CP.

JAMA

1.Erkoç MA, Bereketoğlu C, Alptekin D. Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri. aktd. 2010;19:168–179.

MLA

Erkoç, Mehmet Ali, vd. “Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri”. Arşiv Kaynak Tarama Dergisi, c. 19, sy 3, Eylül 2010, ss. 168-79, https://izlik.org/JA65XS73CP.

Vancouver

1.Mehmet Ali Erkoç, Ceyhun Bereketoğlu, Davut Alptekin. Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri. aktd [Internet]. 01 Eylül 2010;19(3):168-79. Erişim adresi: https://izlik.org/JA65XS73CP

Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri

Genetic Risk Factors in Chronic Obstructive Lung Disease (COPD)

Öz

Anahtar Kelimeler

Kronik Obstrüktif Akciğer Hastalığında (KOAH) Genetik Risk Faktörleri

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

IZ

Kaynak Göster