Effect of Kruppel-like Transcription Factor KLF1 on HbA2 and HbF Values
Abstract
Krüppel-like factors are a family of transcription factors capable of binding GC-rich sequences, have emerged as critical regulators of functions that play important roles in many fundamental biologic processes, including development, proliferation, differentiation and apoptosis. KLF1 (EKLF) was the first KLF member to be discovered. It is an erythroid-specific transcription factor that is essential for erythropoiesis. In this review, we first give information about the structure, functions and variants of KLF1. The effects of KLF1 on fetal hemoglobin (HbF) and hemoglobin A2 (HbA2) values will be discussed.
Keywords
References
- 1- Cao Z, Sun X, Icli B, Wara AK, Feinberg MW. Role of Kruppel-like factors in leukocyte development, function, and disease. Blood. 2010; 116(22):4404-14.
- 2- Pearson R, Fleetwood J, Eaton S, Crossley M, Bao S. Kruppel-like transcription factors: a functional family. Int J Biochem Cell Biol. 2008;40(10): 1996-2001
- 3- Suzuki T, Aizawa K, Matsumura T, Nagai R. Vascular implications of the Kruppel-like family of transcription factors. Arterioscler Thromb Vasc Biol. 2005;25(6):1135-1141.
- 4- Kaczynski J, Cook T, Urrutia R. Sp1- and Kruppellike transcription factors. Genome Biol. 2003;4(2): 206.
- 5- Chen C, Benjamin MS, Sun X, Otto KB, Guo P, Dong XY. KLF5 promotes cell proliferation and tumorigenesis through gene regulation and the TSU-Pr1 human bladder cancer cell line. Int J Cancer, 2006;118 (6), 1346-1355.
- 6- Bateman NW, Tan D, Pestell RG, Black JD, Black AR. Intestinal tumor progression is associated with altered function of KLF5. J Biol Chem,2004; 279 (13), 12093-12101.
- 7- Van Vliet J, Turner J, Crossley M. Human Kruppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription. Nucleic Acids Res.2000; 28: 1955–1962.
- 8- McConnell BB, Yang VW. Mammalian Krüppel-like factors in health and diseases. Physiol Rev. 2010; 90(4):1337-81.
- 9- Miller IJ, Bieker JJ. A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins. Mol Cell Biol1993;13(5):2776-2786.
- 10- Grech L, Borg J. Control of globin gene expression by Kruppel-like Factors. Journal of The Malta Chamber of Scientists.2014; 2(1): 66-77.
