Effect of Kruppel-like Transcription Factor KLF1 on HbA2 and HbF Values
Abstract
Krüppel-like factors are a family of transcription factors capable of binding GC-rich sequences, have emerged as critical regulators of functions that play important roles in many fundamental biologic processes, including development, proliferation, differentiation and apoptosis. KLF1 (EKLF) was the first KLF member to be discovered. It is an erythroid-specific transcription factor that is essential for erythropoiesis. In this review, we first give information about the structure, functions and variants of KLF1. The effects of KLF1 on fetal hemoglobin (HbF) and hemoglobin A2 (HbA2) values will be discussed.
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