Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar

Figen Abatay Sel; Fatma Savran Oğuz

doi:10.17827/aktd.984446

TR EN

Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar

Abstract

Endoplazmik retikulum (ER), sekretuar yolağın ilk kompartımanı olup eritrosit ve sperm hücreleri gibi oldukça özelleşmiş ökaryotik hücreler hariç büyük ölçüde tüm hücrelerde bulunan, çift katmanlı membranöz intraselüler bir organeldir. ER birçok hücresel fonksiyona dahil olmaktadır. Hücresel proteinlerin yaklaşık 1/3’ünün üretiminde ve katlanmasında görev alıp hücresel homeostazın devamlılığını sürdürmekle görevlidir. Protein üretim fabrikası gibi çalışması yanında, Ca+2 depolama ve düzenleme, lipit üretme ve depolama ve glikoz metabolizması işlemlerine de dahil olmaktadır. Bu görevlerin yanında ER homeostazını sürdürebilmek için, ER stres sinyal yolakları olan “Katlanmamış Protein Cevabı” ile hücre homeostazı sağlanmaya çalışılır. ER homeostazı, hatalı ya da katlanmamış protein katlanması ve mutant protein birikmesinin dahil olduğu birçok patolojik olayla ilişkili olarak ER stresine sebebiyet verebilmektedir. Bu derlemede endoplazmik retikulumun katlanmamış protein cevabı ve katlanmamış protein cevabı ile ilişkili hastalıklar tartışılmıştır.

Keywords

Endoplazmik Retikulum, UPR, GER, DER, ER Stresi

Supporting Institution

Derleme makalesi olduğu için herhangi finansal bir destek alınmamıştır.

Project Number

Derleme makalesi olduğu için herhangi bir etik kurul onayı alınmamıştır.

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Details

Primary Language

Turkish

Subjects

Health Care Administration

Journal Section

Review

Authors

Figen Abatay Sel ^*
0000-0002-1155-1284
Türkiye

Fatma Savran Oğuz
0000-0002-6018-8936
Türkiye

Publication Date

March 31, 2022

Submission Date

August 18, 2021

Acceptance Date

December 27, 2021

Published in Issue

Year 2022 Volume: 31 Number: 1

DOI

https://doi.org/10.17827/aktd.984446

IZ

https://izlik.org/JA48KT59DG

APA

Abatay Sel, F., & Oğuz, F. S. (2022). Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar. Arşiv Kaynak Tarama Dergisi, 31(1), 35-45. https://doi.org/10.17827/aktd.984446

AMA

1.Abatay Sel F, Oğuz FS. Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar. Arşiv Kaynak Tarama Dergisi. 2022;31(1):35-45. doi:10.17827/aktd.984446

Chicago

Abatay Sel, Figen, and Fatma Savran Oğuz. 2022. “Endoplazmik Retikulumda Katlanmamış Protein Cevabı Ile İlişkili Hastalıklar”. Arşiv Kaynak Tarama Dergisi 31 (1): 35-45. https://doi.org/10.17827/aktd.984446.

EndNote

Abatay Sel F, Oğuz FS (March 1, 2022) Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar. Arşiv Kaynak Tarama Dergisi 31 1 35–45.

IEEE

[1]F. Abatay Sel and F. S. Oğuz, “Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar”, Arşiv Kaynak Tarama Dergisi, vol. 31, no. 1, pp. 35–45, Mar. 2022, doi: 10.17827/aktd.984446.

ISNAD

Abatay Sel, Figen - Oğuz, Fatma Savran. “Endoplazmik Retikulumda Katlanmamış Protein Cevabı Ile İlişkili Hastalıklar”. Arşiv Kaynak Tarama Dergisi 31/1 (March 1, 2022): 35-45. https://doi.org/10.17827/aktd.984446.

JAMA

1.Abatay Sel F, Oğuz FS. Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar. Arşiv Kaynak Tarama Dergisi. 2022;31:35–45.

MLA

Abatay Sel, Figen, and Fatma Savran Oğuz. “Endoplazmik Retikulumda Katlanmamış Protein Cevabı Ile İlişkili Hastalıklar”. Arşiv Kaynak Tarama Dergisi, vol. 31, no. 1, Mar. 2022, pp. 35-45, doi:10.17827/aktd.984446.

Vancouver

1.Figen Abatay Sel, Fatma Savran Oğuz. Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar. Arşiv Kaynak Tarama Dergisi. 2022 Mar. 1;31(1):35-4. doi:10.17827/aktd.984446

This journal is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar

Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar

Abstract

Keywords

Unfolded Protein Response Related Diseases in Endoplasmic Reticulum

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