Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar

Figen Abatay Sel; Fatma Savran Oğuz

doi:10.17827/aktd.984446

TR EN

Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar

Öz

Endoplazmik retikulum (ER), sekretuar yolağın ilk kompartımanı olup eritrosit ve sperm hücreleri gibi oldukça özelleşmiş ökaryotik hücreler hariç büyük ölçüde tüm hücrelerde bulunan, çift katmanlı membranöz intraselüler bir organeldir. ER birçok hücresel fonksiyona dahil olmaktadır. Hücresel proteinlerin yaklaşık 1/3’ünün üretiminde ve katlanmasında görev alıp hücresel homeostazın devamlılığını sürdürmekle görevlidir. Protein üretim fabrikası gibi çalışması yanında, Ca+2 depolama ve düzenleme, lipit üretme ve depolama ve glikoz metabolizması işlemlerine de dahil olmaktadır. Bu görevlerin yanında ER homeostazını sürdürebilmek için, ER stres sinyal yolakları olan “Katlanmamış Protein Cevabı” ile hücre homeostazı sağlanmaya çalışılır. ER homeostazı, hatalı ya da katlanmamış protein katlanması ve mutant protein birikmesinin dahil olduğu birçok patolojik olayla ilişkili olarak ER stresine sebebiyet verebilmektedir. Bu derlemede endoplazmik retikulumun katlanmamış protein cevabı ve katlanmamış protein cevabı ile ilişkili hastalıklar tartışılmıştır.

Anahtar Kelimeler

Endoplazmik Retikulum, UPR, GER, DER, ER Stresi

Destekleyen Kurum

Derleme makalesi olduğu için herhangi finansal bir destek alınmamıştır.

Proje Numarası

Derleme makalesi olduğu için herhangi bir etik kurul onayı alınmamıştır.

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Derleme

Yazarlar

Figen Abatay Sel ^*
0000-0002-1155-1284
Türkiye

Fatma Savran Oğuz
0000-0002-6018-8936
Türkiye

Yayımlanma Tarihi

31 Mart 2022

Gönderilme Tarihi

18 Ağustos 2021

Kabul Tarihi

27 Aralık 2021

Yayımlandığı Sayı

Yıl 2022 Cilt: 31 Sayı: 1

DOI

https://doi.org/10.17827/aktd.984446

IZ

https://izlik.org/JA48KT59DG

APA

Abatay Sel, F., & Oğuz, F. S. (2022). Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar. Arşiv Kaynak Tarama Dergisi, 31(1), 35-45. https://doi.org/10.17827/aktd.984446

AMA

1.Abatay Sel F, Oğuz FS. Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar. aktd. 2022;31(1):35-45. doi:10.17827/aktd.984446

Chicago

Abatay Sel, Figen, ve Fatma Savran Oğuz. 2022. “Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar”. Arşiv Kaynak Tarama Dergisi 31 (1): 35-45. https://doi.org/10.17827/aktd.984446.

EndNote

Abatay Sel F, Oğuz FS (01 Mart 2022) Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar. Arşiv Kaynak Tarama Dergisi 31 1 35–45.

IEEE

[1]F. Abatay Sel ve F. S. Oğuz, “Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar”, aktd, c. 31, sy 1, ss. 35–45, Mar. 2022, doi: 10.17827/aktd.984446.

ISNAD

Abatay Sel, Figen - Oğuz, Fatma Savran. “Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar”. Arşiv Kaynak Tarama Dergisi 31/1 (01 Mart 2022): 35-45. https://doi.org/10.17827/aktd.984446.

JAMA

1.Abatay Sel F, Oğuz FS. Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar. aktd. 2022;31:35–45.

MLA

Abatay Sel, Figen, ve Fatma Savran Oğuz. “Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar”. Arşiv Kaynak Tarama Dergisi, c. 31, sy 1, Mart 2022, ss. 35-45, doi:10.17827/aktd.984446.

Vancouver

1.Figen Abatay Sel, Fatma Savran Oğuz. Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar. aktd. 01 Mart 2022;31(1):35-4. doi:10.17827/aktd.984446

Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar

Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar

Öz

Anahtar Kelimeler

Unfolded Protein Response Related Diseases in Endoplasmic Reticulum

Öz

Anahtar Kelimeler

Destekleyen Kurum

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Kaynakça

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Konular

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