Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar

Figen Abatay Sel; Fatma Savran Oğuz

doi:10.17827/aktd.984446

TR EN

Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar

Öz

Endoplazmik retikulum (ER), sekretuar yolağın ilk kompartımanı olup eritrosit ve sperm hücreleri gibi oldukça özelleşmiş ökaryotik hücreler hariç büyük ölçüde tüm hücrelerde bulunan, çift katmanlı membranöz intraselüler bir organeldir. ER birçok hücresel fonksiyona dahil olmaktadır. Hücresel proteinlerin yaklaşık 1/3’ünün üretiminde ve katlanmasında görev alıp hücresel homeostazın devamlılığını sürdürmekle görevlidir. Protein üretim fabrikası gibi çalışması yanında, Ca+2 depolama ve düzenleme, lipit üretme ve depolama ve glikoz metabolizması işlemlerine de dahil olmaktadır. Bu görevlerin yanında ER homeostazını sürdürebilmek için, ER stres sinyal yolakları olan “Katlanmamış Protein Cevabı” ile hücre homeostazı sağlanmaya çalışılır. ER homeostazı, hatalı ya da katlanmamış protein katlanması ve mutant protein birikmesinin dahil olduğu birçok patolojik olayla ilişkili olarak ER stresine sebebiyet verebilmektedir. Bu derlemede endoplazmik retikulumun katlanmamış protein cevabı ve katlanmamış protein cevabı ile ilişkili hastalıklar tartışılmıştır.

Anahtar Kelimeler

Endoplazmik Retikulum, UPR, GER, DER, ER Stresi

Destekleyen Kurum

Derleme makalesi olduğu için herhangi finansal bir destek alınmamıştır.

Proje Numarası

Derleme makalesi olduğu için herhangi bir etik kurul onayı alınmamıştır.

Unfolded Protein Response Related Diseases in Endoplasmic Reticulum

Öz

The endoplasmic reticulum (ER) is the first compartment of the secretory pathway and is a bilayer membranous intracellular organelle found in almost all cells except highly specialized eukaryotic cells such as erythrocytes and sperm cells. The ER is involved in many different cellular functions. ER contributes to the production and folding of approximately one-third of cellular proteins, and plays an important role for the maintenance of cellular homeostasis. In addition to, it acts as a protein synthesis factory, contributes to the storage and regulation of calcium, to the synthesis and storage of lipids, and glucose metabolism. Besides these features, specific ER stress signaling pathways, known as the ‘unfolded protein response’, are required for maintaining ER homeostasis. ER homeostasis can be given cause for many pathological events, including protein misfolding or accumulation of mutant protein, which can lead to ER stress. In this review, unfolded protein response of the endoplasmic reticulum and diseases associated with unfolded protein response are discussed.

Anahtar Kelimeler

Endoplasmic reticulum, RER, SER, UPR, ER stress

Proje Numarası

Derleme makalesi olduğu için herhangi bir etik kurul onayı alınmamıştır.

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Derleme

Yazarlar

Figen Abatay Sel ^*
0000-0002-1155-1284
Türkiye

Fatma Savran Oğuz
0000-0002-6018-8936
Türkiye

Yayımlanma Tarihi

31 Mart 2022

Gönderilme Tarihi

18 Ağustos 2021

Kabul Tarihi

27 Aralık 2021

Yayımlandığı Sayı

Yıl 2022 Cilt: 31 Sayı: 1

DOI

https://doi.org/10.17827/aktd.984446

IZ

https://izlik.org/JA48KT59DG

APA

Abatay Sel, F., & Oğuz, F. S. (2022). Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar. Arşiv Kaynak Tarama Dergisi, 31(1), 35-45. https://doi.org/10.17827/aktd.984446

AMA

1.Abatay Sel F, Oğuz FS. Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar. aktd. 2022;31(1):35-45. doi:10.17827/aktd.984446

Chicago

Abatay Sel, Figen, ve Fatma Savran Oğuz. 2022. “Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar”. Arşiv Kaynak Tarama Dergisi 31 (1): 35-45. https://doi.org/10.17827/aktd.984446.

EndNote

Abatay Sel F, Oğuz FS (01 Mart 2022) Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar. Arşiv Kaynak Tarama Dergisi 31 1 35–45.

IEEE

[1]F. Abatay Sel ve F. S. Oğuz, “Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar”, aktd, c. 31, sy 1, ss. 35–45, Mar. 2022, doi: 10.17827/aktd.984446.

ISNAD

Abatay Sel, Figen - Oğuz, Fatma Savran. “Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar”. Arşiv Kaynak Tarama Dergisi 31/1 (01 Mart 2022): 35-45. https://doi.org/10.17827/aktd.984446.

JAMA

1.Abatay Sel F, Oğuz FS. Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar. aktd. 2022;31:35–45.

MLA

Abatay Sel, Figen, ve Fatma Savran Oğuz. “Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar”. Arşiv Kaynak Tarama Dergisi, c. 31, sy 1, Mart 2022, ss. 35-45, doi:10.17827/aktd.984446.

Vancouver

1.Figen Abatay Sel, Fatma Savran Oğuz. Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar. aktd. 01 Mart 2022;31(1):35-4. doi:10.17827/aktd.984446

Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar

Öz

Anahtar Kelimeler

Destekleyen Kurum

Proje Numarası

Unfolded Protein Response Related Diseases in Endoplasmic Reticulum

Öz

Anahtar Kelimeler

Proje Numarası

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

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