Leptin resistance and obesity are associated with reduced leptin receptors and diminished maximal leptin signaling capacity; and leptin resistance confers increased susceptibility to diet-induced obesity. In essence, the augmented leptin accompanying obesity contributes to leptin resistance. Leptin resistance promotes further obesity, leading to a vicious cycle of escalating metabolic devastation.
Leptin direnci ve obezite leptin reseptörlerinde düşme, maximal leptin sinyal kapasitesi ve diyetle indükte obeziteye duyarlılıktaki artış ile belirmektedir. Öz de artan leptinin obeziteye katkısı leptin direncine dayanmaktadır. Leptin direnci daha fazla obezite ile yıkıcı bir döngüye dönüşmektedir.
Primary Language | Turkish |
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Journal Section | Review |
Authors | |
Publication Date | March 1, 2007 |
Published in Issue | Year 2007 Volume: 16 Issue: 1 |