Leptin Resistance and Obesity

Yıl 2007, Cilt: 16 Sayı: 1, 50 - 57, 01.03.2007

Aşkın Hekimoğlu

Öz

Leptin resistance and obesity are associated with reduced leptin receptors and diminished maximal leptin signaling capacity; and leptin resistance confers increased susceptibility to diet-induced obesity. In essence, the augmented leptin accompanying obesity contributes to leptin resistance. Leptin resistance promotes further obesity, leading to a vicious cycle of escalating metabolic devastation.

Anahtar Kelimeler

Leptin, Obesity

Leptin Direnci ve Obezite

Öz

Leptin direnci ve obezite leptin reseptörlerinde düşme, maximal leptin sinyal kapasitesi ve diyetle indükte obeziteye duyarlılıktaki artış ile belirmektedir. Öz de artan leptinin obeziteye katkısı leptin direncine dayanmaktadır. Leptin direnci daha fazla obezite ile yıkıcı bir döngüye dönüşmektedir.

Anahtar Kelimeler

Leptin, Obezite

Kaynakça

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