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Antimikrobiyal Peptidler ve Tıpta Kullanım Alanları

Yıl 2021, Cilt: 30 Sayı: 2, 53 - 58, 30.06.2021

Öz

Bakterilerden insanlara birçok canlı organizmaları için antimikrobiyal peptidleri üretmektedir. Bakterilerin antibiyotiklere karşı gösterdiği direncin durdurulamaz boyuta gelmesinden sonra bakterilere karşı yeni nesil bir çözüm arayışına gidilmiştir. Bu çözüm arayışında antimikrobiyal peptidlerle yapılan çalışmalarda umut verici sonuçlar alınmıştır. Daha istenilen popülariteye ulaşılamasa da dirençli bakteriler karşısında antimikrobiyal peptidlerle istenilen sonuçlara ulaşılması umulmaktadır. Bu peptidler yediğimiz birçok gıdada doğal gıda koruyucusu olarak çok yaygın kullanılmasından antimikrobiyal kumaş geliştirilmesine kadar geniş bir alanda kullanılmaktadır. Şimdiden kanser dahil birçok hastalığa deva olabileceği klinik araştırmalarla ortaya konulmuştur.

Kaynakça

  • 1 Aguilar-Toala JE, Deering AJ, and Liceaga AM. New Insights into the Antimicrobial Properties of Hydrolysates and Peptide Fractions Derived from Chia Seed (Salvia hispanica L.), Probiotics Antimicrob Proteins, 2020;
  • 2 Sobanbua S, Dolkittikul S, Nakphaichit M, Keawsompong S, and Nitisinprasert S. Antimicrobial peptide presenting potential strain-specific real time polymerase chain reaction assay for detecting the probiotic Lactobacillus reuteri KUB-AC5 in chicken intestine, Poult Sci, 2020; 99:526-35.
  • 3 Delpech G, Ceci M, Lissarrague S, Garcia Allende L, Baldaccini B, and Sparo M. In vitro activity of the antimicrobial peptide AP7121 against the human methicillin-resistant biofilm producers Staphylococcus aureus and Staphylococcus epidermidis, Biofouling, 2020; 36:266-75.
  • 4 Tavares LS, De Souza VC, Schmitz Nunes V, Nascimento Silva O, De Souza GT, Farinazzo Marques L, Capriles Goliatt PVZ, Facio Viccini L, Franco OL, and De Oliveira Santos M. Antimicrobial peptide selection from Lippia spp leaf transcriptomes, Peptides, 2020; 129:170317.
  • 5 Paton S, Moore G, Campagnolo L, and Pottage T. Antimicrobial surfaces for use on inhabited space craft: A review, Life Sci Space Res (Amst), 2020; 26:125-31.
  • 6 Henrique De Oliveira Almeida L, Ramalho De Oliveira CF, De Souza Rodrigues M, Neto SM, Boleti AP, Taveira GB, De Oliveira Mello E, Gomes VM, Lucas Dos Santos E, Crusca E, Jr., Franco OL, Cardoso MH, and Rodrigues Macedo ML. Adepamycin: Design, synthesis and biological properties of a new peptide with antimicrobial properties, Arch Biochem Biophys, 2020; 108487.
  • 7 Tan A, Suzuki R, Yokoyama C, Yano S, and Konno H. Antimicrobial activity and secondary structure of a novel peptide derived from ovalbumin, J Pept Sci, 2020; e3276.
  • 8 Chen RC, and Lan CY. Human Antimicrobial Peptide Hepcidin 25-Induced Apoptosis in Candida albicans, Microorganisms, 2020; 8:
  • 9 Juknius T, Jukniene I, Tamulevicius T, Ruzauskas M, Pampariene I, Oberauskas V, Jurkeviciute A, Vasiliauskas A, and Tamulevicius S. Preclinical Study of a Multi-Layered Antimicrobial Patch Based on Thin Nanocomposite Amorphous Diamond Like Carbon Films with Embedded Silver Nanoparticles, Materials (Basel), 2020; 13:
  • 10 Ladha G, and Jeevaratnam K. Characterization of purified antimicrobial peptide produced by Pediococcus pentosaceus LJR1, and its application in preservation of white leg shrimp, World J Microbiol Biotechnol, 2020; 36:72.
  • 11 Chelliah R, Saravanakumar K, Daliri EB, Kim JH, Lee JK, Jo HY, Madar IH, Kim SH, Ramakrishnan SR, Rubab M, Barathikannan K, Ofosu FK, Subin H, Eun-Ji P, Elahi F, Wang MH, and Oh DH. An effective datasets describing antimicrobial peptide produced from Pediococcus acidilactici - purification and mode of action determined by molecular docking, Data Brief, 2020; 31:105745.
  • 12 Mandell JB, J AK, Deslouches B, and Urish KL. Direct antimicrobial activity of cationic amphipathic peptide WLBU2 against Staphylococcus aureus biofilms is enhanced in physiologic buffered saline, J Orthop Res, 2020;
  • 13 Savini F, Loffredo MR, Troiano C, Bobone S, Malanovic N, Eichmann TO, Caprio L, Canale VC, Park Y, Mangoni ML, and Stella L. Binding of an antimicrobial peptide to bacterial cells: Interaction with different species, strains and cellular components, Biochim Biophys Acta Biomembr, 2020; 1862:183291.
  • 14 Yang S, Dong Y, Aweya JJ, Xie T, Zeng B, Zhang Y, and Liu GM. Antimicrobial activity and acting mechanism of Tegillarca granosa hemoglobin-derived peptide (TGH1) against Vibrio parahaemolyticus, Microb Pathog, 2020; 147:104302.
  • 15 Anand U, Nandy S, Mundhra A, Das N, Pandey DK, and Dey A. A review on antimicrobial botanicals, phytochemicals and natural resistance modifying agents from Apocynaceae family: Possible therapeutic approaches against multidrug resistance in pathogenic microorganisms, Drug Resist Updat, 2020; 51:100695.
  • 16 Van Der Weide H, Cossio U, Gracia R, Te Welscher YM, Ten Kate MT, Van Der Meijden A, Marradi M, Ritsema JaS, Vermeulen-De Jongh DMC, Storm G, Goessens WHF, Loinaz I, Van Nostrum CF, Llop J, Hays JP, and Bakker-Woudenberg I. Therapeutic efficacy of novel antimicrobial peptide AA139-nanomedicines in a multidrug-resistant Klebsiella pneumoniae pneumonia-septicemia model in rats, Antimicrob Agents Chemother, 2020;
  • 17 Wang H, He H, Chen X, Zhou M, Wei M, Xi X, Ma C, Du Q, Chen T, Shaw C, and Wang L. A Novel Antimicrobial Peptide (Kassinatuerin-3) Isolated from the Skin Secretion of the African Frog, Kassina senegalensis, Biology (Basel), 2020; 9:
  • 18 Pineiro SA, and Cerniglia CE. Antimicrobial drug residues in animal-derived foods: Potential impact on the human intestinal microbiome, J Vet Pharmacol Ther, 2020;
  • 19 Sader HS, Castanheira M, Streit JM, Carvalhaes CG, and Mendes RE. Frequency and antimicrobial susceptibility of bacteria causing bloodstream infections in pediatric patients from United States (US) medical centers (2014-2018): therapeutic options for multidrug-resistant bacteria, Diagn Microbiol Infect Dis, 2020; 98:115108.
  • 20 Parducho KR, Beadell B, Ybarra TK, Bush M, Escalera E, Trejos AT, Chieng A, Mendez M, Anderson C, Park H, Wang Y, Lu W, and Porter E. The Antimicrobial Peptide Human Beta-Defensin 2 Inhibits Biofilm Production of Pseudomonas aeruginosa Without Compromising Metabolic Activity, Front Immunol, 2020; 11:805.
  • 21 Patil PS, Kasare SL, Haval NB, Khedkar VM, Dixit PP, Rekha EM, Sriram D, and Haval KP. Novel isoniazid embedded triazole derivatives: synthesis, antitubercular and antimicrobial activity evaluation, Bioorg Med Chem Lett, 2020; 127434.
  • 22 Xiong K, Chen X, Hu H, Hou H, Gao P, and Zou L. Antimicrobial Effect of a Peptide Containing Novel Oral Spray on Streptococcus mutans, Biomed Res Int, 2020; 2020:6853652.
  • 23 Bakthavatchalam YD, Rao SV, Isaac B, Manesh A, Nambi S, Swaminathan S, Nagvekar V, Nangia V, John PV, and Veeraraghavan B. A comparative assessment of clinical, pharmacological and antimicrobial profile of novel anti-methicillin-resistant Staphylococcus aureus agent levonadifloxacin: Therapeutic role in nosocomial and community infections, Indian J Med Microbiol, 2019; 37:478-87.

Antimicrobial Peptides and Their Medical Applications

Yıl 2021, Cilt: 30 Sayı: 2, 53 - 58, 30.06.2021

Öz

It produces antimicrobial peptides for many living organisms, from bacteria to humans. After the resistance of bacteria against antibiotics has reached an unstoppable dimension, a new generation solution has been searched against bacteria. In the search for this solution, promising results have been obtained in studies with antimicrobial peptides. It is hoped to achieve desired results with antimicrobial peptides against resistant bacteria, although more desired popularity cannot be achieved. These peptides are widely used in many foods we eat as a natural food preservative, from antimicrobial fabric development. It has already been demonstrated by clinical research that it can cure many diseases, including cancer.

Kaynakça

  • 1 Aguilar-Toala JE, Deering AJ, and Liceaga AM. New Insights into the Antimicrobial Properties of Hydrolysates and Peptide Fractions Derived from Chia Seed (Salvia hispanica L.), Probiotics Antimicrob Proteins, 2020;
  • 2 Sobanbua S, Dolkittikul S, Nakphaichit M, Keawsompong S, and Nitisinprasert S. Antimicrobial peptide presenting potential strain-specific real time polymerase chain reaction assay for detecting the probiotic Lactobacillus reuteri KUB-AC5 in chicken intestine, Poult Sci, 2020; 99:526-35.
  • 3 Delpech G, Ceci M, Lissarrague S, Garcia Allende L, Baldaccini B, and Sparo M. In vitro activity of the antimicrobial peptide AP7121 against the human methicillin-resistant biofilm producers Staphylococcus aureus and Staphylococcus epidermidis, Biofouling, 2020; 36:266-75.
  • 4 Tavares LS, De Souza VC, Schmitz Nunes V, Nascimento Silva O, De Souza GT, Farinazzo Marques L, Capriles Goliatt PVZ, Facio Viccini L, Franco OL, and De Oliveira Santos M. Antimicrobial peptide selection from Lippia spp leaf transcriptomes, Peptides, 2020; 129:170317.
  • 5 Paton S, Moore G, Campagnolo L, and Pottage T. Antimicrobial surfaces for use on inhabited space craft: A review, Life Sci Space Res (Amst), 2020; 26:125-31.
  • 6 Henrique De Oliveira Almeida L, Ramalho De Oliveira CF, De Souza Rodrigues M, Neto SM, Boleti AP, Taveira GB, De Oliveira Mello E, Gomes VM, Lucas Dos Santos E, Crusca E, Jr., Franco OL, Cardoso MH, and Rodrigues Macedo ML. Adepamycin: Design, synthesis and biological properties of a new peptide with antimicrobial properties, Arch Biochem Biophys, 2020; 108487.
  • 7 Tan A, Suzuki R, Yokoyama C, Yano S, and Konno H. Antimicrobial activity and secondary structure of a novel peptide derived from ovalbumin, J Pept Sci, 2020; e3276.
  • 8 Chen RC, and Lan CY. Human Antimicrobial Peptide Hepcidin 25-Induced Apoptosis in Candida albicans, Microorganisms, 2020; 8:
  • 9 Juknius T, Jukniene I, Tamulevicius T, Ruzauskas M, Pampariene I, Oberauskas V, Jurkeviciute A, Vasiliauskas A, and Tamulevicius S. Preclinical Study of a Multi-Layered Antimicrobial Patch Based on Thin Nanocomposite Amorphous Diamond Like Carbon Films with Embedded Silver Nanoparticles, Materials (Basel), 2020; 13:
  • 10 Ladha G, and Jeevaratnam K. Characterization of purified antimicrobial peptide produced by Pediococcus pentosaceus LJR1, and its application in preservation of white leg shrimp, World J Microbiol Biotechnol, 2020; 36:72.
  • 11 Chelliah R, Saravanakumar K, Daliri EB, Kim JH, Lee JK, Jo HY, Madar IH, Kim SH, Ramakrishnan SR, Rubab M, Barathikannan K, Ofosu FK, Subin H, Eun-Ji P, Elahi F, Wang MH, and Oh DH. An effective datasets describing antimicrobial peptide produced from Pediococcus acidilactici - purification and mode of action determined by molecular docking, Data Brief, 2020; 31:105745.
  • 12 Mandell JB, J AK, Deslouches B, and Urish KL. Direct antimicrobial activity of cationic amphipathic peptide WLBU2 against Staphylococcus aureus biofilms is enhanced in physiologic buffered saline, J Orthop Res, 2020;
  • 13 Savini F, Loffredo MR, Troiano C, Bobone S, Malanovic N, Eichmann TO, Caprio L, Canale VC, Park Y, Mangoni ML, and Stella L. Binding of an antimicrobial peptide to bacterial cells: Interaction with different species, strains and cellular components, Biochim Biophys Acta Biomembr, 2020; 1862:183291.
  • 14 Yang S, Dong Y, Aweya JJ, Xie T, Zeng B, Zhang Y, and Liu GM. Antimicrobial activity and acting mechanism of Tegillarca granosa hemoglobin-derived peptide (TGH1) against Vibrio parahaemolyticus, Microb Pathog, 2020; 147:104302.
  • 15 Anand U, Nandy S, Mundhra A, Das N, Pandey DK, and Dey A. A review on antimicrobial botanicals, phytochemicals and natural resistance modifying agents from Apocynaceae family: Possible therapeutic approaches against multidrug resistance in pathogenic microorganisms, Drug Resist Updat, 2020; 51:100695.
  • 16 Van Der Weide H, Cossio U, Gracia R, Te Welscher YM, Ten Kate MT, Van Der Meijden A, Marradi M, Ritsema JaS, Vermeulen-De Jongh DMC, Storm G, Goessens WHF, Loinaz I, Van Nostrum CF, Llop J, Hays JP, and Bakker-Woudenberg I. Therapeutic efficacy of novel antimicrobial peptide AA139-nanomedicines in a multidrug-resistant Klebsiella pneumoniae pneumonia-septicemia model in rats, Antimicrob Agents Chemother, 2020;
  • 17 Wang H, He H, Chen X, Zhou M, Wei M, Xi X, Ma C, Du Q, Chen T, Shaw C, and Wang L. A Novel Antimicrobial Peptide (Kassinatuerin-3) Isolated from the Skin Secretion of the African Frog, Kassina senegalensis, Biology (Basel), 2020; 9:
  • 18 Pineiro SA, and Cerniglia CE. Antimicrobial drug residues in animal-derived foods: Potential impact on the human intestinal microbiome, J Vet Pharmacol Ther, 2020;
  • 19 Sader HS, Castanheira M, Streit JM, Carvalhaes CG, and Mendes RE. Frequency and antimicrobial susceptibility of bacteria causing bloodstream infections in pediatric patients from United States (US) medical centers (2014-2018): therapeutic options for multidrug-resistant bacteria, Diagn Microbiol Infect Dis, 2020; 98:115108.
  • 20 Parducho KR, Beadell B, Ybarra TK, Bush M, Escalera E, Trejos AT, Chieng A, Mendez M, Anderson C, Park H, Wang Y, Lu W, and Porter E. The Antimicrobial Peptide Human Beta-Defensin 2 Inhibits Biofilm Production of Pseudomonas aeruginosa Without Compromising Metabolic Activity, Front Immunol, 2020; 11:805.
  • 21 Patil PS, Kasare SL, Haval NB, Khedkar VM, Dixit PP, Rekha EM, Sriram D, and Haval KP. Novel isoniazid embedded triazole derivatives: synthesis, antitubercular and antimicrobial activity evaluation, Bioorg Med Chem Lett, 2020; 127434.
  • 22 Xiong K, Chen X, Hu H, Hou H, Gao P, and Zou L. Antimicrobial Effect of a Peptide Containing Novel Oral Spray on Streptococcus mutans, Biomed Res Int, 2020; 2020:6853652.
  • 23 Bakthavatchalam YD, Rao SV, Isaac B, Manesh A, Nambi S, Swaminathan S, Nagvekar V, Nangia V, John PV, and Veeraraghavan B. A comparative assessment of clinical, pharmacological and antimicrobial profile of novel anti-methicillin-resistant Staphylococcus aureus agent levonadifloxacin: Therapeutic role in nosocomial and community infections, Indian J Med Microbiol, 2019; 37:478-87.
Toplam 23 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Derleme
Yazarlar

Suzan Elif Akün 0000-0003-0460-3899

Umut Kökbaş 0000-0003-4028-3458

Yayımlanma Tarihi 30 Haziran 2021
Kabul Tarihi 6 Nisan 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 30 Sayı: 2

Kaynak Göster

AMA Akün SE, Kökbaş U. Antimikrobiyal Peptidler ve Tıpta Kullanım Alanları. aktd. Haziran 2021;30(2):53-58.