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Charged Particle Interactions of Human Organs and Tissues in Heavy Ion Therapy; Effective Atomic Number and Electron Density

Year 2020, , 196 - 206, 20.05.2020
https://doi.org/10.35414/akufemubid.692641

Abstract

In this work, various organs of human and tissues were studied in terms of the effective atomic numbers (Zeff) and electron densities (Ne) in the continuous kinetic energy region for different types of heavy ions. Variations of Zeff and Ne with kinetic energy were investigated and significant variations were noted. In addition, water and tissue equivalences of the given materials with respect to their Zeff and Ne were evaluated based on the results obtained. The best water equivalents were found to be Urinary Bladder_Urine for H, He and C ions and Skeleton Cartilage for Ne ion since differences in Zeff relative to water for H (≤%3), He (≤%1), C (≤%1) and Ne (≤%6) ions were significantly low. Moreover, variations in water equivalences of the materials have been discussed in detail in the continuous energy region. The reported data should be useful when heavy ions are intended to be used in these materials for radiotherapy and dosimetry applications as they represent the interaction of ions with these materials in the continuous kinetic energy region.

References

  • Banaś, C.D., Braziewicz, J., Buraczewska, I., Jaskóła, M., Kaźmierczak, U., Korman, A., Lankoff, A., Lisowska, H., Szefliński, Z., Wojewódzka, M., Wójcik, A., 2018. Biological effects of mixed-ion beams. Part 1: Effect of irradiation of the CHO-K1 cells with a mixed -ion beam containing the carbon and oxygen ions. Appl. Radiat. Isot. 139, 304-309.
  • Büyükyıldız, M., 2017a. Investigation of radiological properties of some shielding materials on charged and uncharged radiation interaction for neutron generator. Radiat. Effec. Deffec. Solids, 172, 216-234.
  • Büyükyıldız, M., 2017b. A study of effective atomic numbers and electron densities of some vitamins for electron, H, He and C ion interactions. Eur. Phys. J. Plus, 132, 1-8.
  • Gallasa, R.R., Arico, G., Burigo, L.N., Gehrke, T., Jakůbek, J., Granja, C., Tureček, D., Martišíkovác, M., 2017. A novel method for assessment of fragmentation and beam -material interactions in helium ion radiotherapy with a miniaturized setup. Physica Medica, 42, 116-126.
  • Kurudirek, M., 2014a. Effective atomic numbers, water and tissue equivalence properties of human tissues, tissue equivalents and dosimetric materials for total electron interaction in the energy region 10 keV–1 GeV. Appl. Radiat. Isot. 94, 1-7.
  • Kurudirek, M., 2014b. Effective atomic numbers and electron densities of some human tissues and dosimetric materials for mean energies of various radiation sources relevant to radiotherapy and medical applications. Radiat. Phys. Chem. 102, 139-146.
  • Kurudirek, M., 2015. Studies on heavy charged particle interaction, water equivalence and Monte Carlo simulation in some gel dosimeters, water, human tissues and water Phantoms. Nucl. Instrum. Methods A. 795, 239-252.
  • Kurudirek, M., Onaran, T., 2015. Calculation of effective atomic number and electron density of essential biomolecules for electron, proton, alpha particle and multi -energetic photon interactions. Radiat. Phys. Chem. 112, 125-138.
  • Manjunatha, H.C., Rudraswamy, B. 2012. Photon interaction parameters of dosimetric interest in bone. Health. Phys. 10, 322-329.
  • Mann, K.S., Kurudirek, M., Sidhu, G.S. 2012. Verification of dosimetric materials to be used as tissue-substitutes in radiological diagnosis. Appl. Radiat. Isot. 70, 681,691.
  • Manohara, S.R., Hanagodimath, S.M., Gerward, L., 2008. Energy dependence of effective atomic numbers for photon energy absorption and photon interaction: studies of some biological molecules in the energy range 1 keV-20 MeV. Med. Phys. 35, 388-401. Manohara, S.R., Hanagodimath, S.M., Gerward, L., 2011. Energy absorption buildup factors of human organs and tissues at energies and penetration depths relevant for radiotherapy and diagnostics. J. Appl. Clin. Med. Phys. 12, 3557-3565.
  • Mohamad, O., Yamada, S., Durante, M., 2018. Clinical indications for Carbon ion radiotherapy. Clinical Oncology, 30, 317-329.
  • Parthasaradhi, K., Rao, B.M., Prasad, S.G., 1989. Effective atomic numbers of biological materials in the energy region 1 to 50 MeV for photons, electrons and He ions. Med. Phys. 16, 653-654.
  • Prasad, S.G., Parthasaradhi, K., Bloomer, W.D., 1997. Effective atomic numbers of composite materials for total and partial interaction processes for photons, electrons and protons. Med. Phys. 24, 883-885.
  • Rao, B.V., Raju, M.L., Narasimham, K.L., Parthasarahi, K., Rao, B.M., 1985. Interaction of low-energy photons with biological materials and effective atomic number. Med. Phys. 12, 745-748.
  • Shivaramu, 2002. Effective atomic numbers for photon energy absorption and photon attenuation of tissues from human organs. Med. Dosim. 27, 1-9.
  • Singh, V.P., Badiger, N.M., 2016. Studies on photon buildup for some thermoluminescent dosimetric compounds. Indian. J. Phys. 90, 259-269.
  • Yang, N.C., Leichner, P.K., Hawkins, W.G., 1987. Effective atomic numbers for low-energy total photon interactions in human tissues. Med. Phys. 14, 759-766.
  • Ziegler, J.F., Ziegler, M.D., Biersack, J.P., 2010. SRIM - The stopping and range of ions in matter (2010). Nucl. Instrum. Methods B 268, 1818-1823.

Ağır İyon Terapide İnsan Organları ve Dokularının Yüklü Parçacık Etkileşimleri; Etkin Atom Numarası ve Elektron Yoğunluğu

Year 2020, , 196 - 206, 20.05.2020
https://doi.org/10.35414/akufemubid.692641

Abstract

Bu çalışmada, farklı iyon tipleri için sürekli kinetik enerji aralığında birçok insan organ ve dokuları için etkin atom numaraları (Zeff) ve elektron yoğunlukları (Ne) çalışılmıştır. Zeff ve Ne ‘in kinetic enerji ile değişimi incelenmiş ve önemli değişimler not edilmiştir. Ayrıca elde edilen sonuçlara dayalı olarak Zeff ve Ne için verilen malzemelerin su ve doku eşdeğerleri değerlendirilmiştir. En iyi su eşdeğerlikleri H, He ve C iyonları için idrar kesesi ve Ne iyonu için iskelet kıkırdağı olarak bulundu, çünkü suya nispeten Zeff’deki farklılıklar H (≤%3), He (≤%1), C (≤%1) ve Ne (≤%6) iyonları için önemli ölçüde düşüktü. Ayrıca malzemelerin su eşdeğerliklerindeki değişimler sürekli enerji aralığında tartışılmıştır. Rapor edilen veriler, sürekli kinetik enerji aralığında bu malzemelerle iyonların etkileşimini gösterdiklerinden dolayı, ağır iyonlar radyoterapi ve dozimetri uygulamaları için bu materyallerde kullanılmak için hedeflendiğinde kullanışlı olmalıdırlar.

References

  • Banaś, C.D., Braziewicz, J., Buraczewska, I., Jaskóła, M., Kaźmierczak, U., Korman, A., Lankoff, A., Lisowska, H., Szefliński, Z., Wojewódzka, M., Wójcik, A., 2018. Biological effects of mixed-ion beams. Part 1: Effect of irradiation of the CHO-K1 cells with a mixed -ion beam containing the carbon and oxygen ions. Appl. Radiat. Isot. 139, 304-309.
  • Büyükyıldız, M., 2017a. Investigation of radiological properties of some shielding materials on charged and uncharged radiation interaction for neutron generator. Radiat. Effec. Deffec. Solids, 172, 216-234.
  • Büyükyıldız, M., 2017b. A study of effective atomic numbers and electron densities of some vitamins for electron, H, He and C ion interactions. Eur. Phys. J. Plus, 132, 1-8.
  • Gallasa, R.R., Arico, G., Burigo, L.N., Gehrke, T., Jakůbek, J., Granja, C., Tureček, D., Martišíkovác, M., 2017. A novel method for assessment of fragmentation and beam -material interactions in helium ion radiotherapy with a miniaturized setup. Physica Medica, 42, 116-126.
  • Kurudirek, M., 2014a. Effective atomic numbers, water and tissue equivalence properties of human tissues, tissue equivalents and dosimetric materials for total electron interaction in the energy region 10 keV–1 GeV. Appl. Radiat. Isot. 94, 1-7.
  • Kurudirek, M., 2014b. Effective atomic numbers and electron densities of some human tissues and dosimetric materials for mean energies of various radiation sources relevant to radiotherapy and medical applications. Radiat. Phys. Chem. 102, 139-146.
  • Kurudirek, M., 2015. Studies on heavy charged particle interaction, water equivalence and Monte Carlo simulation in some gel dosimeters, water, human tissues and water Phantoms. Nucl. Instrum. Methods A. 795, 239-252.
  • Kurudirek, M., Onaran, T., 2015. Calculation of effective atomic number and electron density of essential biomolecules for electron, proton, alpha particle and multi -energetic photon interactions. Radiat. Phys. Chem. 112, 125-138.
  • Manjunatha, H.C., Rudraswamy, B. 2012. Photon interaction parameters of dosimetric interest in bone. Health. Phys. 10, 322-329.
  • Mann, K.S., Kurudirek, M., Sidhu, G.S. 2012. Verification of dosimetric materials to be used as tissue-substitutes in radiological diagnosis. Appl. Radiat. Isot. 70, 681,691.
  • Manohara, S.R., Hanagodimath, S.M., Gerward, L., 2008. Energy dependence of effective atomic numbers for photon energy absorption and photon interaction: studies of some biological molecules in the energy range 1 keV-20 MeV. Med. Phys. 35, 388-401. Manohara, S.R., Hanagodimath, S.M., Gerward, L., 2011. Energy absorption buildup factors of human organs and tissues at energies and penetration depths relevant for radiotherapy and diagnostics. J. Appl. Clin. Med. Phys. 12, 3557-3565.
  • Mohamad, O., Yamada, S., Durante, M., 2018. Clinical indications for Carbon ion radiotherapy. Clinical Oncology, 30, 317-329.
  • Parthasaradhi, K., Rao, B.M., Prasad, S.G., 1989. Effective atomic numbers of biological materials in the energy region 1 to 50 MeV for photons, electrons and He ions. Med. Phys. 16, 653-654.
  • Prasad, S.G., Parthasaradhi, K., Bloomer, W.D., 1997. Effective atomic numbers of composite materials for total and partial interaction processes for photons, electrons and protons. Med. Phys. 24, 883-885.
  • Rao, B.V., Raju, M.L., Narasimham, K.L., Parthasarahi, K., Rao, B.M., 1985. Interaction of low-energy photons with biological materials and effective atomic number. Med. Phys. 12, 745-748.
  • Shivaramu, 2002. Effective atomic numbers for photon energy absorption and photon attenuation of tissues from human organs. Med. Dosim. 27, 1-9.
  • Singh, V.P., Badiger, N.M., 2016. Studies on photon buildup for some thermoluminescent dosimetric compounds. Indian. J. Phys. 90, 259-269.
  • Yang, N.C., Leichner, P.K., Hawkins, W.G., 1987. Effective atomic numbers for low-energy total photon interactions in human tissues. Med. Phys. 14, 759-766.
  • Ziegler, J.F., Ziegler, M.D., Biersack, J.P., 2010. SRIM - The stopping and range of ions in matter (2010). Nucl. Instrum. Methods B 268, 1818-1823.
There are 19 citations in total.

Details

Primary Language English
Subjects Engineering
Journal Section Articles
Authors

Mehmet Büyükyıldız 0000-0003-2025-4916

Publication Date May 20, 2020
Submission Date February 21, 2020
Published in Issue Year 2020

Cite

APA Büyükyıldız, M. (2020). Charged Particle Interactions of Human Organs and Tissues in Heavy Ion Therapy; Effective Atomic Number and Electron Density. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi, 20(2), 196-206. https://doi.org/10.35414/akufemubid.692641
AMA Büyükyıldız M. Charged Particle Interactions of Human Organs and Tissues in Heavy Ion Therapy; Effective Atomic Number and Electron Density. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi. May 2020;20(2):196-206. doi:10.35414/akufemubid.692641
Chicago Büyükyıldız, Mehmet. “Charged Particle Interactions of Human Organs and Tissues in Heavy Ion Therapy; Effective Atomic Number and Electron Density”. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 20, no. 2 (May 2020): 196-206. https://doi.org/10.35414/akufemubid.692641.
EndNote Büyükyıldız M (May 1, 2020) Charged Particle Interactions of Human Organs and Tissues in Heavy Ion Therapy; Effective Atomic Number and Electron Density. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 20 2 196–206.
IEEE M. Büyükyıldız, “Charged Particle Interactions of Human Organs and Tissues in Heavy Ion Therapy; Effective Atomic Number and Electron Density”, Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi, vol. 20, no. 2, pp. 196–206, 2020, doi: 10.35414/akufemubid.692641.
ISNAD Büyükyıldız, Mehmet. “Charged Particle Interactions of Human Organs and Tissues in Heavy Ion Therapy; Effective Atomic Number and Electron Density”. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 20/2 (May 2020), 196-206. https://doi.org/10.35414/akufemubid.692641.
JAMA Büyükyıldız M. Charged Particle Interactions of Human Organs and Tissues in Heavy Ion Therapy; Effective Atomic Number and Electron Density. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi. 2020;20:196–206.
MLA Büyükyıldız, Mehmet. “Charged Particle Interactions of Human Organs and Tissues in Heavy Ion Therapy; Effective Atomic Number and Electron Density”. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi, vol. 20, no. 2, 2020, pp. 196-0, doi:10.35414/akufemubid.692641.
Vancouver Büyükyıldız M. Charged Particle Interactions of Human Organs and Tissues in Heavy Ion Therapy; Effective Atomic Number and Electron Density. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi. 2020;20(2):196-20.


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