Uyku Apnesi Teşhisine Yeni Bir Bakış Açısı: PSSA-g-PANI tabanlı SAW Sensörü Kullanarak İzopren Tespiti

Year 2022, , 16 - 22, 28.02.2022

Cihat Tasaltın , Gülsen Baytemir , Nevin Taşaltın

https://doi.org/10.35414/akufemubid.931030

Abstract

Obstrüktif Uyku Apne Sendromu (OSAS) tarafından tetiklenen hücresel metabolik değişiklikler, nefeste OSAS'ın biyobelirteci olarak izopren saptanarak invazif olarak tespit edilir. Uykuya dalındığında izopren seviyesi 3 ppm'nin üzerine çıkmaya başlar. Bu nedenle, normal koşullar altında solunan nefeste izopren seviyelerinin izlenmesi, uyku apnesi gibi uyku bozukluklarını tespit etmek, izlemek ve kontrol etmek için invazif olmayan bir yöntem sağlayabilir. Bu çalışmada, PSSA-g-PANI tabanlı SAW gaz sensörleri hazırlanmış ve izopren gaza karşı test edilmiştir. Sensör ölçümleri, PSSA-g-PANI tabanlı SAW tipi sensörün yüksek hassasiyetle (1-150) ppm izopren gazı algıladığını ve dolayısıyla PSSA-g-PANI tabanlı SAW tipi sensörün uyku apnesinin izlenmesini ve kontrolünü sağlayabileceğini ortaya koymaktadır.

Keywords

Uyku apnesi, Sensor, Solunan nefes, Izopren

Supporting Institution

Tübitak

Project Number

120N816

A New Perspective towards Diagnosis of Sleep Apnea: Isoprene Detection Using PSSA-g-PANI based SAW Sensor

Abstract

Cellular metabolic changes triggered by Obstructive Sleep Apnea Syndrome (OSAS) are detected invasively by detecting isoprene as a biomarker of OSAS in the breath. When falling asleep, isoprene level begins to increase above 3 ppm. Therefore, monitoring isoprene levels in exhaled breath under normal conditions may provide a non-invasive method to detect, monitor, and control sleep disorders such as sleep apnea. In this study, PSSA-g-PANI based SAW gas sensors were prepared and tested against isoprene gas. Sensor measurements reveal that PSSA-g-PANI based SAW type sensor detected (1-150) ppm isoprene gas with high sensitivity and thus PSSA-g-PANI based SAW type sensor may enable monitor and control of sleep apnea.

Keywords

Sleep apnea, Sensor, Exhaled breath, Isoprene

Project Number

120N816

References

• Bae, S., Lee, J. U., Park H., Jung E. H., Jung J. W., Jo W. H. 2014. Enhanced performance of polymer solar cells with PSSA-g-PANI/Graphene oxide composite as hole transport layer. Solar Energy Materials and Solar Cells, 130, 599-604.
• Ballantine, D. S., Martin, S. J., Ricco, A. J., Frye, G. C., Wohltjen, H., White, R. M., Zellers, E. T. 1997. Acoustic Wave Sensors: Theory, Design, and Physico-Chemical Applications. 1st Edition. Academic Press, San Diego, CA, USA.
• Bikov, A., Hull, J. H., Kunos, L. 2016. Exhaled breath analysis, a simple tool to study the pathophysiology of obstructive sleep apnoea. Sleep Medicine Reviews, 27, 1-8.
• Cailleux, A., Allain, P. 1989. Isoprene and Sleep. Life Sciences, 44, 1877-1880.
• Carpagnano, G. E. 2011. Exhaled Breath Analysis and Sleep. Journal of Clinical Sleep Medicine, 7(5), S34-S37.
• Devkota, J., Ohodnicki, P. R., Greve, D. W. 2017. SAW Sensors for Chemical Vapors and Gas. Sensors, 17(4), 801.
• Finamore, P., Scarlata, S., Cardaci, V., Incalzi, R. A. 2019. Exhaled Breath Analysis in Obstructive Sleep Apnea Syndrome: A Review of the Literature. Medicina, 55(9), 538.
• Gami, A. S., Olson, E. J., Shen, W. K., Wright, R. S., Ballman, K. V., Hodge, D. O., Herges, R. M., Howard, D. E., Somers, V. K. 2013. Obstructive Sleep Apnea and the Risk of Sudden Cardiac Death: A Longitudinal Study of 10,701 Adults. Journals of American College of Cardiology, 62, 610-616.
• Gouma, P. I. 2018. Isoprene sensor/breathalyzer for monitoring sleep disorders. 17th International Meeting on Chemical Sensors – IMCS, Conference Book, 55-56.
• Gouma, P., Prasad, A., Stanacevic, S. 2011. A selective Nanosensor Device for Exhaled Breath Analysis. Journal of Breath Research, 5(3), 037110.
• Göpel, W., Hesse, J., Zemel, J. N. 1991. Chemical and biochemical sensors. Volume 2, VCH Weinheim, 716.
• Göpel, W., Jones, T. A., Kleitz, M., Lundström, I., Seiyama, T. 2008. Sensors, Chemical and Biochemical Sensors. Volume 2 Wiley. John Wiley & Sons: Hoboken, NJ, USA.
• Holty, J.-E. C., Owens, D. K., Dallas, P., Shekelle, P., Qaseem, A., Starkey, M. 2013. Management of Obstructive Sleep Apnea in Adults: A Clinical Practice Guideline from the American College of Physicians. Annals of Internal Medicine, 159(7), 471-483.
• Jakubik, W.P. 2011. Surface acoustic wave-based gas sensors. Thin Solid Films, 520, 986-993.
• King, J., Kupferthaler, A., Frauscher B., Hackner, H., Unterkofler, K. Teschl, G., Hinterhuber, H., Amann, A., and Högl B. 2012. Measurement of endogenous acetone and isoprene in exhaled breath during sleep. Physiological Measurement, 33, 413-428.
• Marcu, A., Nicolae, I., Viespe, C. 2016. Active surface geometrical control of noise in nanowire-SAW sensors. Sensors and Actuators B: Chemical, 231, 469-473.
• Mehra, R., Benjamin, E. J., Shahar, E., Gottlieb, D. J., Nawabit, R., Kirchner, H. L. 2006. Association of nocturnal arrhythmias with sleep-disordered breathing: The sleep heart health study. American Journal of Respiratory Critical Care Medicine, 173, 910-916.
• Mirzaei, A., Leonardi, S. G., Neri, G. 2016. Detection of hazardous volatile organic compounds (VOCs) by metal oxide nanostructures-based gas sensors: A review. Ceramics International, 42(14), 15119-15141.
• Mitchell, R. B., Kelly, J. 2006. Behavior, neurocognition and quality-of-life in children with sleep-disordered breathing. International Journal of Pediatric Otorhinolaryngology, 70, 395-406.
• Peled, N., Kassirer, M., Shitrit, D., Kogan, Y., Shlomi, D., Berliner, A. S., Kramer, M. R. 2007. The association of OSA with insulin resistance, inflammation and metabolic syndrome. Respiratory Medicine, 101(8), 1696-1701.
• Redline, S. 2010. Obstructive Sleep Apnea–Hypopnea and Incident Stroke: The Sleep Heart Health Study. American Journal of Respiratory and Critical Care Medicine, 182, 1332-1333.
• Sabato, R., Guido, P., Salerno, F., Resta, O., Spanevello, A., Barbaro, M. F. 2006. Airway inflammation in patients affected by obstructive sleep apnea. Monaldi Archives Chest Disease, 65, 102-105.
• Salerno-Kennedy, R., Cashman, K. D. 2005. Potential applications of breath isoprene as a biomarker in modern medicine. Wiener Klinische Wochenschrift, 117(5-6), 180-186.
• Schlaud, M., Urschitz, M. S., Urschitz-Duprat, P. M., Poets, C. F., Urschitz-Duprat, P. M. 2004. The German study on sleep-disordered breathing in primary school children: Epidemiological approach, representativeness of study sample, and preliminary screening results. Paediatric and Perinatal Epidemiology, 18, 431-440.
• Stone, K. L., Blackwell, T. L., Ancoli-Israel, S., Barrett-Connor, E., Bauer, D. C., Cauley, J. A., Ensrud, K. E., Hofman, A. R., Mehra, R., Stefanick, M. L. 2016. Sleep Disordered Breathing and Risk of Stroke in Older Community-Dwelling Men. Sleep, 39, 531-540.
• Tasaltin, C., Ebeoglu, M. A., Ozturk, Z. Z. 2012. Acoustoelectric effect on the responses of SAW sensors coated with electrospun ZnO nanostructured thin film. Sensors, 12(9), 12006-12015.
• Tasaltin, C., Gurol, I., Harbeck, M., Musluoglu, E., Ahsen, V., Ozturk, Z.Z. 2010. Synthesis and DMMP sensing properties of fluoroalkyloxy and fluoroaryloxy substituted phthalocyanines in acoustic sensors. Sensors and Actuators B: Chemical, 150, 781–787.
• Viespe, C. 2014. Surface Acoustic Wave Sensors based on Nanoporous Films for Hydrogen Detection. Key Engineering Materials, 605, 331-334.
• Yang, L., Yin, C., Zhang, Z., Zhou, J., Xu, H. 2017. The investigation of hydrogen gas sensing properties of SAW gas sensor based on Pd surface modified SnO2 thin film. Materials Science in Semiconductor Process, 60, 16-28.