Rapid Deswelling of PDMAEMA Hydrogel in Response to pH and Temperature Changes and Its Application in Controlled Drug Delivery
Abstract
In this study, poly(2‐dimethylamino)ethyl methacrylate (PDMAEMA) gels were prepared via in situ
polymerization reaction. Synthesized hydrogel was characterized with FTIR spectroscopy and SEM. The
pH‐ and temperature dependentswelling / deswelling behavior was investigated. The hydrogelshowed
highest value of swelling at pH 2. The rising temperature led to a decrease in swelling ratio due to the
fact that hydrophobic interactions between polymer segments become dominant. Furthermore, it was
observed that PDMAEMA hydrogel exhibited rapid deswelling rate in response to temperature and pH.
The drug release profile of PDMAEMA hydrogel has been reported by using Ibuprofen as a model drug.
Abstract
Details
| Subjects | Engineering |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | April 30, 2015 |
| Submission Date | March 18, 2016 |
| Published in Issue | Year 2016 Volume: 16 Issue: 1 |
Cite
Cited By
Magnetic/pH-sensitive nanocomposite hydrogel based on radiation prepared 2-(N, N′-dimethylamino) ethyl methacrylate/chitosan for in vitro drug delivery application
International Journal of Polymeric Materials and Polymeric Biomaterials
https://doi.org/10.1080/00914037.2021.1941955
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