Synthesis and Antimicrobial Evaluation of Novel 5,8-Dibromo-2-O/Ssubstituted-1,4-naphthoquinone Derivatives

Year 2018, Volume: 18 Issue: 2, 451 - 457, 31.08.2018

Kıymet Berkil Akar , Hasan Kılınç

Abstract

Novel bromo- and O/S-substituted-1,4-naphthoquninones (3a-3i) were synthesized via nucleophilic substitution reactions from 2,5,8-tribromo-1,4-naphthoquinone (1). Antimicrobial evaluation of the newly synthesized derivatives was performed using agar spot method. Compounds 3a, 3b, and 3c exhibited the greatest activity with MIC value of 61,25 μg/mL against P. vulgaris, B. cereus and B.subutilis, and B.cereus, respectively. Results revealed that compound 3c has notable activity against all tested microorganisms.

Keywords

1,4-Naphthoquinone, Nucleophilic, substitution, Antimicrobial activity

Yeni 5,8-Dibromo-2-O/S-sübstitüe-1,4-naftakinon Türevlerinin Sentezi ve Antimikrobiyal Aktivitelerinin Değerlendirilmesi

Abstract

2,5,8-Tribromo-l,4-naftokinon’dan (1) nükleofilik sübstitüsyon reaksiyonları ile yeni bromo- ve O/Ssübstitüe-1,4-naftokininon (3a-3i) türevleri sentezlendi. Yeni sentezlenen türevlerin antimikrobiyal olarak incelenmesi agar spot yöntemi kullanılarak gerçekleştirildi. Bileşik 3a, 3b ve 3c sırasıyla P. vulgaris, B. cereus ve B.subutilis, ve B.cereus'a karşı 61,25 ug/mL’lik MIC değeri ile en büyük aktivite sergiledi. Sonuçlar, bileşik 3c'nin test edilen tüm mikroorganizmalara karşı belirgin etkinliğe sahip olduğunu ortaya koymuştur.

Keywords

1,4-Naftakinon, Nükleofilik, yerdeğiştirme, Antimikrobiyal aktivite

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