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Melissa officinalis Ekstraktlarının Antimikrobiyal Aktivitesinin ve DNA Koruyucu Kapasitesinin Araştırılması

Year 2018, Volume: 18 Issue: 3, 757 - 762, 30.12.2018

Abstract

Bu çalışmada, Melissa officinalis yaprak ekstraktlarının antimikrobiyal, antioksidan kapasiteleri ve H2O2-
indüklenmiş oksidatif hasara karşı DNA koruyucu etkisi incelendi. Melissa officinalis yaprak
ekstraktlarının oksidatif stresten DNA'yı koruyucu etkisi maya comet testi kullanılarak belirlendi. Comet
testi Saccharomyces cerevisiae BY4741 üzerinde uygulandı. Oksidatif strese karşı, ekstrenin İnkübasyon
öncesi ve inkubasyon sırasında uygulanmasında doza bağlı olarak DNA hasarında azalma gözlendi.
Sonuçlar; Melissa officinalis methanolik yaprak ekstraktlarının hidrojen peroksitin zararlı etkisine karşı
DNA'yı koruduğunu gösterdi. Ayrıca Melissa officinalis ekstraktlarının farklı mikroorganizmalar
üzerindeki antimikrobiyal etkisi incelendi. Melissa officinalis ekstraktları tüm test mikroorganizmaları
üzerinde antimikrobiyal etki göstermiştir.

References

  • Akyıl, D., Erdoğmuş, S.F., Eren, Y., Özkara, A. and Korcan, S.F., 2013. Potantial antimicrobial and antimutagenic activities of Astragalus flavescens. Fresenius Environmental Bulletin, 22 (7), 1868-1874.
  • Atanassova, M., Georgieva, S. and Ivancheva, K., 2011. Total phenolic and total flavanoid contents, antioxidant capacity and biological components in medicinal herbs. Journal of the University of Chemical Technology Metallurgy, 46, 81-8.
  • Azevedo, F., Marques, F., Fokt, H., Oliveira, R. and Johansson, B., 2011. Measuring oxidative DNA damage and DNA repair using the yeast comet assay. Yeast, 28, 55–61.
  • Babota, M., Andrei, M., Vlase, L., Crisan, O., Lelciu, I., Gheldiu, A.M., Vodnar, D.C., Crisan, G. and Paltinean, R., 2018. Analysis, antioxidant and antimicrobial activities of Helichrysum arenarium (L.) Moench. and Antennaria dioica (L.) Gaertn. Flowers. Molecules, 23,Doi:10.3390/molecules23020409Phytochemi cal.
  • Bauer, A.W., Kirby, W.M., Sherris, J.C. and Jurck, M., 1996. Antibiotic susceptibility testing by a standard single disc method. American Journal of Clinical Pathology, 451, 493-496.
  • Behravan, J., Mosafa, F., Soudmand, N., Taghiabadi, E., Razavi, B.M. and Karimi, G., 2011. Protective effects of aqueous and ethanolic extracts of Portulaca oleracea L. aerial parts on H2O2-induced DNA damage in lymphocytes by comet assay. Journal of Acapunctur and Merdian Studies, 4(3), 193-197.
  • Birdane, Y.O., Büyükokuroğlu, M.E., Birdane, F.M., Cemek, M. and Yavuz, H., 2007. Antiinflammatory and antinociceptive effects of Melissa officinalis L. in rodents. Revista De Medicina Veterinaria, 158(02), 75-81.
  • Canadanovic-Brunet, J., Cetkovic, G., Djilas, S., Tubas, V., Bodanovic, G., Mandic, A., et al. 2008. Radical scavenging, antibacterial and antiproliferative activities of Melissa officinalis L. extracts. Journal of Medicinal Food, 11(1), 133-143.
  • Cortes-Cabrera, A. and Prieto, J.M., 2010. Application of artificial neural networks to the prediction of the antioxidant activity of essential oils in two experimental in vitro models. Food Chemistry, 118(1), 141-146.
  • Ehsani, A., Alizadeh, O., Hashemi, M., Afshari, A. and Aminzare, M., 2017. Phytochemical, antioxidant and antibacterial properties of Melissa officinalis and Dracocephalum moldavica essential oils. Veterinary Research Forum, 8 (3), 223 - 229.
  • Glei, M. and Pool-Zobel, B.L., 2006. The main catechin of green tea, epigallocatechin-3-gallate (EGCG), reduces bleomycin induced DNA damage in human leucocytes. Toxicology in Vitro, 20, 295-300.
  • Hohmann, J., Zupko, I., Redei, D., Csanyi, M., Falkay, G., Mathe, I., et al., 1999. Protective effects of the aerial parts of Salvia officinalis, Melissa officinalis and Lavandula angustifolia and their constituents against enzyme-dependent and enzyme independent lipid peroxidation. Planta Medica, 65, 576- 578.
  • Karadağlı, S.Z., Agrap, B. and Lermioğlu-Erciyas, F., 2014. Investigation of the protective effect of Cinnamomum cassia bark extract against H2O2-induced oxidative DNA damage in human peripheral blood lymphocytes and antioxidant activity. Marmara Pharmacaeutical Journal, 18(1), 43-48.
  • Karuna, R., Reddy, S.S., Baskar, R. and Saralakumari, D., 2009. Antioxidant potential of aqueous extract of Phyllanthus amarus in rats. Indian Journal of Pharmacology, 41, 64-67.
  • Kaur, P., Chandel, M., Kumar, S., Kumar, N., Singh, B. and Kaur, S., 2010. Modulatory role of alizarin from Rubia cordifolia L. against genotoxicity of mutagens. Food and Chemical Toxicology, 48, 320-325.
  • Korcan, S.E., Aksoy, O., Erdoğmuş, S.F., Ciğerci, İ.H. and Konuk, M., 2013. Evaluation of antibacterial, antioxidant and DNA protective capacity of Chenopodium album's ethanolic leaf extract. Chemosphere, 90(2), 374-379.
  • Lopez, V., Martin, S., Gomez-Serranillos, P.M., Carretero, M.E., Jager, A.K. and Calvo, M.I., 2009. Neuroprotective and neurological properties of Melissa officinalis. Neurochemical Research, 34, 1955-1961.
  • Manach, C., Hubert, J., Liorach, R. and Scalbert, A., 2009. The complex links between dietary phytochemicals and human health deciphered by metabolomics. Molecular Nutrition and Food Research, 53, 1303-1315.
  • Marques, F., Azevedo, F., Johansson, B. and Oliveira, R., 2011. Stimulation of DNA repair in Saccharomyces cerevisiae by Ginkgo biloba leaf extract. Food and Chemical Toxicology, 49, 1361–1366.
  • Mazzanti, G., Battinelli, L., Pompeo, C., et al., 2008. Inhibitory activity of Melissa officinalis L. extracts on Herpes simplex virus type 2 replication. Natural Product Research, 22(16), 1433-1440.
  • Okmen, A.S., 2017. Antibacterial activities of Melissa officinalis L. extracts against various Micrococcus species isolated from football player's shoes and its antioxidant activities. Pharmacophore, 8(4), 8-14.
  • Oliveira, R. and Johansson, B., 2012. DNA repair protocols of the series: Quantitative DNA damage and repair measurement with the yeast comet assay. Methots in Molecular Biology, 920, 101-109 .
  • Phalanisong, P., Vichitphan, K., Han, J. and Vichitphan, S., 2018. High antioxidant and phenolic contents related to antibacterial activity against gastrointestinal pathogenic bacteria of some Thaimedicinal plants. Pharmacognosy Journal, 10, 2, 341- 348.
  • Quincozes-Santos, A., Andreazza, A.C., Gonçalves, C.A., Gottfried, C., 2011. Actions of redoxactive compound resveratrol under hydrogen peroxide insult in C6 astroglial cells. Toxicology in Vitro, 24, 916-920.
  • Serpeloni, J.M., Reis, M.B., Rodrigues, J., Santos, L.C., Vilegas, W., Eliana, A., 2008. In vivo assessment of DNA damage and protective effects of extracts from Miconia species using the comet assay and micronucleus test. Mutagenesis, 23(6), 501–507.
  • Topal, U., Sasaki, M., Goto, M., Otles, S., 2008. Chemical compositions and antioxidant properties of essential oils from nine species of Turkish plants obtained by supercritical carbon dioxide extraction and steam distillation. International Journal of Food Sciences Nutrition, 59 (7-8), 619–634.
  • Tosetti, F., Noonan, D.M., Albini, A., 2009. Metabolic regulation and redox activity as mechanisms for angio prevention by dietary phytochemicals. International Journal of Cancer, 125, 1997-2003.
  • Yılmaz, S., Üstundag, A., Cemiloğlu, U.O., Duydu, Y., 2016, Protective effect of boric acid on oxidative DNA damage in Chinese hamster lung fibroblast V79 cell lines. Cell Journal, 17(4), 748-54.
  • Zandi, P., Ahmadi, L., 2000, Antioxidant effect of plant extracts of Labiatae Family. Journal of Food Science and Technology, 37 (4), 436-439.
Year 2018, Volume: 18 Issue: 3, 757 - 762, 30.12.2018

Abstract

References

  • Akyıl, D., Erdoğmuş, S.F., Eren, Y., Özkara, A. and Korcan, S.F., 2013. Potantial antimicrobial and antimutagenic activities of Astragalus flavescens. Fresenius Environmental Bulletin, 22 (7), 1868-1874.
  • Atanassova, M., Georgieva, S. and Ivancheva, K., 2011. Total phenolic and total flavanoid contents, antioxidant capacity and biological components in medicinal herbs. Journal of the University of Chemical Technology Metallurgy, 46, 81-8.
  • Azevedo, F., Marques, F., Fokt, H., Oliveira, R. and Johansson, B., 2011. Measuring oxidative DNA damage and DNA repair using the yeast comet assay. Yeast, 28, 55–61.
  • Babota, M., Andrei, M., Vlase, L., Crisan, O., Lelciu, I., Gheldiu, A.M., Vodnar, D.C., Crisan, G. and Paltinean, R., 2018. Analysis, antioxidant and antimicrobial activities of Helichrysum arenarium (L.) Moench. and Antennaria dioica (L.) Gaertn. Flowers. Molecules, 23,Doi:10.3390/molecules23020409Phytochemi cal.
  • Bauer, A.W., Kirby, W.M., Sherris, J.C. and Jurck, M., 1996. Antibiotic susceptibility testing by a standard single disc method. American Journal of Clinical Pathology, 451, 493-496.
  • Behravan, J., Mosafa, F., Soudmand, N., Taghiabadi, E., Razavi, B.M. and Karimi, G., 2011. Protective effects of aqueous and ethanolic extracts of Portulaca oleracea L. aerial parts on H2O2-induced DNA damage in lymphocytes by comet assay. Journal of Acapunctur and Merdian Studies, 4(3), 193-197.
  • Birdane, Y.O., Büyükokuroğlu, M.E., Birdane, F.M., Cemek, M. and Yavuz, H., 2007. Antiinflammatory and antinociceptive effects of Melissa officinalis L. in rodents. Revista De Medicina Veterinaria, 158(02), 75-81.
  • Canadanovic-Brunet, J., Cetkovic, G., Djilas, S., Tubas, V., Bodanovic, G., Mandic, A., et al. 2008. Radical scavenging, antibacterial and antiproliferative activities of Melissa officinalis L. extracts. Journal of Medicinal Food, 11(1), 133-143.
  • Cortes-Cabrera, A. and Prieto, J.M., 2010. Application of artificial neural networks to the prediction of the antioxidant activity of essential oils in two experimental in vitro models. Food Chemistry, 118(1), 141-146.
  • Ehsani, A., Alizadeh, O., Hashemi, M., Afshari, A. and Aminzare, M., 2017. Phytochemical, antioxidant and antibacterial properties of Melissa officinalis and Dracocephalum moldavica essential oils. Veterinary Research Forum, 8 (3), 223 - 229.
  • Glei, M. and Pool-Zobel, B.L., 2006. The main catechin of green tea, epigallocatechin-3-gallate (EGCG), reduces bleomycin induced DNA damage in human leucocytes. Toxicology in Vitro, 20, 295-300.
  • Hohmann, J., Zupko, I., Redei, D., Csanyi, M., Falkay, G., Mathe, I., et al., 1999. Protective effects of the aerial parts of Salvia officinalis, Melissa officinalis and Lavandula angustifolia and their constituents against enzyme-dependent and enzyme independent lipid peroxidation. Planta Medica, 65, 576- 578.
  • Karadağlı, S.Z., Agrap, B. and Lermioğlu-Erciyas, F., 2014. Investigation of the protective effect of Cinnamomum cassia bark extract against H2O2-induced oxidative DNA damage in human peripheral blood lymphocytes and antioxidant activity. Marmara Pharmacaeutical Journal, 18(1), 43-48.
  • Karuna, R., Reddy, S.S., Baskar, R. and Saralakumari, D., 2009. Antioxidant potential of aqueous extract of Phyllanthus amarus in rats. Indian Journal of Pharmacology, 41, 64-67.
  • Kaur, P., Chandel, M., Kumar, S., Kumar, N., Singh, B. and Kaur, S., 2010. Modulatory role of alizarin from Rubia cordifolia L. against genotoxicity of mutagens. Food and Chemical Toxicology, 48, 320-325.
  • Korcan, S.E., Aksoy, O., Erdoğmuş, S.F., Ciğerci, İ.H. and Konuk, M., 2013. Evaluation of antibacterial, antioxidant and DNA protective capacity of Chenopodium album's ethanolic leaf extract. Chemosphere, 90(2), 374-379.
  • Lopez, V., Martin, S., Gomez-Serranillos, P.M., Carretero, M.E., Jager, A.K. and Calvo, M.I., 2009. Neuroprotective and neurological properties of Melissa officinalis. Neurochemical Research, 34, 1955-1961.
  • Manach, C., Hubert, J., Liorach, R. and Scalbert, A., 2009. The complex links between dietary phytochemicals and human health deciphered by metabolomics. Molecular Nutrition and Food Research, 53, 1303-1315.
  • Marques, F., Azevedo, F., Johansson, B. and Oliveira, R., 2011. Stimulation of DNA repair in Saccharomyces cerevisiae by Ginkgo biloba leaf extract. Food and Chemical Toxicology, 49, 1361–1366.
  • Mazzanti, G., Battinelli, L., Pompeo, C., et al., 2008. Inhibitory activity of Melissa officinalis L. extracts on Herpes simplex virus type 2 replication. Natural Product Research, 22(16), 1433-1440.
  • Okmen, A.S., 2017. Antibacterial activities of Melissa officinalis L. extracts against various Micrococcus species isolated from football player's shoes and its antioxidant activities. Pharmacophore, 8(4), 8-14.
  • Oliveira, R. and Johansson, B., 2012. DNA repair protocols of the series: Quantitative DNA damage and repair measurement with the yeast comet assay. Methots in Molecular Biology, 920, 101-109 .
  • Phalanisong, P., Vichitphan, K., Han, J. and Vichitphan, S., 2018. High antioxidant and phenolic contents related to antibacterial activity against gastrointestinal pathogenic bacteria of some Thaimedicinal plants. Pharmacognosy Journal, 10, 2, 341- 348.
  • Quincozes-Santos, A., Andreazza, A.C., Gonçalves, C.A., Gottfried, C., 2011. Actions of redoxactive compound resveratrol under hydrogen peroxide insult in C6 astroglial cells. Toxicology in Vitro, 24, 916-920.
  • Serpeloni, J.M., Reis, M.B., Rodrigues, J., Santos, L.C., Vilegas, W., Eliana, A., 2008. In vivo assessment of DNA damage and protective effects of extracts from Miconia species using the comet assay and micronucleus test. Mutagenesis, 23(6), 501–507.
  • Topal, U., Sasaki, M., Goto, M., Otles, S., 2008. Chemical compositions and antioxidant properties of essential oils from nine species of Turkish plants obtained by supercritical carbon dioxide extraction and steam distillation. International Journal of Food Sciences Nutrition, 59 (7-8), 619–634.
  • Tosetti, F., Noonan, D.M., Albini, A., 2009. Metabolic regulation and redox activity as mechanisms for angio prevention by dietary phytochemicals. International Journal of Cancer, 125, 1997-2003.
  • Yılmaz, S., Üstundag, A., Cemiloğlu, U.O., Duydu, Y., 2016, Protective effect of boric acid on oxidative DNA damage in Chinese hamster lung fibroblast V79 cell lines. Cell Journal, 17(4), 748-54.
  • Zandi, P., Ahmadi, L., 2000, Antioxidant effect of plant extracts of Labiatae Family. Journal of Food Science and Technology, 37 (4), 436-439.
There are 29 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Safiye Elif Korcan This is me

Bilgi Aksoy This is me

Sevim Feyza Erdoğmuş

İbrahim Hakkı Ciğerci This is me

Publication Date December 30, 2018
Submission Date January 10, 2018
Published in Issue Year 2018 Volume: 18 Issue: 3

Cite

APA Korcan, S. E., Aksoy, B., Erdoğmuş, S. F., Ciğerci, İ. H. (2018). Melissa officinalis Ekstraktlarının Antimikrobiyal Aktivitesinin ve DNA Koruyucu Kapasitesinin Araştırılması. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi, 18(3), 757-762.
AMA Korcan SE, Aksoy B, Erdoğmuş SF, Ciğerci İH. Melissa officinalis Ekstraktlarının Antimikrobiyal Aktivitesinin ve DNA Koruyucu Kapasitesinin Araştırılması. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi. December 2018;18(3):757-762.
Chicago Korcan, Safiye Elif, Bilgi Aksoy, Sevim Feyza Erdoğmuş, and İbrahim Hakkı Ciğerci. “Melissa Officinalis Ekstraktlarının Antimikrobiyal Aktivitesinin Ve DNA Koruyucu Kapasitesinin Araştırılması”. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 18, no. 3 (December 2018): 757-62.
EndNote Korcan SE, Aksoy B, Erdoğmuş SF, Ciğerci İH (December 1, 2018) Melissa officinalis Ekstraktlarının Antimikrobiyal Aktivitesinin ve DNA Koruyucu Kapasitesinin Araştırılması. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 18 3 757–762.
IEEE S. E. Korcan, B. Aksoy, S. F. Erdoğmuş, and İ. H. Ciğerci, “Melissa officinalis Ekstraktlarının Antimikrobiyal Aktivitesinin ve DNA Koruyucu Kapasitesinin Araştırılması”, Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi, vol. 18, no. 3, pp. 757–762, 2018.
ISNAD Korcan, Safiye Elif et al. “Melissa Officinalis Ekstraktlarının Antimikrobiyal Aktivitesinin Ve DNA Koruyucu Kapasitesinin Araştırılması”. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 18/3 (December 2018), 757-762.
JAMA Korcan SE, Aksoy B, Erdoğmuş SF, Ciğerci İH. Melissa officinalis Ekstraktlarının Antimikrobiyal Aktivitesinin ve DNA Koruyucu Kapasitesinin Araştırılması. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi. 2018;18:757–762.
MLA Korcan, Safiye Elif et al. “Melissa Officinalis Ekstraktlarının Antimikrobiyal Aktivitesinin Ve DNA Koruyucu Kapasitesinin Araştırılması”. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi, vol. 18, no. 3, 2018, pp. 757-62.
Vancouver Korcan SE, Aksoy B, Erdoğmuş SF, Ciğerci İH. Melissa officinalis Ekstraktlarının Antimikrobiyal Aktivitesinin ve DNA Koruyucu Kapasitesinin Araştırılması. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi. 2018;18(3):757-62.