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Determination of the Phytochemical Profiles of Some Hawthorn Taxa Naturally Distributed in Afyonkarahisar

Year 2025, Volume: 25 Issue: 2, 240 - 244

Abstract

Different tissues of species belonging to the Crataegus L. genus of the Rosaceae family, are used in traditional and modern medicine to treat various diseases. Although there are studies on the phenolic compound contents of different Crataegus taxa, their phytochemical components and amounts vary in the regions where they grow naturally. In this study, the phenolic compound contents of five different hawthorn taxa collected from the Central district of Afyonkarahisar province were analyzed by High Performance Liquid Chromatography (HPLC). While the main component in C. monogyna and C. microphylla taxa is (+)−catechin, 1,2−dihydroxybenzene was determined as the main phenolic compound in C. orientalis subsp. szovitsii, C. tanacetifolia and C. orientalis subsp. orientalis taxa. However, naringenin was the phenolic compound detected in the lowest amount in all taxa. The differences determined in the phenolic compound content and amounts in Crataegus taxa are due to the ecological characteristics of the areas where plant tissue samples were taken.

Project Number

18.FEN.BİL.04

References

  • Adnan, A., 2011. Molecular cloning, expression, purification and characterization of the zebrafish catechol-O-methyltransferases. Theses and Dissertations, 503, 1-53.
  • Antoci, V., Mantu, D., Cozma, D.G., Usru, C. and Mangalagiu, I.I., 2014. Hybrid anticancer 1,2-diazine derivatives with multiple mechanism of action. Medical Hypotheses, 82(1), 11-15. https://doi.org/10.1016/j.mehy.2013.10.024
  • Attard, E. and Attard, H., 2019. Nonvitamin and Nonmineral Nutritional Supplements. Nabavi, S.M. and Silva, A.S., Academic Press, 289-293.
  • Belkhir, M., Rebai, O., Dhaouadi, K., Congiu, F., Tuberoso, C.I.G., Amri, M. and Fattouch, S., 2013. Comparative analysis of Tunisian wild Crataegus azarolus (Yellow Azarole) and Crataegus monogyna (Red Azarole) leaf, fruit, and traditionally derived syrup: phenolic profiles and antioxidant and antimicrobial activities of the aqueous-acetone extracts. Journal of Agricultural and Food Chemistry, 61, 9594-9601. https://doi.org/10.1021/jf402874z
  • Bahorun, T., Aumjaud, E., Ramphul, H., Rycha, M., Luximon‐Ramma, A., Trotin, F. and Aruoma, O.I. 2003. Phenolic constituents and antioxidant capacities of Crataegus monogyna (Hawthorn) callus extracts. Food/Nahrung, 47, 191-198. https://doi.org/10.1002/food.200390045
  • Beğen, H.A. and Eminağaoğlu, Ö., 2022. Türkiye Rosaceae familyasına yeni cinsler (Aria, Hedlundia, Torminalis) ile taksonomik katkılar. Turkish Journal of Biodiversity, 5, 36−49. https://doi.org/10.38059/biodiversity.1090331
  • Cadena-Iñiguez, J., Santiago-Osorio, E., Sánchez-Flores, N., Salazar-Aguilar, S., Soto-Hernández, R.M., Riviello-Flores, M.d.l.L., Macías-Zaragoza, V.M. and Aguiñiga-Sánchez, I., 2024. The cancer-protective potential of protocatechuic acid: A narrative review. Molecules, 29(7), 1439. https://doi.org/10.3390/molecules29071439
  • Cloud, A., Vilcins, D. and McEwen, B., 2019. The effect of hawthorn (Crataegus spp.) on blood pressure: a systematic review. Advances in Integrative Medicine, 7, 167–75. https://doi.org/10.1016/j.aimed.2019.09.002
  • Doğan, A., Bulut, G., Senkardes, I. and Tuzlacı, E., 2016. An ethnopharmacological analysis of Rosaceae taxa in Turkey. In WEI International Academic Conference Proceedings. Boston, USA, 51. Hürkul, M.M. and Köroğlu, A., 2019. A ethnobotanical review: The subfamily amygdaloideae (Rosaceae). Fabad Journal of Pharmaceutical Sciences, 44, 35-46.
  • Karar, M.G.E., Pletzer, D., Jaiswal, R., Weingart, H. and Kuhnert, N., 2014. Identification, characterization, isolation and activity against Escherichia coli of quince (Cydonia oblonga) fruit polyphenols. Food Research International, 65, 121-129. https://doi.org/10.1016/j.foodres.2013.10.040
  • Karar, M.G.E. and Kuhnert, N., 2015. UPLC-ESI-Q-TOF-MS/MS Characterization of phenolics from Crataegus monogyna and Crataegus laevigata (Hawthorn) leaves, fruits and their herbal derived drops (Crataegutt Tropfen). Journal of Chemical Biology and Therapeutics, 1, 102. https://doi.org/10.4172/2572-0406.1000102
  • Lin, H.-H., Chen, J.-H., Huang, C.-C. and Wang, C.-J., 2007. Apoptotic Effect of 3,4-dihydroxybenzoic acid on human gastric carcinoma cells involving JNK/p38 MAPK signaling activation. International Journal of Cancer, 120, 2306–2316. https://doi.org/10.1002/ijc.22571
  • Melikoğlu, G., Bitiş, L. and Meriçli, A.H., 2004. Flavonoids of Crataegus microphylla. Natural Product Research, 18, 211-213. https://doi.org/10.1080/14786410310001620673
  • Musial, C., Kuban-Jankowska, A. and Gorska-Ponikowska, M., 2020. Beneficial properties of green tea catechins. International Journal of Molecular Sciences, 21(5), 1744. https://doi.org/10.3390/ijms21051744
  • Nazhand, A., Lucarini, M., Durazzo, A., Zaccardelli, M., Cristarella, S., Souto, S.B. and Santini, A., 2020. Hawthorn (Crataegus spp.): An updated overview on its beneficial properties. Forests, 11, 564. https://doi.org/10.3390/f11050564
  • Shi, G.F., An, L.J., Jiang, B., Guan, S. and Bao, Y.M., 2006. Alpinia protocatechuic acid protects against oxidative damage in vitro and reduces oxidative stress in vivo. Neuroscience Letters, 403, 206–210. https://doi.org/10.1016/j.neulet.2006.02.057
  • Singh, B.N., Shankar, S. and Srivastava, R.K., 2011. Green tea catechin, epigallocatechin-3-gallate (EGCg), mechanisms, perspectives and clinical applications. Biochemical Pharmacology, 82, 1807–1821. https://doi.org/10.1016/j.bcp.2011.07.093
  • Svedström, U., Vuorela, H., Kostiainen, R., Huovinen, K., Laakso, I. and Hiltunen, R., 2002. High-performance liquid chromatographic determination of oligomeric procyanidins from dimers up to the hexamer in hawthorn. Journal of Chromatography A, 968, 53–60. https://doi.org/10.1016/S0021-9673(02)01000-2
  • Tajali, A.A. and Khazaeipool, M., 2012. Effects of height and organs on Flavonoits of Crataegus microphylla C. Koch in Iran. International Journal of Biosciences, 2, 54–58.
  • Yang, B. and Liu, P., 2012. Composition and health effects of phenolic compounds in hawthorn (Crataegus spp.) of different origins. Journal of the Science of Food and Agriculture, 92, 1578–90. https://doi.org/10.1002/jsfa.5671

Afyonkarahisar’da Doğal Olarak Yayılış Gösteren Bazı Alıç Taksonlarının Fitokimyasal Profillerinin Belirlenmesi

Year 2025, Volume: 25 Issue: 2, 240 - 244

Abstract

Rosaceae familyasının Crataegus L. cinsine ait türlerin farklı dokuları geleneksel ve modern tıpta çeşitli hastalıkları tedavi etmek amacıyla kullanılmaktadır. Farklı Crataegus taksonlarının fenolik bileşik içerikleri hakkında yapılan çalışmalar bulunsa da bitkilerin doğal olarak yetiştikleri bölgelerde fitokimyasal bileşenleri ve miktarları değişmektedir. Bu araştırmada, Afyonkarahisar ili Merkez ilçesinden toplanan beş farklı alıç taksonunda fenolik bileşik içeriği Yüksek Performanslı Sıvı Kromatografisi (HPLC) ile analiz edilmiştir. C. monogyna’da ve C. microphylla taksonlarında esas bileşen (+)−kateşin olarak belirlenirken, C. orientalis subsp. szovitsii, C. tanacetifolia ve C. orientalis subsp. orientalis taksonlarında 1,2−dihidroksibenzenin esas fenolik bileşik olarak tespit edilmiştir. Bununla birlikte, tüm taksonlarda naringenin en az miktarda tespit edilen fenolik bileşik olmuştur. Crataegus taksonlarında fenolik bileşik içeriği ve miktarlarında belirlenen farklılıklar bitki dokusu örneklerinin alındığı alanların ekolojik özelliklerinden kaynaklanmaktadır.

Project Number

18.FEN.BİL.04

References

  • Adnan, A., 2011. Molecular cloning, expression, purification and characterization of the zebrafish catechol-O-methyltransferases. Theses and Dissertations, 503, 1-53.
  • Antoci, V., Mantu, D., Cozma, D.G., Usru, C. and Mangalagiu, I.I., 2014. Hybrid anticancer 1,2-diazine derivatives with multiple mechanism of action. Medical Hypotheses, 82(1), 11-15. https://doi.org/10.1016/j.mehy.2013.10.024
  • Attard, E. and Attard, H., 2019. Nonvitamin and Nonmineral Nutritional Supplements. Nabavi, S.M. and Silva, A.S., Academic Press, 289-293.
  • Belkhir, M., Rebai, O., Dhaouadi, K., Congiu, F., Tuberoso, C.I.G., Amri, M. and Fattouch, S., 2013. Comparative analysis of Tunisian wild Crataegus azarolus (Yellow Azarole) and Crataegus monogyna (Red Azarole) leaf, fruit, and traditionally derived syrup: phenolic profiles and antioxidant and antimicrobial activities of the aqueous-acetone extracts. Journal of Agricultural and Food Chemistry, 61, 9594-9601. https://doi.org/10.1021/jf402874z
  • Bahorun, T., Aumjaud, E., Ramphul, H., Rycha, M., Luximon‐Ramma, A., Trotin, F. and Aruoma, O.I. 2003. Phenolic constituents and antioxidant capacities of Crataegus monogyna (Hawthorn) callus extracts. Food/Nahrung, 47, 191-198. https://doi.org/10.1002/food.200390045
  • Beğen, H.A. and Eminağaoğlu, Ö., 2022. Türkiye Rosaceae familyasına yeni cinsler (Aria, Hedlundia, Torminalis) ile taksonomik katkılar. Turkish Journal of Biodiversity, 5, 36−49. https://doi.org/10.38059/biodiversity.1090331
  • Cadena-Iñiguez, J., Santiago-Osorio, E., Sánchez-Flores, N., Salazar-Aguilar, S., Soto-Hernández, R.M., Riviello-Flores, M.d.l.L., Macías-Zaragoza, V.M. and Aguiñiga-Sánchez, I., 2024. The cancer-protective potential of protocatechuic acid: A narrative review. Molecules, 29(7), 1439. https://doi.org/10.3390/molecules29071439
  • Cloud, A., Vilcins, D. and McEwen, B., 2019. The effect of hawthorn (Crataegus spp.) on blood pressure: a systematic review. Advances in Integrative Medicine, 7, 167–75. https://doi.org/10.1016/j.aimed.2019.09.002
  • Doğan, A., Bulut, G., Senkardes, I. and Tuzlacı, E., 2016. An ethnopharmacological analysis of Rosaceae taxa in Turkey. In WEI International Academic Conference Proceedings. Boston, USA, 51. Hürkul, M.M. and Köroğlu, A., 2019. A ethnobotanical review: The subfamily amygdaloideae (Rosaceae). Fabad Journal of Pharmaceutical Sciences, 44, 35-46.
  • Karar, M.G.E., Pletzer, D., Jaiswal, R., Weingart, H. and Kuhnert, N., 2014. Identification, characterization, isolation and activity against Escherichia coli of quince (Cydonia oblonga) fruit polyphenols. Food Research International, 65, 121-129. https://doi.org/10.1016/j.foodres.2013.10.040
  • Karar, M.G.E. and Kuhnert, N., 2015. UPLC-ESI-Q-TOF-MS/MS Characterization of phenolics from Crataegus monogyna and Crataegus laevigata (Hawthorn) leaves, fruits and their herbal derived drops (Crataegutt Tropfen). Journal of Chemical Biology and Therapeutics, 1, 102. https://doi.org/10.4172/2572-0406.1000102
  • Lin, H.-H., Chen, J.-H., Huang, C.-C. and Wang, C.-J., 2007. Apoptotic Effect of 3,4-dihydroxybenzoic acid on human gastric carcinoma cells involving JNK/p38 MAPK signaling activation. International Journal of Cancer, 120, 2306–2316. https://doi.org/10.1002/ijc.22571
  • Melikoğlu, G., Bitiş, L. and Meriçli, A.H., 2004. Flavonoids of Crataegus microphylla. Natural Product Research, 18, 211-213. https://doi.org/10.1080/14786410310001620673
  • Musial, C., Kuban-Jankowska, A. and Gorska-Ponikowska, M., 2020. Beneficial properties of green tea catechins. International Journal of Molecular Sciences, 21(5), 1744. https://doi.org/10.3390/ijms21051744
  • Nazhand, A., Lucarini, M., Durazzo, A., Zaccardelli, M., Cristarella, S., Souto, S.B. and Santini, A., 2020. Hawthorn (Crataegus spp.): An updated overview on its beneficial properties. Forests, 11, 564. https://doi.org/10.3390/f11050564
  • Shi, G.F., An, L.J., Jiang, B., Guan, S. and Bao, Y.M., 2006. Alpinia protocatechuic acid protects against oxidative damage in vitro and reduces oxidative stress in vivo. Neuroscience Letters, 403, 206–210. https://doi.org/10.1016/j.neulet.2006.02.057
  • Singh, B.N., Shankar, S. and Srivastava, R.K., 2011. Green tea catechin, epigallocatechin-3-gallate (EGCg), mechanisms, perspectives and clinical applications. Biochemical Pharmacology, 82, 1807–1821. https://doi.org/10.1016/j.bcp.2011.07.093
  • Svedström, U., Vuorela, H., Kostiainen, R., Huovinen, K., Laakso, I. and Hiltunen, R., 2002. High-performance liquid chromatographic determination of oligomeric procyanidins from dimers up to the hexamer in hawthorn. Journal of Chromatography A, 968, 53–60. https://doi.org/10.1016/S0021-9673(02)01000-2
  • Tajali, A.A. and Khazaeipool, M., 2012. Effects of height and organs on Flavonoits of Crataegus microphylla C. Koch in Iran. International Journal of Biosciences, 2, 54–58.
  • Yang, B. and Liu, P., 2012. Composition and health effects of phenolic compounds in hawthorn (Crataegus spp.) of different origins. Journal of the Science of Food and Agriculture, 92, 1578–90. https://doi.org/10.1002/jsfa.5671
There are 20 citations in total.

Details

Primary Language Turkish
Subjects Ecology (Other)
Journal Section Articles
Authors

Melek Korkut 0000-0002-8105-3846

Ahmet Serteser 0000-0003-2792-7239

Mustafa Kargıoğlu 0000-0003-0386-9716

Saliha Aydın 0000-0002-7830-0535

Hakan Terzi 0000-0003-4817-1100

Mustafa Yıldız 0000-0002-6819-9891

Project Number 18.FEN.BİL.04
Early Pub Date March 28, 2025
Publication Date
Submission Date June 7, 2024
Acceptance Date October 24, 2024
Published in Issue Year 2025 Volume: 25 Issue: 2

Cite

APA Korkut, M., Serteser, A., Kargıoğlu, M., Aydın, S., et al. (2025). Afyonkarahisar’da Doğal Olarak Yayılış Gösteren Bazı Alıç Taksonlarının Fitokimyasal Profillerinin Belirlenmesi. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi, 25(2), 240-244.
AMA Korkut M, Serteser A, Kargıoğlu M, Aydın S, Terzi H, Yıldız M. Afyonkarahisar’da Doğal Olarak Yayılış Gösteren Bazı Alıç Taksonlarının Fitokimyasal Profillerinin Belirlenmesi. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi. March 2025;25(2):240-244.
Chicago Korkut, Melek, Ahmet Serteser, Mustafa Kargıoğlu, Saliha Aydın, Hakan Terzi, and Mustafa Yıldız. “Afyonkarahisar’da Doğal Olarak Yayılış Gösteren Bazı Alıç Taksonlarının Fitokimyasal Profillerinin Belirlenmesi”. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 25, no. 2 (March 2025): 240-44.
EndNote Korkut M, Serteser A, Kargıoğlu M, Aydın S, Terzi H, Yıldız M (March 1, 2025) Afyonkarahisar’da Doğal Olarak Yayılış Gösteren Bazı Alıç Taksonlarının Fitokimyasal Profillerinin Belirlenmesi. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 25 2 240–244.
IEEE M. Korkut, A. Serteser, M. Kargıoğlu, S. Aydın, H. Terzi, and M. Yıldız, “Afyonkarahisar’da Doğal Olarak Yayılış Gösteren Bazı Alıç Taksonlarının Fitokimyasal Profillerinin Belirlenmesi”, Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi, vol. 25, no. 2, pp. 240–244, 2025.
ISNAD Korkut, Melek et al. “Afyonkarahisar’da Doğal Olarak Yayılış Gösteren Bazı Alıç Taksonlarının Fitokimyasal Profillerinin Belirlenmesi”. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi 25/2 (March 2025), 240-244.
JAMA Korkut M, Serteser A, Kargıoğlu M, Aydın S, Terzi H, Yıldız M. Afyonkarahisar’da Doğal Olarak Yayılış Gösteren Bazı Alıç Taksonlarının Fitokimyasal Profillerinin Belirlenmesi. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi. 2025;25:240–244.
MLA Korkut, Melek et al. “Afyonkarahisar’da Doğal Olarak Yayılış Gösteren Bazı Alıç Taksonlarının Fitokimyasal Profillerinin Belirlenmesi”. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi, vol. 25, no. 2, 2025, pp. 240-4.
Vancouver Korkut M, Serteser A, Kargıoğlu M, Aydın S, Terzi H, Yıldız M. Afyonkarahisar’da Doğal Olarak Yayılış Gösteren Bazı Alıç Taksonlarının Fitokimyasal Profillerinin Belirlenmesi. Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi. 2025;25(2):240-4.